Health & Environmental Research Online (HERO)


PFBS (375-73-5)


501 References Were Found:

Data/Software
Data/ Software

Online catalog for the Environmental Health Criteria (EHC) monographs

Author: WHO (2018) Geneva, Switzerland: World Health Organization (WHO). HERO ID: 4235832


Data/Software
Data/ Software

Integrated risk information system (IRIS)

Author: U.S. EPA (2018) Washington, DC: U.S. Environmental Protection Agency, Integrated Risk Information System. [Database] HERO ID: 4235833


Technical Report
Technical Report

28-day evaluation of the toxicity (C07040) of perfluorobutane sulfonate (PFBS) (375-73-5) on Harlan Sprague-Dawley rats exposed via gavage

Author: NTP (2018) U.S. Department of Health and Human Services. [NTP] HERO ID: 4309078


Data/Software
Data/ Software

Safe drinking water information system

Author: U.S. EPA (2018) HERO ID: 4339794


Book/Book Chapter
Book/ Chapter

Chapter 18. Female Reproductive System

Authors: Rudmann, DG; Foley, GL (2018) In Wallig, MA; Haschek, WM; Rousseaux, CG; Bolon, B (Eds.), Fundamentals of toxicologic pathology (3rd, pp. 517-545). Cambridge, MA: Academic Press. HERO ID: 4595194

[Less] The female reproductive system is a complicated, hormone-dependent group of tissues that may provide . . . [More] The female reproductive system is a complicated, hormone-dependent group of tissues that may provide an interpretative challenge. The objectives of this chapter are to equip the reader with the background for designing rigorous in vivo experiments, discerning and interpreting study-related findings, and thoughtfully applying these data for the purpose of human safety assessment. The chapter focuses on the most common species used in general toxicology studies—the rat, beagle dog, and cynomolgus monkey. There is a systematic description of the normal, dynamic tissue changes and endocrinology observed in these species during their reproductive cycle. The chapter then presents a review of the responses of the female reproductive system to various xenobiotics, and describes approaches to characterize mechanistically these patterns of toxicity.

Technical Report
Technical Report

National report on human exposure to environmental chemicals. Updated tables, March 2018

Author: CDC (2018) HERO ID: 4616488


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

CCL22 and CCR4 Gene Polymorphisms in Myocardial Infarction: Risk Assessment of rs4359426 and rs2228428 in Iranian Population

Authors: Noori, F; Naeimi, S; Zibaeenezhad, MJ; Gharemirshamlu, FR (2018) HERO ID: 4616540

[Less] BACKGROUND: Myocardial infarction (MI) is an irreversible damage of myocardial tissue . . . [More] BACKGROUND: Myocardial infarction (MI) is an irreversible damage of myocardial tissue caused by prolonged ischemia and hypoxia. A local hypoxia-induced inflammation causes recruitment of leukocytes to the inflammatory site to aid cardiac remodeling and tissue healing. Among various chemokines involved in the process, CCL22 plays an essential role in cardiac cell migrations. In this study, we evaluated the incidence of rs4359426 and rs2228428 SNPs in CCL22/CCR4 genes of MI patients and studied their association with the physiology of the disease.

METHODS: Two hundred patients aged 30 - 70 years diagnosed with myocardial infarction along with 200 agematched healthy controls were registered in the study and their pathophysiological findings were recorded. Genotypic analysis of rs4359426 and rs2228428 in CCL22 and CCR4 genes, respectively, were carried out in patients using PCR-RFLP method and compared with the control group. Successively genotyped SNPs were reviewed for their possible association with the disease or physiological findings using Fisher's exact test.

RESULTS: The frequency of CC genotypes atboth SNPs rs4359426 and rs2228428 in CCL22 and CCR4 genes was significantly higher in MI patients compared to other genotypes.

CONCLUSIONS: Although we could not establish any direct association with the disease due to restricted population size, it is possible that CC genotypesin CCL22 and CCR4 could be considered as risk factors in myocardial infarction.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Disruption in thyroid signaling pathway: A mechanism for the effect of endocrine-disrupting chemicals on child neurodevelopment

Authors: Ghassabian, A; Trasande, L (2018) HERO ID: 4616545


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate

Authors: Chen, L; Hu, C; Tsui, MMP; Wan, T; Peterson, DR; Shi, Q; Lam, PKS; Au, DWT; Lam, JCW; Zhou, B (2018) Environmental Science and Technology 52:4432-4439. HERO ID: 4778765

[Less] Accumulation of perfluorobutanesulfonate (PFBS) is frequently detected in biota, raising concerns about . . . [More] Accumulation of perfluorobutanesulfonate (PFBS) is frequently detected in biota, raising concerns about its ecological safety. However, hazardous effects of PFBS remain largely unexplored, especially for endocrine disrupting potency. In the present study, the multigenerational endocrine disrupting potential of PFBS was investigated by exposing F0 marine medaka eggs to PFBS at different concentrations (0, 1.0, 2.9, and 9.5 μg/L) until sexual maturity. The F1 and F2 generations were reared without continued exposure. Thyroidal disturbances were examined in all three generations. PFBS exposure decreased the levels of 3,5,3'-triiodothyronine (T3) in F0 female blood; however, it increased T3 or thyroxine (T4) levels in F0 brains, in which hyperthyroidism suppressed the local transcription of 5'-deiodinase 2 ( Dio2). Obviously decreased T3 was transferred to F1 eggs, although the parental influences were reversed in F1 larvae. Delayed hatching was coupled with elevated T3 levels in F1 larvae. F1 adults showed comparable symptoms of thyroidal disruption with F0 adults. A slight recovery was noted in the F2 generation, although F2 larvae still exhibited thyroid disruption and synthesized excessive T4. Our results suggested that the offspring suffered more severe dysfunction of the thyroidal axis albeit without direct exposure. This study provided the first molecular insight about PFBS toxicology on the thyroid, beneficial to both human and environmental risk assessment.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis

Authors: Thompson, W; Russell, G; Baragwanath, G; Matthews, J; Vaidya, B; Thompson-Coon, J (2018) Clinical Endocrinology 88:575-584. HERO ID: 4821720

[Less] BACKGROUND: In the last 2 decades, several studies have examined the association between . . . [More] BACKGROUND: In the last 2 decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results.

AIM: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes.

METHODS: We performed systematic literature searches in MEDLINE, EMBASE, PSYCinfo, CINAHL, AMED, BNI, Cochrane, Scopus, Web of Science, GreyLit, Grey Source and Open Grey (latest search: March 2017). We also conducted targeted web searching and performed forwards and backwards citation chasing. Meta-analyses of eligible studies were carried out using the random-effects model.

RESULTS: We identified 39 eligible articles (37 observational studies and 2 randomized controlled trials [RCT]). Meta-analysis showed that maternal subclinical hypothyroidism and hypothyroxinaemia are associated with indicators of intellectual disability in offspring (odds ratio [OR] 2.14, 95% confidence interval [CI] 1.20 to 3.83, P = .01, and OR 1.63, 95% CI 1.03 to 2.56, P = .04, respectively). Maternal subclinical hypothyroidism and hypothyroxinaemia were not associated with attention deficit hyperactivity disorder, and their effect on the risk of autism in offspring was unclear. Meta-analysis of RCTs showed no evidence that levothyroxine treatment for maternal hypothyroxinaemia or subclinical hypothyroidism reduces the incidence of low intelligence quotient in offspring.

LIMITATIONS: Although studies were generally of good quality, there was evidence of heterogeneity between the included observational studies (I2 72%-79%).

CONCLUSION: Maternal hypothyroxinaemia and subclinical hypothyroidism may be associated with intellectual disability in offspring. Currently, there is no evidence that levothyroxine treatment, when initiated 8- to 20-week gestation (mostly between 12 and 17 weeks), for mild maternal thyroid hormone insufficiency during pregnancy reduces intellectual disability in offspring.