Health & Environmental Research Online (HERO)


FtOH 8:2 (678-39-7)


3 References Were Found:

Archival Material
Archival Material

Study information: CEBS accession number 002-02182-0001-0000-6: Fluorotelomer alcohol 8+2

Author: NTP (2017) Available online at https://tools.niehs.nih.gov/cebs3/ntpViews/?studyNumber=002-02182-0001-0000-6. (Aug 5, 2017). [Website] HERO ID: 3860304

[Less] CEBS Accession Number: 002-02182-0001-0000-6 Chemical Name: Fluorotelomer Alcohol 8+2 CASRN: 678-39-7 NTP . . . [More] CEBS Accession Number: 002-02182-0001-0000-6
Chemical Name: Fluorotelomer Alcohol 8+2
CASRN: 678-39-7
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: A74889
Vehicle Control: Dimethyl Sulfoxide
Study Result: Negative

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Effects of per- and polyfluorinated compounds on adult rat testicular cells following in vitro exposure

Authors: Lindeman, B; Maass, C; Duale, N; G├╝tzkow, KB; Brunborg, G; Andreassen, A (2012) Reproductive Toxicology 33:531-537. HERO ID: 1289828

[Less] Testicular toxicity is observed following exposure of rats to per- and polyfluorinated compounds (PFCs). . . . [More] Testicular toxicity is observed following exposure of rats to per- and polyfluorinated compounds (PFCs). Such compounds were also shown to induce oxidative stress and changes in ABC efflux transporters e.g. P-gp, implying two mechanisms which may contribute to testicular toxicity. We studied the toxicity of four PFCs (PFOA, PFNA, 8:2 FTOH and 6:2 FTOH) on primary rat testicular cells. DNA damage was studied by the comet assay including Fpg enzyme treatment to detect oxidative lesions. The levels of the ABC efflux transporters Bcrp1, Oat2 and P-gp were studied by real-time RT-PCR or flow cytometry. A PFNA associated increase in DNA SSBs was attributed to a subpopulation of moderately damaged cells possibly associated with cytotoxicity. No significant increase in oxidative DNA damage was measured for any of the PFCs. Expression levels of ABC efflux transporters suggest that PFCs may increase expression levels of the P-gp protein and the Oat2 gene.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Genetic toxicology of 8-2 telomer B alcohol

Authors: Kennedy, GL; Jung, R; Iwai, H; Shin-Ya, S; Murphy, S; Drouot, N; Finlay, C; Donner, M; Erexson, G; Stankowski, L (2003) Toxicological Sciences 72:209. [Abstract] HERO ID: 3859487