Health & Environmental Research Online (HERO)


ISA-PM (current)


14,006 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Longitudinal associations between ambient air pollution with insulin sensitivity, β-cell function, and adiposity in Los Angeles Latino children: Supplementary material

Authors: Alderete, TL; Habre, R; Toledo-Corral, CM; Berhane, K; Chen, Z; Lurmann, FW; Weigensberg, MJ; Goran, MI; Gilliland, FD (In Press) Diabetes. [Supplemental Data] HERO ID: 3800414


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Supplemental information: Understanding particles emitted from spray and wall-guided gasoline direct injection and flex fuel vehicles operating on ethanol and iso-butanol gasoline blends

Authors: Short, D; Vu, D; Chen, V; Espinoza, C; Berte, T; Karavalakis, G; Durbin, TD; Asa-Awuku, A (In Press) Aerosol Science and Technology. [Supplemental Data] HERO ID: 3554428


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Air pollution-induced placental epigenetic alterations in early life: A candidate miRNA approach

Authors: Tsamou, M; Vrijens, K; Madhloum, N; Lefebvre, W; Vanpoucke, C; Nawrot, TS (In Press) Epigenetics. HERO ID: 3359719

[Less] Particulate matter (PM) exposure during in utero life may entail adverse health outcomes in later-life. . . . [More] Particulate matter (PM) exposure during in utero life may entail adverse health outcomes in later-life. Air pollution's adverse effects are known to alter gene expression profiles, which can be regulated by microRNAs (miRNAs). We investigate the potential influence of air pollution exposure in prenatal life on placental miRNA expression. Within the framework of the ENVIRONAGE birth cohort, we measured the expression of six candidate miRNAs in placental tissue from 210 mother-newborn pairs by qRT-PCR. Trimester-specific PM2.5 exposure levels were estimated for each mother's home address using a spatiotemporal model. Multiple regression models were used to study miRNA expression and in utero exposure to PM2.5 over various time windows during pregnancy. The placental expression of miR-21 (-33.7%, 95% CI: -53.2 to -6.2, P=0.022), miR-146a (-30.9%, 95% CI: -48.0 to -8.1, P=0.012) and miR-222 (-25.4%, 95% CI: -43.0 to -2.4, P=0.034) was inversely associated with PM2.5 exposure during the 2(nd) trimester of pregnancy, while placental expression of miR-20a and miR-21 was positively associated with 1(st) trimester exposure. Tumor suppressor phosphatase and tensin homolog (PTEN) was identified as a common target of the miRNAs significantly associated with PM exposure. Placental PTEN expression was strongly and positively associated (+59.6% per 5 μg/m³ increment, 95% CI: 26.9 to 100.7, P<0.0001) with 3(rd) trimester PM2.5 exposure. Further research is required to establish the role these early miRNA and mRNA expression changes might play in PM-induced health effects. We provide molecular evidence showing that in utero PM2.5 exposure affects miRNAs expression as well as its downstream target PTEN.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Titanium Dioxide Exposure Induces Acute Eosinophilic Lung Inflammation in Rabbits

Authors: Choi, GS; Oak, C; Chun, BK; Wilson, D; Jang, TW; Kim, HK; Jung, M; Tutkun, E; Park, EK (In Press) Industrial Health. HERO ID: 2337959

[Less] Titanium dioxide (TiO2) is increasingly widely used in industrial, commercial and home products. TiO2 . . . [More] Titanium dioxide (TiO2) is increasingly widely used in industrial, commercial and home products. TiO2 aggravates respiratory symptoms by induction of pulmonary inflammation although the mechanisms have not been well investigated. We aimed to investigate lung inflammation in rabbits after intratracheal instillation of P25 TiO2. One ml of 10, 50 and 250 µg of P25 TiO2 was instilled into one of the lungs of rabbits, chest computed-tomography was performed, and bronchoalveolar lavage (BAL) fluid was collected before, at 1 and 24hr after P25 TiO2 exposure. Changes in inflammatory cells in the BAL fluids were measured. Lung pathological assay was also carried out at 24hr after P25 TiO2 exposure. Ground glass opacities were noted in both lungs 1hr after P25 TiO2 and saline (control) instillation. Although the control lung showed complete resolution at 24hr, the lung exposed to P25 TiO2 showed persistent ground glass opacities at 24hr. The eosinophil counts in BAL fluid were significantly increased after P25 TiO2 exposure. P25 TiO2 induced a dose dependent increase of eosinophils in BAL fluid but no significant differences in neutrophil and lymphocyte cell counts were detected. The present findings suggest that P25 TiO2 induces lung inflammation in rabbits which is associated with eosinophilic inflammation.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Outdoor Air Pollution and Incidence of Ischemic and Hemorrhagic Stroke: A Small-Area Level Ecological Study

Authors: Maheswaran, R; Pearson, T; Smeeton, NC; Beevers, SD; Campbell, MJ; Wolfe, CD (In Press) Stroke. HERO ID: 842306

[Less] BACKGROUND AND PURPOSE: Evidence linking outdoor air pollution and incidence of stroke is limited. We . . . [More] BACKGROUND AND PURPOSE: Evidence linking outdoor air pollution and incidence of stroke is limited. We examined effects of outdoor air pollution on the incidence of ischemic and hemorrhagic stroke at the population level focusing on middle-aged and older people. METHODS: We used a small-area level ecological study design and a stroke register set up to capture all incident cases of first-ever stroke occurring in a defined geographical area in south London (948 census output areas) where road traffic contributes to spatial variation in air pollution. Population-weighted averages were calculated for output areas using outdoor nitrogen dioxide and PM(10) concentrations modeled at a 20-m resolution. RESULTS: There were 1832 ischemic and 348 hemorrhagic strokes in 1995 to 2004 occurring among a resident population of 267 839. Mean (SD) concentration was 25.1 (1.2) μg/m(3) (range, 23.3-36.4 μg/m(3)) for PM(10) and 41.4 (3.0) μg/m(3) (range, 35.4-68.0 μg/m(3)) for nitrogen dioxide. For ischemic stroke, adjusted rate ratios per 10-μg/m(3) increase, for all ages, 40 to 64 and 65 to 79 years, respectively, were 1.22 (0.77-1.93), 1.12 (0.55-2.28), and 1.86 (1.10-3.13) for PM(10) and 1.11 (0.93-1.32), 1.13 (0.86-1.50), and 1.23 (0.99-1.53) for nitrogen dioxide. For hemorrhagic stroke, the corresponding rate ratios were 0.52 (0.20-1.37), 0.78 (0.17-3.51), and 0.51 (0.12-2.22) for PM(10) and 0.86 (0.60-1.24), 1.12 (0.66-1.90), and 0.78 (0.44-1.39) for nitrogen dioxide. CONCLUSIONS: Although there was no significant association between outdoor air pollutants and ischemic stroke incidence for all ages combined, there was a suggestion of increased risk among people aged 65 to 79 years. There was no evidence of increased incidence in hemorrhagic stroke.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The development of a pregnancy PBPK Model for Bisphenol A and its evaluation with the available biomonitoring data

Authors: Sharma, RP; Schuhmacher, M; Kumar, V (2018) Science of the Total Environment 624:55-68. HERO ID: 4471201

[Less] Recent studies suggest universal fetal exposure to Bisphenol A (BPA) and its association with the adverse . . . [More] Recent studies suggest universal fetal exposure to Bisphenol A (BPA) and its association with the adverse birth outcomes. Estimation of the fetal plasma BPA concentration from the maternal plasma BPA would be highly useful to predict its associated risk to this specific population. The objective of current work is to develop a pregnancy-physiologically based pharmacokinetic (P-PBPK) model to predict the toxicokinetic profile of BPA in the fetus during gestational growth, and to evaluate the developed model using biomonitoring data obtained from different pregnancy cohort studies. To achieve this objective, first, the adult PBPK model was developed and validated with the human BPA toxicokinetic data. This validated human PBPK model was extended to develop a P-PBPK model, which included the physiological changes during pregnancy and the fetus sub-model. The developed model would be able to predict the BPA pharmacokinetics (PKs) in both mother and fetus. Transplacental BPA kinetics parameters for this study were taken from the previous pregnant mice study. Both oral and dermal exposure routes were included into the model to simulate total BPA internal exposure. The impact of conjugation and deconjugation of the BPA and its metabolites on fetal PKs was investigated. The developed P-PBPK model was evaluated against the observed BPA concentrations in cord blood, fetus liver and amniotic fluid considering maternal blood concentration as an exposure source. A range of maternal exposure dose for the oral and dermal routes was estimated, so that simulation concentration matched the observed highest and lowest mother plasma concentration in different cohorts' studies. The developed model could be used to address the concerns regarding possible adverse health effects in the fetus being exposed to BPA and might be useful in identifying critical windows of exposure during pregnancy.

Data/Software
Data/ Software

2014 National Emissions Inventory (NEI) data

Author: U.S. EPA (2018) (Version 2). Washington, DC: U.S. Environmental Protection Agency. HERO ID: 4440637


Technical Report
Technical Report

Probe and monitoring path siting criteria for ambient air quality monitoring

Author: U.S. EPA (2018) § 40 CFR Part 58, Appendix 58, 2018 (Goverment Publishing Office). HERO ID: 4445192

[Less] (a) This appendix contains specific location criteria applicable to SLAMS, NCore, and PAMS ambient air . . . [More] (a) This appendix contains specific location criteria applicable to SLAMS, NCore, and PAMS ambient air quality monitoring probes, inlets, and optical paths after the general location has been selected based on the monitoring objectives and spatial scale of representation discussed in appendix D to this part. Adherence to these siting criteria is necessary to ensure the uniform collection of compatible and comparable air quality data.

(b) The probe and monitoring path siting criteria discussed in this appendix must be followed to the maximum extent possible. It is recognized that there may be situations where some deviation from the siting criteria may be necessary. In any such case, the reasons must be thoroughly documented in a written request for a waiver that describes how and why the proposed siting deviates from the criteria. This documentation should help to avoid later questions about the validity of the resulting monitoring data. Conditions under which the EPA would consider an application for waiver from these siting criteria are discussed in section 10 of this appendix.

(c) The pollutant-specific probe and monitoring path siting criteria generally apply to all spatial scales except where noted otherwise. Specific siting criteria that are phrased with a “must” are defined as requirements and exceptions must be approved through the waiver provisions. However, siting criteria that are phrased with a “should” are defined as goals to meet for consistency but are not requirements.

Technical Report
Technical Report

Pilot study on coarse PM monitoring

Author: U.S. EPA (2018) HERO ID: 4445486

[Less] The U.S. Environmental Protection Agency (EPA) conducted this field study in 2010 and 2011 to evaluate . . . [More] The U.S. Environmental Protection Agency (EPA) conducted this field study in 2010 and 2011 to evaluate the challenges in sampling and analyzing coarse aerosol, the precision of coarse PM (PMc) mass species measurements using dichotomous (dichot) samplers, and mass balance of PMc. The study database is publicly available through the EPA Air Quality System (AQS) to EPA personnel, atmospheric scientists, and others concerned with the science of PM air pollution, related health effects, and human exposure to the coarse PM fraction of particulate matter. Additional samplers—including paired PM10 and PM2.5 Federal Reference Method (FRM) samplers to calculate PM10-2.5 mass and species concentrations by the difference method, and semi-continuous monitors—were operated to further characterize coarse PM and aid in the interpretation of any differences between dichot data and difference method data. The results of this study may be used to establish routine field operating procedures and laboratory standard operating procedures (SOPs) for use in PMc speciation monitoring.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Geospatial hot spot analysis of lung cancer patients correlated to fine particulate matter (PM2.5) and industrial wind in Eastern Thailand

Authors: Zhang, H; Tripathi, NK (2018) HERO ID: 4165060

[Less] Lung cancer is the most common type of cancer and is the major cause of death first among males and . . . [More] Lung cancer is the most common type of cancer and is the major cause of death first among males and second among females in Thailand. Lung cancer is highly related to particulate matter (PM)-especially fine particulates with a diameter of 2.5 mu m or less (PM2.5). Recent studies have indicated a strong correlation between fine particulate matter (PM25) and lung function diseases. Therefore, this study aims to investigate and explore the phenomenon of lung cancer and its spatial correlation to mortality and PM2.5 in Eastern Thailand from 2008 to 2012 using multidisciplinary techniques. The cancer registry was utilized as data inventory and geographical information system (GIS), Global Moran's I, Getis-Ord G statistics, Average Nearest Neighbor (ANN) tool, Inverse Distance Weighting (IDW), Local Indicators of Spatial Autocorrelation (LISA), and ordinary least square (OLS) methods to generate the PM2.5 maps to create hot spots in Eastern Thailand. The results visualize and analyze lung cancer hot spots and are adjusted for known factors such as sex and age of lung cancer patients. Choropleth maps of lung cancer incidence and mortality rates, generated for the first time, revealed that the number of male cancer patients is higher than that of females in Eastern Thailand. Global autocorrelation demonstrated considerable spatial clustering of lung cancer incidence and mortality. 91.56% of the lung cancer patients belonged to the age group of above 50 in both sexes. Significant relationships were found between the PM2.5 variable and the spatial patterns of lung cancer incidence and mortality. The Chonburi and Chanthaburi provinces were found to be the major hot spots for lung cancer incidence, which are close to industrial areas. These findings are useful in identifying the cancer registry information globally as well as locally. This study also provides a useful set of tools to identify and create hot spots in the developing countries where data and resources are major limitations. (C) 2017 Elsevier Ltd. All rights reserved.