Health & Environmental Research Online (HERO)


PFBS (375-73-5)


661 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Air-stable binuclear Titanium(IV) salophen perfluorobutanesulfonate with zinc power catalytic system and its application to C-S and C-Se bond formation

Authors: Wang, L; Qiao, Jie; Wei, J; Liang, Z; Xu, X; Li, N (2020) HERO ID: 6416096


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Interaction between hypoxia and perfluorobutane sulfonate on developmental toxicity and endocrine disruption in marine medaka embryos

Authors: Tang, L; Liu, M; Song, S; Hu, C; Lam, PKS; Lam, JCW; Chen, L (2020) Aquatic Toxicology 222:105466. HERO ID: 6325002

[Less] The co-occurrence of hypoxia and xenobiotics is extremely common in natural environments, highlighting . . . [More] The co-occurrence of hypoxia and xenobiotics is extremely common in natural environments, highlighting the necessity to elicit their interaction on aquatic toxicities. In the present study, marine medaka embryos were exposed to various concentrations (nominal 0, 1, 3.3 and 10 mg/L) of perfluorobutane sulfonate (PFBS), an environmental pollutant of emerging concern, under either normoxia (6.9 mg/L) or hypoxia (1.7 mg/L) condition. After acute exposure till 15 days post-fertilization, single or combined toxicities of PFBS and hypoxia on embryonic development (e.g., mortality, hatching and heartbeat) and endocrine systems were investigated. Sex and thyroid hormones were measured by enzyme-linked immunosorbent assay. Transcriptional changes of endocrine genes were determined by quantitative real-time PCR assays. Co-exposure to 10 mg/L PFBS and hypoxia caused a further reduction in survival rate and heart beat compared to single exposure. PFBS induced a precocious hatching, while no larvae hatched under hypoxia condition. By disturbing the balance of sex hormones, either PFBS or hypoxia single exposure produced an anti-estrogenic activity in medaka larvae. However, PFBS and hypoxia combinations reversed to estrogenic activity in co-exposed larvae. Variation in disrupting pattern may be attributed to the interactive effects on steroidogenic pathway involving diverse cytochrome P450 enzymes. Regarding thyroid system, PFBS exposure caused detriments of multiple processes along thyroidal axis (e.g., feedback regulation, synthesis and transport of thyroid hormones, receptor-mediated signaling and thyroid gland development), while hypoxia potently impaired the development and function of thyroid gland. Combinations of PFBS and hypoxia interacted to dysregulate the function of thyroid endocrine system. In summary, the present study revealed the dynamic interaction of PFBS pollutant and hypoxia on aquatic developmental toxicities and endocrine disruption. Considering the frequent co-occurrence of xenobiotics and hypoxia, current results would be beneficial to improve our understanding about their interactive mechanisms and provide baseline evidences for accurate ecological risk evaluation.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish

Authors: Tang, L; Song, S; Hu, C; Lam, JC; Liu, M; Zhou, B; Lam, PKS; Chen, L (2020) Chemical Research in Toxicology. HERO ID: 6416398

[Less] The present study exposed adult zebrafish to 0, 10 and 100 μg/L PFBS with or without dietary supplement . . . [More] The present study exposed adult zebrafish to 0, 10 and 100 μg/L PFBS with or without dietary supplement of probiotic Lactobacillus rhamnosus. Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants.

Journal Article
Journal Article

High temperature extensional rheology of commercially available polycarbonate mixed with flame retardant salts

Authors: Sur, S; Chellamuthu, M; Rothstein, J (2020) HERO ID: 6415993


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Behavioural effects and bioconcentration of per- and polyfluoroalkyl substances (PFASs) in zebrafish (Danio rerio) embryos

Authors: Menger, F; Pohl, J; Ahrens, L; Carlsson, G; Örn, S (2020) Chemosphere 245:125573. HERO ID: 6311635

[Less] Per- and polyfluoroalkyl substances (PFASs) are contaminants of emerging concern (CECs) that cause concern . . . [More] Per- and polyfluoroalkyl substances (PFASs) are contaminants of emerging concern (CECs) that cause concern regarding their environmental impact and risk to human health. In this study, zebrafish (Danio rerio) embryos were exposed to PFASs for six days, to investigate behaviour toxicity and bioconcentration factor (BCF). Nine individual PFASs (five C4-C8 perfluoroalkyl carboxylates (PFCAs) (PFPeA, PFHxA, PFHpA, PFOA, PFNA), three C4, C6 and C8 perfluoroalkyl sulfonates (PFSAs) (PFBS, PFHxS, PFOS) and 6:2 fluorotelomersulfonate (6:2 FTSA)) and a mixture of these were investigated at seven concentrations ranging from environmentally relevant to acutely toxic levels. In exposed embryos, significant differences were found in total swimming distance (PFHpA, PFOA, PFNA, PFHxS, PFOS, 6:2 FTSA, PFAS mixture), burst activity (PFOA, PFNA, PFHxS, PFOS, PFAS mixture) and startle response (PFNA, PFHxS, PFOS, PFAS mixture). Toxicity was only observed at concentrations well above environmental levels. The toxicity of the PFAS mixture generally followed that of the individual substances, but the mixture reduced the potencies of individual PFASs. BCF was determined for all nine PFASs and ranged between 0.9 (PFPeA) and 2700 (PFOS). Long-chain PFASs (C8) and PFASs with sulfonate as an active group showed the greatest toxic potential, while short-chain PFASs (C6 and C7) also caused significant behaviour alterations and accumulated in the embryos. To our knowledge, this is the first study to compare the behaviour toxicity of a PFAS mixture with that of the individual PFASs. Follow-up studies are needed to identify the mechanistic responses to PFAS mixtures.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Spatiotemporal distribution, sources and ecological risks of perfluorinated compounds (PFCs) in the Guanlan River from the rapidly urbanizing areas of Shenzhen, China

Authors: Wu, J; Junaid, M; Wang, Z; Sun, W; Xu, N (2020) Chemosphere 245:125637. HERO ID: 6320589

[Less] Limited studies have demonstrated the environmental concerns of perfluorinated compounds (PFCs) in the . . . [More] Limited studies have demonstrated the environmental concerns of perfluorinated compounds (PFCs) in the rivers flowing through the rapidly urbanizing areas. Therefore, this study aims to investigate the spatial and temporal distribution, major sources and ecological risks of PFCs in the surface water samples, collecting from the Guanlan River, Shenzhen, China. The concentrations of ∑PFCs ranged from 11.3 to 384 ng/L, with a mean value of 81.8 ng/L in the dry season, and ranged from 6.90 to 619 ng/L, with a mean value of 339 ng/L in the wet season. Short-chain PFCs such as perfluorohexane sulfonate (PFHxS) and perfluorobutane sulfonate (PFBS) were detected as the predominant compounds. Further, the spatiotemporal distribution revealed significantly higher levels of PFCs in the wet season than those in the dry season, and relatively higher levels in the tributaries than those in the mainstream. Source apportionment highlighted the industrial discharges, domestic wastewater, precipitation, and wastewater treatment plants as the major sources of PFCs. Moreover, the population density and associated urban sewage emissions observed as important indicators for PFCs uneven distribution in the area. The ecological risk assessment revealed perfluorotetradecanoic acid (PFTA, C14) posed high ecological risks to the aquatic organisms (especially for mysid) in the Guanlan River. Taken all together, this study not only unveiled the characteristics of PFCs contamination in the rapidly urbanizing catchment, but also provided the baseline data for policy makers to protect the ecological environment of the urban rivers in the rapidly growing area.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Exposure of adult mice to perfluorobutanesulfonate impacts ovarian functions through hypothyroxinemia leading to down-regulation of Akt-mTOR signaling

Authors: Cao, XY; Liu, J; Zhang, YJ; Wang, Y; Xiong, JW; Wu, J; Chen, L (2020) Chemosphere 244:125497. HERO ID: 6324501

[Less] Perfluorobutanesulfonate (PFBS), a short-chain perfluoroalkyl substance, is used in many industrial . . . [More] Perfluorobutanesulfonate (PFBS), a short-chain perfluoroalkyl substance, is used in many industrial products. Preliminary evidence suggests that exposure to PFBS may increase the risk of infertility. The aim of this study was to investigate the influence of PFBS on ovarian function. Herein, we show that exposure of adult female mice to PFBS (200 mg/kg/day) (PFBS-mice) caused a decrease in the levels of serum total triiodothyronine and thyroxine, which depended on the activation of peroxisome proliferator-activated receptor α (PPARα). The numbers of secondary, early antral and antral follicles were reduced in PFBS-mice with an increase in the atretic follicles, and these changes were recovered by the replacement of L-thyroxinein or the treatment with PPARα antagonist GW6471. PFBS-induced hypothyroxinemia led to a decrease in the levels of Akt, mTOR and p70S6K phosphorylation in ovarian granular cells and cumulus cells, which suppressed the proliferation of these cells and enhanced autophagic death of granular cells and cumulus cells. The levels of serum estradiol and progesterone were reduced in PFBS-mice with a low expression of the steroidogenic genes Star and P450scc in ovarian tissues, which were sensitive to the replacement of L-thyroxinein or the blockade of PPARα. The results indicate that exposure to PFBS (≥200 mg/kg/day) through reducing thyroid hormones causes down-regulation of Akt-mTOR signaling in granular cells and cumulus cells, leading to the deficits in the development of follicles and the biosynthesis of ovarian hormones.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS

Authors: Gaballah, S; Swank, A; Sobus, JR; Howey, XM; Schmid, J; Catron, T; Mccord, J; Hines, E; Strynar, M; Tal, T (2020) Environmental Health Perspectives 128:47005. HERO ID: 6356901

[Less] BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are a diverse class of industrial . . . [More] BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are a diverse class of industrial chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is associated with developmental toxicity, prompting their replacement with short-chain and fluoroether compounds. There is growing public concern over the safety of replacement PFAS.

OBJECTIVE: We aimed to group PFAS based on shared toxicity phenotypes.

METHODS: Zebrafish were developmentally exposed to 4,8-dioxa-3H-perfluorononanoate (ADONA), perfluoro-2-propoxypropanoic acid (GenX Free Acid), perfluoro-3,6-dioxa-4-methyl-7-octene-1-sulfonic acid (PFESA1), perfluorohexanesulfonic acid (PFHxS), perfluorohexanoic acid (PFHxA), perfluoro-n-octanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), or 0.4% dimethyl sulfoxide (DMSO) daily from 0-5 d post fertilization (dpf). At 6 dpf, developmental toxicity and developmental neurotoxicity assays were performed, and targeted analytical chemistry was used to measure media and tissue doses. To test whether aliphatic sulfonic acid PFAS cause the same toxicity phenotypes, perfluorobutanesulfonic acid (PFBS; 4-carbon), perfluoropentanesulfonic acid (PFPeS; 5-carbon), PFHxS (6-carbon), perfluoroheptanesulfonic acid (PFHpS; 7-carbon), and PFOS (8-carbon) were evaluated.

RESULTS: PFHxS or PFOS exposure caused failed swim bladder inflation, abnormal ventroflexion of the tail, and hyperactivity at nonteratogenic concentrations. Exposure to PFHxA resulted in a unique hyperactivity signature. ADONA, PFESA1, or PFOA exposure resulted in detectable levels of parent compound in larval tissue but yielded negative toxicity results. GenX was unstable in DMSO, but stable and negative for toxicity when diluted in deionized water. Exposure to PFPeS, PFHxS, PFHpS, or PFOS resulted in a shared toxicity phenotype characterized by body axis and swim bladder defects and hyperactivity.

CONCLUSIONS: All emerging fluoroether PFAS tested were negative for evaluated outcomes. Two unique toxicity signatures were identified arising from structurally dissimilar PFAS. Among sulfonic acid aliphatic PFAS, chemical potencies were correlated with increasing carbon chain length for developmental neurotoxicity, but not developmental toxicity. This study identified relationships between chemical structures and in vivo phenotypes that may arise from shared mechanisms of PFAS toxicity. These data suggest that developmental neurotoxicity is an important end point to consider for this class of widely occurring environmental chemicals. https://doi.org/10.1289/EHP5843.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A sensitive method for simultaneous determination of 12 classes of per- and polyfluoroalkyl substances (PFASs) in groundwater by ultrahigh performance liquid chromatography coupled with quadrupole orbitrap high resolution mass spectrometry

Authors: Liu, S; Junaid, M; Zhong, W; Zhu, Y; Xu, N (2020) Chemosphere 251:126327. HERO ID: 6315759

[Less] Per- and polyfluoroalkyl substances (PFASs) comprise a large group of chemicals with diverse physicochemical . . . [More] Per- and polyfluoroalkyl substances (PFASs) comprise a large group of chemicals with diverse physicochemical properties, which make their simultaneous determination a challenging task. A trace analytical method based on ultrahigh performance liquid chromatography-quadrupole Orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was developed for simultaneous determination of 54 PFASs belonging to 12 classes in groundwater, including 24 perfluorocarbons and 30 precursors. This method provided good linearity of calibration standards (R2 > 0.99), excellent method limits of quantification (MLOQs) (0.5-250 pg/L), satisfactory matrix spiking recoveries (63%-148%), high precision (intra-day relative standard deviations (RSDs) 1.4-11.4%, inter-day RSDs 1.6-12.9%, and inter-week RSDs 2.1-12.7%), and short runtime (13 min), suitable for high throughput studies. The newly established method was successfully applied to detect PFASs in the groundwater samples collected from Hebei Province, China. Twenty PFASs were detected with the total concentration of 0.3-32.9 ng/L, indicating the contamination level similar to that in drinking water. The dominant PFASs were perfluorobutanesulfonate (PFBS), perfluorobutanoic acid (PFBA), perfluoropentanoic acid (PFPeA) and perfluorooctanoic acid (PFOA). In addition, 6:2 fluorotelomer phosphate diester (6:2 diPAP) and 6:2 fluorotelomer sulfonate (6:2 FTS) were found as the major precursors. The total PFAS concentrations were lower than the cumulative permissible limit of 70 ng/L for PFOS and PFOA recommended by the United States Environmental Protection Agency (USEPA) for drinking water in 2016. In a nutshell, this study provided a fast and sensitive method based on HRMS for the simultaneous analysis of a wide range of PFASs, present at trace levels in groundwater samples.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Removal of eight perfluoroalkyl acids from aqueous solutions by aeration and duckweed

Authors: Zhang, W; Liang, Y (2020) Science of the Total Environment 724:138357. HERO ID: 6356904

[Less] Poly- and perfluoroalkyl substances (PFAS) are surfactants. Leveraging their surface active feature, . . . [More] Poly- and perfluoroalkyl substances (PFAS) are surfactants. Leveraging their surface active feature, this work investigated using aeration to remove perfluoroalkyl acids (PFAAs) from aqueous solutions. Eight PFAAs were spiked to either deionized water or Hoagland solution at three pHs. After 7 h of aeration, removals of perfluorobutanoic acid (PFBA), perfluoropentanoic acid (PFPeA), perfluorobutanesulfonic acid (PFBS), and perfluorohexanoic acid (PFHxA) were marginal and much lower than those of and perfluoroheptanoic acid (PFHpA), perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS). In deionized water, close to 80% of PFOA and PFOS at 200 ppb were removed when the pH was 2.3. The Hoagland solution at pH 2.3 and 5.0 benefited removal of long-chain PFAS at 2 ppb, but not at 200 ppb. With duckweed growing on the Hoagland solution surface, >95% of PFHpA, PFHxS, PFOA, and PFOS at 200 ppb were removed after 2 weeks. Aeration enhanced duckweed uptake of PFHxS, PFOA, and PFOS at 2 ppb significantly. Specific to PFOS, duckweed accumulated 14.4% of this compound initially spiked at 2 ppb in 2 weeks. These results demonstrated that aeration plus duckweed could be a viable and scalable remediation solution for surface water contaminated by PFAS.