Health & Environmental Research Online (HERO)


FtOH 8:2 (678-39-7)


175 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Synthesis of Bifunctional Terminal Octasilicate-Core Dendrimer Containing Fluorocarbon and Hydrocarbon Chains

Authors: Irie, Y; Yuasa, S; Imoto, H; Naka, K (2017) Journal of Polymer Science. Part A, Polymer Chemistry 55:912-918. HERO ID: 3857418

[Less] A bifunctional terminal organic-inorganic dendrimer with fluorocarbon and hydrocarbon units at its terminal . . . [More] A bifunctional terminal organic-inorganic dendrimer with fluorocarbon and hydrocarbon units at its terminal groups was successfully prepared by a hydrosilylation reaction, and a combination of a ring-opening reaction and condensation reaction of octakis(propenylsuccinicanhydrido)polyhedraloctasilicate (OS-SA) with 1-decanol and 1H,1H,2H,2H-perfluoro-1-decanol. The structure of the OS-core dendrimer bearing the decyl and 1H,1H,2H,2H-heptadecafluorodecyl groups (OS-CF) was fully characterized by FT-IR, NMR spectra, and MALDI TOF MS spectrum. The crystallinity of the fluorinated domains in OS-CF decreased in comparison with that in I-CF and the fluorocarbon/hydrocarbon chains form no ordered structure due to suppression of the molecular motion of their branches resulting from the rigid inorganic core. The composite films of PMMA containing OS-CF were prepared through solution blending of PMMA with various concentrations of OS-CF (5, 10, and 20 wt %). The refractive index of the neat PMMA film is 1.49, and the refractive indices of the composite films containing OS-CF decrease linearly with increases in the OS-CF weight fraction. (c) 2017 Wiley Periodicals, Inc.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluoroalkyl acids and their precursors in indoor air sampled in children's bedrooms

Authors: Winkens, K; Koponen, J; Schuster, J; Shoeib, M; Vestergren, R; Berger, U; Karvonen, AM; Pekkanen, J; Kiviranta, H; Cousins, IT (2017) Environmental Pollution 222:423-432. HERO ID: 3857420

[Less] The contamination levels and patterns of perfluoroalkyl acids (PFAAs) and their precursors in indoor . . . [More] The contamination levels and patterns of perfluoroalkyl acids (PFAAs) and their precursors in indoor air of children's bedrooms in Finland, Northern Europe, were investigated. Our study is among the most comprehensive indoor air monitoring studies (n = 57) and to our knowledge the first one to analyse air in children's bedrooms for PFASs (17 PFAAs and 9 precursors, including two acrylates, 6:2 FTAC and 6:2 FTMAC). The most frequently detected compound was 8:2 fluorotelomer alcohol (8:2 FTOH) with the highest median concentration (3570 pg/m(3)). FTOH concentrations were generally similar to previous studies, indicating that in 2014/2015 the impact of the industrial transition had been minor on FTOH levels in indoor air. However, in contrast to earlier studies (with one exception), median concentrations of 6:2 FTOH were higher than 10:2 FTOH. The C8 PFAAs are still the most abundant acids, even though they have now been phased out by major manufacturers. The mean concentrations of FOSE/As, especially MeFOSE (89.9 pg/m(3)), were at least an order of magnitude lower compared to previous studies. Collectively the comparison of FTOHs, PFAAs and FOSE/FOSAs with previous studies indicates that indoor air levels of PFASs display a time lag to changes in production of several years. This is the first indoor air study investigating 6:2 FTMAC, which was frequently detected (58%) and displayed some of the highest maximum concentrations (13 000 pg/m(3)). There were several statistically significant correlations between particular house and room characteristics and PFAS concentrations, most interestingly higher EtFOSE air concentrations in rooms with plastic floors compared to wood or laminate.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Geochemical and Hydrologic Factors Controlling Subsurface Transport of Poly- and Perfluoroalkyl Substances, Cape Cod, Massachusetts

Authors: Weber, AK; Barber, LB; Leblanc, DR; Sunderland, EM; Vecitis, CD (2017) Environmental Science and Technology 51:4269-4279. HERO ID: 3859471

[Less] Growing evidence that certain poly- and perfluoroalkyl substances (PFASs) are associated with negative . . . [More] Growing evidence that certain poly- and perfluoroalkyl substances (PFASs) are associated with negative human health effects prompted the U.S. Environmental Protection Agency to issue lifetime drinking water health advisories for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in 2016. Given that groundwater is a major source of drinking water, the main objective of this work was to investigate geochemical and hydrological processes governing the subsurface transport of PFASs at a former fire training area (FTA) on Cape Cod, Massachusetts, where PFAS-containing aqueous film-forming foams were used historically. A total of 148 groundwater samples and 4 sediment cores were collected along a 1200-m-long downgradient transect originating near the FTA and analyzed for PFAS content. The results indicate that unsaturated zones at the FTA and at hydraulically downgradient former domestic wastewater effluent infiltration beds both act as continuous PFAS sources to the groundwater despite 18 and 20 years of inactivity, respectively. Historically different PFAS sources are evident from contrasting PFAS composition near the water table below the FTA and wastewater-infiltration beds. Results from total oxidizable precursor assays conducted using groundwater samples collected throughout the plume suggest that some perfluoroalkyl acid precursors at this site are transporting with perfluoroalkyl acids.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Uptake, Translocation, and Metabolism of 8:2 Fluorotelomer Alcohol in Soybean (Glycine max L. Merrill)

Authors: Zhang, H; Wen, B; Hu, X; Wu, Y; Pan, Y; Huang, H; Liu, L; Zhang, S (2016) Environmental Science and Technology 50:13309-13317. HERO ID: 3859253

[Less] Biotransformation of fluorotelomer alcohols (FTOHs) is widely considered as an additional source of . . . [More] Biotransformation of fluorotelomer alcohols (FTOHs) is widely considered as an additional source of perfluorocarboxylic acids (PFCAs) in environmental biota. Compared with the extensive studies conducted in animals and microbes, biotransformation pathways of FTOHs in plants are still unclear. In this study, a hydroponic experiment was conducted to investigate the uptake, translocation and metabolism of 8:2 FTOH in soybean (Glycine max L. Merrill) over 144 h. 8:2 FTOH and its metabolites were found in all parts of soybean plants. At the end of the exposure, 7:3 FTCA [F(CF2)7CH2CH2COOH] was the primary metabolite in roots and stems, while PFOA [F(CF2)7COOH] was predominant in leaves. PFOA and 7:3 FTCA in the soybean-solution system accounted for 6.01 and 5.57 mol % of the initially applied 8:2 FTOH, respectively. Low levels of PFHpA [F(CF2)6COOH] and PFHxA [F(CF2)5COOH] in solutions and soybean roots resulted from microbial metabolism and plant root uptake. Glutathione-conjugated metabolites in soybean tissues were also identified. The activities of alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase in soybean roots increased during the exposure, suggesting their roles in 8:2 FTOH metabolism in soybean. This study provides important information for a better understanding of the uptake and metabolism of FTOHs and fluorotelomer-based compounds in plants.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Engineering artificial communities for enhanced FTOH degradation

Authors: Lewis, M; Kim, MH; Wang, N; Chu, KH (2016) Science of the Total Environment 572:935-942. HERO ID: 3859228

[Less] Fluorotelomer alcohols (FTOHs, [F(CF2)nCH2CH2OH]) are concerned environmental pollutants with perfluorinated . . . [More] Fluorotelomer alcohols (FTOHs, [F(CF2)nCH2CH2OH]) are concerned environmental pollutants with perfluorinated carbon chains. FTOHs can be biotransformed; however, the extent, the pace of the defluorination, and types of metabolites produced vary depending on degradative microorganisms under different environment. In this study, we examined ways to increase the effectiveness of the FTOH defluorination process to less persistent major metabolites. Defined mixed cultures and bioaugmented microbial cultures were engineered to study their ability to biotransform 6:2 fluorotelomer alcohol [F(CF2)6CH2CH2OH]. The effects of carbon sources and the concentration of carbon sources were also examined. All experiments resulted in 5:2 sFTOH [F(CF2)5CH(OH)CH3] as the primary metabolite at the end point. The carbon sources resulted in different amounts of pathway utilization as well as overall changes in effectiveness. The best overall effectiveness was observed when cosubstrate carbon was kept at low concentrations. Pathway II was best utilized by the P. butanovora+P. fluorescens mixed culture, with lactate having a slight negative impact on pathway II utilization. Additional carbon to augmented activated sludge resulted in decreased 6:2 FTOH biotransformation by 60%. Enrichment cultures showed that shorter chain FTOHs are easier to degrade, with the n-octane enriched culture transforming 20% of 8:2 FTOH, 60% of 6:2 FTOH and 70% of 4:2 FTOH. The microbial communities of the enrichment cultures and the alkane hydroxylase gene were also examined to help understand FTOH biotransformation mechanisms.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Neutral polyfluoroalkyl substances in the atmosphere over the northern South China Sea

Authors: Lai, S; Song, J; Song, T; Huang, Z; Zhang, Y; Zhao, Y; Liu, G; Zheng, J; Mi, W; Tang, J; Zou, S; Ebinghaus, R; Xie, Z (2016) Environmental Pollution 214:449-455. HERO ID: 3359624

[Less] Neutral Polyfluoroalkyl substances (PFASs) in the atmosphere were measured during a cruise campaign . . . [More] Neutral Polyfluoroalkyl substances (PFASs) in the atmosphere were measured during a cruise campaign over the northern South China Sea (SCS) from September to October 2013. Four groups of PFASs, i.e., fluorotelomer alcohols (FTOHs), fluorotelomer acrylates (FTAs), fluorooctane sulfonamides (FOSAs) and fluorooctane sulfonamidoethanols (FASEs), were detected in gas samples. FTOHs was the predominant PFAS group, accounting for 95.2-99.3% of total PFASs (ΣPFASs), while the other PFASs accounted for a small fraction of ΣPFASs. The concentrations of ΣPFASs ranged from 18.0 to 109.9 pg m(-3) with an average of 54.5 pg m(-3). The concentrations are comparable to those reported in other marine atmosphere. Higher concentrations of ΣPFASs were observed in the continental-influenced samples than those in other samples, pointing to the substantial contribution of anthropogenic sources. Long-range transport is suggested to be a major pathway for introducing gaseous PFASs into the atmosphere over the northern SCS. In order to further understand the fate of gaseous PFASs during transport, the atmospheric decay of neutral PFASs under the influence of reaction with OH radicals and atmospheric physical processes were estimated. Concentrations of 8:2 FTOH, 6:2 FTOH and MeFBSE from selected source region to the atmosphere over the SCS after long-range transport were predicted and compared with the observed concentrations. It suggests that the reaction with OH radicals may play an important role in the atmospheric decay of PFAS during long-range transport, especially for shorted-lived species. Moreover, the influence of atmospheric physical processes on the decay of PFAS should be further considered.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A fast and sensitive method for the simultaneous analysis of a wide range of per- and polyfluoroalkyl substances in indoor dust using on-line solid phase extraction-ultrahigh performance liquid chromatography-time-of-flight-mass spectrometry

Authors: Padilla-Sánchez, JA; Haug, LS (2016) Journal of Chromatography A 1445:36-45. HERO ID: 3360146

[Less] A fast and sensitive method for simultaneous determination of 18 traditional and 6 alternative per- . . . [More] A fast and sensitive method for simultaneous determination of 18 traditional and 6 alternative per- and polyfluoroalkyl substances (PFASs) using solid-liquid extraction (SLE), off-line clean-up using activated carbon and on-line solid phase extraction-ultrahigh performance liquid chromatography-time-of-flight-mass spectrometry (on-line SPE-UHPLC-TOF-MS) was developed. The extraction efficiency was studied and recoveries in range the 58-114% were obtained. Extraction and injection volumes were also optimized to 2mL and 400μL, respectively. The method was validated by spiking dust from a vacuum cleaner bag that had been found to contain low levels of the PFASs in focus. Low method detection limits (MDLs) and method quantification limits (MQLs) in the range 0.008-0.846ngg(-1) and 0.027-2.820ngg(-1) were obtained, respectively. For most of the PFASs, the accuracies were between 70 and 125% in the range from 2 to100ngg(-1) dust. Intra-day and inter-day precisions were in general well below 30%. Analysis of a Standard Reference Material (SRM 2585) showed high accordance with results obtained by other laboratories. Finally, the method was applied to seven indoor dust samples, and PFAS concentrations in the range 0.02-132ngg(-1) were found. The highest median concentrations were observed for some of the alternative PFASs, such as 6:2-diPAP (25ngg(-1)), 8:2-diPAP (49ngg(-1)), and PFOPA (23ngg(-1)), illustrating the importance of inclusion of new PFASs in the analytical methods.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Neutral and ionic per- and polyfluoroalkyl substances (PFASs) in atmospheric and dry deposition samples over a source region (Tianjin, China)

Authors: Yao, Y; Chang, S; Sun, H; Gan, Z; Hu, H; Zhao, Y; Zhang, Y (2016) Environmental Pollution 212:449-456. HERO ID: 3361010

[Less] Per- and polyfluoroalkyl substances (PFASs) were detected in the atmosphere of a source region in Tianjin, . . . [More] Per- and polyfluoroalkyl substances (PFASs) were detected in the atmosphere of a source region in Tianjin, China. Fluorotelomer alcohols (FTOHs) were the dominant neutral PFASs in the atmosphere with total concentrations of 93.6-131 pg/m(3) and 8:2 FTOH contributing the most, whereas perfluorooctane sulfonamide derivatives (PFOSAs) were two magnitudes lower or undetected. In comparison, ionic PFASs (perfluoroalkyl carboxyl acids (PFCAs)) in the atmosphere were detected at similar or even higher levels. At wastewater treatment plants (WWTPs), the air over influent was found with higher levels of FTOHs than over aeration tank and effluent; whereas in the air over the aeration tank, the concentrations of PFOSAs and nonvolatile ionic PFASs substantially increased, suggesting a possible direct release of ionic PFASs to the atmosphere besides the atmospheric conversion from volatile precursors. In the air phase, a low proportion (1-5%) of PFCAs was subjected to dry deposition in the source region. Interestingly, the dry-deposition-to-bulk-air ratios of PFCA analogues were the lowest at medium chain lengths (C8 and C9) and increased with either shorter or longer chain length. The extraordinary affinity of shorter-chain PFCAs (C6-C7) to particles was presumed to be due to their smaller molecular size favoring the interactions between the carboxyl head groups and specific sorption sites on particulate matter.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Poly- and perfluoroalkyl substances (PFASs) in indoor dust and food packaging materials in Egypt: Trends in developed and developing countries

Authors: Shoeib, T; Hassan, Y; Rauert, C; Harner, T (2016) Chemosphere 144:1573-1581. HERO ID: 3363752

[Less] PFASs concentrations in dust samples collected from three microenvironments in Cairo ranged from 1.3 . . . [More] PFASs concentrations in dust samples collected from three microenvironments in Cairo ranged from 1.3 to 69 ng g(-1) with FTOHs being dominant. The 8:2 FTOH was detected in all samples. Among the FOSAs and FOSEs the MeFOSE was dominant while among ionic PFASs, PFOS and PFOA were most prominent. The concentrations of PFASs were among the lowest worldwide. Correlations between worldwide concentrations of PFOS + PFOA and country development indexes highlight higher usage and human exposure in more developed countries. Food packaging was analyzed for PFSAs, PFCAs and PAPs. The 6:2 and 8:2 monoPAPs were found to be above the MDL in 18% of the samples. PFOA was detected in 79% of the samples with median concentration of 2.40 ng g(-1). PFOS was detected in 58% of the samples with median concentration of 0.29 ng g(-1) while PFHxS and PFDS were below detection limit. Different human exposure scenarios were estimated.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Identification of biomarkers of exposure to FTOHs and PAPs in humans using a targeted and nontargeted analysis approach

Authors: Dagnino, S; Strynar, MJ; Mcmahen, RL; Lau, CS; Ball, C; Garantziotis, S; Webster, TF; Mcclean, MD; Lindstrom, AB (2016) Environmental Science and Technology 50:10216-10225. HERO ID: 3460580

[Less] Although historic perfluorinated compounds are currently under scrutiny and growing regulatory control . . . [More] Although historic perfluorinated compounds are currently under scrutiny and growing regulatory control in the world, little is known about human exposure to other polyfluorinated compounds presently in use. Fluorotelomer alcohols (FTOHs) and polyfluoroalkyl phosphate esters (PAPs) are known to degrade to terminal perfluorinated acids and toxic reactive intermediates through metabolic pathways. Therefore, it is important to characterize their human exposure by the identification of unique biomarkers. With the use of liquid chromatography-mass spectrometry-time-of-flight analysis (LC-MS-TOF), we developed a workflow for the identification of metabolites for the 8:2 FTOH and 8:2 diPAP. Analysis of serum and urine of dosed rats indicated the 8:2 FTOH-sulfate and the 8:2 diPAP as potential biomarkers. These compounds, as well as 25 other fluorinated compounds and metabolites, were analyzed in human serum and urine samples from the general population (n = 100) and office workers (n = 30). The 8:2 FTOH-sulfate was measured for the first time in human samples in 5 to 10% of the serum samples, ranging from 50 to 80 pg/mL. The 8:2 diPAP was measured in 58% of the samples, ranging from 100 to 800 pg/mL. This study indicates the FTOH-sulfate conjugate as a biomarker of exposure to FTOHs and PAPs in humans.