Health & Environmental Research Online (HERO)


PFDoA (307-55-1)


12 References Were Found:

Technical Report
Technical Report

Perfluorododecanoic acid ( 307-55-1 ). Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (in Japanese). Japan Existing Chemicals Database.

Author: CIPCJ (2017) HERO ID: 3862191


Technical Report
Technical Report

Perfluorododecanoic acid (307-55-1). In vitro mammalian chromosome aberration test (in Japanese). Japan Existing Chemical Data Base(JECDB)

Author: CIPCJ (2017) HERO ID: 3862317


Technical Report
Technical Report

Perfluorododecanoic acid (307-55-1 ). Bacterial reverse mutation test (in Japanese). Japan Existing Chemical Data Base (JECDB)

Author: CIPCJ (2017) HERO ID: 3862262


Technical Report
Technical Report

Safety data sheet. Version 4.5. Tricosafluorododecanoic acid. Product number 406449. CAS-No. 307-55-1

Author: Sigma-Aldrich (2017) HERO ID: 3980877


Technical Report
Technical Report

Human health tier II assessment for indirect precursors of long-chain perfluorocarboxylic acids (PFCAs)

Author: NICNAS (2017) Australian Government, Department of Health, National Industrial Chemicals Notification and Assessment Scheme. HERO ID: 3874962


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status: Supplemental material

Authors: Zhou, Y; Hu, LW; Qian, ZM; Chang, JJ; King, C; Paul, G; Lin, S; Chen, PC; Lee, YL; Dong, GH (2016) Environment International 94. [Supplemental Data] HERO ID: 3981185

Abstract: Supplementary materials

Book/Book Chapter
Book/ Chapter

Fluorine compounds, organic

Authors: Siegemund, G; Schwertfeger, W; Feiring, A; Smart, B; Behr, F; Vogel, H; McKusick, B; Kirsch, P (2016) In Ullmann's encyclopedia of industrial chemistry. online: John Wiley and Sons, Inc. HERO ID: 3980878

[Less] Organic fluorine compounds are characterized by their carbon–fluorine bond. Fluorine can replace any . . . [More] Organic fluorine compounds are characterized by their carbon–fluorine bond. Fluorine can replace any hydrogen atom in linear or cyclic organic molecules because the difference between the van der Waals radii for hydrogen (0.12 nm) and fluorine (0.14 nm) is small compared to that of other elements (e.g., chlorine 0.18 nm). Thus, as in hydrocarbon chemistry, organic fluorine chemistry deals with a great variety of species. When all valences of a carbon chain are satisfied by fluorine, the zig-zagshaped carbon skeleton is twisted out of its plane in the form of a helix. This situation allows the electronegative fluorine substituents to envelop the carbon skeleton completely and shield it from chemical (especially nucleophilic) attack. Several other properties of the carbon–fluorine bond contribute to the fact that highly fluorinated alkanes are the most stable organic compounds. These include low polarizability and high bond energies, which increase with increasing substitution by fluorine (bond energies: C–F bond in CH3F, 448 kJ/mol; C–H bond in CH4, 417 kJ/mol; C–Cl bond in CH3Cl, 326 kJ/mol; and C–F bond in CF4, 486 kJ/mol).

The cumulative negative inductive effect of the fluorine in perfluoroalkyl groups may reverse the polarity of adjacent single bonds (e.g., in the pair H3C ◅ I and F3C ▻ I) or double bonds (e.g., CH3Cδ‡H ˆ CδH2 and CF3 CδH ˆ Cδ‡H2). Fluorine substitution changes the reactivity of olefins and carbonyl compounds. Polyfluorinated olefins possess an electron-deficient double bond, which reacts preferentially with nucleophiles. Carboxy groups are affected by the presence of an adjacent perfluoroalkyl radical. In carboxylic acids, the acidity is markedly increased. In other carbonyl compounds, the reactivity is increased without any fundamental change in the chemistry of the compound. Correspondingly, the basicity of amines is reduced by the introduction of fluorine. Fluorine attached to the ring of aromatic compounds acts mainly as a paradirecting substituent, whereas perfluoroalkyl groups behave as meta-directing substituents.

Naturally, the influence of fluorine is greatest in highly fluorinated and perfluorinated compounds. The fact that these compounds have a high thermal stability and chemical resistance and are physiologically inert makes them suitable for many applications for which hydrocarbons are not. Properties that are exploited commercially include high thermal and chemical stability, low surface tension, and good dielectric properties, for example, in fluoropolymers, perfluorinated oils and inert fluids.

Individual fluorine atoms or perfluoroalkyl groups do not change the technical properties of a hydrocarbon fundamentally. However, this is not the case with physiological properties. A fluorine atom in a bioactive material may simulate a hydrogen atom, and although this does not prevent metabolic processes from occurring, the end products may be ineffective or toxic. Accordingly, such fluorine compounds are important in, for example, pesticides and pharmaceuticals.

A general overview of the scientific literature on organofluorine chemistry was published in 2013 [1]; commercial applications of fluorine products are reviewed in [2–4].

Technical Report
Technical Report

Draft toxicological profile for perfluoroalkyls

Author: ATSDR (2015) HERO ID: 3859918


Technical Report
Technical Report

Committee for Risk Assessment RAC - Annex 1 - Background document to the Opinion proposing harmonised classification and labelling at EU level of Nonadecafluorodecanoic acid (PFDA) [1] and its ammonium (PFD-A) [2] and sodium (PFD-S) [3] salts Nonadecafluorodecanoic acid [1], ammonium nonadecafluorodecanoate [2], sodium nonadecafluorodecanoate [3]

Author: ECHA (2015) Helsinki, Finland: European Chemicals Agency. HERO ID: 3860050


Technical Report
Technical Report

Member State Committee support document for identification of tricosafluorododecanoic acid as a substance of very high concern because of its vPvB properties

Author: ECHA (2012) European Chemicals Agency. HERO ID: 3874956