Health & Environmental Research Online (HERO)


PFHxA (307-24-4)


249 References Were Found:

Technical Report
Technical Report

Safety data sheet. Version 5.2. Undecafluorohexanoic acid. Product number 29226. CAS-No 307-24-4

Author: Sigma-Aldrich (2017) [Fact Sheet] HERO ID: 3980883


Technical Report
Technical Report

Environment tier II assessment for short-chain perfluorocarboxylic acids and their direct precursors. CAS registry numbers: 307-24-4, 21615-47-4, 2706-90-3, 68259-11-0, 375-22-4, 336-59-4

Author: NICNAS (2017) Australian Government Department of Health, National Industrial Chemicals Notification and Assessment Scheme. HERO ID: 3860584


Technical Report
Technical Report

Human health tier II assessment for short chain perfluorocarboxylic acids and their direct precursors

Author: NICNAS (2017) Australian Government, Department of Health, National Industrial Chemicals Notification and Assessment Scheme. HERO ID: 3860585


Technical Report
Technical Report

Case study from SEURAT-1: Perfluoroalkyl acids: direct acting toxicant category supported by SEURAT-1 data

Author: ECHA (2017) HERO ID: 3878517


Data/Software
Data/ Software

Toxicokinetic evaluation (C20613) of perfluorohexanoic acid (307-24-4) in Harlan Sprague-Dawley rats exposed via gavage or intravenous injection

Author: NTP (2017) HERO ID: 3899973


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluoroalkyl acids in surface waters and tapwater in the Qiantang River watershed-Influences from paper, textile, and leather industries

Authors: Lu, GH; Gai, N; Zhang, P; Piao, HT; Chen, S; Wang, XC; Jiao, XC; Yin, XC; Tan, KY; Yang, YL (2017) Chemosphere 185:610-617. HERO ID: 3859699

[Less] Perfluoroalkyl acids (PFAAs) are widely used as multi-purpose surfactants or water/oil repellents. In . . . [More] Perfluoroalkyl acids (PFAAs) are widely used as multi-purpose surfactants or water/oil repellents. In order to understand the contamination level and compositional profiles of PFAAs in aqueous environment in textile, leather, and paper making industrial areas, surface waters and tap waters were collected along the watershed of the Qiantang River where China's largest textile, leather, and paper making industrial bases are located. For comparison, surface water and tapwater samples were also collected in Hangzhou and its adjacent areas. 17 PFAAs were analyzed by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry. The results show that the total concentrations of PFAAs (ΣPFAAs) in the Qiantang River waters ranged from 106.1 to 322.9 ng/L, averaging 164.2 ng/L. The contamination levels have been found to be extremely high, comparable to the levels of the most serious PFAA contamination in surface waters of China. The PFAA composition profiles were characterized by the dominant PFOA (average 58.1% of the total PFAAs), and PFHxA (average 18.8%). The ΣPFAAs in tap water ranged from 9.5 to 174.8 ng/L, showing PFAA compositional pattern similar to the surface waters. Good correlations between PFAA composition profiles in tap waters and the surface waters were observed.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Serum concentrations of per- and poly-fluoroalkyl substances and factors associated with exposure in the general adult population in South Korea

Authors: Lee, JH; Lee, CK; Suh, CH; Kang, HS; Hong, CP; Choi, SN (2017) International Journal of Hygiene and Environmental Health 220:1046-1054. HERO ID: 3858472

[Less] Per- and polyfluoroalkyl substances (PFASs) are ubiquitous contaminants found worldwide, including in . . . [More] Per- and polyfluoroalkyl substances (PFASs) are ubiquitous contaminants found worldwide, including in South Korea. As a result, they are frequently detected in Koreans. However, there is limited representative data and information on potential sources in Korea. Therefore, we measured the serum concentrations of ten PFASs in nationally representative samples of the Korean population (n=1874, 18-69 years) and evaluated the factors associated with their exposure. Serum PFOS, PFDA, PFOA, and PFNA were detected in nearly all participants (83.1-99.9%). However, serum PFPA, PFHxA, and PFHpA were almost undetected (<0.5% of participants). PFOS had the highest population-weighted geometric mean of 10.23ng/mL (95% CI: 9.99-10.47), which was followed by PFOA with 2.85ng/mL (95% CI: 2.73-2.97) and PFDA with 2.17ng/mL (95% CI: 2.12-2.23). PFNA, PFDA, PFHxS, PFOA, and PFOS concentrations were higher in males (p<0.001) and older adults (p<0.001). PFNA was higher in those who used wax, polish, and water-resistant materials (adjusted proportional change=1.14; 95% CI: 1.08-1.22), and those who ate cooked fish (1.16; 95% CI: 1.03-1.31) compared to those who ate nearly no fish. PFDA was higher in those who used herbicides and pesticides (1.05; 95% CI: 1.02-1.09), those who drank beverages in a plastic bag on a daily basis (1.10; 95% CI: 1.03-1.19), and those who ate raw fish (1.15; 95% CI: 1.03-1.29) or cooked fish (1.13; 95% CI: 1.05-1.23) compared to those who ate nearly no fish. PFHxS was higher in those who used traditional Korean health supplement foods (1.08; 95% CI: 1.01-1.15). PFOA was higher in those who used plastic wrap in a microwave daily or weekly (1.08; 95% CI: 1.00-1.16), and those who used disposable paper cups (1.07; 95% CI: 1.01-1.13). PFOS was lower in underweight participants (0.84; 95%CI: 0.75-0.93) compared to those who were obese, and higher in those who exercised regularly (1.08; 95% CI: 1.03-1.14) or irregularly (1.06, 95% CI: 1.01-1.12) compared to those who did not exercise. Subjects who used severely damaged Teflon appliances had lower concentrations of PFOA (0.78, 95% CI: 0.65-0.95), while regular use of Gore-Tex goods was related to higher PFNA (1.15, 95% CI: 1.03-1.28) and PFDA (1.11; 95% CI: 1.02-1.20) levels. These findings suggest that most Koreans are frequently exposed to PFASs, and that serum concentrations of PFASs vary with age, sex, and exposure factors.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes

Authors: Siebenaler, R; Cameron, R; Butt, CM; Hoffman, K; Higgins, CP; Stapleton, HM (2017) Chemosphere 184:687-693. HERO ID: 3858477

[Less] The ubiquitous use of poly- and perfluoroalkyl substances (PFASs) in a variety of industrial and consumer . . . [More] The ubiquitous use of poly- and perfluoroalkyl substances (PFASs) in a variety of industrial and consumer products has resulted in chronic exposure in most industrialized nations, and led to measurable concentrations in blood and other tissues in humans across all life stages; however, behavioral attributes that relate to exposure are not well studied. To further investigate how behavior may relate to PFAS exposure, 37 adults were recruited from central North Carolina. Participants provided blood samples and behavioral questionnaires were administered, asking questions about a variety of household, dietary, and behavioral outcomes. Six PFAAs, including PFHxA (geometric mean: 0.14 ng/mL), PFOA (1.57 ng/mL), PFNA (0.67 ng/mL), PFDA (0.28 ng/mL), PFHxS (3.17 ng/mL) and PFOS (4.96 ng/mL) were detected in >50% of the samples. Generally, males had higher serum levels than females across all chemicals, and levels were very similar to NHANES levels; however, PFHxS and PFDA levels were higher in our study population. Several personal characteristics and behaviors were associated with serum PFAS levels. Reported use of filtration devices was associated with lower levels of PFOA (28% lower, p = 0.03), but higher levels of PFHxA (122% higher, p = 0.04). Serum PFHxS levels were also elevated in individuals that vacuumed less often, and in individuals that reported consuming more microwavable foods. These results suggest that personal behaviors may be important determinants of PFAS exposures.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Tissue toxicokinetics of perfluoro compounds with single and chronic low doses in male rats

Authors: Iwabuchi, K; Senzaki, N; Mazawa, D; Sato, I; Hara, M; Ueda, F; Liu, W; Tsuda, S (2017) Journal of Toxicological Sciences 42:301-317. HERO ID: 3859701

[Less] To examine the kinetics of low doses of perfluoro compounds (PFCs), we administered perfluorohexanoic . . . [More] To examine the kinetics of low doses of perfluoro compounds (PFCs), we administered perfluorohexanoic acid (C6A), perfluorooctanoic acid (C8A), perfluorononanoic acid (C9A) and perfluorooctane sulfonate (C8S) with a single oral dose (50-100 μg/kg BW), and in drinking water at 1, 5, and 25 μg/L for one and three months to male rats; and examined the distribution in the brain, heart, liver, spleen, kidney, whole blood and serum. C6A was very rapidly absorbed, distributed and eliminated from the tissues with nearly the same tissue t1/2 of 2-3 hr. Considering serum Vd, and the tissue delivery, C6A was mainly in the serum with the lowest delivery to the brain; and no tissue accumulation was observed in the chronic studies as estimated from the single dose study. For the other PFCs, the body seemed to be an assortment of independent one-compartments with a longer elimination t1/2 for the liver than the serum. The concentration ratio of liver/serum increased gradually from C0 to a steady state. The high binding capacity of plasma protein may be the reason for the unusual kinetics, with only a very small fraction of free PFCs moving gradually to the liver. Although the tissue specific distribution was time dependent and different among the PFCs, the Vd and ke of each tissue were constant throughout the study. The possibility of extremely high C6A accumulation in the human brain and liver was suggested, by comparing the steady state tissue concentration of this study with the human data reported by Pérez et al. (2013).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The use of carbon adsorbents for the removal of perfluoroalkyl acids from potable reuse systems

Authors: Inyang, M; Dickenson, ERV (2017) Chemosphere 184:168-175. HERO ID: 3858250

[Less] Bench- and pilot-scale sorption tests were used to probe the performance of several biochars at removing . . . [More] Bench- and pilot-scale sorption tests were used to probe the performance of several biochars at removing perfluoroalkyl acids (PFAA) from field waters, compared to granular activated carbon (GAC). Screening tests using organic matter-free water resulted in hardwood (HWC) (Kd = 41 L g(-1)) and pinewood (PWC) (Kd = 49 L g(-1)) biochars having the highest perfluorooctanoic acid (PFOA) removal performance that was comparable to bituminous coal GAC (Kd = 41 L g(-1)). PWC and HWC had a stronger affinity for PFOA sorbed in Lake Mead surface water (KF = 11 mg((1-n)) L(n) g(-1)) containing a lower (2 mg L(-1)) dissolved organic carbon (DOC) concentration than in a tertiary-filtered wastewater (KF = 8 mg((1-n)) L(n) g(-1)) with DOC of 4.9 mg L(-1). A pilot-scale study was performed using three parallel adsorbers (GAC, anthracite, and HWC biochar) treating the same tertiary-filtered wastewater. Compared to HWC, and anthracite, GAC was the most effective in mitigating perfluoropentanoic acid (PFPnA), perfluorohexanoic acid (PHxA), PFOA, perfluorooctane sulfonic acid (PFOS), and DOC (45-67% removed at 4354 bed volumes) followed by HWC, and then anthracite. Based on bench- and pilot-scale results, shorter-chain PFAA [perfluorobutanoic acid (PFBA), PFPnA, or PFHxA] were more difficult to remove with both biochar and GAC than the longer-chain, PFOS and PFOA.