Health & Environmental Research Online (HERO)


6:2 monoPAP (57678-01-0)


6 References Were Found:

Archival Material
Archival Material

M566800: Mono[2-(perfluorohexyl)ethyl] phosphate. CAS Number: 57678-01-0

Author: TRC Canada (2017) Available online at https://www.trc-canada.com/product-detail/?CatNum=M566800. [Website] HERO ID: 3981231


Technical Report
Technical Report

ACE and JChem acidity and basicity calculator, ACE UKY-4.2 & Marvin JS by ChemAxon: 6:2 Fluorotelomer phosphate monoester (6:2 monoPAP; CASRN 57678-01-0)

Authors: Grossman, RB; Finkel, R (2017) Lexington, KY: University of Kentucky & Pearson Education. HERO ID: 3982640


Technical Report
Technical Report

Draft toxicological profile for perfluoroalkyls

Author: ATSDR (2015) HERO ID: 3859918


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Simultaneous determination of mono- and disubstituted polyfluoroalkyl phosphates in drinking water by liquid chromatography-electrospray tandem mass spectrometry

Authors: Ding, H; Peng, H; Yang, M; Hu, J (2012) Journal of Chromatography A 1227:245-252. HERO ID: 1038497

[Less] A sensitive liquid chromatography-electrospray tandem mass spectrometry method was established for the . . . [More] A sensitive liquid chromatography-electrospray tandem mass spectrometry method was established for the simultaneous determination of five monosubstituted polyfluoroalkyl phosphates (monoPAPs) and eight disubstituted polyfluoroalkyl phosphates (diPAPs) in drinking water. Complete separation and good retention for 13 polyfluoroalkyls phosphates (PAPs) were achieved with a Waters ACUITY UPLC BEH C8 column using a mixture of methanol/water containing 0.1% NHâ‚„OH as the mobile phases. Extraction of drinking water samples was performed on weak anion exchange (WAX) cartridges, and the recoveries of target compounds were from 65 to 110%. The limits of quantization (LOQs) for 13 analytes were in the range of 0.4-40 ng/L. This method was applied to analyze the PAPs in drinking water samples from three cities in China. Of the 13 PAPs, six PAPs including 6:2 monoPAP (13.0 ng/L), 8:2 monoPAP (3.6 ng/L), 10:1 monoPAP (4.3-70.3 ng/L), 10:2 monoPAP (1.4-5.6 ng/L), 8:2 diPAP (0.10 ng/L), and 10:1 diPAP (0.8-3.8 ng/L) were detected.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Exploring indirect sources of human exposure to perfluoroalkyl carboxylates (PFCAs): evaluating uptake, elimination, and biotransformation of polyfluoroalkyl phosphate esters (PAPs) in the rat

Authors: D'eon, JC; Mabury, SA (2011) Environmental Health Perspectives 119:344-350. HERO ID: 2580387

[Less] BACKGROUND: Perfluorinated carboxylic acids (PFCAs) are ubiquitous in human sera worldwide. . . . [More] BACKGROUND: Perfluorinated carboxylic acids (PFCAs) are ubiquitous in human sera worldwide. Biotransformation of the polyfluoroalkyl phosphate esters (PAPs) is a possible source of PFCA exposure, because PAPs are used in food-contact paper packaging and have been observed in human sera.

OBJECTIVES: We determined pharmacokinetic parameters for the PAP monoesters (monoPAPs) and PAP diesters (diPAPs), as well as biotransformation yields to the PFCAs, using a rat model.

METHODS: The animals were dosed intravenously or by oral gavage with a mixture of 4:2, 6:2, 8:2, and 10:2 monoPAP or diPAP chain lengths. Concentrations of the PAPs and PFCAs, as well as metabolic intermediates and phase II metabolites, were monitored over time in blood, urine, and feces.

RESULTS: The diPAPs were bioavailable, with bioavailability decreasing as the chain length increased from 4 to 10 perfluorinated carbons. The monoPAPs were not absorbed from the gut; however, we found evidence to suggest phosphate-ester cleavage within the gut contents. We observed biotransformation to the PFCAs for both monoPAP and diPAP congeners.

CONCLUSIONS: Using experimentally derived biotransformation yields, perfluorooctanoic acid (PFOA) sera concentrations were predicted from the biotransformation of 8:2 diPAP at concentrations observed in human serum. Because of the long human serum half-life of PFOA, biotransformation of diPAP even with low-level exposure could over time result in significant exposure to PFOA. Although humans are exposed directly to PFCAs in food and dust, the pharmacokinetic parameters determined here suggest that PAP exposure should be considered a significant indirect source of human PFCA contamination.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Biodegradation of polyfluoroalkyl phosphates as a source of perfluorinated acids to the environment

Authors: Lee, H; D'eon, J; Mabury, SA (2010) Environmental Science and Technology 44:3305-3310. HERO ID: 1274414

[Less] Wastewater treatment plants (WWTPs) have been identified as a major source of perfluorocarboxylates . . . [More] Wastewater treatment plants (WWTPs) have been identified as a major source of perfluorocarboxylates (PFCAs) to aqueous environments. The observed increase in PFCA mass flows from WWTP influent to effluent suggests the biodegradation of commercial fluorinated materials within the WWTP. Commercial fluorinated surfactants are used as greaseproofing agents in food-contact paper products as well as leveling and wetting agents. As WWTPs are likely the major fate of these surfactants, their biodegradation may be a source of PFCA production. One class of commercial surfactants, the polyfluoroalkyl phosphates (PAPs), have been observed in WWTP sludge. While PAPs have been shown to degrade into PFCAs in a rat model, the present study investigates their microbial fate to determine whether the biodegradation of PAPs within a WWTP-simulated system will contribute to the load of PFCAs released. PAPs are applied commercially in mixed formulations of different chain lengths and substitution at the phosphate center. The effect of chain length and phosphate substitution on the biodegradation of PAPs was investigated by incubating mixtures of 4:2, 6:2, 8:2, and 10:2 monosubstituted PAPs (monoPAPs) in an aerobic microbial system and by separately incubating the 6:2 monoPAP and 6:2 disubstituted PAP (diPAP) for 92 days. Headspace sampling revealed production of the fluorotelomer alcohols (FTOHs) from the hydrolysis of the PAP phosphate ester linkages. Analysis of the aqueous phase revealed microbial transformation of the PAPs to the final PFCA products was possible. The majority of the oxidation products observed were consistent with previous investigations that have suggested fluorotelomer precursor compounds degrade predominantly via a beta-oxidation-like mechanism. However, in this study, the detection of odd-chain PFCAs suggests that other pathways may be important. The present study demonstrated microbially mediated biodegradation of PAPs to PFCAs. This observation, together with the diPAP concentrations observed in WWTP sludge, suggest PAPs-containing commercial products may be a significant contributor to the increased PFCA mass flows observed in WWTP effluents.