Health & Environmental Research Online (HERO)


PFOA (335-67-1) and PFOS (1763-23-1)


2,191 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Do concentrations of perfluoroalkylated acids (PFAAs) in isopods reflect concentrations in soil and songbirds? A study using a distance gradient from a fluorochemical plant

Authors: Groffen, T; Eens, M; Bervoets, L (2019) Science of the Total Environment 657:111-123. HERO ID: 5080482

[Less] Perfluoroalkylated acids (PFAAs) are persistent chemicals that have been detected globally in the environment . . . [More] Perfluoroalkylated acids (PFAAs) are persistent chemicals that have been detected globally in the environment and in wildlife. Although it is known that PFAAs sorb to solid matrices, little is known on PFAA concentrations in soils. PFAA pollution has often been studied in aquatic invertebrates. However, this has rarely been done on terrestrial species. In the present study, we examined whether the concentrations of 15 PFAAs in isopods (Oniscidae), collected at a fluorochemical plant and in four other areas, representing a gradient in distance from the pollution source (1 km to 11 km), were related to those in the soil and in eggs of a songbird, the great tit (Parus major), collected in the same areas. Additionally, we examined the effect of physicochemical properties such as total organic carbon (TOC) and clay content on the relationship between the concentrations in soil and isopods. Finally, we examined the composition profile in the soil and isopods. Mean PFOS and PFOA concentrations of 1700 ng/g dw and 24 ng/g dw were detected in the soil at the plant. PFOS and PFPeA were the dominant PFAAs in isopods and were detected at mean concentrations of 253 and 108 ng/g ww, respectively. The great tit eggs showed elevated mean PFOS concentrations of 55,970 ng/g ww. In most cases, PFAA concentrations decreased with increasing distance from the plant. As PFAA concentrations in isopods were correlated with concentrations in the soils, isopods could serve as a bioindicator for PFAA concentrations in soils. Additionally, there were indications that isopods could also serve as a bioindicator for PFAA concentrations in eggs of great tits. However, these indications were only the case at two locations, showing the need to further monitor the possibilities of using isopods as a bioindicator for PFAA concentrations in song bird eggs. CAPSULE: Elevated PFAA concentrations in isopods reflected concentrations in songbird eggs and in soil, indicating that trophic transfer of PFAAs from soil, via isopods, to songbirds might play a role in the PFAA exposure of terrestrial songbirds.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Determination of 21 perfluoroalkyl substances and organophosphorus compounds in breast milk by liquid chromatography coupled to orbitrap high-resolution mass spectrometry

Authors: Beser, MI; Pardo, O; Beltrán, J; Yusà, V (2019) Analytica Chimica Acta 1049:123-132. HERO ID: 5080502

[Less] The human exposure to perfluoroalkyl (PFASs) and organophosphorus (OPs) compounds is a cause of concern . . . [More] The human exposure to perfluoroalkyl (PFASs) and organophosphorus (OPs) compounds is a cause of concern and its determination in biological matrices, including human milk, is an emergent approach for evaluate their exposure. A comprehensive strategy for the quantitative determination of 21 PFASs and OPs compounds in breast milk was developed. The proposed method includes an extraction and clean-up procedure based on the QuEChERs methodology followed by an ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) determination. The full-scan mass data were acquired with a resolution of 50000 FWHM and a mass accuracy better than 5 ppm. Method validation was performed in terms of recovery, repeatability, linearity and limit of quantification. The obtained recoveries varied between 70 and 120% with a precision (RSD) lower than 25%. The limit of quantification (LOQ) ranged between 1.9 and 19.0 ng g-1 lipid weight for OPs, and between 0.066 ng mL-1 and 0.666 ng mL-1 for PFASs. A breast milk reference material was used in order to check the validated method. The developed analytical strategy was applied to 20 breast milk samples collected from mothers living in the Valencian Region (Spain). All of the OPs analyzed except tris(2-chloroethyl) phosphate (TCEP) were detected in at least one sample. In all samples, perfluoro-n-pentanoic acid (PFPeA), perfluoro-n-octanoic acid (PFOA) and sodium perfluoro-1-octanesulfonate (PFOS) were the most frequently detected analytes. Concentration of total OPs (∑OPs) and total PFASs (∑PFASs) ranged from 1.9 to 37.7 ng g-1 lipid weight and from 0.066 to 0.356 ng mL-1, respectively.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluoroalkyl acids in paired serum, urine, and hair samples: Correlations with demographic factors and dietary habits

Authors: Kim, DH; Lee, JH; Oh, JE (2019) Environmental Pollution 248:175-182. HERO ID: 5080622

[Less] We analyzed paired serum, urine, and hair samples from 94 Korean children and adults to investigate . . . [More] We analyzed paired serum, urine, and hair samples from 94 Korean children and adults to investigate levels of 11 perfluoroalkyl acids (PFAAs). The effects of demographic factors and dietary habits on PFAA exposure were also assessed based on the paired samples. The total PFAA concentrations were 2.4-31 ng/mL in serum, not detected-9.5 ng/mL in urine, and 0.48-15 ng/g in hair. Levels of perfluoropentanoic acid (PFPeA) and perfluorohexanoic acid (PFHxA), which have short carbon chains, were 1.5-5 fold higher in urine and hair than in serum. The PFAA concentrations in serum exhibited a decreasing trend with age from young childhood to adolescence, followed by an increasing trend after adolescence. For most PFAA species, concentrations in serum were higher in adult males than in adult females (p < 0.01). No sex difference was evident in the urine and hair samples. In addition, there was no age difference in the urine samples, but in the hair samples, we observed higher concentrations of PFAAs in children than in the other age groups (p < 0.01). The consumption rates of fish and water showed significant correlations with serum (positive correlation) and hair (negative) concentrations, respectively. No relationships between serum and hair/urine levels for most PFAAs were observed, except between serum and hair levels for perfluorooctanoic acid (PFOA).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Renal function and isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS): Isomers of C8 Health Project in China

Authors: Wang, J; Zeng, XW; Bloom, MS; Qian, Z; Hinyard, LJ; Belue, R; Lin, S; Wang, SQ; Tian, YP; Yang, M; Chu, C; Gurram, N; Hu, LW; Liu, KK; Yang, BY; Feng, D; Liu, RQ; Dong, GH (2019) Chemosphere 218:1042-1049. HERO ID: 5080583

[Less] Perfluoroalkyl substances (PFASs) are widely-utilized synthetic chemicals commonly found in industrial . . . [More] Perfluoroalkyl substances (PFASs) are widely-utilized synthetic chemicals commonly found in industrial and consumer products. Previous studies have examined associations between PFASs and renal function, yet the results are mixed. Moreover, evidence on the associations of isomers of PFASs with renal function in population from high polluted areas is scant. To help to address this data gap, we used high performance liquid chromatography-mass spectrometry to measure serum isomers of perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), and other PFASs from 1612 adults residing in Shenyang, China, and characterized their associations with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). Results showed that after adjusted for multiple confounding factors, most of the higher fluorinated PFASs, except for PFOA and PFDA, were negatively associated with eGFR and positively associated with CKD. Compared with linear PFOS (n-PFOS), branched PFOS isomers (Br-PFOS) were more strongly associated with eGFR (Br-PFOS; β = -1.22, 95%CI: 2.02, -0.42; p = 0.003 vs. n-PFOS; β = -0.16, 95%CI: 0.98, 0.65; p = 0.691) and CKD (Br-PFOS; OR = 1.27; 95% CI: 1.02, 1.58; p = 0.037 vs. n-PFOS; OR = 0.98; 95% CI: 0.80, 1.20; p = 0.834). In conclusion, branched PFOS isomers were negatively associated with renal function whereas their linear counterparts were not. Given widespread exposure to PFASs, potential nephrotoxic effects are of great public health concern, Furthermore, longitudinal research on the potential nephrotoxic effects of PFASs isomers will be necessary to more definitively assess the risk.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluoroalkyl substances exposure and risk of polycystic ovarian syndrome related infertility in Chinese women

Authors: Wang, W; Zhou, W; Wu, S; Liang, F; Li, Y; Zhang, J; Cui, L; Feng, Y; Wang, Y (2019) Environmental Pollution 247:824-831. HERO ID: 5080500

[Less] Perfluoroalkyl substances (PFASs) are a family of synthetic, fluorinated organic compounds. They have . . . [More] Perfluoroalkyl substances (PFASs) are a family of synthetic, fluorinated organic compounds. They have been widely used in industrial applications and consumer products and widespread in the environment, wildlife and human. Experimental and epidemiologic evidence suggested that PFASs are capable of interfering with endocrine processes and have potential reproductive and developmental toxicities. Polycystic ovarian syndrome (PCOS), one of the main reasons of female infertility, is a common endocrine disorder in reproductive age women. We performed a case-control study to evaluate associations between PCOS-related infertility and PFASs concentrations in plasma. A total of 180 infertile PCOS-cases and 187 healthy controls were recruited from the Center for Reproductive Medicine of Shandong University. Blood specimens were collected at enrollment and analyzed for ten PFASs using liquid chromatography-tandem mass spectrometry. Multivariable logistic regression procedure was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for each PFAS. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) were the dominant PFASs in the plasma of participants, with the median concentration of 5.07 ng/mL and 4.05 ng/mL, respectively. The median levels of individual PFAS were not significantly different between PCOS-cases and controls. While adjusted for the potential confounders (age, BMI, household income, education level, employment status, age at menarche, menstrual volume), the plasma concentration of perfluorododecanoic acid (PFDoA), a 12 carbons lengths of perfluorocarboxylic acids, was associated with a significantly increased risk of PCOS-related infertility (medium vs low tertile: OR = 2.36, 95% CI: 1.12, 4.99, P = 0.02; high vs low tertile: OR = 3.04, 95% CI: 1.19, 7.67, P = 0.02), with the P trend 0.01. No significant relationship was observed between PCOS-related infertility and other PFAS analytes in the adjusted model, despite perfluoroundecanoic acid showed a negative association (P trend 0.03). The potential reproductive health effects of PFASs and the underlying mechanisms merit further investigation in the future.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prenatal exposure to perfluorobutanesulfonic acid and childhood adiposity: A prospective birth cohort study in Shanghai, China

Authors: Chen, Q; Zhang, X; Zhao, Y; Lu, W; Wu, J; Zhao, S; Zhang, J; Huang, L (2019) Chemosphere 226:17-23. HERO ID: 5080578

[Less] BACKGROUND: Several per- and polyfluoroalkyl substances (PFAS) have been phased out . . . [More] BACKGROUND: Several per- and polyfluoroalkyl substances (PFAS) have been phased out due to their adverse effects, and replaced by the short-chain perfluorobutanesulfonic acid (PFBS). However, the long-term impacts of PFBS on human health are unknown.

OBJECTIVE: We aimed to investigate the association between prenatal exposure to PFAS, especially PFBS and childhood adiposity at 5 years of age.

METHODS: We conducted a prospective birth cohort study involving 1,140 pregnant women from 2012 to 2017 in Shanghai. Fetal umbilical cord blood was collected at birth. A total of 404 children (196 girls) completed the adiposity measurements using a bioelectrical impedance analysis method and cord plasma PFAS measurements using LC-MS/MS. Multivariable linear models after adjustment for potential confounders were used to evaluate the associations between PFAS and childhood adiposity.

RESULTS: The median concentration of PFAS in the cord plasma ranged from 0.05 (PFBS) to 6.74 ng/mL (PFOA). Results of multivariable linear regression found that in girls, PFBS had a significant positive association with waist circumference and waist to height ratio (P-values < 0.05). Girls in the highest tertile of PFBS concentrations had more fat mass, as well as higher body fat percentage, waist circumference, and waist to height ratio compared to those in the lowest tertile. However, girls in the second tertile of PFDoA had lower body fat percentage, waist circumference and fat mass.

CONCLUSIONS: Adiposity at 5 years of age shows a positive association with prenatal exposure to PFBS in girls. These findings need to be further verified in larger prospective studies.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Comprehensive analysis of photoinitiators and primary aromatic amines in food contact materials using liquid chromatography High-Resolution Mass Spectrometry

Authors: Sanchis, Y; Coscollà, C; Yusà, V (2019) Talanta 191:109-118. HERO ID: 5080281

[Less] A comprehensive strategy for the analysis of UV-ink photoinitiators and primary aromatic amines (PAAS) . . . [More] A comprehensive strategy for the analysis of UV-ink photoinitiators and primary aromatic amines (PAAS) in food-packaging materials such as, juice tetrabricks, pouches and bags has been developed using liquid chromatography coupled to Orbitrap High-Resolution Mass Spectrometry (LC-Orbitrap-HRMS). The methodology includes both quantitative target analysis and post-run target screening analysis. The quantitative method was validated after a previous optimisation of the single-stage Orbitrap fragmentation through the Higher-Energy Collisional Dissociation (HCD) Cell. Overall, the quantitative method presented recoveries ranging from 78% to 119%, with a precision (RSD) lower than 20%, for the 18 substances in the scope of the target method. Limit of quantification (LOQ) for UV-inks photoinitiators ranged from 0.5 µg/kg-1 for Isopropyl Thioxanthone (ITX) and 2-Ethylhexyl 4-(dimethylamino) benzoate (EHDAB) to 5 µg/kg-1 for the rest of photoinitiators. LOQ for PAAs were 2 µg/kg-1 except for aniline (ANL) and 3,3' dimethylbenzidine (3,3'-DMB) which was 2.5 µg/kg-1 in the two studied simulants (acetic acid 3% and ethanol 50%). For post-run target screening a customized theoretical database, that included Bisphenols, Polyfluorinated compounds (PFCs), Phosphorus Flame Retardants (PFRs) and other substances was built. For identification purposes, a mass accuracy lower than 5 ppm, and some diagnostic ions including isotopes and/or fragments were used. The strategy was applied to 18 samples collected in the Valencian region (Spain). No compounds were detected when the standardised migration test was applied. However, in the destructive test, benzophenone and EHDAB were determined from tetrabrick and pouch materials. In the post-run target analysis two PFCs (Perfluorooctanoic acid and Perfluoro-1-butanesulfonate) and four PFRs (2-ethylhexyl diphenyl phosphate, tris(2-choloroisopropyl) phosphate, triphenyl phosphate and 2-ethylhexyl diphenyl phosphate) were identified.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Effect of perfluorodecanoic acid on pig oocyte viability, intracellular calcium levels and gap junction intercellular communication during oocyte maturation in vitro

Authors: Domínguez, A; Salazar, Z; Betancourt, M; Ducolomb, Y; Casas, E; Fernández, F; Bahena, I; Salomón, A; Teteltitla, M; Martínez, R; Chaparro, A; Cuapio, P; Salazar-López, C; Bonilla, E (2019) Toxicology In Vitro 58:224-229. HERO ID: 5080569

[Less] Perfluorodecanoic acid (PFDA) is a synthetic perfluorinated compound, which has been reported to exert . . . [More] Perfluorodecanoic acid (PFDA) is a synthetic perfluorinated compound, which has been reported to exert adverse effects on somatic cells. However, its effects on germ cells have not been studied to date. The aim of the present study was to analyze the effects of PFDA on the viability, intracellular calcium levels and gap junction intercellular communication (GJIC) during porcine oocyte maturation in vitro. PFDA negatively impacted oocyte viability (medium lethal concentration, LC50 = 7.8 μM) and maturation (medium inhibition of maturation, IM50 = 3.8 μM). Oocytes exposed to 3.8 μM PFDA showed higher levels of intracellular calcium relative to control oocytes. In addition, GJIC among the cumulus cells and the oocyte was disrupted. The effects of PFDA on oocyte calcium homeostasis and intercellular communication seem to be responsible for the inhibition of oocyte maturation and oocyte death. In addition, since the deleterious effects of PFDA on oocyte viability, maturation and GJIC are significantly stronger than the previously reported effects of another widely used perfluorinated compound (Perfluorooctane sulfonate) in the same model, the use of PFDA in consumer products is questioned.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Adverse maternal, fetal, and postnatal effects of hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague-Dawley rats

Authors: Conley, JM; Lambright, CS; Evans, N; Strynar, MJ; Mccord, J; Mcintyre, BS; Travlos, GS; Cardon, MC; Medlock-Kakaley, E; Hartig, PC; Wilson, VS; Gray, LE, Jr (2019) Environmental Health Perspectives 127:1-13. HERO ID: 5024654

[Less] Hexafluoropropylene oxide dimer acid ((HFPO-DA), GenX) is a member of the per- and polyfluoroalkyl substances . . . [More] Hexafluoropropylene oxide dimer acid ((HFPO-DA), GenX) is a member of the per- and polyfluoroalkyl substances (PFAS) chemical class and elevated levels have been detected in surface water, air, and treated drinking water in the United States and Europe.

Objectives: Characterize the potential maternal and postnatal toxicities of oral HFPODA in rats during sexual differentiation. Given that some PFAS activate peroxisome proliferator activated receptors (PPARs), assess if HFPO-DA affects androgendependent development or interferes with estrogen, androgen, or glucocorticoid receptor activity.

Methods: Steroid receptor activity was assessed with a suite of in vitro transactivation assays and Sprague-Dawley rats were used to assess maternal, fetal, and postnatal effects of HFPO-DA exposure. Dams were dosed daily via oral gavage during male reproductive development (gestation day 14-18). We evaluated fetal testes, maternal and fetal livers, maternal serum clinical chemistry, and reproductive development of F1 animals.

Results: HFPO-DA displayed negligible in vitro receptor activity and did not impact testosterone production or expression of genes key to male reproductive development in the fetal testis; however, in vivo exposure during gestation produced higher maternal liver weights (≥62.5 mg/kg), lower maternal serum thyroid hormone and lipid profiles (≥30 mg/kg), and upregulated gene expression related to PPAR signaling pathways in maternal and fetal livers (≥1 mg/kg). Further, the pilot postnatal study indicated lower female body weight and lower weights of male reproductive tissues in F1 animals.

Conclusions: HFPO-DA exposure produced multiple effects similar to prior toxicity evaluations on PFAS, such as PFOS and PFOA, but at higher oral doses. The mean dam serum concentration from the lowest dose group was 4-fold greater than the maximum serum concentration detected in a worker in a HFPO-DA manufacturing facility. Research is needed examining the mechanisms and downstream events linked to the adverse effects of PFAS, and mixture-based studies evaluating multiple PFAS.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prenatal exposure to persistent organic pollutants in Northern Tanzania and their distribution between breast milk, maternal blood, placenta and cord blood

Authors: Müller, MHB; Polder, A; Brynildsrud, OB; Grønnestad, R; Karimi, M; Lie, E; Manyilizu, WB; Mdegela, RH; Mokiti, F; Murtadha, M; Nonga, HE; Skaare, JU; Solhaug, A; Lyche, JL (2019) Environmental Research 170:433-442. HERO ID: 5080599

[Less] Human exposure to persistent organic pollutants (POPs) begins during pregnancy and may cause adverse . . . [More] Human exposure to persistent organic pollutants (POPs) begins during pregnancy and may cause adverse health effects in the fetus or later in life. The present study aimed to assess prenatal POPs exposure to Tanzanian infants and evaluate the distribution of POPs between breast milk, maternal blood, placenta and cord blood. For assessment of prenatal exposure, 48 maternal blood samples from Mount Meru Regional Referral Hospital (MMRRH), Arusha Tanzania, were analyzed for organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), brominated flame retardants (BFRs), dioxin-like (DL) activity and perfluorinated alkyl substances (PFASs). For evaluation of POPs distribution between maternal/infant compartments, breast milk, placenta and cord blood corresponding to the maternal blood were analyzed for OCPs, PCBs and BFRs. In maternal blood, p,p´- DDE was detected in 100% of the samples ranging between 29 and 1890 ng/g lipid weight (lw). PCB-153 was the only PCB detected in maternal blood, with detection rate of 29% and concentrations up to 116 ng/g lw. BDE-47 was detected in 65% of the maternal blood samples, ranging between