Health & Environmental Research Online (HERO)


PFOA (335-67-1) and PFOS (1763-23-1)


4,339 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Removal of eight perfluoroalkyl acids from aqueous solutions by aeration and duckweed

Authors: Zhang, W; Liang, Y (2020) Science of the Total Environment 724:138357. HERO ID: 6356904

[Less] Poly- and perfluoroalkyl substances (PFAS) are surfactants. Leveraging their surface active feature, . . . [More] Poly- and perfluoroalkyl substances (PFAS) are surfactants. Leveraging their surface active feature, this work investigated using aeration to remove perfluoroalkyl acids (PFAAs) from aqueous solutions. Eight PFAAs were spiked to either deionized water or Hoagland solution at three pHs. After 7 h of aeration, removals of perfluorobutanoic acid (PFBA), perfluoropentanoic acid (PFPeA), perfluorobutanesulfonic acid (PFBS), and perfluorohexanoic acid (PFHxA) were marginal and much lower than those of and perfluoroheptanoic acid (PFHpA), perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS). In deionized water, close to 80% of PFOA and PFOS at 200 ppb were removed when the pH was 2.3. The Hoagland solution at pH 2.3 and 5.0 benefited removal of long-chain PFAS at 2 ppb, but not at 200 ppb. With duckweed growing on the Hoagland solution surface, >95% of PFHpA, PFHxS, PFOA, and PFOS at 200 ppb were removed after 2 weeks. Aeration enhanced duckweed uptake of PFHxS, PFOA, and PFOS at 2 ppb significantly. Specific to PFOS, duckweed accumulated 14.4% of this compound initially spiked at 2 ppb in 2 weeks. These results demonstrated that aeration plus duckweed could be a viable and scalable remediation solution for surface water contaminated by PFAS.

Journal Article
Journal Article

Hyphenated High Performance Liquid Chromatography-Tandem Mass Spectrometry Techniques for the Determination of Perfluorinated Alkylated Substances in Lombardia Region in Italy, Profile Levels and Assessment: One Year of Monitoring Activities During 2018

Authors: Barreca, S; Busetto, M; Colzani, L; Clerici, L; Marchesi, V; Tremolada, L; Daverio, D; Dellavedova, P (2020) HERO ID: 6392504

[Less] In this research paper, we report a hyphenated technique based on ultra-high performance liquid chromatography-tandem . . . [More] In this research paper, we report a hyphenated technique based on ultra-high performance liquid chromatography-tandem mass spectrometry for the determination of twelve Perfluorinated Alkylated Substances in surface and groundwater samples from Lombardia Region during the monitoring activities in 2018 as new emerging and toxic pollutants. A green analytic method, developed by using an online Solid Phase Extraction coupled with UHPLC-MS/MS and previously validated, was applied for 4992 determinations conducted on 416 samples from 109 different sampling stations. Among the results, PFOS, PFOA, PFBA, PFBS, PFPeA and PFHxA were identified as the most abundant analytes detected. PFASs concentrations, in most cases, were below the limits of quantification and, in the cases where the limits of quantification have been exceeded, the values found were lower than Italy directive. PFOS is an exception and in fact this compound was detected in 76% of analyzed samples (surface and ground waters). Solid phase extraction with high performance liquid chromatography-tandem Mass Spectrometry has proved to be a very good Hyphenated techniques able to detect low concentrations of pollutants in surface and groundwater samples.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

High throughput analysis of 21 perfluorinated compounds in drinking water, tap water, river water and plant effluent from southern China by supramolecular solvents-based microextraction coupled with HPLC-Orbitrap HRMS

Authors: Liang, M; Xian, Y; Wang, B; Hou, X; Wang, L; Guo, X; Wu, Y; Dong, H (2020) HERO ID: 6416396

[Less] The present work reported a high-throughput strategy for the analysis of 21 perfluorinated compounds . . . [More] The present work reported a high-throughput strategy for the analysis of 21 perfluorinated compounds (PFCs) in drinking water, tap water, river water and plant effluent from southern China by supramolecular solvent (SUPARS) vortex-mixed microextraction combined with high performance liquid chromatography-Orbitrap high resolution mass spectrometry (HPLC-Orbitrap HRMS). The SUPRAS without heating assistance is less solvent-consumption, meeting the requirements for green environmental protection and sustainable development. Parameters in the microextraction such as volume of dodecanol and tetrahydrofuran (THF), vortexing extraction and centrifugation time, salt concentration were investigated. The optimal extraction conditions were 250 μL of undecanol, 1.0 mL of THF and 20.0% (w/v, 4 g) NaCl. Under the optimum conditions, method limit of detection and method limit of quantitation in the ranges of 0.01-0.08 μg/L and 0.03-0.25 μg/L, good recoveries (72.5-117.8%) and intra-day precision (1.1-11.2%, n = 6), high enrichment factors (48-78) were obtained. The developed method was successfully applied for analysis of PFCs in 13 drinking water, tap water, river water and plant effluent samples collected from southern China. Perfluorobutane sulfonic acid was detected in one river water with concentration of 0.48 μg/L and 1H,1H,2H,2H-Perfluorooctane sulfonic acid was detected in one river water and two plant effluent samples with concentrations in the range of 0.14-0.67 μg/L.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Degradation of hexafluoropropylene oxide oligomer acids as PFOA alternatives in simulated nanofiltration concentrate: Effect of molecular structure

Authors: Bao, Y; Cagnetta, G; Huang, Jun; Yu, G (2020) HERO ID: 6302277

[Less] Hexafluoropropylene oxide (HFPO) oligomer acids are an important class of perfluorooctanic acid (PFOA) . . . [More] Hexafluoropropylene oxide (HFPO) oligomer acids are an important class of perfluorooctanic acid (PFOA) alternatives used in fluoropolymer production. Their chemical structure presents a periodical -CF3 branch and oxygen bridge. In particular, hexafluoropropylene oxide dimer, trimer and tetramer acid (HFPO-DA, HFPO-TA and HFPO-TeA) have been globally detected in waters, and are thought to exert an even greater potential ecological risk than PFOA. Moreover, different to PFOA, HFPO-DA has been demonstrated to be strongly oxidation-resistant, and thus its removal is more challenging. In this study, the degradability of HFPO-TA and HFPO-TeA, as well as a perfluoropolyether carboxylic acid without a -CF3 branch (TeA-w), was investigated. Unlike HFPO-DA, HFPO-TA and HFPO-TeA could be oxidized under UV/persulfate, which was attributed to the changed molecular configuration and weakened protective effect of the -CF3 branch on a-carbon atoms against SO4- attack. As a result, the oxidability of these HFPO acids increases with the number of oxygen bridges (i.e. HFPO-TeA > HFPO-TA > HFPO-DA). However, oxidation is found to be a risky approach for HFPO-TA and HFPO-TeA removal owing to significant generation and accumulation of HFPO-DA. On the contrary, HFPO-TA and HFPO-TeA were effectively degraded without accumulation of (by)products in a strong reductive system (UV/sulfite). HFPO oligomer acid degradation in both oxidative and reductive systems always follows a similar pathway; namely, HFPO-TeA -> HFPO-TA -> HFPO-DA. Nanofiltration is potentially one of the best available technologies for HFPO oligomer removal from drinking water, but safe concentrate disposal should be a consideration. Given this, we performed degradation of HFPO-DA/TA/TeA mixture in simulated nanofiltration concentrate. More than 99.7% of the three substances were removed within 60 min, and a complete fluoride recovery was obtained 120 min later. This corroborated that reduction by UV/sulfite is a potential complementary technology for nanofiltration in drinking water deep treatment aimed at removing HFPO oligomer acid contamination.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Evaluation of residues in hen eggs after exposure of laying hens to water containing per- and poly-fluoroalkyl substances

Authors: Wilson, TB; Stevenson, G; Crough, R; de Araujo, J; Fernando, N; Anwar, A; Scott, T; Quinteros, JA; Scott, PC; Archer, MJG (2020) HERO ID: 6356902

[Less] Per- and poly-fluoroalkyl substances (PFAS) have been used in aqueous film-forming foams (AFFF) used . . . [More] Per- and poly-fluoroalkyl substances (PFAS) have been used in aqueous film-forming foams (AFFF) used in firefighting, resulting in soil and groundwater contamination and leading to human exposure via animal products grown in contaminated areas. This study reports the relationship between PFAS intake by hens and the PFAS concentrations in the edible parts of eggs. Laying hens were exposed via drinking water to different concentrations of four PFAS compounds (Perfluorooctane sulfonate (PFOS), Perfluorohexane sulfonate (PFHxS), Perfluorooctanoic acid (PFOA) and Perfluorohexanoic acid (PFHxA)) over 61 days. Egg PFAS residues were assessed for a further 30 days after exposure ceased. The target concentrations of PFAS were 0, 0.3, 3, 30 and 300 µg/L for the treatment groups T1-T5, respectively, and PFAS residues were determined from the eggs collected every second day. There was a linear correlation between the PFAS concentrations in the drinking water of hens and those detected in the egg, which could be useful in estimating PFAS concentrations in the egg by measuring water concentrations. Exposure of hens to drinking water with PFAS concentrations below the Australian Government Department of Health limits (PFOS/PFHxS, 0.07 µg/L; PFOA, 0.56 µg/L), and with no other sources of PFAS exposure, is unlikely to result in egg PFAS concentrations that would exceed the 10% limit set by Food Standards Australia New Zealand (FSANZ) for human consumption. This article is protected by copyright. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Examining NTA performance and potential using fortified and reference house dust as part of EPA's Non-Targeted Analysis Collaborative Trial (ENTACT)

Authors: Newton, , SR; Sobus, , JR; Ulrich, EM; Singh, RR; Chao, A; Mccord, J; Laughlin-Toth, S; Strynar, M (2020) Analytical and Bioanalytical Chemistry. HERO ID: 6391243

[Less] Non-targeted analysis (NTA) methods are being increasingly used to aid in the identification of unknown . . . [More] Non-targeted analysis (NTA) methods are being increasingly used to aid in the identification of unknown compounds in the environment, a problem that has challenged environmental chemists for decades. Despite its increased use, quality assurance practices for NTA have not been well established. Furthermore, capabilities and limitations of certain NTA methods have not been thoroughly evaluated. Standard reference material dust (SRM 2585) was used here to evaluate the ability of NTA to identify previously reported compounds, as well as a suite of 365 chemicals that were spiked at various stages of the analytical procedure. Analysis of the unaltered SRM 2585 extracts revealed that several previously reported compounds can be identified by NTA, and that correct identification was dependent on concentration. A manual inspection of unknown features in SRM 2585 revealed the presence of two chlorinated and fluorinated compounds in high abundance, likely precursors to perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS). A retrospective analysis of data from the American Healthy Homes Survey revealed that these compounds were present in 42% of sampled homes. Spiking the dust at various stages of sample preparation revealed losses from extraction, cleanup, and instrumental analysis; the log Kow for individual compounds influenced the overall recovery levels but no pattern could be discerned from the various degrees of interference that the matrix had on the ionization efficiency of the spiked chemicals. Analysis of the matrix-free chemical mixture at low, medium, and high concentrations led to more correct identifications than analysis at one, very high concentration. Varying the spiked amount and identifying reported compounds at known concentrations allowed an estimation of the lower limits of identification (LOIs) for NTA, analogous to limits of detection in targeted analysis. The LOIs were much lower than levels in dust that would be likely to cause bioactivity in humans, indicating that NTA is useful for identifying and monitoring compounds that may be of toxicological concern. Graphical abstract.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Organic contaminants sorbed to microplastics affect marine medaka fish early life stages development

Authors: Le Bihanic, F; Clérandeau, C; Cormier, B; Crebassa, JC; Keiter, SH; Beiras, R; Morin, B; Bégout, ML; Cousin, X; Cachot, J (2020) HERO ID: 6505745

[Less] The role of polyethylene microplastics 4-6 μm size (MPs) in the toxicity of environmental compounds . . . [More] The role of polyethylene microplastics 4-6 μm size (MPs) in the toxicity of environmental compounds to fish early life stages (ELS) was investigated. Marine medaka Oryzias melastigma embryos and larvae were exposed to suspended MPs spiked with three model contaminants: benzo(a)pyrene (MP-BaP), perfluorooctanesulfonic acid (MP-PFOS) and benzophenone-3 (MP-BP3) for 12 days. There was no evidence of MPs ingestion but MPs agglomerated on the surface of the chorion. Fish ELS exposed to virgin MPs did not show toxic effects. Exposure to MP-PFOS decreased embryonic survival and prevented hatching. Larvae exposed to MP-BaP or MP-BP3 exhibited reduced growth, increased developmental anomalies and abnormal behavior. Compared to equivalent waterborne concentrations, BaP and PFOS appeared to be more embryotoxic when spiked on MPs than when alone in seawater. These results suggest a relevant pollutant transfer by direct contact of MPs to fish ELS that should be included in the ecotoxicological risk assessment of MPs.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Distribution of micropollutants in estuarine and sea water along the Portuguese coast

Authors: Sousa, JCG; Barbosa, MO; Ribeiro, ARL; Ratola, N; Pereira, MFR; Silva, AMT (2020) HERO ID: 6505749

[Less] This work provides the first spatial distribution report of micropollutants (MPs) in the entire Portuguese . . . [More] This work provides the first spatial distribution report of micropollutants (MPs) in the entire Portuguese coast, comprising the ocean shore (sea water, SW) and whenever possible the nearest river discharging on it (estuarine water, EW). This surface water monitoring programme aimed to assess the spatial distribution of 37 MPs with a wide chemical nature, including some substances prioritized by the European Union Directive 39/2013/EU and contaminants of emerging concern targeted in the Watch List of Decisions 495/2015/EU and 840/2018/EU. The risk quotients were estimated in each sampling point for the detected MPs. High concentrations of diclofenac, tramadol and carbamazepine were determined, the latter with medium to high risk for algae. Some pharmaceuticals and perfluorooctanesulfonic acid (PFOS) were broadly distributed, maybe due to the direct discharge into the sea. Atrazine and alachlor were found in the majority of the samples, with alachlor levels often considered as medium to high risk.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Transplacental Transfer of Per- and Polyfluoroalkyl Substances (PFASs): Differences between Preterm and Full-Term Deliveries and Associations with Placental Transporter mRNA Expression

Authors: Li, J; Cai, D; Chu, C; Li, Q; Zhou, Y; Hu, L; Yang, B; Dong, G; Zeng, X; Chen, D (2020) HERO ID: 6505874

[Less] Previous studies demonstrated that per- and polyfluoroalkyl substances (PFASs) can cross the human placental . . . [More] Previous studies demonstrated that per- and polyfluoroalkyl substances (PFASs) can cross the human placental barrier. However, their transplacental transfer efficiencies (TTEs) have not been investigated in preterm delivery, and the role of placental transport proteins has rarely been explored. Our study hypothesized that the TTEs of PFASs could differ between preterm and full-term deliveries, and some placental transporters could be involved in active maternofetal PFAS transfer. In the present study, the median TTEs of 16 individual PFAS chemicals or isomers were determined to be 0.23 to 1.72 in matched maternal-cord serum pairs with preterm delivery (N = 86), which were significantly lower than those (0.35 to 2.26) determined in full-term delivery (N = 187). Significant associations were determined between the TTEs of several PFASs and the mRNA expression levels of selected transporters located on the brush border membrane. The association patterns also significantly differed between preterm and full-term deliveries and exhibited a chemical-specific manner. For example, the expression of MRP2 exhibited significantly positive associations with the TTEs of linear and branched perfluorooctanesulfonic acid (PFOS) isomers in full-term delivery, but negative, nonsignificant associations were observed in preterm delivery. This is the first study to compare the transplacental transfer of PFASs between preterm and full-term deliveries and indicate that some placental transport proteins could be involved in active transmission. The mechanisms underlying the cross-placental transfer of PFASs require further investigations to better elucidate their risks to fetal health and birth outcomes.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Exposure of female mice to perfluorooctanoic acid suppresses hypothalamic kisspeptin-reproductive endocrine system through enhanced hepatic fibroblast growth factor 21 synthesis, leading to ovulation failure and prolonged dioestrus

Authors: Zhang, Y; Cao, X; Chen, L; Qin, Y; Xu, Y; Tian, Y; Chen, L (2020) HERO ID: 6505878

[Less] Perfluorooctanoic acid (PFOA) is widely used in household applications. High-dose exposure to PFOA has . . . [More] Perfluorooctanoic acid (PFOA) is widely used in household applications. High-dose exposure to PFOA has been associated with increased risks of infertility and premature ovarian insufficiency in woman. PFOA can alter hepatic gene expression by activating peroxisome proliferator-activated receptor α (PPARα). The present study investigated whether exposure to PFOA via PPARα activation alters the synthesis of hepatic fibroblast growth factor 21 (FGF21) to disturb female neuroendocrine and reproductive function. In the present study, we show that the oral administration of PFOA (2 or 5 mg kg-1 ) in adult female mice (PFOA mice) caused prolonged dioestrous, a reduction in the number of corpora lutea and decreased levels of hypothalamic gonadotrophin-releasing hormone, serum progesterone and luteinising hormone (LH). Exposure to PFOA decreased the expression of vasopressin in the suprachiasmatic nucleus (SCN) and kisspeptin in the anteroventral periventricular nucleus (AVPV) with deficits in preovulation or oestrogen-induced LH surge. PFOA via activation of PPARα increased dose-dependently hepatic FGF21 expression, leading to elevated serum and hypothalamic FGF21 concentrations. Treatment of PFOA mice with the PPARα antagonist GW6471 or the FGF21 inhibitor PD173074 rescued SCN vasopressin and AVPV-kisspeptin expression. Either administration of GW6471 and PD173074 or treatment with vasopressin and the G protein coupled receptor 54 agonist kisspeptin-10 in PFOA-mice was able to recover the regular oestrous cycle, ovulation ability, LH surge production and reproductive hormone levels. The present study provides in vivo evidence that exposure to PFOA (≥2 mg kg-1 ) in mice causes down-regulation of the kisspeptin-reproductive endocrine system by enhancing PPARα-mediated hepatic FGF21 expression. The liver-brain reproductive endocrine disorder caused by PFOA exposure may lead to prolonged dioestrous and ovulation failure.