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Diisobutyl Phthalate (DIBP) Final

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514 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Occurrence and Profiles of Phthalates in Foodstuffs from China and Their Implications for Human Exposure

Authors: Guo, Y; Zhang, Z; Liu, L; Li, Y; Ren, N; Kannan, K (In Press) Journal of Agricultural and Food Chemistry. HERO ID: 1311703

[Less] Phthalate esters are used in a wide variety of consumer products, and human exposure to this class of . . . [More] Phthalate esters are used in a wide variety of consumer products, and human exposure to this class of compounds is widespread. Nevertheless, studies on dietary exposure of humans to phthalates are limited. In this study, nine phthalate esters were analyzed in eight categories of foodstuffs (n = 78) collected from Harbin and Shanghai, China, in 2011. Dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), benzyl butyl phthalate (BzBP), and diethylhexyl phthalate (DEHP) were frequently detected in food samples. DEHP was the major compound found in most of the food samples, with concentrations that ranged from below the limit of quantification (LOQ) to 762 ng/g wet weight (wt). The concentrations of phthalates in food samples from China were comparable to concentrations reported for several other countries, but the profiles were different; DMP was found more frequently in Chinese foods than in foods from other countries. The estimated daily dietary intake of phthalates (EDI(diet)) was calculated based on the concentrations measured and the daily ingestion rates of food items. The EDI(diet) values for DMP, DEP, DIBP, DBP, BzBP, and DEHP (based on mean concentrations) were 0.092, 0.051, 0.505, 0.703, 0.022, and 1.60 μg/kg-bw/d, respectively, for Chinese adults. The EDI(diet) values calculated for phthalates were below the reference doses suggested by the United States Environmental Protection Agency (EPA). Comparison of total daily intakes, reported previously based on a biomonitoring study, with the current dietary intake estimates suggests that diet is the main source of DEHP exposure in China. Nevertheless, diet accounted for only <10% of the total exposure to DMP, DEP, DBP, and DIBP, which suggested the existence of other sources of exposure to these phthalates.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Assessment of chemical coexposure patterns based upon phthalate biomonitoring data within the 2007/2008 National Health and Nutrition Examination Survey

Authors: Qian, H; Chen, M; Kransler, KM; Zaleski, RT (2015) Journal of Exposure Science and Environmental Epidemiology 25:249-255. HERO ID: 2345931

[Less] As regulatory initiatives increasingly call for an understanding of the cumulative risks from chemical . . . [More] As regulatory initiatives increasingly call for an understanding of the cumulative risks from chemical mixtures, evaluating exposure data from large biomonitoring programs, which may inform these cumulative risk assessments, will improve the understanding of occurrence and patterns of coexposures. Here we have analyzed the urinary metabolite data for six phthalates (di-butyl phthalate; di-isobutyl phthalate; butyl-benzyl phthalate; bis(2-ethylhexyl) phthalate; di-isononyl phthalate; and di-isodecyl phthalate) in the 2007/2008 National Health and Nutrition Examination Survey (NHANES) data set. For the total data set (N=2604), the co-occurrence of multiple phthalates at the upper percentile of exposure was infrequent. There were no individuals in the NHANES sample who were exposed to >95th percentiles for all six phthalates. For 75% of individuals, none of the six phthalates were above the 95th percentile of their respective exposure distributions. These data suggest that high exposure to multiple phthalates is infrequent in the NHANES population. This analysis solely focused on the pattern of contribution of individual phthalates to total exposure. It did not address the pattern of contribution to potential risk. The approach presented could potentially be used to provide insight into understanding the coexposure patterns for other chemicals.Journal of Exposure Science and Environmental Epidemiology advance online publication, 23 April 2014; doi:10.1038/jes.2014.24.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Single dose ivabradine versus intravenous metoprolol for heart rate reduction before coronary computed tomography angiography (CCTA) in patients receiving long-term calcium channel-blocker therapy

Authors: Celik, O; Atasoy, M; Ertürk, M; Yalçin, A; Aksu, H; Diker, M; Aktürk, I; Atasoy, I (2014) Acta Radiologica. HERO ID: 2241694

[Less] BACKGROUND: In patients with contraindication for beta-blockers who are also under . . . [More] BACKGROUND: In patients with contraindication for beta-blockers who are also under long-term calcium channel-blocker therapy for any reason, ivabradine may be used as an alternative treatment to achieve the target heart rate.

PURPOSE: To assess whether single dose oral ivabradine in patients referred for coronary computed tomography angiography (CCTA) is safe and can significantly decrease heart rate compared to intravenous (i.v.) metoprolol in patients receiving long-term calcium channel-blocker therapy.

MATERIAL AND METHODS: One-hundred and twenty patients who were under calcium channel-blocker therapy referred for CCTA were randomized to premedication with single dose (15 mg) ivabradine (n = 63) or i.v. metoprolol (5-10 mg) (n = 62). Hearth rate (HR) was assessed at admission (HR1), prescan (HR2), and during CCTA scan (HR3) for all patients. Blood pressure (BP) was measured before medication (BP1) and immediately before CCTA scan (BP2).

RESULTS: Although the HR averages of two groups were not significantly different before medication (HRIv1 = 80 ± 7 bpm vs. HRβ1 = 81 ± 7 bpm; P = 0.42), significant HR reduction was observed in the ivabradine group (HRIv3 = 62 ± 7 bpm) when compared to the metoprolol group (HRβ3 = 66 ± 6 bpm; P = 0.001). Decreases in HR forivabradine (18 ± 6 bpm) was significantly higher than for metoprolol (15 ± 4 bpm; P = 0.003) without relevant side-effects. Ivabradine showed no significant effect on either systolic BP or diastolic BP (siBPIv1, 139 ± 10; siBPIv2, 138 ± 10; P = 0.260; diBPIv1, 81 ± 7; diBPIv2, 81 ± 6; P = 0.59). Nevertheless, metoprolol group demonstrated significant reduction in both SiBP and DiBP (siBPβ1, 136 ± 11; siBPβ2 130 ± 11; P < 0.001; diBPβ1, 81 ± 6; diBPβ2, 78 ± 6; P < 0.001).

CONCLUSION: Single dose ivabradine is safe and significantly more effective than i.v. metoprolol in decreasing HR in patients under calcium channel-blocker therapy.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Contamination of Polyvinyl Chloride Cling Films from Cardboard Packaging

Authors: Guazzotti, V; Piergiovanni, L; Vestrucci, G; Limbo, S (2014) Packaging Technology and Science 27:17-27. HERO ID: 2242992

[Less] An analytical screening was undertaken with the aim of investigating the occurrence of di-isobutylphthalate . . . [More] An analytical screening was undertaken with the aim of investigating the occurrence of di-isobutylphthalate (DIBP) in polyvinyl chloride (PVC) cling films for food contact applications and its source of contamination throughout a converting process. Although raw plastic materials used by producers are free from phthalates and analytical evidences confirm their absence after the extrusion process, DIBP can be found in final rolls packaged into cardboard packaging during storage. A solvent extraction Gas Chromatography/Mass Spectrometry (GC/MS) analysis was applied on several intermediate products and at different stages taken from the converting process, with the aim of identifying the source of contamination. Different cardboard cores and folding cardboards made of recycled fibres were analyzed, and some of them resulted highly contaminated by DIBP. The storage of final cling films with these materials increased DIBP transfer into PVC. To investigate the possible DIBP transfer mechanism from contaminated paper and adsorption by plastic materials through the gas phase, kinetic experiments were performed in a model system. Results obtained at 20 degrees C, 30 degrees C and 40 degrees C showed a considerable uptake of DIBP into PVC; Weibull model parameters estimated from the experimental data suggested an initial rate of the process dependent on temperature. In addition, to evaluate the partitioning behaviour, adsorption isotherms of DIBP into paper, PVC and low low density polyethylene (LLDPE) cling film were obtained at 40 degrees C. Copyright (c) 2012 John Wiley & Sons, Ltd.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The Role of Two Different Internal Donors (Phthalate and 1,3-Diether) on the Formation of Surface Structure in MgCl2-Supported Ziegler-Natta Catalysts and Their Catalytic Performance of Propylene Polymerization

Authors: Song, BoG; Ihm, S (2014) Journal of Applied Polymer Science 131. HERO ID: 2347852

[Less] The role of two different internal donors [a phthalate (diisobutylphthalate) and a 1,3-diether (2,2-diisobutyl-1,3-dimethoxypropane)] . . . [More] The role of two different internal donors [a phthalate (diisobutylphthalate) and a 1,3-diether (2,2-diisobutyl-1,3-dimethoxypropane)] on the formation of surface structure in MgCl2-supported Ziegler-Natta catalysts and their catalytic performance of propylene polymerization was investigated by comparing and correlating the catalyst structures and the polymerization characteristics. In the catalyst formation, the 1,3-diether had better affinity for the MgCl2 surface than the phthalate and the 1,3-diether generated the (110) surface more than the (104) surface while the phthalate generated both the (110) and (104) surfaces of MgCl2. With both donors introduced, the (110) and (104) surfaces were generated simultaneously, although the (110) surface was dominant due to the higher affinity via the 1,3-diether. In addition, it seemed probable that the active sites formed on the (110) plane showed isospecific characteristics in the presence of a donor while those formed on the (104) plane could be isospecific regardless of a donor. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40536.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Rapid Screening of Trace Phthalate Estersin-Wine Using Ion Mobility Spectrometry

Authors: Peng Li-Ying; Wang Wei-Guo; Wang Xin; Chen Wen-Dong; Chen Chuang; Cheng Sha-Sha; Liang Xi-Xi; Zhou Qing-Hua; Li Jing-Hua; Li Hai-Yang (2014) Chinese Journal of Analytical Chemistry / Fen Xi Hua Xue 42:278-282. HERO ID: 2347867

[Less] Phthalic acid ester is a kind of common environmental pollutants. Here, a method for fast screening . . . [More] Phthalic acid ester is a kind of common environmental pollutants. Here, a method for fast screening trace phthalic acid ester in wine was constructed based on ion mobility spectrometry (IMS). Tube temperature and inlet temperature were optimized, and five typical phthalic acid esters were detected successively. Under the optimal tube temperature of 90 degrees C and inlet temperature of 160 degrees C, the limits of detection for dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP) and diethylhexyl phthalate (DEHP) are 0.14, 0.06, 0.14, 0.44 and 0.02 mg/L, respectively, and the relative standard deviation (RSD) of 9 times measurements are less than 8.9%. The analytical time for single sample is less than 95 s. At last, five types of white wines were analyzed and the suspicious problem samples were successfully screened. And a home. made ion trap mass spectrometer was used to verify the product ions of phthalic acid ester detected by IMS and the interferences in wines can be avoided with acetone as dopant. The results demonstrate that the IMS can be used for rapid screening of trace phthalate esters in wine.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Optimisation of an analytical method and results from the inter-laboratory comparison of the migration of regulated substances from food packaging into the new mandatory European Union simulant for dry foodstuffs

Authors: Jakubowska, N; Beldì, G; Peychès Bach, A; Simoneau, C (2014) Food Additives & Contaminants: Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment. HERO ID: 2241690

[Less] This paper presents the outcome of the development, optimisation and validation at European Union level . . . [More] This paper presents the outcome of the development, optimisation and validation at European Union level of an analytical method for using poly(2,6-diphenyl phenylene oxide - PPPO), which is stipulated in Regulation (EU) No. 10/2011, as food simulant E for testing specific migration from plastics into dry foodstuffs. Two methods for fortifying respectively PPPO and a low-density polyethylene (LDPE) film with surrogate substances that are relevant to food contact were developed. A protocol for cleaning the PPPO and an efficient analytical method were developed for the quantification of butylhydroxytoluene (BHT), benzophenone (BP), diisobutylphthalate (DiBP), bis(2-ethylhexyl) adipate (DEHA) and 1,2-cyclohexanedicarboxylic acid, diisononyl ester (DINCH) from PPPO. A protocol for a migration test from plastics using small migration cells was also developed. The method was validated by an inter-laboratory comparison (ILC) with 16 national reference laboratories for food contact materials in the European Union. This allowed for the first time data to be obtained on the precision and laboratory performance of both migration and quantification. The results showed that the validation ILC was successful even when taking into account the complexity of the exercise. The results showed that the method performance was 7-9% repeatability standard deviation (rSD) for most substances (regardless of concentration), with 12% rSD for the high level of BHT and for DiBP at very low levels. The reproducibility standard deviation results for the 16 European Union laboratories were in the range of 20-30% for the quantification from PPPO (for the three levels of concentrations of the five substances) and 15-40% from migration experiments from the fortified plastic at 60°C for 10 days and subsequent quantification. Considering the lack of data previously available in the literature, this work has demonstrated that the validation of a method is possible both for migration from a film and for quantification into a corresponding simulant for specific migration.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Phthalate metabolites in urine and asthma, allergic rhinoconjunctivitis and atopic dermatitis in preschool children

Authors: Callesen, M; Bekö, G; Weschler, CJ; Langer, S; Brive, L; Clausen, G; Toftum, J; Sigsgaard, T; Høst, A; Jensen, TK (2014) International Journal of Hygiene and Environmental Health 217:645-652. HERO ID: 2241691

[Less] Phthalate esters are among the most ubiquitous of indoor pollutants and have been associated with various . . . [More] Phthalate esters are among the most ubiquitous of indoor pollutants and have been associated with various adverse health effects. In the present study we assessed the cross-sectional association between eight different phthalate metabolites in urine and allergic disease in young children. As part of the Danish Indoor Environment and Children's Health study, urine samples were collected from 440 children aged 3-5 years, of whom 222 were healthy controls, 68 were clinically diagnosed with asthma, 76 with rhinoconjunctivitis and 81 with atopic dermatitis (disease subgroups are not mutually exclusive; some children had more than one disease). There were no statistically significant differences in the urine concentrations of phthalate metabolites between cases and healthy controls with the exception of MnBP and MECPP, which were higher in healthy controls compared with the asthma case group. In the crude analysis MnBP and MiBP were negatively associated with asthma. In the analysis adjusted for multiple factors, only a weak positive association between MEP in urine and atopic dermatitis was found; there were no positive associations between any phthalate metabolites in urine and either asthma or rhinoconjunctivitis. These findings appear to contradict earlier studies. Differences may be due to higher exposures to certain phthalates (e.g., BBzP) via non-dietary pathways in earlier studies, phthalates serving as surrogates for an agent associated with asthma (e.g., PVC flooring) in previous studies but not the present study or altered cleaning habits and the use of "allergy friendly" products by parents of children with allergic disease in the current study in contrast to studies conducted earlier.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

MgCl2-Supported Ziegler-Natta Catalyst Containing Dibenzoyl Sulfide Donor for Propylene Polymerization

Authors: Kim, G; Um, BH; Son, KiC; Oh, K; Koh, H (2014) Journal of Applied Polymer Science 131. HERO ID: 2347887

[Less] Polypropylene (PP) was synthesized in the presence of Ziegler-Natta catalysts composed of MgCl2-TiCl4-internal . . . [More] Polypropylene (PP) was synthesized in the presence of Ziegler-Natta catalysts composed of MgCl2-TiCl4-internal donor/AlR3-external donor. Diisobutyl phthalate is a well-known internal donor in current PP production. Nevertheless, phthalates are often blamed as endocrine disruptors. The objective is to find an ecofriendly internal donor producing PP with maintaining its physical properties. When using dibenzoyl sulfide, synthesized PP shows the superiority to diisobutyl phthalate in the activity of catalyst (40 vs. 22 kg PP/g catalyst), the isotacticity of polymer (99.5 vs. 98.0 wt % of heptane insolubles), and the molecular weight distribution of PP product (M-w/M-n = 4.8 vs. 4). (C) 2014 Wiley Periodicals, Inc.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Chemical Constituents from Gentiana algida Pall

Authors: Yang, A; Men, Yun; Han, Han; Yang, Lin; Shi, X; Wu, Rui; Guo, W (2014) Advanced Materials Research 881-883:419-422. HERO ID: 2504152

[Less] Eight compounds were isolated from the ethanol extract of G. algida Pall, the structure of these compounds . . . [More] Eight compounds were isolated from the ethanol extract of G. algida Pall, the structure of these compounds were identified as: oleic acid(1), linoleic acid(2), octacosanoic acid(3), beta-sitosterol(4), 2,3-dihydroxybenzoic acid ethyl ester(5), n-butyl isobutyl phthalate(6), daucosterol(7), 5,8-dimethoxy furocoumarin(8). These structures were identified by NMR MS IR and other spectroscopic techniques. These compounds were isolated from this plant for the first time.