Health & Environmental Research Online (HERO)


Per- and Polyfluoroalkyl Substances (PFAS)


250 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Preliminary assessment on the bioaccessibility of contaminants of emerging concern in raw and cooked seafood

Authors: Alves, RN; Maulvault, AL; Barbosa, VL; Cunha, S; Kwadijk, CJ; Álvarez-Muñoz, D; Rodríguez-Mozaz, S; Aznar-Alemany, Ò; Eljarrat, E; Barceló, D; Fernandez-Tejedor, M; Tediosi, A; Marques, A (2017) Food and Chemical Toxicology 104:69-78. HERO ID: 3603324

[Less] A preliminary assessment of the bioaccessibility of contaminants of emerging concern (CeCs), including . . . [More] A preliminary assessment of the bioaccessibility of contaminants of emerging concern (CeCs), including perfluorinated compounds (PFCs; i.e. PFOS and PFUnA), brominated flame retardants (BFRs; i.e. BDE47, BDE100, α-HBCD) and pharmaceuticals and personal care products (PPCPs; i.e. venlafaxine, methylparaben and UV-filter OC) was performed in seafood species available in the European markets. Additionally, the effect of steaming on CeCs bioaccessibility was also investigated for the first time. Overall, steaming affected differentially contaminants' concentrations, for instance, decreasing PFOS levels in flounder, but increasing both BDE47 and BDE100. CeCs bioaccessibility varied according to seafood species and contaminant group, i.e. in general, lower bioaccessibility values were obtained for PBDEs (<70%, except for mackerel), while PFCs and PPCPs revealed higher bioaccessibility percentages (between 71 and 95%). The lowest bioaccessibility value was obtained for α-HBCD (mussel; 14%), whereas the highest percentage was observed in venlafaxine (mullet; 95%). Our preliminary study reports also, for the first time, the effects of steaming on CeCs bioaccessibility. In most cases, bioaccessibility was not affected by cooking, however, a decrease was observed in PBDEs and venlafaxine bioaccessibility in steamed mussels and mullet, respectively, thus lowering the potential health risks associated with seafood consumption.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Associations between perfluorinated alkyl acids in blood and ovarian follicular fluid and ovarian function in women undergoing assisted reproductive treatment

Authors: Mccoy, JA; Bangma, JT; Reiner, JL; Bowden, JA; Schnorr, J; Slowey, M; O'Leary, T; Guillette, LJ; Parrott, BB (2017) Science of the Total Environment 605-606:9-17. HERO ID: 3858475

[Less] Endocrine disrupting contaminants, in combination with other environmental variables, are associated . . . [More] Endocrine disrupting contaminants, in combination with other environmental variables, are associated with altered reproductive health. Assisted reproductive technology (ART) procedures offer valuable opportunities to explore the connections between environmental contaminants in the ovarian microenvironment and measures of fertility, including impaired responsiveness to gonadotropins. Here, we investigate an emerging class of environmental contaminants, the perfluorinated alkyl acids (PFAAs), to determine whether ovarian contaminant levels are associated with measures of ovarian responsiveness and fertility outcomes in a South Carolina population of women undergoing ART. Levels of PFAAs in plasma and follicular fluid samples collected from women undergoing ovarian stimulation were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS). Six PFAAs were detected in both plasma and follicular fluid. PFAA concentrations in plasma correlate strongly to those detected in ovary and, with the exception of one compound, remain stable throughout ovarian stimulation. The concentration of PFHxS in follicular fluid inversely relates to baseline follicle counts. While no significant relationships were detected between ovarian response measures and PFAA concentrations, we identified a negative relationship between follicular fluid PFDA and PFuNA and blastocyst conversion rates. Our assessments indicate that plasma levels of PFAAs serve as a sound proxy of those in the ovarian compartment and that follicular fluid levels of specific PFAA compounds are inversely related to important clinical measures of reproductive health including baseline follicle count and post-fertilization success.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Sorption of perfluoroalkyl phosphonates and perfluoroalkyl phosphinates in soils

Authors: Lee, H; Mabury, SA (2017) Environmental Science and Technology 51:3197-3205. HERO ID: 3603165

[Less] Perfluoroalkyl phosphonates (PFPAs) and perfluoroalkyl phosphinates (PFPiAs) are recently discovered . . . [More] Perfluoroalkyl phosphonates (PFPAs) and perfluoroalkyl phosphinates (PFPiAs) are recently discovered perfluoroalkyl acids (PFAAs) that have been widely detected in house dust, aquatic biota, surface water, and wastewater environments. The sorption of C6, C8, and C10 monoalkylated PFPAs and C6/C6, C6/C8, and C8/C8 dialkylated PFPiAs was investigated in seven soils of varying geochemical parameters. Mean distribution coefficients, logKd*, ranged from 0.2 to 2.1 for the PFPAs and PFPiAs and were generally observed to increase with perfluoroalkyl chain length. The logKd* of PFPiAs calculated here (1.6-2.1) were similar to those previously measured for the longer-chain perfluorodecane sulfonate (1.9, PFDS) and perfluoroundecanoate (1.7, PFUnA) in sediments, but overall when compared as a class, were greater than those for the perfluoroalkane sulfonates (-0.8-1.9, PFSAs), perfluoroalkyl carboxylates (-0.4-1.7, PFCAs), and PFPAs (0.2-1.5). No single soil-specific parameter, such as pH and organic carbon content, was observed to control the sorption of PFPAs and PFPiAs, the lack of which may be attributed to competing interferences in the naturally heterogeneous soils. The PFPAs were observed to desorb to a greater extent and likely circulate as aqueous contaminants in the environment, while the more sorptive PFPiAs would be preferentially retained by environmental solid phases.

Technical Report
Technical Report

Perfluoro-n-undecanoic acid ( 2058-94-8 ). Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (in Japanese). Japan Existing Chemical Data Base (JECDB)

Author: CIPCJ (2017) HERO ID: 3927191


Technical Report
Technical Report

Perfluoro-n-undecanoic acid ( 2058-94-8 ). Bacterial Reverse Mutation Test (in Japanese). Japan Existing Chemical Data Base (JECDB)

Author: CIPCJ (2017) HERO ID: 3927192


Technical Report
Technical Report

Perfluoro-n-undecanoic acid ( 2058-94-8 ). In Vitro Mammalian Chromosome Aberration Test (in Japanese). Japan Existing Chemical Data Base (JECDB)

Author: CIPCJ (2017) HERO ID: 3927193


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Analysis of perfluoroalkyl and polyfluoroalkyl substances in serum and plasma by solvent precipitation-isotope dilution-direct injection-LC/ MS/MS

Author: Harrington, LM (2017) Analytical Methods 9:473-481. HERO ID: 3858558

[Less] A validated liquid chromatography tandem mass spectrometry (LC/MS/MS) method is presented for the analysis . . . [More] A validated liquid chromatography tandem mass spectrometry (LC/MS/MS) method is presented for the analysis of per- and polyfluoroalkyl substances (PFAS) in serum and plasma. The method employs stableisotope labeled internal standard (IS) and surrogate recover standard (SRS) spiked serum or plasma samples that are mixed and precipitated with acetonitrile. Quantitation is performed with stable-isotope IS solvent (50 : 50 acetonitrile : water) calibration using one direct injection (DI) chromatographic analysis of precipitated sample supernate. The analytical method includes fifteen stable isotope labeled ISs, four SRSs ([1,2,3,4-C-13(4)]PFOA, [1,2-C-13(2)]PFUnA, [1,2,3,4-C-13(4)]PFOS, [2,3,4-C-13(3)]PFBA), and sixteen target analytes perfluoroalkyl carboxylic acids (PFCAs) (C4-C12), perfluoroalkyl sulfonic acids (PFSAs) (C4, C6, C8), N-ethyl perfluorooctane sulfonamido acetate (EtFOSAA), N-methyl perfluorooctane sulfonamido acetate (MeFOSAA), perfluorooctane sulfonamide (FOSA), and perfluorobutane sulfonamide (FBSA). Mean recoveries of control human plasma fortified with method target analytes over the range 2.5-175 ng mL(-1) (10-700 ng mL(-1) PFOS) are 83.7-103% with relative standard deviations (RSDs) of <= 14% (PFBA = 19%). Mean recoveries and RSDs of control human plasma fortified with mixed branched and linear isomer PFOA and PFHS (2.5 & 10.0 ng mL(-1)), and PFOS (10 & 40 ng mL(-1)) were 83.2% (RSD +/- 7.7%), 101% (RSD +/- 4.9%), and 101% (RSD +/- 6.5%) respectively. Mean recoveries of control bovine serum fortified with the method target analytes over the lower concentration range 0.250-175 ng mL(-1) (1-700 ng mL(-1) PFOS) are 82.8-103% with RSDs <= 15% (MeFOSAA = 16%, EtFOSAA = 17%). Mean recoveries and RSDs for 736 American Red Cross (ARC) study plasma samples fortified with SRSs at 1 ng mL(-1) were 89.0% (+/- 7.3% RSD) for [1,2,3,4-C-13(4)]PFOA, 91.8% (+/- 10% RSD) for [1,2-C-13(2)]PFUnA, and 89.4% (+/- 7.9% RSD) for [1,2,3,4-C-13(4)]PFOS.

Technical Report
Technical Report

Safety data sheet. Version 5.3. Perfluoroundecanoic acid. Product number 446777. CAS-No. 2058-94-8

Author: Sigma-Aldrich (2017) St. Louis, MO: Sigma-Aldrich. [Fact Sheet] HERO ID: 3981223


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Variation and accumulation patterns of poly- and perfluoroalkyl substances (PFAS) in European perch (Perca fluviatilis) across a gradient of pristine Swedish lakes

Authors: Åkerblom, S; Negm, N; Wu, P; Bishop, K; Ahrens, L (2017) Science of the Total Environment 599-600:1685-1692. HERO ID: 3858483

[Less] This study assessed variations in the concentrations of poly- and perfluoroalkyl substances (PFAS) in . . . [More] This study assessed variations in the concentrations of poly- and perfluoroalkyl substances (PFAS) in European perch (Perca fluviatilis) in Swedish lakes and the extent to which fish size, age and indicators of fish trophic ecology (δ(15)N and δ(13)C) correlate with the sum of individual PFAS concentrations (ΣPFAS). Fish muscle tissue samples (n=80) were taken from six lakes across Sweden and analysed using solid-liquid extraction followed by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). PFAS levels in the lakes were affected by atmospheric deposition in relatively pristine areas with no direct point source of PFAS in the catchment. PFTeDA, PFUnDA, PFTriDA, PFDoDA, PFDA, PFOS and 6:2 FTSA were detected with a frequency between 68% and 99% and were included in the statistical evaluation. ΣPFAS differed between lakes (ANOVA: F=50.6, p<0.0001): fish from lakes in southern Sweden (lake Gårdsjön, 58°03'N, 12°01'E) showed elevated levels of PFAS, with a maximum ΣPFAS of 3.4ng g(-1) wet weight (ww) (mean±SD: 0.99±0.63ng g(-1) ww), while the lowest levels were found in lake Björntjärn (0.31±0.08ng g(-1) ww) in northern Sweden (63°54'N, 18°51'E). PFOS was most abundant in perch from south-western Sweden, while other long-chain perfluorocarbons (>10 carbon atoms) were relatively more abundant in lakes in northern Sweden. Pearson correlation coefficients indicated that concentrations of PFAS in perch did not show any relation to fish size or age and were negatively correlated with trophic position of the fish (δ(15)N). It was also found that ΣPFAS were negatively correlated with both latitude and altitude. The PFAS data in this study represent national background concentrations in freshwater fish across Swedish lakes.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluorinated alkylated substances and brominated flame retardants in serum of the Czech adult population

Authors: Sochorová, L; Hanzlíková, L; Černá, M; Drgáčová, A; Fialová, A; Švarcová, A; Gramblička, T; Pulkrabová, J (2017) International Journal of Hygiene and Environmental Health 220:235-243. HERO ID: 3858506

[Less] Persistent organic pollutants, such as perfluorinated alkylated substances (PFASs) and brominated flame . . . [More] Persistent organic pollutants, such as perfluorinated alkylated substances (PFASs) and brominated flame retardants (BFRs) are widespread in the environment and most of them are bioaccumulated in wildlife and humans. The present study is the first investigation to reveal the PFAS and BFR levels of serum samples in the adult population of the Czech Republic. Altogether, 300 serum samples from blood donors in four cities were examined. In all samples 19 PFASs and 33 BFRs, including some of their metabolites, were targeted. The analyses were performed using ultra high performance liquid chromatography coupled with tandem mass spectrometry or gas chromatography with mass spectrometry (according to the type of analyte). PFASs, with the carbon chain length C6 and higher, dominated in all samples. Perfluorooctanesulfonate (PFOS; median: 2.43ng/mL), perfluorooctanoic acid (PFOA; median: 0.756ng/mL), perfluorodecanoic acid (PFDA; median: 0.145ng/mL) and perfluorohexanesulfonate (PFHxS; median: 0.184ng/mL) were detected in 100% of samples. Perfluorononanoic acid (PFNA; median: 0.325ng/mL) and perfluoroundecanoic acid (PFUdA; median: 0.058ng/mL) in 99.7% and 96.0% of samples, respectively. We observed statistically significant associations (p<0.05) between selected PFAS concentrations and the locality, gender, age of donors and education level. None of the BFRs was detected above the LOQ in more than 9% of the samples. The most frequently detected representatives of this group were congeners of polybrominated diphenyl ethers, namely BDE-47 (in 8.7%; range: 0.496-5.44ng/g lipid weight (l.w.)), BDE-99 (in 6.0%; range: 0.706-9.46ng/g l.w.), BDE-153 (in 7.3%; range: 0.736-6.44ng/g l.w.) and BDE-209 (in 7.0%; range: 13.7-2693ng/g l.w.).