Health & Environmental Research Online (HERO)


Per- and Polyfluoroalkyl Substances (PFAS)


4,280 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration

Authors: Dzierlenga, AL; Robinson, VG; Waidyanatha, S; Devito, MJ; Eifrid, MA; Gibbs, ST; Granville, CA; Blystone, CR (2019) Xenobiotica 1-11. HERO ID: 5916078

[Less] Poly- and perfluorinated alkyl substances (PFAS) are environmentally persistent chemicals associated . . . [More] Poly- and perfluorinated alkyl substances (PFAS) are environmentally persistent chemicals associated with many adverse health outcomes. The National Toxicology Program evaluated the toxicokinetics (TK) of several PFAS to provide context for toxicologic findings.Plasma TK parameters and tissue (liver, kidney, brain) concentrations are reported for perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) or perfluorodecanoic acid (PFDA) after single-dose administration in male and female Hsd:Sprague-Dawley® (SD) rats.Generally, longer Tmax and elimination half-lives, and slower clearance f, were correlated with longer chain length. Male rats administered PFOA had a prolonged half-life compared to females (215 h vs. 2.75), while females had faster clearance and smaller plasma area under the curve (AUC). Females administered PFHxA had a shorter half-life (2 h vs. 9) than males and faster clearance with a smaller plasma AUC, although this was less pronounced than PFOA. There was no sex difference in PFDA half-life. Female rats administered PFDA had a higher plasma AUC/dose than males, and a slower clearance. PFDA had the highest levels in the liver of the PFAS evaluated.Profiling the toxicokinetics of these PFAS allows for comparison among subclasses, and more direct translation of rodent toxicity to human populations.

Technical Report
Technical Report

28-day evaluation of the toxicity (C06100) of perfluorohexane sulfonate potassium salt (PFHSKslt) (3871-99-6) on Harlan Sprague-Dawley rats exposed via gavage

Author: NTP (2018) U.S. Department of Health and Human Services. [NTP] HERO ID: 4309363


Technical Report
Technical Report

28-day evaluation of the toxicity (C91069) of Wyeth 14,643 (WY) (50892-23-4) on Harlan Sprague-Dawley rats exposed via gavage

Author: NTP (2018) U.S. Department of Health and Human Services. [NTP] HERO ID: 4309212


Archival Material
Archival Material

TOX-96: 1-Perfluorobutanesulfonic acid (375-73-5), potassium perfluorohexanesulfonate (3871-99-6), perfluorooctane sulfonate (1763-23-1), WY-14643 (50892-23-4). Chemical Effects in Biological Systems (CEBS)

Author: NTP (2018) Available online at https://manticore.niehs.nih.gov/cebssearch/publication/TOX-96. (Aug 2, 2018). [Website] HERO ID: 4309557


Archival Material
Archival Material

TOX-97: Perfluorohexanoic acid (307-24-4), perfluorooctanoic acid (335-67-1), perfluorononanoic acid (375-95-1), perfluorodecanoic acid (335-76-2), WY-14643 (50892-23-4). Chemical Effects in Biological Systems (CEBS)

Author: NTP (2018) Available online at https://manticore.niehs.nih.gov/cebssearch/publication/TOX-97. (Apr 4, 2018). [Website] HERO ID: 4309651


Archival Material
Archival Material

Study information. Genetic toxicology - micronucleus. Perfluorobutane sulfonate (PFBS)

Author: NTP (2018) Available online at https://tools.niehs.nih.gov/cebs3/ntpViews/?studyNumber=002-01134-0002-0000-3. [Website] HERO ID: 4322521


Technical Report
Technical Report

Investigation of sources to PFHxS in the environment

Author: Norwegian Environment Agency (2018) Munich, Germany: BiPRO GmbH. HERO ID: 4774673


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Sono-chemical treatment of per- and poly-fluoroalkyl compounds in aqueous film-forming foams by use of a large-scale multi-transducer dual-frequency based acoustic reactor

Authors: Gole, VL; Sierra-Alvarez, R; Peng, H; Giesy, JP; Deymier, P; Keswani, M (2018) Ultrasonics Sonochemistry 45:213-222. HERO ID: 4771045

[Less] Aqueous film-forming foams (AFFFs) contain a mixture of organic chemicals, including per- and poly-fluorinated, . . . [More] Aqueous film-forming foams (AFFFs) contain a mixture of organic chemicals, including per- and poly-fluorinated, alkyl sulfonate substances (PFAS) (1-5%, w/w). Some longer-chain PFAS can be toxic, moderately bioaccumulative and persistent in the environment. In the present work, decomposition of PFAS present in two commercially available AFFFs (ANSUL- and 3M-) was investigated using a sono-chemical reactor of volume 91 L. The reactor consists of 12 transducers with operating frequencies of 1 MHz or 500 kHz and total input power of 12 kW. Degradation of PFASs performed using various dilutions of AFFF revealed that release of F- and SO4-2 ions was inversely proportional to initial pH of up to 4. Defluorination of ANSUL-AFFF resulted in an increase in the concentration of F- released from 55.6 ± 0.3 µM (500× dilution) to 58.6 ± 0.6 (25× dilution), while for 3M AFFF it increased from 19.9 ± 0.7 µM (500× dilution) to 217.1 ± 2.4 µM (25× dilution). Though amounts of F- released were less for ANSUL-AFFF than for 3M-AFFF, there was a considerable increase in removal of TOC and release of SO4-2 present in ANSUL-AFFF. Approximately 90.5% and 26.6% reduction of perfluoroalkyl sulfonates (PFSA) and perfluoroalkyl carboxylates (PFCA) in 3M, respectively, and 38.4% reduction of fluorotelomer sulfonates in ANSUL-AFFF were achieved in 13 h. Estimated costs of energy for the treatment of ANSUL-AFFF and 3M-AFFF at a 500× dilution were $0.015 ± 0.0001/L and $0.019 ± 0.0002/L, respectively.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prenatal maternal serum concentrations of per- and polyfluoroalkyl substances in association with autism spectrum disorder and intellectual disability [Supplementary materials]

Authors: Lyall, K; Yau, VM; Hansen, R; Kharrazi, M; Yoshida, CK; Calafat, AM; Windham, G; Croen, LA (2018) Environmental Health Perspectives 126. HERO ID: 5235063

[Less] BACKGROUND: Emerging work has examined neurodevelopmental outcomes following prenatal . . . [More] BACKGROUND: Emerging work has examined neurodevelopmental outcomes following prenatal exposure to per- and polyfluoroalkyl substances (PFAS), but few studies have assessed associations with autism spectrum disorder (ASD).

OBJECTIVES: Our objective was to estimate associations of maternal prenatal PFAS concentrations with ASD and intellectual disability (ID) in children.

METHODS: Participants were from a population-based nested case-control study of children born from 2000 to 2003 in southern California, including children diagnosed with ASD (n=553), ID without autism (n=189), and general population (GP) controls (n=433). Concentrations of eight PFAS from stored maternal sera collected at 15-19 wk gestational age were quantified and compared among study groups. We used logistic regression to obtain adjusted odds ratios for the association between prenatal PFAS concentrations (parameterized continuously and as quartiles) and ASD versus GP controls, and separately for ID versus GP controls.

RESULTS: Geometric mean concentrations of most PFAS were lower in ASD and ID groups relative to GP controls. ASD was not significantly associated with prenatal concentrations of most PFAS, though significant inverse associations were found for perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) [adjusted ORs for the highest vs. lowest quartiles 0.62 (95% CI: 0.41, 0.93) and 0.64 (95% CI: 0.43, 0.97), respectively]. Results for ID were similar.

CONCLUSIONS: Results from this large case-control study with prospectively collected prenatal measurements do not support the hypothesis that prenatal exposure to PFAS is positively associated with ASD or ID. https://doi.org/10.1289/EHP1830.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

Authors: Chiu, WA; Guyton, KZ; Martin, MT; Reif, DM; Rusyn, I (2018) Altex 35:51-64. HERO ID: 3981309

[Less] Evidence regarding carcinogenic mechanisms serves a critical role in International Agency for Research . . . [More] Evidence regarding carcinogenic mechanisms serves a critical role in International Agency for Research on Cancer (IARC) Monograph evaluations. Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to supplement other mechanistic evidence. In Monograph V110, HTS profiles were compared between perfluorooctanoic acid (PFOA) and prototypical activators across multiple nuclear receptors. For Monograph V112 -113, HTS assays were mapped to 10 key characteristics of carcinogens identified by an IARC expert group, and systematically considered as an additional mechanistic data stream. Both individual assay results and ToxPi-based rankings informed mechanistic evaluations. Activation of multiple nuclear receptors in HTS assays showed that PFOA targets peroxisome proliferator activated and other receptors. ToxCast assays substantially covered 5 of 10 key characteristics, corroborating literature evidence of "induces oxidative stress" and "alters cell proliferation, cell death or nutrient supply" and filling gaps for "modulates receptor-mediated effects." Thus, ToxCast HTS data were useful both in evaluating specific mechanistic hypotheses and in the overall evaluation of mechanistic evidence. However, additional HTS assays are needed to provide more comprehensive coverage of the 10 key characteristics of carcinogens that form the basis of current IARC mechanistic evaluations.