Health & Environmental Research Online (HERO)


PFBS (375-73-5)


57 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Air-stable binuclear Titanium(IV) salophen perfluorobutanesulfonate with zinc power catalytic system and its application to C-S and C-Se bond formation

Authors: Wang, L; Qiao, Jie; Wei, J; Liang, Z; Xu, X; Li, N (2020) HERO ID: 6416096


Journal Article
Journal Article

High temperature extensional rheology of commercially available polycarbonate mixed with flame retardant salts

Authors: Sur, S; Chellamuthu, M; Rothstein, J (2020) HERO ID: 6415993


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Behavioural effects and bioconcentration of per- and polyfluoroalkyl substances (PFASs) in zebrafish (Danio rerio) embryos

Authors: Menger, F; Pohl, J; Ahrens, L; Carlsson, G; Örn, S (2020) Chemosphere 245:125573. HERO ID: 6311635

[Less] Per- and polyfluoroalkyl substances (PFASs) are contaminants of emerging concern (CECs) that cause concern . . . [More] Per- and polyfluoroalkyl substances (PFASs) are contaminants of emerging concern (CECs) that cause concern regarding their environmental impact and risk to human health. In this study, zebrafish (Danio rerio) embryos were exposed to PFASs for six days, to investigate behaviour toxicity and bioconcentration factor (BCF). Nine individual PFASs (five C4-C8 perfluoroalkyl carboxylates (PFCAs) (PFPeA, PFHxA, PFHpA, PFOA, PFNA), three C4, C6 and C8 perfluoroalkyl sulfonates (PFSAs) (PFBS, PFHxS, PFOS) and 6:2 fluorotelomersulfonate (6:2 FTSA)) and a mixture of these were investigated at seven concentrations ranging from environmentally relevant to acutely toxic levels. In exposed embryos, significant differences were found in total swimming distance (PFHpA, PFOA, PFNA, PFHxS, PFOS, 6:2 FTSA, PFAS mixture), burst activity (PFOA, PFNA, PFHxS, PFOS, PFAS mixture) and startle response (PFNA, PFHxS, PFOS, PFAS mixture). Toxicity was only observed at concentrations well above environmental levels. The toxicity of the PFAS mixture generally followed that of the individual substances, but the mixture reduced the potencies of individual PFASs. BCF was determined for all nine PFASs and ranged between 0.9 (PFPeA) and 2700 (PFOS). Long-chain PFASs (C8) and PFASs with sulfonate as an active group showed the greatest toxic potential, while short-chain PFASs (C6 and C7) also caused significant behaviour alterations and accumulated in the embryos. To our knowledge, this is the first study to compare the behaviour toxicity of a PFAS mixture with that of the individual PFASs. Follow-up studies are needed to identify the mechanistic responses to PFAS mixtures.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Spatiotemporal distribution, sources and ecological risks of perfluorinated compounds (PFCs) in the Guanlan River from the rapidly urbanizing areas of Shenzhen, China

Authors: Wu, J; Junaid, M; Wang, Z; Sun, W; Xu, N (2020) Chemosphere 245:125637. HERO ID: 6320589

[Less] Limited studies have demonstrated the environmental concerns of perfluorinated compounds (PFCs) in the . . . [More] Limited studies have demonstrated the environmental concerns of perfluorinated compounds (PFCs) in the rivers flowing through the rapidly urbanizing areas. Therefore, this study aims to investigate the spatial and temporal distribution, major sources and ecological risks of PFCs in the surface water samples, collecting from the Guanlan River, Shenzhen, China. The concentrations of ∑PFCs ranged from 11.3 to 384 ng/L, with a mean value of 81.8 ng/L in the dry season, and ranged from 6.90 to 619 ng/L, with a mean value of 339 ng/L in the wet season. Short-chain PFCs such as perfluorohexane sulfonate (PFHxS) and perfluorobutane sulfonate (PFBS) were detected as the predominant compounds. Further, the spatiotemporal distribution revealed significantly higher levels of PFCs in the wet season than those in the dry season, and relatively higher levels in the tributaries than those in the mainstream. Source apportionment highlighted the industrial discharges, domestic wastewater, precipitation, and wastewater treatment plants as the major sources of PFCs. Moreover, the population density and associated urban sewage emissions observed as important indicators for PFCs uneven distribution in the area. The ecological risk assessment revealed perfluorotetradecanoic acid (PFTA, C14) posed high ecological risks to the aquatic organisms (especially for mysid) in the Guanlan River. Taken all together, this study not only unveiled the characteristics of PFCs contamination in the rapidly urbanizing catchment, but also provided the baseline data for policy makers to protect the ecological environment of the urban rivers in the rapidly growing area.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Exposure of adult mice to perfluorobutanesulfonate impacts ovarian functions through hypothyroxinemia leading to down-regulation of Akt-mTOR signaling

Authors: Cao, XY; Liu, J; Zhang, YJ; Wang, Y; Xiong, JW; Wu, J; Chen, L (2020) Chemosphere 244:125497. HERO ID: 6324501

[Less] Perfluorobutanesulfonate (PFBS), a short-chain perfluoroalkyl substance, is used in many industrial . . . [More] Perfluorobutanesulfonate (PFBS), a short-chain perfluoroalkyl substance, is used in many industrial products. Preliminary evidence suggests that exposure to PFBS may increase the risk of infertility. The aim of this study was to investigate the influence of PFBS on ovarian function. Herein, we show that exposure of adult female mice to PFBS (200 mg/kg/day) (PFBS-mice) caused a decrease in the levels of serum total triiodothyronine and thyroxine, which depended on the activation of peroxisome proliferator-activated receptor α (PPARα). The numbers of secondary, early antral and antral follicles were reduced in PFBS-mice with an increase in the atretic follicles, and these changes were recovered by the replacement of L-thyroxinein or the treatment with PPARα antagonist GW6471. PFBS-induced hypothyroxinemia led to a decrease in the levels of Akt, mTOR and p70S6K phosphorylation in ovarian granular cells and cumulus cells, which suppressed the proliferation of these cells and enhanced autophagic death of granular cells and cumulus cells. The levels of serum estradiol and progesterone were reduced in PFBS-mice with a low expression of the steroidogenic genes Star and P450scc in ovarian tissues, which were sensitive to the replacement of L-thyroxinein or the blockade of PPARα. The results indicate that exposure to PFBS (≥200 mg/kg/day) through reducing thyroid hormones causes down-regulation of Akt-mTOR signaling in granular cells and cumulus cells, leading to the deficits in the development of follicles and the biosynthesis of ovarian hormones.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Application of zero-valent iron coupled with biochar for removal of perfluoroalkyl carboxylic and sulfonic acids from water under ambient environmental conditions

Authors: Liu, Y; Ptacek, CJ; Baldwin, RJ; Cooper, JM; Blowes, DW (2020) Science of the Total Environment 719:137372. HERO ID: 6315690

[Less] Advanced oxidation and reduction processes have been intensively investigated as potential methods to . . . [More] Advanced oxidation and reduction processes have been intensively investigated as potential methods to promote the decomposition of perfluoroalkyl substances (PFASs). However, extreme operational conditions such as highly acidic pH, high temperature, and high pressure are required to promote degradation reactions, which makes these technologies costly and less feasible for full-scale applications. The objective of this study was to evaluate the effectiveness of zero-valent iron (ZVI) alone and a mixture of ZVI and biochar (ZVI + BC) for removal of seven target PFASs from water under ambient environmental conditions. Target PFASs included three perfluoroalkyl carboxylic acids (PFCAs) [perfluorooctanoic acid (PFOA, C8-PFCA), perfluoroheptanoic acid (C7-PFCA), and perfluorohexanoic acid (C6-PFCA)] and four perfluoroalkyl sulfonic acids (PFSAs) [perfluorooctane sulfonic acid (PFOS, C8-PFSA), perfluoroheptane sulfonic acid (C7-PFSA), perfluorohexane sulfonic acid (C6-PFSA), and perfluorobutane sulfonic acid (C4-PFSA)]. Batch test results show that PFSAs (up to 94% removal) were more effectively removed than PFCAs (up to 60% removal) when utilizing either ZVI or (ZVI + BC). About 20-60% of input PFOA (~18,550 μg L-1) and 90-94% of input PFOS (~18,580 μg L-1) were removed by ZVI alone or the mixture of (ZVI + BC). The removal efficiencies of PFCAs and PFSAs by reactive media increased with increasing chain length, from 0 to 17% for short-chain PFCAs (C6-C7) and 20 to 70% for short-chain PFSAs (C4-C7). About 5-10% of input PFOA and PFOS was partially defluorinated by ZVI alone as indicated by F- release; however, the defluorination efficiency may be underestimated due to the sorption of F- by the reactive media. Overall, the reactive mixture (ZVI + BC) may be an effective and environmentally sustainable material for removing PFASs from water under ambient environmental conditions.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Potential sources and sediment-pore water partitioning behaviors of emerging per/polyfluoroalkyl substances in the South Yellow Sea

Authors: Feng, X; Ye, M; Li, Y; Zhou, J; Sun, B; Zhu, Y; Zhu, L (2020) Journal of Hazardous Materials 389:122124. HERO ID: 6315693

[Less] Emerging per/polyfluoroalkyl substances (PFASs) have received great concerns, but there are few data . . . [More] Emerging per/polyfluoroalkyl substances (PFASs) have received great concerns, but there are few data in the coastal environment, which play an essential role in their global transport. In this study, surface water and sediment samples were collected in the South Yellow Sea close to Jiangsu Province China, and 26 legacy as well as emerging PFASs were investigated. Perfluorooctanoic acid (PFOA) and perfluorobutane sulfonate (PFBS) were predominant in the coastal water of the South Yellow Sea with a relatively higher level than other coastal regions in the world. PFBS and 6:2 fuorotelomer sulfonic acid (6:2 FTSA) were two major alternatives of perfluorooctane sulfonate (PFOS) which were used in textile surface treatment and fire-fighting foams, respectively. Multiple receptor models identified that fluoropolymer manufacture, textile and food packages were three major sources of PFASs in the South Yellow Sea. The partitioning behaviors of PFASs between sediment and pore water in the marine environment were compared, and the partitioning coefficients of hexafluoropropylene oxide trimer acid (HFPO-TA) and 6:2 chlorinated polyfluorinated ether sulfonic acid (6:2 F-53B) were reported for the first time, which exhibited stronger partition in sediment than their predecessors. The results provide important hints to understand the environmental transport of PFASs in the marine environment.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Per- and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells

Authors: Sørli, JB; Låg, M; Ekeren, L; Perez-Gil, J; Haug, LS; Da Silva, E; Matrod, MN; Gützkow, KB; Lindeman, B (2020) Toxicology In Vitro 62:104656. HERO ID: 5918817

[Less] The toxicity of some per- and polyfluoroalkyl substances (PFASs), such as perfluorooctane sulfonate . . . [More] The toxicity of some per- and polyfluoroalkyl substances (PFASs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been studied thoroughly, showing that systemic PFASs targets the lungs. However, regulators lack data to assess the impact of other PFASs on the lungs and alternative methods to test substances for lung toxicity are needed. We combined two in vitro models to assess toxicity to the respiratory system; i) a lung surfactant (LS) function assay to assess the acute inhalation toxicity potential, and ii) a cell model with human bronchial epithelial cells to study pro-inflammatory potential and modulation of inflammatory responses. We tested salts of four PFASs: perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), PFOS, and PFOA as well as the fluorotelomer 8:2 FTOH. The results show that PFHxS, PFOA and PFOS can inhibit LS function. High PFOS concentrations induced a pro-inflammatory response, measured as increased IL-1α/β release. Moderate concentrations of PFOS suppressed release of the chemokines CXCL8 and CXCL10, whereas both PFOS and PFOA stimulated the release of the pro-inflammatory cytokine IL-1β in immune stimulated human bronchial epithelial cells. These findings support the concern that some PFASs may increase the risk of acute lung toxicity and of airway infections.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Binding specificities of estrogen receptor with perfluorinated compounds: A cross species comparison

Authors: Qiu, Z; Qu, K; Luan, F; Liu, Y; Zhu, Y; Yuan, Y; Li, H; Zhang, H; Hai, Y; Zhao, C (2020) HERO ID: 6304523

[Less] BACKGROUND: Perfluorinated compounds (PFCs) were reported to result in the endocrine . . . [More] BACKGROUND: Perfluorinated compounds (PFCs) were reported to result in the endocrine disruption by activating the estrogen receptor (ER) and inducing ER-mediated transcriptions.

OBJECTIVE: The aim of the present work was to perform cross-species comparisons on the characteristics of eight PFCs binding to humans ERα and to rats ERα.

METHODS: In the present work, in vivo tests, including serum estradiol level assay and immunohistochemical staining, fluorescence assay and molecular models were applied.

RESULTS: Based on the in vivo experiments, the exposure of PFOA and PFOS to female rats was proved to increase the ERα expression in the terus, suggesting that PFCs may act as estrogenic compounds to activate ERα in vivo. The further fluorescence assay presented that these eight PFCs have stronger binding abilities to human ERα than to rat ERα. In addition, the differences in binding specificities between human ERα and rat ERα were identified in the process of molecular dynamics modeling with the term of helix position and the ability of coregulator recruitment. It can be found that more and stronger charge clamps could form between PFCs with human ERα than with rat ERα. Also, the eight PFCs presented lower binding energies in human ERα systems, which proved that eight PFCs presented much stronger binding abilities with human ERα.

DISCUSSION: In all, it can be concluded that PFCs might be more sensitive to human ERα than to that of rats, which also suggested the greater susceptibility to adverse effects on humans. The present work was a beginning assessment of a cross-species comparison, providing important information on health impacts of PFCs in humans.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

Authors: Behr, AC; Plinsch, C; Braeuning, A; Buhrke, T (2020) Toxicology In Vitro 62:104700. HERO ID: 6305866

[Less] Perfluoralkylated substances (PFAS) such as perfluorooctanoic acid (PFOA) or perfluorooctanesulfonic . . . [More] Perfluoralkylated substances (PFAS) such as perfluorooctanoic acid (PFOA) or perfluorooctanesulfonic acid (PFOS) are used to produce, e.g., surface coatings with water- and dirt-repellent properties. These substances have been shown to be hepatotoxic in rodents, and the mechanism of action is mostly attributed to the PFAS-mediated activation of the peroxisome proliferator-activated receptor alpha (PPARα). In the present study, we investigated by using luciferase-based reporter gene assays whether PFOA, PFOS and six alternative PFAS can activate, in addition to PPARα, eight other human nuclear receptors. All tested PFAS except for perfluorobutanesulfonic acid (PFBS) were able to activate human PPARα. Perfluoro-2-methyl-3-oxahexanoic acid (PMOH) and 3H-perfluoro-3-[(3-methoxypropoxy) propanoic acid] (PMPP) were weak agonists of human PPARγ. The other human nuclear receptors (PPARδ, CAR, PXR, FXR, LXRα, RXRα and RARα) were not affected by any PFAS tested in this study. Although PMOH was more effective than PFOA in stimulating PPARα in the transactivation assay, it was less effective in stimulating PPARα-dependent target gene expression in human HepG2 hepatocarcinoma cells. Notably, any effect observed in this in vitro study only occurred at concentrations higher than 10 μM of the respective PFAS which is in all cases several magnitudes above the average blood concentration in the Western population. Thus, the results suggest that nuclear receptor activation may only play a minor role in potential PFAS-mediated adverse effects in humans.