Health & Environmental Research Online (HERO)


PFHxA (307-24-4)


326 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

In vitro and in silico evaluations of binding affinities of perfluoroalkyl substances to baikal seal and human peroxisome proliferator-activated receptor α

Authors: Ishibashi, H; Hirano, M; Kim, EY; Iwata, H (2019) Environmental Science and Technology 53:2181-2188. HERO ID: 5024210

[Less] In this study, we assessed the binding affinities of perfluoroalkyl substances (PFASs), including perfluoroalkyl . . . [More] In this study, we assessed the binding affinities of perfluoroalkyl substances (PFASs), including perfluoroalkyl carboxylates (PFCAs) and perfluoroalkyl sulfonates (PFSAs), to the ligand-binding domains (LBDs) of Baikal seal ( Pusa sibirica; bs) and human (h) peroxisome proliferator-activated receptor alpha (PPARα). An in vitro competitive binding assay showed that six PFCAs and two PFSAs could bind to recombinant bs and hPPARα LBD proteins in a dose-dependent manner. The relative binding affinities (RBAs) of PFASs to bsPPARα were as follows: PFOS > PFDA > PFNA > PFUnDA > PFOA > PFHxS > PFHpA > PFHxA. The RBAs to bsPPARα showed a significant positive correlation with those to hPPARα. In silico PPARα homology modeling predicted that there were two ligand-binding pockets (LBPs) in the bsPPARα and hPPARα LBDs. Structure-activity relationship analyses suggested that the binding potencies of PFASs to PPARα might depend on LBP binding cavity volume, hydrogen bond interactions, the number of perfluorinated carbons, and the hydrophobicity of PFASs. Interspecies comparison of the in vitro binding affinities revealed that bsPPARα had higher preference for PFASs with long carbon chains than hPPARα. The in silico docking simulations suggested that the first LBP of bsPPARα had higher affinities than that of hPPARα; however, the second LBP of bsPPARα had lower affinities than that of hPPARα. To our knowledge, this is the first evidence showing interspecies differences in the binding of PFASs to PPARαs and their structure-activity relationships.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Leaching and bioavailability of selected perfluoroalkyl acids (PFAAs) from soil contaminated by firefighting activities

Authors: Bräunig, J; Baduel, C; Barnes, CM; Mueller, JF (2019) Science of the Total Environment 646:471-479. HERO ID: 5079692

[Less] Historical usage of aqueous film-forming foam (AFFF) at firefighting training grounds (FTGs) is a potential . . . [More] Historical usage of aqueous film-forming foam (AFFF) at firefighting training grounds (FTGs) is a potential source of perfluoroalkyl acids (PFAAs) to the surrounding environment. In this study the leaching of PFAAs from field contaminated soil and their uptake into biota was investigated. Soil was sampled from FTGs at two airports and the total as well as the leachable concentration of 12 PFAAs was determined. A greenhouse study was carried out to investigate the uptake of PFAAs from soils into earthworms (Eisenia fetida) and wheat grass (Elymus scaber). Perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) were the most dominant PFAAs in all soils samples, with concentrations of PFOS reaching 13,400 ng/g. Leachable concentrations of PFOS and PFHxS reached up to 550 μg/L and 22 μg/L, respectively. In earthworms concentrations of PFOS reached 65,100 ng/g after a 28-day exposure period, while in wheat grass the highest concentration was measured for uptake of PFHxS (2,800 ng/g) after a 10-week growth-period. Bioaccumulation factors (BAFs) for earthworms ranged from 0.1 for perfluorohexanoic acid (PFHxA) to 23 for perfluorododecanoic acid (PFDoA) and initially showed a decreasing trend with increasing perfluoroalkyl chain length, followed by an increase with increasing perfluoroalkyl chain length for perfluoroalkyl carboxylic acids (PFCAs). In wheat grass the highest BAF was found for perfluorobutanoic acid (BAF = 70), while the lowest was observed for perfluorononanoic acid (BAF = 0.06). BAFs in wheat grass decreased with increasing perfluoroalkyl chain length for both PFCAs and perfluoroalkyl sulfonic acids (PFSAs). The results show that PFAAs readily leach from impacted soils and are bioaccumulated into earthworms and plants in an analyte dependent way. This shows considerable potential for PFAAs to move away from the original source either by leaching or uptake into ecological receptors, which may be a potential entry route into the terrestrial foodweb.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Occurrence of perfluorinated compounds in agricultural environment, vegetables, and fruits in regions influenced by a fluorine-chemical industrial park in China

Authors: Li, P; Oyang, X; Zhao, Y; Tu, T; Tian, X; Li, L; Zhao, Y; Li, J; Xiao, Z (2019) Chemosphere 225:659-667. HERO ID: 5079816

[Less] The occurrence of perfluorinated compounds (PFCs) in vegetables and fruits, as well as agricultural . . . [More] The occurrence of perfluorinated compounds (PFCs) in vegetables and fruits, as well as agricultural environment, was investigated in the downstream regions of Changshu fluorine-chemical industrial park (CFCIP) in China. Twenty-one PFCs were analyzed in irrigation water, agricultural soil, typical vegetables, and fruits, with the maximum total PFC concentrations of 369.9 ng/L, 64.7 ng/g dw, 11.5 ng/g ww, and 10.5 ng/g ww, respectively. Short-chained perfluoroalkyl carboxylic acids (PFCAs) such as perfluorooctanoic acid (PFOA), perfluorobutanoic acid (PFBA), and perfluorohexanoic acid were the dominant PFCs in terms of their concentrations and detection frequency. PFCs in irrigation water and agricultural soils showed a decreasing trend with increasing distance from CFCIP, while this pattern was not observed in agricultural products. The predominant compounds varied in different vegetables and fruits. Simultaneous bioaccumulation of PFBA and PFOA was found in melons and solanaceous species and pears. Leafy vegetables and grapes exhibited high bioaccumulation of PFOA and PFBA, respectively. Health risk assessment by calculating estimated daily intake showed that no direct risk was caused by the consumption of vegetables and fruits for the residents in the investigated regions. However, the tolerable weekly intake of PFOA exceeded the established thresholds for the adult residents. A comprehensive health assessment of the dietary exposure of PFCs, including all exposure pathways, in fluorine-chemical industrial park-impacted regions is needed.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Effects of fluorescent dissolved organic matters (FDOMs) on perfluoroalkyl acids (PFAAs) in lake and river water

Authors: Liu, WX; He, W; Wu, JY; Wu, WJ; Xu, FL (2019) Science of the Total Environment 666:598-607. HERO ID: 5080217

[Less] This study presents the effects of fluorescent dissolved organic matters (FDOM) on perfluoroalkyl acids . . . [More] This study presents the effects of fluorescent dissolved organic matters (FDOM) on perfluoroalkyl acids (PFAAs) in western Lake Chaohu and its inflow rivers. The surface water samples from the 27 sites in western Lake Chaohu and its inflow rivers were collected in March and September 2013. The contents of PFAAs and the FDOM in the water samples were measured by a high-performance liquid chromatograph - mass spectrometer (HPLC-MS) and by a fluorescence spectrophotometer, respectively. The temporal-spatial distributions of PFAAs and FDOM, as well as their interrelationships, were investigated. Eleven PFAA components were detected, and the mean concentration of total PFAAs (TPFAAs) in western Lake Chaohu and its inflow rivers were 12.93 ± 5.19 ng/L and 11.84 ± 9.50 ng/L, respectively. PFOA was the predominant contaminant in two regions (7.13 ± 3.07 ng/L and 4.30 ± 2.14 ng/L) followed by PFHxA (1.72 ± 0.80 ng/L and 1.42 ± 1.41 ng/L) and PFBA (1.44 ± 0.78 ng/L and 1.37 ± 0.78 ng/L). The mean concentration of total FDOM in western Lake Chaohu and its inflow rivers were 220.0 ± 40.30 μg quinine sulfate units (Q.S.)/L and 406.3 ± 213.1 μg Q.S./L, respectively. The significant, positive correlations were observed between the PFAAs and FDOMs in both the lake area and the inflow rivers. However, no significant correlation was observed between PFAAs and the dissolved organic carbon (DOC) in the lake area. This finding indicated that the residues and distributions of PFAAs were significantly dependent on the compositions of dissolved organic matters (DOM) and not on the total content of DOM.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: Isomers of C8 Health Project in China

Authors: Nian, M; Li, QQ; Bloom, M; Qian, ZM; Syberg, KM; Vaughn, MG; Wang, SQ; Wei, Q; Zeeshan, M; Gurram, N; Chu, C; Wang, J; Tian, YP; Hu, LW; Liu, KK; Yang, BY; Liu, RQ; Feng, D; Zeng, XW; Dong, GH (2019) Environmental Research 172:81-88. HERO ID: 5080307

[Less] Exposure to chemicals may affect liver enzyme to increase the risk of liver diseases. Perfluoroalkyl . . . [More] Exposure to chemicals may affect liver enzyme to increase the risk of liver diseases. Perfluoroalkyl acids (PFAAs) are one kind of persistent organic pollutants with hepatotoxic effect in organism. However, data is scarce to characterize the hepatotoxic effects of specific structural PFAA isomers in general population. To address this data gap, we evaluated the association between serum PFAAs concentration and liver function biomarkers in the Isomers of C8 Health Project in China. High performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to measure 18 serum PFAAs, except for linear and branched isomers of PFOA/PFOS, nine perfluorinated carboxylic acids (PFCAs) and two perfluorinated sulfonic acids (PFSAs) were also included, in 1605 adult residents of Shenyang, China. Values for nine serum liver function biomarkers were determined by full-automatic blood biochemical analyzer. Linear regression was used to evaluate associations between PFAAs and continuous liver function biomarkers and logistic regression to assess markers dichotomized per clinical reference intervals. Results indicated that serum PFAAs concentrations were associated with liver biomarker levels suggestive of hepatotoxicity, especially for liver cell injury. For example, a 1 ln-unit increase in total- perfluorooctanoic acid (PFOA) exposure was associated with a 7.4% [95% confidence interval (CI): 3.9%, 11.0%] higher alanine aminotransferase (ALT) level in serum. Interestingly, we observed association between branched PFAA isomers and liver biomarkers. For example, one ln-unit increase in branched perfluorooctane sulfonate (PFOS) isomers exposure was associated with a 4.3% increase in ALT level (95% CI: 1.2%, 7.4%) and a 33.0% increased odds of having abnormal ALT (95% CI: 5.0%, 67.0%). Also, we found that PFNA had positive association with ALT [(6.2%, 95% CI: 3.1%, 9.4%) and AST levels (2.5%, 95% CI: 0.5%, 4.5%)]. Logistic regression results showed that PFPeA, PFHxA, PFNA, PFDoDA, PFTrDA and PFTeDA had statistically association with abnormal prealbumin. Conclusively, our results support previous studies showing association between PFAAs exposure and liver function biomarkers. We found new evidence that branched PFAAs isomer exposure is associated with the risk of clinically relevant hepatocellular dysfunction.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Contamination of groundwater with per- and polyfluoroalkyl substances (PFAS) from legacy landfills in an urban re-development precinct

Authors: Hepburn, E; Madden, C; Szabo, D; Coggan, TL; Clarke, B; Currell, M (2019) Environmental Pollution 248:101-113. HERO ID: 5080507

[Less] The extent of per- and polyfluoroalkyl substances (PFAS) in groundwater surrounding legacy landfills . . . [More] The extent of per- and polyfluoroalkyl substances (PFAS) in groundwater surrounding legacy landfills is currently poorly constrained. Seventeen PFAS were analysed in groundwater surrounding legacy landfills in a major Australian urban re-development precinct. Sampling locations (n = 13) included sites installed directly in waste material and down-gradient from landfills, some of which exhibited evidence of leachate contamination including elevated concentrations of ammonia-N (≤106 mg/L), bicarbonate (≤1,740 mg/L) and dissolved methane (≤10.4 mg/L). Between one and fourteen PFAS were detected at all sites and PFOS, PFHxS, PFOA and PFBS were detected in all samples. The sum of detected PFAS (∑14PFAS) varied from 26 ng/L at an ambient background site to 5,200 ng/L near a potential industrial point-source. PFHxS had the highest median concentration (34 ng/L; range: 2.6-280 ng/L) followed by PFOS (26 ng/L; range: 1.3-4,800 ng/L), PFHxA (19 ng/L; range:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluorohexanoic acid toxicity, part I: Development of a chronic human health toxicity value for use in risk assessment

Authors: Luz, AL; Anderson, JK; Goodrum, P; Durda, J (2019) Regulatory Toxicology and Pharmacology 103:41-55. HERO ID: 5080589

[Less] Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary . . . [More] Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used globally today. The transition to short-chain fluorotelomer-based products as a cornerstone in replacement fluorochemistry has raised questions regarding potential human health risks associated with exposure to fluorotelomer-based substances and therefore, PFHxA. Here, we present a critical review of data relevant to such a risk assessment, including epidemiological studies and in vivo and in vitro toxicity studies that examined PFHxA acute, subchronic, and chronic toxicity. Key findings from toxicokinetic and mode-of-action studies are also evaluated. Sufficient data exist to conclude that PFHxA is not carcinogenic, is not a selective reproductive or developmental toxicant, and does not disrupt endocrine activity. Collectively, effects caused by PFHxA exposure are largely limited to potential kidney effects, are mild and/or reversible, and occur at much higher doses than observed for perfluorooctanoic acid (PFOA). A chronic human-health-based oral reference dose (RfD) for PFHxA of 0.25 mg/kg-day was calculated using benchmark dose modeling of renal papillary necrosis from a chronic rat bioassay. This RfD is four orders of magnitude greater than the chronic oral RfD calculated by the U.S. Environmental Protection Agency for PFOA. The PFHxA RfD can be used to inform public health decisions related to PFHxA and fluorotelomer precursors for which PFHxA is a terminal degradant. These findings clearly demonstrate that PFHxA is less hazardous to human health than PFOA. The analyses presented support site-specific risk assessments as well as product stewardship initiatives for current and future short-chain fluorotelomer-based products.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Subtle morphometric, behavioral and gene expression effects in larval zebrafish exposed to PFHxA, PFHxS and 6:2 FTOH

Authors: Annunziato, KM; Jantzen, CE; Gronske, MC; Cooper, KR (2019) Aquatic Toxicology 208:126-137. HERO ID: 5080590

[Less] Recent studies of perfluoroalkylated substances (PFASs) have focused on the toxicity of long chain PFASs, . . . [More] Recent studies of perfluoroalkylated substances (PFASs) have focused on the toxicity of long chain PFASs, such as PFOS or PFOA, which have been demonstrated to cause an array of developmental and behavioral effects. However, less is known about low molecular weight PFASs and alternatives. This study examined the morphometric and behavioral effects in zebrafish following developmental exposures of C6 PFASs: perfluorohexanoic acid, PFHxA, perfluorohexane sulfonate, PFHxS, and 6:2 fluorotelomer alcohol, 6:2 FTOH. Embryos were exposed to 0.02-20 μM concentrations of these compounds from the high stage (˜3 h post fertilization, hpf) until 120 hpf. Morphometric and gene expression endpoints were examined at 120 hpf. Genes selected for analysis were previously shown to be altered in zebrafish developmentally exposed to PFOS and PFOA. Additionally, exposed larvae were transferred to clean water and reared until 14 days post fertilization, dpf, when behavioral assays were completed and morphometric endpoints examined. While PFHxA was found to be the most acutely toxic at 120 hpf, few morphometric effects were observed. Gene expression was the most sensitive endpoint with significant increased tgfb1a, bdnf, and ap1s1 expression observed with PFHxA exposure. PFHxS exposure produced morphometric effects in the larvae, specifically increased length and yolk sac area at 2 and 20 μM. This phenotype persisted to the 14 dpf time point, where these larvae additionally displayed decreased distance traveled and crosses through the center of the arena of the behavioral assay. Exposure to 6:2 FTOH caused no morphometric effects at 120 hpf, and this compound was the least acutely toxic. However, expression of both tgfb1a and bdnf were increased by greater than 2 fold change at this time point. Effects also persisted to 14 dpf where a significant increase in distance traveled and velocity were observed in the behavioral assay. This study demonstrates effects on behavioral, morphometric and gene expression endpoints with developmental PFHxA, PFHxS, and 6:2 FTOH exposures in zebrafish.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluoroalkyl acids in paired serum, urine, and hair samples: Correlations with demographic factors and dietary habits

Authors: Kim, DH; Lee, JH; Oh, JE (2019) Environmental Pollution 248:175-182. HERO ID: 5080622

[Less] We analyzed paired serum, urine, and hair samples from 94 Korean children and adults to investigate . . . [More] We analyzed paired serum, urine, and hair samples from 94 Korean children and adults to investigate levels of 11 perfluoroalkyl acids (PFAAs). The effects of demographic factors and dietary habits on PFAA exposure were also assessed based on the paired samples. The total PFAA concentrations were 2.4-31 ng/mL in serum, not detected-9.5 ng/mL in urine, and 0.48-15 ng/g in hair. Levels of perfluoropentanoic acid (PFPeA) and perfluorohexanoic acid (PFHxA), which have short carbon chains, were 1.5-5 fold higher in urine and hair than in serum. The PFAA concentrations in serum exhibited a decreasing trend with age from young childhood to adolescence, followed by an increasing trend after adolescence. For most PFAA species, concentrations in serum were higher in adult males than in adult females (p < 0.01). No sex difference was evident in the urine and hair samples. In addition, there was no age difference in the urine samples, but in the hair samples, we observed higher concentrations of PFAAs in children than in the other age groups (p < 0.01). The consumption rates of fish and water showed significant correlations with serum (positive correlation) and hair (negative) concentrations, respectively. No relationships between serum and hair/urine levels for most PFAAs were observed, except between serum and hair levels for perfluorooctanoic acid (PFOA).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Occurrence, sources and health risk of polyfluoroalkyl substances (PFASs) in soil, water and sediment from a drinking water source area

Authors: Cao, X; Wang, C; Lu, Y; Zhang, M; Khan, K; Song, S; Wang, P; Wang, C (2019) Ecotoxicology and Environmental Safety 174:208-217. HERO ID: 5080637

[Less] Polyfluoroalkyl substances (PFASs) enter into environmental metric via various pathways in the process . . . [More] Polyfluoroalkyl substances (PFASs) enter into environmental metric via various pathways in the process of manufacturing and consuming the products containing PFASs. Yuqiao reservoir (YQR) is a major drinking water source in Tianjin of China, where little attention was given to PFASs. To explore the occurrence, source and risk of 17 PFASs, multi-media environmental including soil, water, and sediment were sampled from this water source area. The ∑PFASs concentrations of surface water, groundwater, soil and sediment ranged from 5.839 to 120.885 ng/L, 1.426 to 17.138 ng/L, 0.622 to 5.089 μg/kg dw, and 0.240 to 1.210 μg/kg dw respectively. Some short-chained (C4-C8) PFASs were detected widely such as PFOA, PFBA, PFHxA, PFBS, PFHpA and PFPeA in surface water and groundwater, with the detection frequency of >78%, and PFBA and PFOA dominated in the 17 PFASs. In addition, the correlations between total PFASs and TOC were significant at 0.05 level, especially in surface water with R2 = 0.9165 (p = 0.011). In terms of vertical distribution characteristics of ∑PFASs, the ∑PFASs in four sediment cores showed a decreasing trend at first, and then an increasing trend from the bottom to the top associated with TOC. PFBA/PFOA and PFHpA/PFOA showed better linear correlations with R2 of 0.5541 (p = 0.039), and for PFNA/PFOA and PFHpA/PFOA with R2 of 0.6312 (p = 0.032) at the 0.05 level in the surface water, which indicated that sewage and atmospheric precipitation were the major sources. Though the RQ results based on the measured concentrations and reference values in environmental media revealed lower risks, the potential hazard may occur due to accumulation characteristics and long-distance transmission capability of PFASs. Hence, the corresponding management strategies should be taken, such as control over emission at source, product substitution and strengthening legislation, to eliminate potential risks to human health.