Health & Environmental Research Online (HERO)


Per- and Polyfluoroalkyl Substances (PFAS)


11 References Were Found:

Technical Report
Technical Report

Toxicokinetic evaluation (C20619) of fluorotelomer alcohol 8+2 (678-39-7) in Harlan Sprague-Dawley rats exposed via gavage or intravenous injection

Author: NTP (2017) National Toxicology Program. HERO ID: 3874923


Technical Report
Technical Report

Environment tier II assessment for indirect precursors to perfluorooctanoic acid (pfoa). CAS registry numbers: 678-39-7, 1996-88-9, 93705-98-7, 68187-42-8, 53515-73-4.

Author: NICNAS (2017) Sydney, NW, Australia: National Industrial Chemicals Notification and Assessment Scheme. HERO ID: 3860296

[Less] This assessment was carried out under the National Industrial Chemicals Notification and Assessment . . . [More] This assessment was carried out under the National Industrial Chemicals Notification and Assessment Scheme (NICNAS). This scheme has been established by the Industrial Chemicals (Notification and Assessment) Act 1989 (the Act), to aid in the protection of the Australian people and the environment by assessing the risks of industrial chemicals, providing information and making recommendations to promote their safe use.

As part of reforms regarding Existing Chemicals, NICNAS has implemented a new framework to address the human health and environmental impacts of previously unassessed industrial chemicals listed on the Australian Inventory of Chemical Substances (AICS).

The Inventory Multi-tiered Assessment and Prioritisation (IMAP) framework was developed with significant input from stakeholders. The framework provides a more rapid, flexible and transparent approach for the assessment of existing chemicals.

Stage One of this program, which is being undertaken over four years from 1 July 2012, is examining 3000 chemicals meeting characteristics identified by stakeholders as needing priority assessment. This includes chemicals for which NICNAS already holds exposure information, chemicals identified as a concern or for which regulatory action has been taken overseas, and chemicals detected in international studies analysing chemicals present in babies' umbilical cord blood.

The IMAP framework is a science and risk-based model designed to align the assessment effort with the human health and environmental impacts of chemicals. It has three tiers of assessment, with the assessment effort increasing with each tier. The Tier I assessment is a high throughput approach using tabulated electronic data. The Tier II assessment is an evaluation of risk on a substance-by-substance or chemical category-by-category basis. Tier III assessments are conducted to address specific concerns that could not be resolved during the Tier II assessment.

NICNAS assessments are carried out by staff employed by the Australian Government Department of Health and the Australian Government Department of the Environment. The human health and environment risk assessments are being conducted and published separately, using information available at the time, and may be undertaken at different tiers.

This chemical/group of chemicals is/are being assessed at Tier II because the Tier I assessment indicated that it needed further investigation.

For more detail on the new program please visit: www.nicnas.gov.au.

Archival Material
Archival Material

Danish (Q)SAR database: [FtOH 8:2 CASRN 678-39-7]

Author: DTU Food (2017) HERO ID: 3980825


Archival Material
Archival Material

Study information: CEBS accession number 002-02182-0001-0000-6: Fluorotelomer alcohol 8+2

Author: NTP (2017) Available online at https://tools.niehs.nih.gov/cebs3/ntpViews/?studyNumber=002-02182-0001-0000-6. (Aug 5, 2017). [Website] HERO ID: 3860304

[Less] CEBS Accession Number: 002-02182-0001-0000-6 Chemical Name: Fluorotelomer Alcohol 8+2 CASRN: 678-39-7 NTP . . . [More] CEBS Accession Number: 002-02182-0001-0000-6
Chemical Name: Fluorotelomer Alcohol 8+2
CASRN: 678-39-7
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: A74889
Vehicle Control: Dimethyl Sulfoxide
Study Result: Negative

Technical Report
Technical Report

Screening assessment perfluorooctanoic acid, its salts, and its precursors

Author: EC/HC (2012) Environment Canada and Health Canada. HERO ID: 3860053


Technical Report
Technical Report

CLH report: Proposal for harmonised classification and labelling; based on regulation (EC) no 1272/2008 (CLP regulation), annex VI, part 2; substance name: 8:2 fluorotelomer alcohol (8:2 FTOH); EC number: 211-648-0; CAS number: 678-39-7

Author: ECHA (2012) Helsinki, Finland: European Chemicals Agency. HERO ID: 3980827


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prediction of aqueous solubility, vapor pressure and critical micelle concentration for aquatic partitioning of perfluorinated chemicals

Authors: Bhhatarai, B; Gramatica, P (2011) Environmental Science and Technology 45:8120-8128. HERO ID: 3980826

[Less] The majority of perfluorinated chemicals (PFCs) are of increasing risk to biota and environment due . . . [More] The majority of perfluorinated chemicals (PFCs) are of increasing risk to biota and environment due to their physicochemical stability, wide transport in the environment and difficulty in biodegradation. It is necessary to identify and prioritize these harmful PFCs and to characterize their physicochemical properties that govern the solubility, distribution and fate of these chemicals in an aquatic ecosystem. Therefore, available experimental data (10-35 compounds) of three important properties: aqueous solubility (AqS), vapor pressure (VP) and critical micelle concentration (CMC) on per- and polyfluorinated compounds were collected for quantitative structure-property relationship (QSPR) modeling. Simple and robust models based on theoretical molecular descriptors were developed and externally validated for predictivity. Model predictions on selected PFCs were compared with available experimental data and other published in silico predictions. The structural applicability domains (AD) of the models were verified on a bigger data set of 221 compounds. The predicted properties of the chemicals that are within the AD, are reliable, and they help to reduce the wide data gap that exists. Moreover, the predictions of AqS, VP, and CMC of most common PFCs were evaluated to understand the aquatic partitioning and to derive a relation with the available experimental data of bioconcentration factor (BCF).

Technical Report
Technical Report

Letter Re: 8EHQ-0708-15412C 1-Decanol, 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluoro- CAS # 678-39-7. 8(e)/FYI ID Number: 8EHQ-0708-15412C. Document Control Number: 89080000262

Author: DHGC (2008) Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. [TSCA Submission] HERO ID: 3927499


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Predicting the partitioning behavior of various highly fluorinated compounds

Authors: Arp, HPH; Niederer, C; Goss, KaiUwe (2006) Environmental Science and Technology 40:7298-7304. HERO ID: 3285350

[Less] Due to their high degree of fluorination, highly fluorinated compounds (HFCs) have unique substance . . . [More] Due to their high degree of fluorination, highly fluorinated compounds (HFCs) have unique substance properties that differ from many other organic contaminants. To predict the environmental behavior of HFCs, models that predict both absorptive and adsorptive partitioning are needed; however, the accuracy of existing models has not heretofore been thoroughly investigated for these compounds. This report has two parts: first we show that a well-established polyparameter linear free energy relationship used to predict experimental adsorption constants underestimates values for HFCs by several orders of magnitude. We found a mechanistic explanation for the model's inaccuracy and adjusted it accordingly. In the second part of this report, we evaluate various models that predict saturated subcooled liquid vapor pressure (p(L)*), air-water partition constant (K-aw), and the octanol-water partition constant (K-ow) based on molecular structure. These parameters are typically required for general environmental fate and transport models. Here, we found that SPARC and COSMOtherm make predictions usually within 1 order of magnitude of the experimental value, while the commonly used EPI SUITE and ClogP perform more inaccurately. The least accurate predictions occurred with ClogP for the fluorotelomer alcohols, where the estimated values were off by 2 to almost 5 orders of magnitude.

Technical Report
Technical Report

Letter Re: 8EHQ-0105-15412 1-Decanol, 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluoro- CAS # 678-39-7. 8(e)/FYI ID Number: 8EHQ-0105-15412 B: Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e

Author: DuPont Haskell Lab (2005) (Document Control Number: 89050000204). Washington, D.C.: U.S. Environmental Protection Agency. [TSCA Submission] HERO ID: 3927515

[Less] This letter is to inform you of the results of a recently completed absorption, distribution, metabolism, . . . [More] This letter is to inform you of the results of a recently completed absorption, distribution, metabolism, and elimination (ADME) study in the rat, along with comparative in vitro metabolism experiments using rat and human hepatocytes with the above referenced test material. This letter is "For Your Information" as a follow-up to qualitative data supplied to the Agency on November 25, 2002 [AR226-1141].