Health & Environmental Research Online (HERO)


PFBS (375-73-5)


257 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Interactions of perfluoroalkyl substances with a phospholipid bilayer studied by neutron reflectometry

Authors: Nouhi, Y; Ahrens, L; Kabayama, HH; Hughes, NAV; Campana, M; Gutfreund, P; Palsson, GK; Vorobiev, AA; Hellsing, MS (2018) Journal of Colloid and Interface Science 511:474-481. HERO ID: 4234858

[Less] The interactions between perfluoroalkyl substances (PFASs) and a phospholipid bilayer (1,2-dimyristoyl-sn-glycero-3-phosphocholine) . . . [More] The interactions between perfluoroalkyl substances (PFASs) and a phospholipid bilayer (1,2-dimyristoyl-sn-glycero-3-phosphocholine) were investigated at the molecular level using neutron reflectometry. Representative PFASs with different chain length and functional groups were selected in this study including: perfluorobutane sulfonate (PFBS), perfluorohexanoate (PFHxA), perfluorohexane sulfonate (PFHxS), perfluorononanoate (PFNA), perfluorooctane sulfonate (PFOS), and perfluorooctane sulfonamide (FOSA). All PFASs were found to interact with the bilayer by incorporation, indicating PFAS ability to accumulate once ingested or taken up by organisms. The interactions were observed to increase with chain length and vary with the functional group as SO2NH2(FOSA)>SO2O-(PFOS)>COO-(PFNA). The PFAS hydrophobicity, which is strongly correlated with perfluorocarbon chain length, was found to strongly influence the interactions. Longer chain PFASs showed higher tendency to penetrate into the bilayer compared to the short-chain compounds. The incorporated PFASs could for all substances but one (PFNA) be removed from the lipid membrane by gentle rinsing with water (2mLmin-1). Although short-chain PFASs have been suggested to be the potentially less bioaccumulative alternative, we found that in high enough concentrations they can also disturb the bilayer. The roughness and disorder of the bilayer was observed to increase as the concentration of PFASs increased (in particular for the high concentrations of short-chain substances i.e. PFHxA and PFBS), which can be an indication of aggregation of PFASs in the bilayer.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Different biotransformation behaviors of perfluorooctane sulfonamide in wheat (Triticum aestivum L.) from earthworms (Eisenia fetida)

Authors: Zhao, S; Zhou, T; Wang, B; Zhu, L; Chen, M; Li, D; Yang, L (2018) Journal of Hazardous Materials 346:191-198. HERO ID: 4234855

[Less] Perfluorooctane sulfonamide (PFOSA) is a precursor of perfluorooctane sulfonic acid (PFOS) and can be . . . [More] Perfluorooctane sulfonamide (PFOSA) is a precursor of perfluorooctane sulfonic acid (PFOS) and can be broken down to PFOS in environment and biota. In the present work, PFOSA was spiked in soil and its biodegradation in soil, uptake and metabolism in wheat (Triticum aestivum L.) and earthworms (Eisenia fetida) were investigated. The results indicated that PFOSA could be biodegraded to highly stable PFOS, which has the same perfluorinated carbon chain length as PFOSA, by microbes in soil. PFOSA could be taken up by wheat root and earthworm from soil with higher bioaccumulation ability than PFOS. In both wheat and earthworms, PFOSA also degraded to PFOS. However, other shorter-chain perfluoroalkane sulfonates (PFSAs), including perfluorohexane sulfonate (PFHxS) and perfluorobutane sulfonate (PFBS), were observed in wheat, but not in soil and earthworms, suggesting that wheat displayed distinctly different degradation mechanisms to PFOSA from soil microbes and earthworms.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs

Authors: Sanchez Garcia, D; Sjödin, M; Hellstrandh, M; Norinder, U; Nikiforova, V; Lindberg, J; Wincent, E; Bergman, Å; Cotgreave, I; Munic Kos, V (2018) Chemico-Biological Interactions 281:1-10. HERO ID: 4234856

[Less] Many chemicals accumulate in organisms through a variety of different mechanisms. Cationic amphiphilic . . . [More] Many chemicals accumulate in organisms through a variety of different mechanisms. Cationic amphiphilic drugs (CADs) accumulate in lysosomes and bind to membranes causing phospholipidosis, whereas many lipophilic chemicals target adipose tissue. Perfluoroalkyl substances (PFASs) are widely used as surfactants, but many of them are highly bioaccumulating and persistent in the environment, making them notorious environmental toxicants. Understanding the mechanisms of their bioaccumulation is, therefore, important for their regulation and substitution with new, less harmful chemicals. We compared the highly bioaccumulative perfluorooctanesulfonic acid PFOS to its three less bioaccumulative alternatives perfluorooctanoic acid (PFOA), perfluorohexanoic acid (PFHxA) and perfluorobutane sulfonic acid (PFBS), in their ability to accumulate and remain in lung epithelial cells (NCI-H292) and adipocytes (3T3-L1K) in vitro. As a reference point we tested a set of cationic amphiphilic drugs (CADs), known to highly accumulate in cells and strongly bind to phospholipids, together with their respective non-CAD controls. Finally, all compounds were examined for their ability to bind to neutral lipids and phospholipids in cell-free systems. Cellular accumulation and retention of the test compounds were highly correlated between the lung epithelial cells and adipocytes. Interestingly, although an anion itself, intensities of PFOS accumulation and retention in cells were comparable to those of CAD compounds, but PFOS failed to induce phospholipidosis or alter lysosomal volume. Compared to other lipophilicity measures, phospholipophilicity shows the highest correlation (Rˆ2 = 0.75) to cellular accumulation data in both cell types and best distinguishes between high and low accumulating compounds. This indicates that binding to phospholipids may be the most important component in driving high cellular accumulation in lung epithelial cells, as well as in adipocytes, and for both CADs and bioaccumulating PFASs. Obtained continuous PLS models based on compound's affinity for phospholipids and neutral lipids can be used as good prediction models of cellular accumulation and retention of PFASs and CADs.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluorooctane sulfonate and perfluorobutane sulfonate removal from water by nanofiltration membrane: The roles of solute concentration, ionic strength, and macromolecular organic foulants

Authors: Wang, J; Wang, Lei; Xu, C; Zhi, Rui; Miao, Rui; Liang, T; Yue, X; Lv, Y; Liu, T (2018) HERO ID: 4234861

[Less] The influence of solute concentration, ionic strength, and macromolecular organic matter on the rejection . . . [More] The influence of solute concentration, ionic strength, and macromolecular organic matter on the rejection of perfluorooctane sulfonate (PFOS) and perfluorobutane sulfonate (PFBS) via nanofiltration (NF) was investigated using poly(piperazineamide) membranes. The results showed that compared with PFBS (steady-state rejection < 69%), PFOS with the larger molecular size and stronger hydrophobicity displayed higher retention (steady-state rejection > 88%) in all water matrices. Rejection of PFOS and PFBS increased with higher solute concentrations, attributable to enhanced size exclusion resulting from pore blockage. As ionic strength increased from 0 to 100 mM, PFOS retention increased from 89.6% to 91.9%; conversely, PFBS rejection declined from 48.9% to 20.5%. These phenomena, in conjunction with the decrease in membrane flux and charge with increasing ionic strength, suggest that the retention of PFOS and PFBS was dominated by size exclusion and electrostatic repulsion, respectively. In addition, model macromolecular organic foulants-bovine serum albumin (BSA) and sodium alginate (SA)-influenced the rejection of PFOS and PFBS significantly. The presence of BSA and SA caused improved PFOS rejection, while adsorption dominated PFOS retention before the formation of an organic fouling layer and size exclusion was dominant after formation of the layer. As for PFBS feed systems, SA facilitated PFBS rejection, while BSA only contributed to PFBS removal temporarily and thereafter led to decreased PFBS rejection. From further consideration of the characteristics of membrane surface charge variation and organic fouling, it is concluded that electrostatic repulsion was the preponderant retention mechanism for PFBS during the entire organic fouling process.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkane sulfonates (PFSAs) contamination level in spices

Authors: Surma, M; Piskula, M; Wiczkowski, W; Zieliński, H (2017) European Food Research and Technology 243:297-307. HERO ID: 3856674

[Less] Spices have been used since ancient times. Although they have been employed mainly as flavoring and . . . [More] Spices have been used since ancient times. Although they have been employed mainly as flavoring and coloring agents, their role in food safety is of increasing concern. In this study, the usefulness of a modified QuEChERS method, based on the d-SPE, with micro-HPLC-MS/MS system for the determination of selected perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkane sulfonates (PFSAs) in spices was addressed. The commonly used spices in Spain and Slovakia were investigated. The studies showed the presence of perfluorooctanoic acid in 19 spices of Spanish and Slovak origin, and it ranged from 0.11 ng g(-1) for garlic to 0.67 ng g(-1) for peppermint. The perfluorobutanoic acid was quantified in 10 Slovak spices (from 1.13 ng g(-1) for allspice to 37.82 ng g(-)1 for star anise), whereas perfluorobutane sulfonate was identified only in 12 Spanish spices and it ranged from 0.24 ng g(-1) for cinnamon to 1.01 ng g(-1) for coriander. In contrast, perfluoroheptanoic acid was identified only in Slovak cardamom (1.94 ng g(-1)) and coriander (0.74 ng g(-1)). The average consumption of spices in Europe is approximately 0.5 g day(-1), while in Asia and northern Africa, it is many times higher. Average content of PFASs in this evaluation has a value 4.67 ng g(-1) giving 2.33 ng day(-1) per person. This study showed that daily used spices may contribute to the overall contamination of food by perfluoroalkyl substances.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Structural characterization of the [C(n)C(1)im][C4F9SO3] ionic liquid series: Alkyl versus perfluoroalkyl side chains

Authors: Shimizu, K; Freitas, AA; Canongia Lopes, JN (2017) Journal of Molecular Liquids 226:28-34. HERO ID: 3857453

[Less] This work represents an essential step towards the understanding at a molecular level of the bulk structure . . . [More] This work represents an essential step towards the understanding at a molecular level of the bulk structure of ionic liquids (ILs) that exhibit both an hydrogenated and a perfluorinated alkyl side chain. Molecular Dynamics (MD) simulations were performed along the 1-alkyl-3-methylimidazolium perfluorobutylsulfonate homologous series, [C(n)C(1)im][C4F9SO3] (2 <= n <= 12) in order to study in a systematic way the effect on the bulk structure of the change of the ratios between polar and nonpolar moieties and between hydrogenated and fluorinated moieties. The MD trajectories were used to calculate global and partial structure factors, S(q), of each IL. The low-q peaks obtained from the deconvolution of the total S(q) functions were assigned to characteristic lengths of the polar network and non-polar domains, also computed via the appropriate pair radial distribution functions. Finally, several aggregation analyses were performed in order to emphasize the bicontinuous nature of the liquids and its systematic and complex evolution along the series. (C) 2016 Elsevier B.V. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluorinated alkyl substances (PFASs) in northern Spain municipal solid waste landfill leachates

Authors: Fuertes, I; Gómez-Lavín, S; Elizalde, MP; Urtiaga, A (2017) Chemosphere 168:399-407. HERO ID: 3856464

[Less] Landfill leachates have been recognized as significant secondary sources of poly- and perfluoroalkyl . . . [More] Landfill leachates have been recognized as significant secondary sources of poly- and perfluoroalkyl substances (PFASs). This study presents data on the occurrence and concentration of 11 perfluoroalkyl carboxylates (PFCAs) and 5 perfluoroalkyl sulfonates (PFSAs) in leachates from 4 municipal solid waste landfill sites located across northern Spain. To the best of our knowledge, this is the first report of the presence of PFASs in Spanish landfill leachates. Two of the landfill sites applied on-site treatment using membrane bioreactors (MBR), and its effect on PFASs occurrence is also reported. Total PFASs (∑PFASs) in raw leachates reached 1378.9 ng/L, while in treated samples ∑PFASs was approximately two-fold (3162.3 ng/L). PFCAs accounted for the majority of the detected PFASs and perfluorooctanoic acid (PFOA) was the dominant compound in raw leachates (42.6%), followed by shorter chain PFHxA (30.1%), PFPeA and PFBA. The age of the sites might explain the PFASs pattern found in raw leachates as all of them were stabilized leachates. However, PFASs profile was different in treated samples where the most abundant compound was PFHxA (26.5%), followed by linear perfluorobutane sulfonate (L-PFBS) (18.7%) and PFOA (17.7%). The overall increase of the PFASs content as well as the change in the PFASs profile after the MBR treatment, could be explained by the possible degradation of PFASs precursors such as fluorotelomer alcohols or fluorotelomer sulfonates. Using the volume of leachates generated in the landfill sites, that served 1.8 million people, the discharge of 16 ∑PFASs contained in the landfill leachates was estimated as 1209 g/year.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones

Authors: Li, Y; Cheng, Y; Xie, Z; Zeng, F (2017) Scientific Reports 7:43380. HERO ID: 3856460

[Less] In this study, eight perfluorinated alkyl substances (PFASs) and five thyroid hormones (TSH, FT4, FT3, . . . [More] In this study, eight perfluorinated alkyl substances (PFASs) and five thyroid hormones (TSH, FT4, FT3, TGAb, and TMAb) were determined in 202 human serum samples of the general population of Guangdong, Guangxi and Hainan provinces in southern China. Σ8PFASs concentrations ranged from 0.85 to 24.3 ng/mL with a mean value of 4.66 ng/mL. The PFASs composition profiles of human serum samples nearly make no difference at different locations. A significant increase was observed for ∑8PFASs, PFOS, and PFHxS concentrations with age (p < 0.01). Gender-related differences were found; PFOS, PFHxS, PFBS, and PFOA levels were higher in males (p < 0.05), and the mean concentration of ∑8PFASs was 1.5 times greater in males (6.02 ng/mL) than in females (4.15 ng/mL). PFOS and ∑8PFASs were significantly negatively correlated with FT3 and FT4 and positively correlated with TSH while PFPeA and PFHxA were significantly positively correlated with TGAb and TMAb in all the samples. The opposite associations between FT3, TSH and PFOS, PFOA and PFHxS levels in hypothyroidism and hyperthyroidism group indicate that the PFOS, PFOA and PFHxS enhance the negative feedback mechanisms of the thyroid gland.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Ecological effect and risk towards aquatic plants induced by perfluoroalkyl substances: Bridging natural to culturing flora

Authors: Zhou, Y; Wang, T; Jiang, Z; Kong, X; Li, Q; Sun, Y; Wang, P; Liu, Z (2017) Chemosphere 167:98-106. HERO ID: 3856468

[Less] In the present study, the concentrations and proportions of perfluoroalkyl substances (PFASs) in water . . . [More] In the present study, the concentrations and proportions of perfluoroalkyl substances (PFASs) in water and sediments (in different seasons) from the Qing River were investigated. The highest concentration of PFASs in water (207.59 ng L(-1)) was found in summer. The composition of PFASs in water changed with time, perfluorobutane sulfonate (PFBS) was the predominant compound in spring and summer, while long-chain PFASs, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), started to increase in autumn and winter. The PFASs concentration in sediments ranged from 0.96 to 4.05 ng g(-1) dw. The proportion of long-chain PFASs was higher than that of short-chain PFASs in sediments, the dominant component in sediments was PFOA with a contribution of 24.6-75.4% to total PFASs in sediments, followed by PFOS. The concentrations of PFASs in roots of emergent plants were relatively higher than those in submerged plants. However, the translocation effect of PFASs was not remarkable. Bioaccumulation factors (BAFs) of the aquatic plants indicated the absorption of PFASs were effective. BAFs in submerged plants basically increased with increasing chain length accordingly. In general, aquatic plants had the absorption preference for long-chain PFASs, especially PFOS, which was the predominant compounds in both submerged and emergent plants. Based on the results above, hornworts were selected to be cultivated indoor in the nutrient solution spiked gradient concentrations of PFOS to assess the general ecological risk. The results revealed that hornworts were resistant to PFOS and might be used as remediation flora to eliminate PFOS contamination.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Uptake and elimination kinetics of perfluoroalkyl substances in submerged and free-floating aquatic macrophytes: Results of mesocosm experiments with Echinodorus horemanii and Eichhornia crassipes

Authors: Pi, N; Ng, JZ; Kelly, BC (2017) Water Research 117:167-174. HERO ID: 3856456

[Less] Studies investigating the bioaccumulation behavior of perfluoroalkyl substances (PFASs) in aquatic macrophytes . . . [More] Studies investigating the bioaccumulation behavior of perfluoroalkyl substances (PFASs) in aquatic macrophytes are limited. The present study involved controlled mesocosm experiments to assess uptake and elimination rate constants (ku,ke), bioconcentration factors (BCFs) and translocation factors (TFs) of several perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkane sulfonic acids (PFSAs) in two aquatic plant species, including one submerged species (Echinodorus horemanii) and one free-floating species (Eichhornia crassipes). The results indicated all PFASs were readily accumulated in these aquatic macrophytes. ku and BCFs increased with increasing perfluoroalkyl chain length. For PFCAs and PFSAs with identical perfluoroalkyl chain length, the corresponding PFSA exhibited higher bioaccumulation potential. On a whole-plant basis, the bioaccumulation potential of PFASs in submerged and free-floating macrophytes were comparable, indicating sorption to plant biomass is similar in the different species. Conversely, when considering accumulation in foliage, BCFs in the free-floating macrophyte were substantially lower compared to submerged species, especially for longer-chain PFASs. Compounds with shorter perfluoroalkyl chain length (PFBS, PFPeA and PFHxA) exhibited preferential translocation to leaf tissue (TFs >1). BCFs exhibited a sigmoidal relationship with pefluoroalkyl chain length, membrane-water distribution coefficients (Dmw), protein-water distribution coefficients (Dpw) and organic-water partition coefficients (Koc). For these trends, maximum BCF values were exhibited by long-chain PFCAs, with a log Dmw, log Dpw and log Koc of 6.47, 5.72 and 5.04, respectively. These findings are useful for future design and implementation of phytoremediation systems, as well for future develop of mechanistic models for predicting the environmental fate and distribution of these contaminants of concern.