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Mirex (2385-85-5)




  • 1.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Ploidy patterns in hepatic tumors induced by Mirex

    Authors: Abraham, R; Benitz, KF; Mankes, R
    (1983) Experimental and Molecular Pathology 38:271-282.
    Minus Sign. Click to see only selected choices. The effects of chronic exposure to dietary Mirex was investigated in rat livers over a 13 month period. . . . Plus Sign. Click to expand choices. The effects of chronic exposure to dietary Mirex was investigated in rat livers over a 13 month period. The distribution of ploidy (diploid and tetraploid nuclei) in nodular and nonnodular areas was analyzed in a Coulter Counter fitted with a Channelizer. The nodules, such as adenomas and carcinomas, were identified in histologic sections obtained from companion samples, part of which was used for analysis of nuclear ploidy. The carcinogen disturbed the distribution of nuclei in the ploidy classes, selectively reducing the number of tetraploid cells. This reduction in tetraploid cells corresponded to the nature of the tumor, the most significant effect being noted in hepatocellular carcinomas.
    Tagged With: ToxNet, 08/2015 Litsearch Results, PubMed
  • 2.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Individual and combined effects of mirex and polychlorinated biphenyls on mouse liver-cells

    Authors: Abraham, R; Koepke, UC; Goldberg, L; Coulston, F
    (1974) Toxicology and Applied Pharmacology 29:128-129.
    Minus Sign. Click to see only selected choices. Liver enlargement, proliferation of smooth endoplasmic reticulum and increases in microsomal enzymes . . . Plus Sign. Click to expand choices. Liver enlargement, proliferation of smooth endoplasmic reticulum and increases in microsomal enzymes are common hepatic responses of rodents to the administration of single polychlorinated compounds, but little is known regarding the combined effects of 2 such compounds. A study was therefore undertaken of a mixture of polychlorinated biphenyls (PCB) (Aroclor 1254) and Mirex in Charles River CD-1 mice. The compounds were administered in the diet at the following levels for 7 days: group I, chow; group II, PCB 500 ppm; group III, Mirex 90 ppm; and group IV, Mirex 90 ppm and PCB 500 ppm. Loss of body weight, increases in liver weight and demethylase activity were recorded in all 3 experimental groups, being most pronounced in group IV. Glucose 6-phosphatase activity was decreased in groups II and III and remained unchanged in group IV. In mice of group IV there were striking structural changes in hepatic lysosomes, with formulation of large myeloid bodies (lysosomes containing cellular debris) and numerous autophagic vacuoles that were PAS-positive and stained for acid phosphatase. These changes were reflected in the elevated activities of both total and sedimentable acid phosphatase. The lysosomes were normal in all other groups. Further changes included loss of glycogen in groups III and IV and hepatic cell necrosis in group IV. The capacity of the combination of toxicants to elicit unique lysosomal responses posed questions regarding the biological interaction between environmental chemicals. (Author abstract by permission) (Abstract No. 135)
    Tagged With: 08/2015 Litsearch Results, ToxNet, WOS

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  • 3.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    The in vivo effects of dietary mirex on hepatic lactic dehydrogenase and glutamic oxaloacetic transaminase levels of the rat

    Authors: Abston, PA; Yarbrough, JD
    (1974) Journal of Agricultural and Food Chemistry 22:66-68.
    Minus Sign. Click to see only selected choices. PESTAB Adult male and female Sprague�Dawley rats were fed standard laboratory chow, ad libitum containing . . . Plus Sign. Click to expand choices. PESTAB Adult male and female Sprague�Dawley rats were fed standard laboratory chow, ad libitum containing mirex in concentrations of 10, 50, 100, and 200 ppm for 4 weeks. Liver homogenates were analyzed for lactic dehydrogenase and glutamic-oxaloacetic transaminase activity. Male liver LDH levels were reduced approxmiately 50% in the 100 and 200 ppm of mirex exposed animals, as compared to control animals, by 2 weeks of dietary mirex and persisted through the test period. Liver GOT levels showed a steady decrease in activity, exhibiting a 60-65% decrease at the end of the 4-week treatment period. With 10 ppm of dietary mirex, male liver LDH levels showed no significant change during the 4-week period, while liver GOT levels were reduced about 26% at the end of 3 weeks. Female rat liver homogenates exhibited an approximate 24% decrease in LDH levels after 3 weeks of dietary feeding of 100 ppm of mirex, while liver GOT levels were reduced about 35% when compared to control animals at 3 weeks. Female rats fed 50 ppm of mirex showed an approximate 25% reduction of LDH levels and about a 28% decrease in GPT liver levels after 4 weeks of exposure. (Author abstract reprinted by permission of the American Chemical Society)
    Tagged With: ToxNet, 08/2015 Litsearch Results, PubMed
  • 4.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Toxicosis of mirex for chick embryos and chickens hatched from eggs inoculated with mirex

    Authors: Abuelgasim, A; Ringer, R; Sanger, V
    (1982) Avian Diseases 26:34-39.
    Minus Sign. Click to see only selected choices. Mirex, a hydrocarbon, was mixed with corn oil and injected into chick embryos to test its toxic effect. . . . Plus Sign. Click to expand choices. Mirex, a hydrocarbon, was mixed with corn oil and injected into chick embryos to test its toxic effect. At a concentration of 0 05 mg mirex/egg, embryo mortality was 40%, at 0.5 mg/egg, mortality was 49%, and at 5.0 mg/egg, mortality reached 81%. Mortality of control eggs injected with corn oil alone was 36%. The body weights of newly hatched chickens and of 4-week-old chicks were not different from those of controls. No clinical signs of disease were seen during the 4 weeks of observation. However, liver weights were increased at all 3 dosages when the birds were killed at 4 weeks, but spleen and bursal weights were not. The results support the decision to discontinue the use of mirex as a pesticide in the environment for controlling the fire ant (Solenopsis sp.) until a better means of presenting it can be found.
    Tagged With: ToxNet, 08/2015 Litsearch Results, PubMed
  • 5.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Thyroid hormone deiodination in tissues of American plaice, Hippoglossoides platessoides: characterization and short-term responses to polychlorinated biphenyls (PCBs) 77 and 126

    Authors: Adams, BA; Cyr, DG; Eales, JG
    (2000) Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology 127:367-378.
    Minus Sign. Click to see only selected choices. We have described the tissue distribution and properties of thyroid hormone (TH) deiodination activities . . . Plus Sign. Click to expand choices. We have described the tissue distribution and properties of thyroid hormone (TH) deiodination activities of the marine American plaice, Hippoglossoides platessoides. We then studied the 1- or 4-week responses of the plaice liver and brain deiodination activities and the plasma thyroxine (T4) and 3,5,3'-triiodothyronine (T3) levels to an intraperitoneal injection (5-500 ng/g) of the polychlorinated biphenyl (PCB) congeners 77 (3,3'-4,4'-tetrachlorobiphenyl) or 126 (3,3',4,4',5-pentachlorobiphenyl). T4 and 3,3'5'-triiodothyronine (rT3) outer-ring deiodination (ORD) activities were greater in liver than in kidney, gill, heart, brain, intestine or muscle; inner-ring deiodination (IRD) activity occurred in all tissues but was consistently higher in brain. Deiodination characteristics (optimal pH, optimal dithiothreitol concentration, responses to inhibitors and apparent Km values of 0.6-4 nM) fell in the same rage as those of low-Km deiodinases in other teleosts. Deiodination activities were maximal when assayed at 25 degrees C but uniformly low over the natural range of 0-9 degrees C. Neither PCB 77 nor PCB 126 altered brain T4ORD activity or plasma T4 levels (P < 0.05). However, at 1 week post injection hepatic T4ORD activity was increased and plasma T3 levels lowered by PCB 77 (5 and 25 ng/g), while hepatic IRD activity was increased by PCB 126 (50 and 500 ng/g). Neither PCB 77, PCB 126 nor selected hydroxylated. PCBs given in vitro compared with T4 for binding sites on plasma proteins or altered hepatic deiodination activity, indicating no direct action on plasma proteins or deiodinases We conclude that plaice TH deiodination tissue distribution and characteristics resemble those of other teleosts. Deiodination activities are low at natural assay temperatures but at 1 week show some responses to PCBs 77 and 126.
    Tagged With: 08/2015 Litsearch Results, PubMed, WOS
  • 6.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Possible nephrotoxic effect of carbon tetrabromide and its interaction with chlordecone

    Authors: Agarwal, AK; Berndt, WO; Mehendale, HM
    (1983) Toxicology Letters 17:57-62.
    Minus Sign. Click to see only selected choices. The hepatotoxic and nephrotoxic effects of CBr4 were studied in male Sprague-Dawley rats following a . . . Plus Sign. Click to expand choices. The hepatotoxic and nephrotoxic effects of CBr4 were studied in male Sprague-Dawley rats following a single i.p. administration in a dose range of 25 to 125 microliter/kg to animals maintained for 15 days either on normal diet or a diet containing 10 ppm chlordecone (CD). At these doses, CBr4 did not cause hepatotoxic effects when given alone or in combination with prior exposure to CD. CBr4 caused renal dysfunction characterized by oliguria, aciduria and hypo-osmolality, and these effects were abolished by dietary CD pretreatment. In vitro incubation of renal cortical slices obtained from CBr4-treated animals revealed a significant depression of organic anion transport, i.e., decreased transport of p-aminohippurate (PAH). Organic cation transport was unaffected as judged by accumulation of tetraethylammonium (TEA). CBr4-induced renal dysfunction appeared unrelated to depressed PAH transport since CD pretreatment which abolished renal dysfunction failed to restore PAH transport. These results show that CD does not potentiate CBr4 hepatotoxicity and the nephrotoxic effects of this halomethane are abolished by prior exposure to CD.
    Tagged With: 08/2015 Litsearch Results, PubMed, ToxNet
  • 7.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Absence of potentiation of bromoform hepatotoxicity and lethality by chlordecone

    Authors: Agarwal, AK; Mehendale, HM
    (1983) Toxicology Letters 15:251-257.
    Minus Sign. Click to see only selected choices. Our previous studies indicated that the toxicity of chloro- or bromo-methanes is potentiated by chlordecone . . . Plus Sign. Click to expand choices. Our previous studies indicated that the toxicity of chloro- or bromo-methanes is potentiated by chlordecone (CD). The present work was conducted to study the effect of prior dietary exposure to CD on toxicity of bromoform. Male S-D rats (175-200 g) were fed 0 or 10 ppm CD in the powdered ration for 15 days. Bromoform (25 to 300 microliters/kg) was given i.p. on day 15. 24 h later, hepatotoxicity was assessed by functional, biochemical and histopathological parameters. Excretion of phenolphthalein glucuronide in bile and the rate of bile flow were unaltered by either bromoform or CD-bromoform combination. Serum enzymes (GPT, GOT and isocitric dehydrogenase (ICD) were also not significantly elevated by any treatment. The results suggest that, unlike chloroform, CHBr3 does not act as a potent hepatotoxin and that its effects are not potentiated by CD to any significant extent.
    Tagged With: 08/2015 Litsearch Results, PubMed, ToxNet, WOS
  • 8.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    CCl4-induced alterations in Ca++ homeostasis in chlordecone and phenobarbital pretreated animals

    Authors: Agarwal, AK; Mehendale, HM
    (1984) Life Sciences 34:141-148.
    Minus Sign. Click to see only selected choices. Male S-D rats were maintained on normal powdered diet or on the same diet containing 10 ppm chlordecone . . . Plus Sign. Click to expand choices. Male S-D rats were maintained on normal powdered diet or on the same diet containing 10 ppm chlordecone or 225 ppm phenobarbital for 15 days. On day 15, all the animals received a single ip injection of either corn oil or a subtoxic dose of CCl4 (25-200 microliter/kg) in corn oil vehicle (1 ml/kg). The animals were sacrificed 12 hrs later. Liver microsomal cytochrome P-450 and Ca++ levels in whole liver, mitochondria, microsomes and cytosol were determined. Cytochrome P-450 induction was greater with phenobarbital pretreatment than with chlordecone but the CCl4 induced destruction of cytochrome P-450 was almost similar in both groups and progressive with the dose of CCl4. CCl4 given to animals on normal diet in a dose range of 25-200 microliter/kg did not significantly alter the cytochrome P-450 levels. These findings are consistent with greater bioactivation of CCl4 after the above two pretreatments. There was a massive accumulation of Ca++ in chlordecone and phenobarbital pretreated animals after CCl4 administration. Cytosolic Ca++ levels remained high despite the mitochondrial and microsomal sequestration. This perturbation of hepatocellular Ca++ homeostasis might lead to hepatic lesion and hepatic failure. Chlordecone or phenobarbital alone do not alter hepatic Ca++ levels. These findings suggest that excessive accumulation of Ca++ may be causally related to the progression of hepatotoxic response due to CCl4 in chlordecone treated animals.
    Tagged With: 08/2015 Litsearch Results, PubMed
  • 9.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Chlordecone potentiation of CCl4 hepatotoxicity in ovariectomized rats

    Authors: Agarwal, AK; Mehendale, HM
    (1984) Toxicology 29:315-323.
    Minus Sign. Click to see only selected choices. Previous reports from this laboratory have established the propensity of chlordecone to potentiate the . . . Plus Sign. Click to expand choices. Previous reports from this laboratory have established the propensity of chlordecone to potentiate the hepatotoxicity and lethality in male and female rats. The present study was designed to investigate the hepatotoxicity of CCl4 in chlordecone (CD) pretreated, ovariectomized rats. Ten days after bilateral ovariectomy, the rats were maintained on a dietary protocol of either 0 or 10 ppm chlordecone and on the day 15, they received a single i.p. injection of either corn oil (1 ml/kg) or 25 microliter CCl4/kg in corn oil. Hepatic function, serum enzyme levels and histopathological changes were assessed 24 h after CCl4 challenge as functional biochemical, and morphological parameters of hepatotoxicity. Hepatobiliary function was markedly impaired and serum enzyme levels were elevated in ovariectomized rats receiving the same treatment but not significantly different from normal females receiving the chlordecone and CCl4 combination. Histological findings indicated a greater degree of centrilobular hepatic necrosis accompanied by extensive fatty infiltration. This study suggests that chlordecone sensitizes the liver in ovariectomized rats as well to amplify the toxic effects of CCl4.
    Tagged With: WOS, ToxNet, 08/2015 Litsearch Results, PubMed
  • 10.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Effect of adrenalectomy on chlordecone potentiation of carbontetrachloride hepatotoxicity

    Authors: Agarwal, AK; Mehendale, HM
    (1983) Fundamental and Applied Toxicology 3:507-511.
    Minus Sign. Click to see only selected choices. The propensity of chlordecone (CD) to potentiate CCl4 hepatotoxicity in rats of either sex has been . . . Plus Sign. Click to expand choices. The propensity of chlordecone (CD) to potentiate CCl4 hepatotoxicity in rats of either sex has been well documented. The objective of the present study was to investigate the hepatotoxic effects of CD-CCl4 interaction in adrenalectomized rats. Adrenalectomized rats were maintained on 0 or 10 ppm CD and on day 15 they received a single ip injection of 25 microL CCl4/kg. Hepatotoxicity was assessed by hepatofunctional, biochemical and histopathological parameters, 24 hrs after CCl4 challenge. CCl4-induced hepatobiliary dysfunction and elevation of serum enzymes (GPT, GOT, ICD and OCT) were evident. Hepatic dysfunction was most severe in adrenalectomized rats receiving CD-CCl4 combination treatment. Histopathology of liver exhibited extensive fatty infiltration in the entire lobular structure accompanied by some necrosis. These data indicate that the capacity of CD to potentiate CCl4 hepatotoxicity is unaffected in adrenalectomized rats.
    Tagged With: 08/2015 Litsearch Results, PubMed, ToxNet, WOS
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