Health & Environmental Research Online (HERO)


Per- and Polyfluoroalkyl Substances (PFAS)


13 References Were Found:

Technical Report
Technical Report

Genetic toxicity evaluation of perfluorododecanoic acid (PFDOA) in Salmonella/E.coli mutagenicity test or ames test. Study A24072.

Author: NTP (2020) HERO ID: 6337696


Technical Report
Technical Report

Genetic toxicity evaluation of fluorotelomer alcohol 8+2 in Salmonella/E.coli mutagenicity test or ames test. Study A74889.

Author: NTP (2020) National Toxicology Program. HERO ID: 6311608


Technical Report
Technical Report

Toxicokinetic evaluation (C20619) of fluorotelomer alcohol 8+2 (678-39-7) in Harlan Sprague-Dawley rats exposed via gavage or intravenous injection

Author: NTP (2017) National Toxicology Program. HERO ID: 3874923


Technical Report
Technical Report

Environment tier II assessment for indirect precursors to perfluorooctanoic acid (pfoa). CAS registry numbers: 678-39-7, 1996-88-9, 93705-98-7, 68187-42-8, 53515-73-4.

Author: NICNAS (2017) Sydney, NW, Australia: National Industrial Chemicals Notification and Assessment Scheme. HERO ID: 3860296

[Less] This assessment was carried out under the National Industrial Chemicals Notification and Assessment . . . [More] This assessment was carried out under the National Industrial Chemicals Notification and Assessment Scheme (NICNAS). This scheme has been established by the Industrial Chemicals (Notification and Assessment) Act 1989 (the Act), to aid in the protection of the Australian people and the environment by assessing the risks of industrial chemicals, providing information and making recommendations to promote their safe use.

As part of reforms regarding Existing Chemicals, NICNAS has implemented a new framework to address the human health and environmental impacts of previously unassessed industrial chemicals listed on the Australian Inventory of Chemical Substances (AICS).

The Inventory Multi-tiered Assessment and Prioritisation (IMAP) framework was developed with significant input from stakeholders. The framework provides a more rapid, flexible and transparent approach for the assessment of existing chemicals.

Stage One of this program, which is being undertaken over four years from 1 July 2012, is examining 3000 chemicals meeting characteristics identified by stakeholders as needing priority assessment. This includes chemicals for which NICNAS already holds exposure information, chemicals identified as a concern or for which regulatory action has been taken overseas, and chemicals detected in international studies analysing chemicals present in babies' umbilical cord blood.

The IMAP framework is a science and risk-based model designed to align the assessment effort with the human health and environmental impacts of chemicals. It has three tiers of assessment, with the assessment effort increasing with each tier. The Tier I assessment is a high throughput approach using tabulated electronic data. The Tier II assessment is an evaluation of risk on a substance-by-substance or chemical category-by-category basis. Tier III assessments are conducted to address specific concerns that could not be resolved during the Tier II assessment.

NICNAS assessments are carried out by staff employed by the Australian Government Department of Health and the Australian Government Department of the Environment. The human health and environment risk assessments are being conducted and published separately, using information available at the time, and may be undertaken at different tiers.

This chemical/group of chemicals is/are being assessed at Tier II because the Tier I assessment indicated that it needed further investigation.

For more detail on the new program please visit: www.nicnas.gov.au.

Archival Material
Archival Material

Danish (Q)SAR database: [FtOH 8:2 CASRN 678-39-7]

Author: DTU Food (2017) HERO ID: 3980825


Archival Material
Archival Material

Study information: CEBS accession number 002-02182-0001-0000-6: Fluorotelomer alcohol 8+2

Author: NTP (2017) Available online at https://tools.niehs.nih.gov/cebs3/ntpViews/?studyNumber=002-02182-0001-0000-6. (Aug 5, 2017). [Website] HERO ID: 3860304

[Less] CEBS Accession Number: 002-02182-0001-0000-6 Chemical Name: Fluorotelomer Alcohol 8+2 CASRN: 678-39-7 NTP . . . [More] CEBS Accession Number: 002-02182-0001-0000-6
Chemical Name: Fluorotelomer Alcohol 8+2
CASRN: 678-39-7
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: A74889
Vehicle Control: Dimethyl Sulfoxide
Study Result: Negative

Technical Report
Technical Report

CLH report: Proposal for harmonised classification and labelling; based on regulation (EC) no 1272/2008 (CLP regulation), annex VI, part 2; substance name: 8:2 fluorotelomer alcohol (8:2 FTOH); EC number: 211-648-0; CAS number: 678-39-7

Author: ECHA (2012) Helsinki, Finland: European Chemicals Agency. HERO ID: 3980827


Technical Report
Technical Report

Screening assessment perfluorooctanoic acid, its salts, and its precursors

Author: EC/HC (2012) Environment Canada and Health Canada. HERO ID: 3860053


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prediction of aqueous solubility, vapor pressure and critical micelle concentration for aquatic partitioning of perfluorinated chemicals

Authors: Bhhatarai, B; Gramatica, P (2011) Environmental Science and Technology 45:8120-8128. HERO ID: 3980826

[Less] The majority of perfluorinated chemicals (PFCs) are of increasing risk to biota and environment due . . . [More] The majority of perfluorinated chemicals (PFCs) are of increasing risk to biota and environment due to their physicochemical stability, wide transport in the environment and difficulty in biodegradation. It is necessary to identify and prioritize these harmful PFCs and to characterize their physicochemical properties that govern the solubility, distribution and fate of these chemicals in an aquatic ecosystem. Therefore, available experimental data (10-35 compounds) of three important properties: aqueous solubility (AqS), vapor pressure (VP) and critical micelle concentration (CMC) on per- and polyfluorinated compounds were collected for quantitative structure-property relationship (QSPR) modeling. Simple and robust models based on theoretical molecular descriptors were developed and externally validated for predictivity. Model predictions on selected PFCs were compared with available experimental data and other published in silico predictions. The structural applicability domains (AD) of the models were verified on a bigger data set of 221 compounds. The predicted properties of the chemicals that are within the AD, are reliable, and they help to reduce the wide data gap that exists. Moreover, the predictions of AqS, VP, and CMC of most common PFCs were evaluated to understand the aquatic partitioning and to derive a relation with the available experimental data of bioconcentration factor (BCF).

Technical Report
Technical Report

Letter Re: 8EHQ-0708-15412C 1-Decanol, 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluoro- CAS # 678-39-7. 8(e)/FYI ID Number: 8EHQ-0708-15412C. Document Control Number: 89080000262

Author: DHGC (2008) Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. [TSCA Submission] HERO ID: 3927499