Health & Environmental Research Online (HERO)


Methylmercury


41,570 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Methylmercury-induced developmental toxicity is associated with oxidative stress and cofilin phosphorylation. Cellular and human studies

Authors: Caballero, B; Olguin, N; Campos, F; Farina, M; Ballester, F; Lopez-Espinosa, MJ; Llop, S; Rodríguez-Farré, E; Suñol, C (In Press) NeuroToxicology. HERO ID: 3456423

[Less] Environmental exposure to methylmercury (MeHg) during development is of concern because it is easily . . . [More] Environmental exposure to methylmercury (MeHg) during development is of concern because it is easily incorporated in children's body both pre- and post-natal, it acts at several levels of neural pathways (mitochondria, cytoskeleton, neurotransmission) and it causes behavioral impairment in child. We evaluated the effects of prolonged exposure to 10-600nM MeHg on primary cultures of mouse cortical (CCN) and of cerebellar granule cells (CGC) during their differentiation period. In addition, it was studied if prenatal MeHg exposure correlated with altered antioxidant defenses and cofilin phosphorylation in human placentas (n=12) from the INMA cohort (Spain). Exposure to MeHg for 9days in vitro (DIV) resulted in protein carbonylation and in cell death at concentrations ≥200nM and ≥300nM, respectively. Exposure of CCN and CGC to non-cytotoxic MeHg concentrations for 5 DIV induced an early concentration-dependent decrease in cofilin phosphorylation. Furthermore, in both cell types actin was translocated from the cytosol to the mitochondria whereas cofilin translocation was found only in CGC. Translocation of cofilin and actin to mitochondria in CGC occurred from 30nM MeHg onwards. We also found an increased expression of cortactin and LIMK1 mRNA in CGC but not in CCN. All these effects were prevented by the antioxidant probucol. Cofilin phosphorylation was significantly decreased and a trend for decreased activity of glutathione reductase and glutathione peroxidase was found in the fetal side of human placental samples from the highest (20-40μg/L) MeHg-exposed group when compared with the low (<7μg/L) MeHg-exposed group. In summary, cofilin dephosphorylation and oxidative stress are hallmarks of MeHg exposure in both experimental and human systems.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Toxic element concentrations in the bottlenose (Tursiops truncatus), striped (Stenella coeruleoalba) and Risso's (Grampus griseus) dolphins stranded in eastern Adriatic Sea

Authors: Bilandžić, N; Sedak, M; Đokić, M; Đuras Gomerčić, M; Gomerčić, T; Zadravec, M; Benić, M; Prevendar Crnić, A (In Press) Bulletin of Environmental Contamination and Toxicology. HERO ID: 1255499

[Less] Concentrations of cadmium (Cd), arsenic (As), mercury (Hg) and lead (Pb) were measured in muscle, liver . . . [More] Concentrations of cadmium (Cd), arsenic (As), mercury (Hg) and lead (Pb) were measured in muscle, liver and kidney of three cetacean species, the bottlenose (Tursiops truncatus), striped (Stenella coeruleoalba) and Risso's (Grampus griseus) dolphins from the Croatian waters of the Adriatic Sea. In all three dolphin species Cd levels decreased in tissues in the order: kidney > liver > muscle, while As and Pb decreased in the order: liver > kidney > muscle for striped and Risso's dolphins, but with the order reversed for liver and kidney in the bottlenose dolphin for Pb. Levels of Hg consistently followed the order: liver > muscle > kidney, with mean concentrations in the liver being 11-34 times higher than in the other tissues. The highest mean concentrations of trace elements were measured in Risso's dolphins at 14.9 μg/g wet weight, for Cd in the kidney, and concentrations in the liver of 2.41, 1,115 and 0.63 μg/g for As, Hg and Pb, respectively. Statistically significant differences between the three dolphin species were determined for Cd, Hg and Pb in liver tissues, for As in muscle and for Cd in kidney. Significant correlations of metals between tissues were determined in all three species. The results presented give an indication of the environmental condition with regard to the content of toxic metals along the eastern coast of the Adriatic Sea.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A baseline study of metals in cod (Gadus morhua) from the North Sea and coastal Norwegian waters, with focus on mercury, arsenic, cadmium and lead

Authors: Julshamn, K; Duinker, A; Nilsen, BM; Nedreaas, K; Maage, A (In Press) Marine Pollution Bulletin. HERO ID: 1597305

[Less] This study is one of several baseline studies that will provide basic and reliable information about . . . [More] This study is one of several baseline studies that will provide basic and reliable information about the content of undesirable substances in important species of fish caught in Norwegian waters. Concentrations of metals in the muscle and livers of 516 cod caught at 22 positions in the North Sea were analysed. An additional 687 cod were caught from 13 fjords and coastal areas along the coast of Norway. Three out of 1203 samples of muscle exceeded the maximum limit of 0.5mgHgkg(-1) wet weight set by the EU for foodstuffs. The mercury concentration in cod muscle was higher and the cadmium concentration in the liver was lower in the North Sea and coastal areas in the southern part of Norway than in the Barents Sea and coastal areas in the northern part of Norway. These differences are perhaps caused by differences in the cod diet.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Heavy metals of the Tibetan top soils: Level, source, spatial distribution, temporal variation and risk assessment

Authors: Sheng, J; Wang, X; Gong, P; Tian, L; Yao, T (In Press) Environmental Science and Pollution Research. HERO ID: 1070482

[Less] OBJECTIVE: Due to its high elevation, rare human activities and proximity to south Asia where industries . . . [More] OBJECTIVE: Due to its high elevation, rare human activities and proximity to south Asia where industries are highly developed, it is required to investigate the fragile environment of the Tibetan Plateau. We are aiming to obtain the concentration level, source, spatial distribution, temporal variation and potential environmental risk of Tibetan soils. METHODS: A total of 128 surf ace soil samples were collected and analyzed f or V, Cr, Mn, Co, Ni, Cu, Zn, As, Cd and Pb, and an additional 111 samples were analyzed f or Hg and total organic carbon. Concentration comparisons coupled with multivariate statistics were used to analysis the sources of elements of soils. We also carried out Risk assessment on the soils. RESULTS: Concentrations of Hg, Cr, Ni, Cd and Pb are slightly higher than those of the late 1970s. Concentrations of Cr and Ni are higher than averaged world background values. Tibetan soils present a high natural As concentration level. DISCUSSION: Anthropogenic sources may partly contribute to the elevated Hg, Cd and Pb concentrations. Cr and Ni are mainly originated from soil parent materials. Soil elements in Anduo and Qamdo regions may threaten the health of local people. CONCLUSION: Heavy metal elements of Tibetan Plateau are mainly from the natural source. Arsenic present a high background level. Soil elements in Anduo and Qamdo regions may threaten the health of local people, which should be of concern to scientists and the government.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Selenium, arsenic, and mercury in fish inhabiting a fly ash exposure gradient: Interspecific bioaccumulation patterns and elemental associations

Author: Reash, RJ (In Press) Environmental Toxicology and Chemistry. HERO ID: 1015880

[Less] Releases from coal ash impoundments can be a significant source of trace elements to the aquatic environment. . . . [More] Releases from coal ash impoundments can be a significant source of trace elements to the aquatic environment. In the present study, whole body concentrations of arsenic, mercury, and selenium in various fish species inhabiting streams receiving a gradient of fly ash exposure are reported. High exposure sites had elevated water concentrations of arsenic, molybdenum, selenium, and sulfate. Fish were collected during two seasons in 2007. Mercury concentrations in all fish samples were low (range = 0.012-0.99 mg/kg dry wt); highest arsenic concentrations occurred in fish from high exposure sites. Whole body selenium concentrations were low at reference sites but increased as the magnitude of fly exposure increased. For all sites combined, a significant (r2 = 0.60) correlation was observed between the geometric mean of each species' whole body selenium concentration and log-transformed water selenium concentration. A significant inverse relationship was apparent with log-transformed whole body mercury and selenium concentrations (r2 = 0.56 for all species and sites combined), suggesting that high tissue selenium levels antagonistically regulated mercury bioaccumulation. Sunfish (Lepomis sp.) from high and medium-exposure sites had significantly higher selenium body residues, but significantly lower mercury, relative to fish from low exposure and reference sites. Ninety percent of fish from high exposure sites had a surplus of selenium whereas all fish from reference sites had Se/Hg molar ratios < 1.0. These ratios increased as water selenium increased. Where fish have moderate to high exposure to fly ash-influenced water, selenium tissue levels can be expected to be elevated (as well as arsenic, in some cases), but tissue mercury concentrations will likely be low. Environ. Toxicol. Chem. © 2012 SETAC.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Metal interactions in mice under environmental stress

Authors: García-Sevillano, MA; Jara-Biedma, R; González-Fernández, M; García-Barrera, T; Gómez-Ariza, JL (In Press) BioMetals. HERO ID: 1677561

[Less] A metallomic analytical approach based on the use of size exclusion chromatography coupled to ICP-MS . . . [More] A metallomic analytical approach based on the use of size exclusion chromatography coupled to ICP-MS has been used to obtain metal profiles related to overexpression or inhibition of metal-binding biomolecules, which is connected to exposure experiment of laboratory mice Mus musculus to toxic metals, such as Cd, Hg and As. Exposure to Cd induces the formation of Cd-metallothionein in liver that reveals the protective role of this organ; however, exposure to Hg reduces the intensity of the peak associated to Cu-superoxide dismutase (Cu-SOD) while Hg-SOD peak increases, which suggests the competence of Cu and Hg for the active sites of SOD in liver that causes mercury translocation to kidney, in which the concentration of Hg as Hg-metallothionein increases drastically to be excreted by urine. It has been also observed the protective effect of selenium on mercury toxicity in blood plasma, which produces decreasing of the intensity of Se-protein in plasma with Hg exposure and correlative increases of Hg-albumin that transport mercury to kidney for excretion. Finally, arsenic exposure provokes the accumulation of small metabolites of this element, such as dimethylarsenic and monomethylarsenic for excretion. The application of the metallomic approach to liver extracts from free-living mouse Mus spretus shows the overexpression of Cu, Zn and Cd-peaks at 7 kDa (related to metal-metallothionein) in environmental contaminated sites, as well as the increase of peaks related to Cu- and Zn-SOD and Zn-albumin. However, in kidney, can be checked the presence of high concentration of arsenic small metabolites in contaminated areas, similarly to results found in exposure experiments. In addition, the application of a metabolomic approach based on direct infusion mass spectrometry to organ extracts (liver, kidney and serum) from mice (M. musculus) exposed to arsenic reveals important metabolic changes related to antioxidative activity, membrane cell damage, energy metabolism and arsenic elimination. Similar results were obtained from free-living mouse (M. spretus) from areas contaminated with arsenic. The integration of metallomics and metabolomics results provides a more comprehensive evaluation about the biological response in exposure experiments to toxic metals as well as in environmental assessment of contamination.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Biosorption of heavy metals by lactic acid bacteria and identification of mercury binding protein

Authors: Kinoshita, H; Sohma, Y; Ohtake, F; Ishida, M; Kawai, Y; Kitazawa, H; Saito, T; Kimura, K (In Press) Research in Microbiology. HERO ID: 1579288

[Less] Heavy metals cause various health hazards. Using lactic acid bacteria (LAB), we tested the biosorption . . . [More] Heavy metals cause various health hazards. Using lactic acid bacteria (LAB), we tested the biosorption of heavy metals e.g. cadmium (Cd) (II), lead (Pb) (II), arsenic (As) (III), and mercury (Hg) (II). Cd (II) sorption was tested in 103 strains using atomic absorption spectrophotometery (AAS). Weissella viridescens MYU 205 (1×10(8) cells/ml) decreased Cd (II) levels in citrate buffer (pH 6.0) from one ppm to 0.459 ± 0.016 ppm, corresponding to 10.46 μg of Cd (II). After screening, 11 LAB strains were tested using various pH (pH 4.0, 5.0, 6.0, 7.0) showing the sorption was acid sensitive; and was cell concentration dependent, where the Cd (II) concentration decreased from one ppm to 0.042 (max) / 0.255 (min) ppm at 1×10(10) cells/ml. Additionally, the biosorption of Pb (II), As (III), and Hg (II) were tested using an inductively coupled plasma mass spectrometer (ICP-MS). The Hg (II) concentration was reduced the most followed by Pb (II) and As (III). Many of the bacterial cell surface proteins of W. viridescens MYU 205 showed binding to Hg (II) using the Hg (II) column assay. Having a CXXC motif, a ∼14 kDa protein may be one of the Hg (II) binding proteins. LAB biosorption may aid the detoxification of people exposed to heavy metals.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Sources and spatial distribution of heavy metals in scleractinian coral tissues and sediments from the Bocas del Toro Archipelago, Panama

Authors: Berry, KLE; Seemann, J; Dellwig, O; Struck, U; Wild, C; Leinfelder, RR (In Press) Environmental Monitoring and Assessment. HERO ID: 1597286

[Less] Marine ecosystems worldwide are threatened by aquatic pollution; however, there is a paucity in data . . . [More] Marine ecosystems worldwide are threatened by aquatic pollution; however, there is a paucity in data from the Caribbean region. As such, five heavy metals (arsenic, cadmium, copper, zinc, mercury) were measured in tissues of the scleractinian corals Porites furcata and Agaricia tenuifolia and in adjacent sediments in the Bocas del Toro Archipelago, Panama. Samples were collected from five reef sites along a gradient of distance from an international shipping port and were analysed using inductively coupled plasma optical emission spectrometry and atomic absorption spectrophotometry for mercury. Copper and zinc were the most abundant metals and ranged from 11 to 63 mg kg(-1) and from 31 to 185 mg kg(-1) in coral tissues, respectively. The highest concentration of each metal was measured in P. furcata tissues, with copper and mercury concentrations significantly higher in P. furcata than in A. tenuifolia at every site. These results suggest that P. furcata has a higher affinity for metal accumulation and storage than A. tenuifolia. With the exception of cadmium, metal concentrations in coral tissues were generally elevated at coral reefs in closer proximity to the port; however, this pattern was not observed in sediments. Hard coral cover was lowest at reefs in closest proximity to the port, suggesting that metal pollution from port-related activities is influencing hard coral abundance at nearby coral reefs.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Genotypic differences in arsenic, mercury, lead and cadmium in milled rice (Oryza sativa L.)

Authors: Jiang, S; Shi, C; Wu, J (In Press) International Journal of Food Sciences and Nutrition. HERO ID: 1022002

[Less] The contents of arsenic, mercury, lead and cadmium in milled rice were determined. Among 216 genotypes, . . . [More] The contents of arsenic, mercury, lead and cadmium in milled rice were determined. Among 216 genotypes, the As, Hg, Pb and Cd contents were ranged from 5.06 to 296.45, 2.46 to 65.85, 4.16 to 744.95 and 5.91 to 553.40 ng/g, respectively. Six genotypes with lower contents of toxic metal elements were selected. The averages of As and Pb contents for indica rice were higher than those of japonica rice, while the averages of Hg and Cd contents were in contrast. Compared with white brown rice, the milled rice from black and red brown rice contained lower contents of four elements. Significant negative correlation was found between As content and alkaline spread value. Significant correlations were observed between As and aspartic acid (Asp) content, Hg and Asp or leucine contents, Pb and cysteine or methionine contents. Cd content was significantly negatively correlated with protein and 14 amino acid contents.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Twenty-four-hour urinary trace element excretion: Reference intervals and interpretive issues

Authors: Sieniawska, CE; Jung, LC; Olufadi, R; Walker, V (In Press) Annals of Clinical Biochemistry. HERO ID: 1015724

[Less] BACKGROUND: Introduction of inductively coupled plasma mass spectrometry (ICP-MS) into clinical laboratories . . . [More] BACKGROUND: Introduction of inductively coupled plasma mass spectrometry (ICP-MS) into clinical laboratories has led to an increasing application of analyses to risk assessment for toxicity from environmental exposure to trace elements, and in occupational monitoring. Interpretation of results from random urine samples may be problematic and measurement of excretion over 24 h is sometimes preferable. Recent reference data are sparse. METHODS: Twenty-four-hour urine samples from 111 healthy adults from the renal stones clinic in Southampton, UK, were analysed for 31 trace elements using ICP-MS and for zinc using atomic absorption spectroscopy. Non-parametric 0.95 coverage intervals were determined for trace element excretion per 24 h and as a ratio to creatinine, for the full study cohort and separately for men (n = 77) and women (n = 34). RESULTS: Beryllium was undetectable in 95% of samples, bismuth in 87% and uranium in 75%. In comparison with published ranges, reference intervals for this cohort were higher for molybdenum, tin and vanadium, and for arsenic due to inclusion of fish arsenicals. Aluminium, chromium, iron, lead and mercury were lower. In our cohort, 24-h excretion of 17 elements was significantly higher in men than in women. However, when expressed as trace element to creatinine ratios, the situation reversed strikingly. Because of their lower creatinine excretion, ratios for 18 elements were significantly higher for women. CONCLUSIONS: New adult reference intervals were obtained for 24-h urine trace element excretion. Trace element:creatinine ratios must be used cautiously, with separate ranges for men and women.