Health & Environmental Research Online (HERO)


PFOA (335-67-1) and PFOS (1763-23-1)


1,560 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Relationship between peroxisome proliferator-activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells

Authors: Rosenmai, AK; Ahrens, L; le Godec, T; Lundqvist, J; Oskarsson, A (2018) Journal of Applied Toxicology 38:219-226. HERO ID: 4220319

[Less] Peroxisome proliferator-activated receptor alpha (PPARα) is a molecular target for perfluoroalkyl substances . . . [More] Peroxisome proliferator-activated receptor alpha (PPARα) is a molecular target for perfluoroalkyl substances (PFASs). Little is known about the cellular uptake of PFASs and how it affects the PPARα activity. We investigated the relationship between PPARα activity and cellular concentration in HepG2 cells of 14 PFASs, including perfluoroalkyl carboxylates (PFCAs), perfluoroalkyl sulfonates and perfluorooctane sulfonamide (FOSA). Cellular concentrations were determined by high-performance liquid chromatography-tandem mass spectrometry and PPARα activity was determined in transiently transfected cells by reporter gene assay. Cellular uptake of the PFASs was low (0.04-4.1%) with absolute cellular concentrations in the range 4-2500 ng mg-1 protein. Cellular concentration of PFCAs increased with perfluorocarbon chain length up to perfluorododecanoate. PPARα activity of PFCAs increased with chain length up to perfluorooctanoate. The maximum induction of PPARα activity was similar for short-chain (perfluorobutanoate and perfluoropentanoate) and long-chain PFCAs (perfluorododecanoate and perfluorotetradecanoate) (approximately twofold). However, PPARα activities were induced at lower cellular concentrations for the short-chain homologs compared to the long-chain homologs. Perfluorohexanoate, perfluoroheptanoate, perfluorooctanoate, perfluorononanoate (PFNA) and perfluorodecanoate induced PPARα activities >2.5-fold compared to controls. The concentration-response relationships were positive for all the tested compounds, except perfluorooctane sulfonate PFOS and FOSA, and were compound-specific, as demonstrated by differences in the estimated slopes. The relationships were steeper for PFCAs with chain lengths up to and including PFNA than for the other studied PFASs. To our knowledge, this is the first report establishing relationships between PPARα activity and cellular concentration of a broad range of PFASs.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

Authors: Chiu, WA; Guyton, KZ; Martin, MT; Reif, DM; Rusyn, I (2018) Altex 35:51-64. HERO ID: 3981309

[Less] Evidence regarding carcinogenic mechanisms serves a critical role in International Agency for Research . . . [More] Evidence regarding carcinogenic mechanisms serves a critical role in International Agency for Research on Cancer (IARC) Monograph evaluations. Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to supplement other mechanistic evidence. In Monograph V110, HTS profiles were compared between perfluorooctanoic acid (PFOA) and prototypical activators across multiple nuclear receptors. For Monograph V112 -113, HTS assays were mapped to 10 key characteristics of carcinogens identified by an IARC expert group, and systematically considered as an additional mechanistic data stream. Both individual assay results and ToxPi-based rankings informed mechanistic evaluations. Activation of multiple nuclear receptors in HTS assays showed that PFOA targets peroxisome proliferator activated and other receptors. ToxCast assays substantially covered 5 of 10 key characteristics, corroborating literature evidence of "induces oxidative stress" and "alters cell proliferation, cell death or nutrient supply" and filling gaps for "modulates receptor-mediated effects." Thus, ToxCast HTS data were useful both in evaluating specific mechanistic hypotheses and in the overall evaluation of mechanistic evidence. However, additional HTS assays are needed to provide more comprehensive coverage of the 10 key characteristics of carcinogens that form the basis of current IARC mechanistic evaluations.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water

Authors: Li, Y; Fletcher, T; Mucs, D; Scott, K; Lindh, CH; Tallving, P; Jakobsson, K (2018) Occupational and Environmental Medicine 75:46-51. HERO ID: 4238434

[Less] BACKGROUND: Municipal drinking water contaminated with perfluorinated alkyl acids had . . . [More] BACKGROUND: Municipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from 16 December 2013.

OBJECTIVE: To determine the rates of decline in serum perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), and their corresponding half-lives.

METHODS: Up to seven blood samples were collected between June 2014 and September 2016 from 106 participants (age 4-84 years, 53% female).

RESULTS: Median initial serum concentrations were PFHxS, 277 ng/mL (range 12-1660); PFOS, 345 ng/mL (range 24-1500); and PFOA, 18 ng/mL (range 2.4-92). The covariate-adjusted average rates of decrease in serum were PFHxS, 13% per year (95% CI 12% to 15%); PFOS, 20% per year (95% CI 19% to 22%); and PFOA, 26% per year (95% CI 24% to 28%). The observed data are consistent with a first-order elimination model. The mean estimated half-life was 5.3 years (95% CI 4.6 to 6.0) for PFHxS, 3.4 years (95% CI 3.1 to 3.7) for PFOS and 2.7 years (95% CI 2.5 to 2.9) for PFOA. The interindividual variation of half-life was around threefold when comparing the 5th and 95th percentiles. There was a marked sex difference with more rapid elimination in women for PFHxS and PFOS, but only marginally for PFOA.

CONCLUSIONS: The estimated half-life for PFHxS was considerably longer than for PFOS and PFOA. For PFHxS and PFOS, the average half-life is shorter than the previously published estimates. For PFOA the half-life is in line with the range of published estimates.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Riverine inputs and source tracing of perfluoroalkyl substances (PFASs) in Taihu Lake, China

Authors: Ma, X; Shan, G; Chen, M; Zhao, J; Zhu, L (2018) Science of the Total Environment 612:18-25. HERO ID: 3981684

[Less] The occurrence, riverine inputs and sources of perfluoroalkyl substances (PFASs) in Taihu Lake, one . . . [More] The occurrence, riverine inputs and sources of perfluoroalkyl substances (PFASs) in Taihu Lake, one of the largest lakes in China, were investigated by measuring PFASs including the isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) and perfluorohexanesulfonate (PFHxS) in the Lake and its main flow-in rivers. It was found that PFHxS, instead of PFOS or PFOA, was predominant both in the Lake and rivers (45.9-351ng/L), reflecting increasing demand of PFHxS in recent years. The riverine flux of PFASs into the Lake was estimated to be 1255kg/year. The percentage of linear (n-) PFOS and the ratio of 3+5m-/1m-PFOS were combined to indicate indirect source due to biodegradation of PFOS-precursors. The percentage order of n-PFOS was: the Lake (48.7%)the rivers (8.99)>ECF (electrochemical fluorination) product (6.76). These suggested that degradation of PFOS-precursors made distinct contribution to PFOS load in the waters, particularly in the Lake. The Lake and river waters had a consistent proportion of n-PFHxS (89.0%), which was slightly lower than the ECF product (96.0%), indicating it was mainly due to the release from production and application of PFHxS as an active ingredient.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

An overview of advanced reduction processes for bromate removal from drinking water: Reducing agents, activation methods, applications and mechanisms

Authors: Xiao, Q; Yu, S; Li, L; Wang, T; Liao, X; Ye, Y (2017) HERO ID: 3981937

[Less] Bromate (BrO3(-)) is a possible human carcinogen regulated at a strict standard of 10μg/L in drinking . . . [More] Bromate (BrO3(-)) is a possible human carcinogen regulated at a strict standard of 10μg/L in drinking water. Various techniques to eliminate BrO3(-) usually fall into three main categories: reducing bromide (Br(-)) prior to formation of BrO3(-), minimizing BrO3(-) formation during the ozonation process, and removing BrO3(-) from post-ozonation waters. However, the first two approaches exhibit low degradation efficiency and high treatment cost. The third workaround has obvious advantages, such as high reduction efficiency, more stable performance and easier combination with UV disinfection, and has therefore been widely implemented in water treatment. Recently, advanced reduction processes (ARPs), the photocatalysis of BrO3(-), have attracted much attention due to improved performance. To increase the feasibility of photocatalytic systems, the focus of this work concerns new technological developments, followed by a summary of reducing agents, activation methods, operational parameters, and applications. The reaction mechanisms of two typical processes involving UV/sulfite homogeneous photocatalysis and UV/titanium dioxide heterogeneous photocatalysis are further summarized. The future research needs for ARPs to reach full-scale potential in drinking water treatment are suggested accordingly.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver: Supplementary materials

Authors: Yan, S; Zhang, H; Guo, X; Wang, J; Dai, J (2017) Archives of Toxicology 91. [Supplemental Data] HERO ID: 3986361

Abstract: Supplementary materials

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Rapid determination of small molecule pollutants using metal-organic frameworks as adsorbent and matrix of MALDI-TOF-MS

Authors: Wang, S; Niu, H; Zeng, Tao; Zhang, X; Cao, D; Cai, Y (2017) HERO ID: 3981934

[Less] Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been . . . [More] Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been commonly used for the determination of macromolecules owing to the high sensitivity and convenience. However, the direct analysis of small molecule with MALDI-TOF-MS remains a challenge due to the matrix interference in the low mass region. In this paper, metal-organic frameworks (MOFs: MOF-5, MOF-235, Cu-btc MOFs and Uio-66(Zr)-2OH) were successfully used as both adsorbent and significant matrix of MALDI-TOF-MS method for the analysis of small molecule pollutants. Benzo(a)pyrene (BaP) and perfluorinated compounds (PFCs) were chosen as model analytes to investigate the matrix function of MOFs with LDI measurement in positive and negative reflection mode, respectively. As a result, MOFs exhibit high laser desorption/ionization efficiency and function well in both positive-ion and negative ion modes. Compared to the MS spectra with conventional matrices, MS spectra obtained on MOFs matrix are only featured by deprotonated molecule ion peaks without background interference. Furthermore, MOFs, with large surface area and pi-pi stacking structure, can also enrich trace amounts of small molecule pollutants from solution efficiently and quickly. According to these, we developed a simple method in which MOFs-solid-phase extraction (SPE) enrichment was combined with MALDI-TOF-MS to realize the direct analysis of perfluorooctanesulfonate (PFOS) in real water samples. (C) 2016 Elsevier Inc. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Aromatic Esters, Carbinols, and Derivatives Thereof with Perfluorohexyl Residues as Alternatives to Perfluoroalkanecarboxylic and -sulfonic Acids

Authors: Alpers, T; Muesmann, TWT; Temme, O; Christoffers, J (2017) HERO ID: 3981907

[Less] Four perfluorohexyl carbinols have been prepared from the corresponding Grignard reagent and benzaldehyde, . . . [More] Four perfluorohexyl carbinols have been prepared from the corresponding Grignard reagent and benzaldehyde, terephthalaldehyde, isophthalaldehyde, and trimesaldehyde. The corresponding secondary alcohols were then transformed by alkylation and acylation reactions to form a total of 14 ethers (methyl, ethyl, propyl, and n-hexyl ethers) and esters (acetyl and 2-ethylhexanoyl), respectively. Furthermore, 11 perfluoroalkyl carboxylates were prepared from aromatic, heteroaromatic, and aliphatic mono-, di-, tri-, and tetracarboxylic acids and trideca-fluorooctanol. The wettability of all 29 materials was investigated by the water contact angle measurements of thin films on glass surfaces. In up to six cases, contact angles greater than 130 degrees were observed, which indicates that the products might be suitable candidates for the impregnation of surfaces. With their relatively short perfluoroalkyl side-chains and therefore low bioaccumulativity, the target compounds might be beneficial alternatives to established products.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Recovery of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) from dilute water solution by foam flotation

Authors: Lee, YuChi; Wang, PoYen; Lo, SL; Huang, CP (2017) HERO ID: 3981932

[Less] The separation and recovery of surfactants, namely, Perfluorooctane sulfonate (PFOS) and Perfluorooctanoate . . . [More] The separation and recovery of surfactants, namely, Perfluorooctane sulfonate (PFOS) and Perfluorooctanoate (PFOA) was conducted using foam flotation process aided by metallic activators, including Al(III), Fe(III), La(III), Ca(II), Fe(II), and K(I). The PFOS removal efficiency followed the following decreasing order: Fe(III) La(III) > Al(III) > Ca(II) > Fe(II) > K(I). Both PFOS and FPOA had a removal efficiency of > 99% in the presence of 11.5 mM of Fe(III) in 5 min. High Fe(III) dose and elevated initial PFOS and PFOA concentration enhanced surfactant removal. PFOS and PFOA removal also increased with decreasing pH with maximum removal occurring at the lowest pH of 2.3 studied; whereas no significant removal was observed at pH >= 6. At high pH, hydroxide ion (OH-) competed with PFOS or PFOA for Fe3+ and formed ferric hydroxo species that impeded surfactant removal. However, by adjusting the pH of the concentrate scum to 7.0, approximately 84-91% of PFOS and PFOA could be recovered. Foam flotation using ferric ion as activator, is a simple, fast, and cost-effective method of broad environmental friendly applications for the separation and recovery of PFOS and PFOA from dilute water solutions. (C) 2016 Elsevier B.V. All rights reserved.

Journal Article
Journal Article

Fabrication of Ag/AgBr/Ga2O3 heterojunction composite with efficient photocatalytic activity

Authors: Liu, Q; Yu, Z; Li, M; Hou, Y; Sun, Lei; Wang, Li; Peng, Z; Chen, D; Liu, Y (2017) HERO ID: 3981828

[Less] A novel Ag/AgBr/Ga2O3 composite with heterojunction microstructure was synthesized by using chemical . . . [More] A novel Ag/AgBr/Ga2O3 composite with heterojunction microstructure was synthesized by using chemical deposition followed by UV reduction method. High resolution transmission electron microscopy showed that Ga2O3 microparticles were tightly attached with Ag/AgBr to form a heterojunction. UV-vis diffuse reflectance spectra revealed that light response capability of Ga2O3 was enhanced significantly when combined with Ag/AgBr. The degradation efficiency of methyl orange within 30 min under UV light irradiation with Ag/AgBr/Ga2O3, Ag/AgBr and Ga2O3 were 89%, 74% and 48%, respectively. Ag/AgBr/Ga2O3 not only showed excellent photocatalytic activity under UV light, but also exhibited efficient photocatalysis capacity under visible light. Furthermore, the mechanism of charge separation in the heterojunction under UV light irradiation was proposed. (C) 2017 Elsevier B.V. All rights reserved.