Health & Environmental Research Online (HERO)


Per- and Polyfluoroalkyl Substances (PFAS)


4,238 References Were Found:

Technical Report
Technical Report

28-day evaluation of the toxicity (C06100) of perfluorohexane sulfonate potassium salt (PFHSKslt) (3871-99-6) on Harlan Sprague-Dawley rats exposed via gavage

Author: NTP (2018) U.S. Department of Health and Human Services. [NTP] HERO ID: 4309363


Archival Material
Archival Material

TOX-97: Perfluorohexanoic acid (307-24-4), perfluorooctanoic acid (335-67-1), perfluorononanoic acid (375-95-1), perfluorodecanoic acid (335-76-2), WY-14643 (50892-23-4). Chemical Effects in Biological Systems (CEBS)

Author: NTP (2018) Available online at https://manticore.niehs.nih.gov/cebssearch/publication/TOX-97. (Apr 4, 2018). [Website] HERO ID: 4309651


Technical Report
Technical Report

28-day evaluation of the toxicity (C91069) of Wyeth 14,643 (WY) (50892-23-4) on Harlan Sprague-Dawley rats exposed via gavage

Author: NTP (2018) U.S. Department of Health and Human Services. [NTP] HERO ID: 4309212


Technical Report
Technical Report

TOX-96: 1-Perfluorobutanesulfonic acid (375-73-5), Potassium perfluorohexanesulfonate (3871-99-6), Perfluorooctane sulfonate (1763-23-1), WY-14643 (50892-23-4)

Author: NTP (2018) HERO ID: 4309557


Archival Material
Archival Material

Study information. Genetic toxicology - micronucleus. Perfluorobutane sulfonate (PFBS)

Author: NTP (2018) Available online at https://tools.niehs.nih.gov/cebs3/ntpViews/?studyNumber=002-01134-0002-0000-3. [Website] HERO ID: 4322521


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prenatal Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Association with Autism Spectrum Disorder and Intellectual Disability

Authors: Lyall, K; Yau, VM; Hansen, R; Kharrazi, M; Yoshida, CK; Calafat, AM; Windham, G; Croen, LA (2018) Environmental Health Perspectives 126:017001. HERO ID: 4239287

[Less] BACKGROUND: Emerging work has examined neurodevelopmental outcomes following prenatal . . . [More] BACKGROUND: Emerging work has examined neurodevelopmental outcomes following prenatal exposure to per- and polyfluoroalkyl substances (PFAS), but few studies have assessed associations with autism spectrum disorder (ASD).

OBJECTIVES: Our objective was to estimate associations of maternal prenatal PFAS concentrations with ASD and intellectual disability (ID) in children.

METHODS: Participants were from a population-based nested case-control study of children born from 2000 to 2003 in southern California, including children diagnosed with ASD (n=553), ID without autism (n=189), and general population (GP) controls (n=433). Concentrations of eight PFAS from stored maternal sera collected at 15-19 wk gestational age were quantified and compared among study groups. We used logistic regression to obtain adjusted odds ratios for the association between prenatal PFAS concentrations (parameterized continuously and as quartiles) and ASD versus GP controls, and separately for ID versus GP controls.

RESULTS: Geometric mean concentrations of most PFAS were lower in ASD and ID groups relative to GP controls. ASD was not significantly associated with prenatal concentrations of most PFAS, though significant inverse associations were found for perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) [adjusted ORs for the highest vs. lowest quartiles 0.62 (95% CI: 0.41, 0.93) and 0.64 (95% CI: 0.43, 0.97), respectively]. Results for ID were similar.

CONCLUSIONS: Results from this large case-control study with prospectively collected prenatal measurements do not support the hypothesis that prenatal exposure to PFAS is positively associated with ASD or ID. https://doi.org/10.1289/EHP1830.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition

Authors: Harris, MH; Oken, E; Rifas-Shiman, SL; Calafat, AM; Ye, X; Bellinger, DC; Webster, TF; White, RF; Sagiv, SK (2018) HERO ID: 4442261

[Less] BACKGROUND: Per- and polyfluoroalkyl substances (PFASs) are suspected developmental . . . [More] BACKGROUND: Per- and polyfluoroalkyl substances (PFASs) are suspected developmental toxicants, but epidemiological evidence on neurodevelopmental effects of PFAS exposure is inconsistent. We examined associations of prenatal and childhood PFAS exposure with performance on assessments of cognition in children.

METHODS: We included mother-child pairs from Project Viva, a longitudinal Boston-area birth cohort enrolled during 1999-2002. We quantified concentrations of eight PFASs, including perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexane sulfonate (PFHxS), in plasma collected from women during pregnancy (median 9.7 weeks gestation) and from children at a visit in mid-childhood (median age 7.7 years). In early childhood (median age 3.2 years) we administered standardized assessments of visual motor skills and vocabulary comprehension, and in mid-childhood we assessed visual motor skills, visual memory, and verbal and non-verbal intelligence. Using multivariable regression, we estimated associations of prenatal and childhood PFAS plasma concentrations with children's cognitive assessment scores, adjusted for relevant covariates including breastfeeding, maternal intelligence, parental education, and household income. Samples sizes ranged from 631 to 971, depending on analysis.

RESULTS: Prenatal PFAS concentrations were associated with both better and worse cognitive performance; children with top quartile prenatal concentrations of some PFASs had better visual motor abilities in early childhood and non-verbal IQ and visual memory in mid-childhood, while children with upper quartile prenatal PFOA and PFOS had lower mid-childhood visual-motor scores. In cross-sectional analyses of mid-childhood PFAS concentrations and cognitive assessments, visual-motor scores on the Wide Range Assessment of Visual Motor Abilities (WRAVMA) (standardized mean = 100, standard deviation = 15) were lower among children with higher PFHxS (fourth quartile (Q4) vs. Q1: -5.0, 95% confidence interval (CI): -9.1, -0.8). Upper quartiles of childhood PFOA and PFOS were also associated with somewhat lower childhood WRAVMA scores, but childhood PFASs were not associated with verbal or non-verbal IQ or visual memory.

CONCLUSIONS: We present evidence suggesting associations of prenatal and childhood PFAS exposure with lower childhood visual motor abilities. Other results were inconsistent, with higher prenatal PFASs associated in some cases with better cognitive outcomes.

Data/Software
Data/ Software

Products: Perfluoroheptanesulfonic acid (CAS 375-92-8)

Author: LookChem (2017) HERO ID: 3981214


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

[Messages of the Federal Environmental Agency regarding perfluorinated and polyfluorinated chemicals (PFC) in drinking water]

Authors: Biegel-Engler, A; Vierke, L; Apel, P; Fetter, E; Staude, C (2017) Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 60:341-346. HERO ID: 3981921


Archival Material
Archival Material

Certificate of analysis. Product: 2H,2H,3H,3H-Perfluorooctanoic acid; Code Number: PC2908; CAS Number: 914637-49-3

Author: Apollo Scientific (2017) Available online at http://www.apolloscientific.co.uk/downloads/coa_typical/PC2908_TypicalCofA.pdf. [Website] HERO ID: 3982542