Health & Environmental Research Online (HERO)


PFBA (375-22-4)


456 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Assessing temporal trends and source regions of per- and polyfluoroalkyl substances (PFASs) in air under the Arctic Monitoring and Assessment Programme (AMAP)

Authors: Wong, F; Shoeib, M; Katsoyiannis, A; Eckhardt, S; Stohl, A; Bohlin-Nizzetto, P; Li, H; Fellin, P; Su, Y; Hung, H (2018) HERO ID: 4220322

[Less] Long-term Arctic air monitoring of per- and polyfluoroalkyl substances (PFASs) is essential in assessing . . . [More] Long-term Arctic air monitoring of per- and polyfluoroalkyl substances (PFASs) is essential in assessing their long-range transport and for evaluating the effectiveness of chemical control initiatives. We report for the first time temporal trends of neutral and ionic PFASs in air from three arctic stations: Alert (Canada, 2006-2014); Zeppelin (Svalbard, Norway, 2006-2014) and Andoya (Norway, 2010-2014). The most abundant PFASs were the perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorobutanoic acid (PFBA), and fluorotelomer alcohols (FTOHs). All of these chemicals exhibited increasing trends at Alert with doubling times (t(2)) of 3.7 years (y) for PFOA, 2.9 y for PFOS, 2.5 y for PFBA, 5.0 y for 8:2 FTOH and 7.0 y for 10:2 FTOH. In contrast, declining or non-changing trends, were observed for PFOA and PFOS at Zeppelin (PFOA, half-life, t(1/2) = 7.2 y; PFOS t(1/2) = 67 y), and Andoya (PFOA t(1/2) = 1.9 y; PFOS t(1/2) = 11 y). The differences in air concentrations and in time trends between the three sites may reflect the differences in regional regulations and source regions. We investigate the source region for particle associated compounds using the Lagrangian particle dispersion model FLEXPART. Model results showed that PFOA and PFOS are impacted by air masses originating from the ocean or land. For instance, PFOA at Alert and PFOS at Zeppelin were dominated by oceanic air masses whereas, PFOS at Alert and PFOA at Zeppelin were influenced by air masses transported from land.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Rotational spectra of 4,4,4-trifluorobutyric acid and the 4,4,4-trifluorobutyric acid-formic acid complex

Authors: Choi, YJ; Trevino, A; Stephens, SL; Cooke, SA; Novick, SE; Lin, Wei (2018) HERO ID: 4220323

[Less] The pure rotational spectra of 4,4,4-trifluorobutyric acid, CF3CH2CH2COOH, and its complex with formic . . . [More] The pure rotational spectra of 4,4,4-trifluorobutyric acid, CF3CH2CH2COOH, and its complex with formic acid were studied by a pulsed nozzle, chirped-pulse Fourier transform microwave spectrometer in the frequency range of 7-13 GHz. The rotational constants and centrifugal distortion constants were determined for the first time. Quantum chemical calculations were carried out exploring possible conformations of 4,4,4-trifluorobutyric acid and the structure of the 4,4,4-trifluorobutyric acid-formic acid complex using B3LYP/aug-cc-pVTZ and MP2/aug-cc-pVTZ calculations. Only one conformer was observed for 4,4,4-trifluorobutyric acid and its complex with formic acid, in agreement with the calculations. Published by Elsevier Inc.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Development and validation of an UHPLC-ESI-QTOF-MS method for quantification of the highly hydrophilic amyloid-β oligomer eliminating all-D-enantiomeric peptide RD2 in mouse plasma

Authors: Hupert, M; Elfgen, A; Schartmann, E; Schemmert, S; Buscher, B; Kutzsche, J; Willbold, D; Santiago-Schübel, B (2018) Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences 1073:123-129. HERO ID: 4220311

[Less] During preclinical drug development, a method for quantification of unlabeled compounds in blood plasma . . . [More] During preclinical drug development, a method for quantification of unlabeled compounds in blood plasma samples from treatment or pharmacokinetic studies in mice is required. In the current work, a rapid, specific, sensitive and validated liquid chromatography mass-spectrometric UHPLC-ESI-QTOF-MS method was developed for the quantification of the therapeutic compound RD2 in mouse plasma. RD2 is an all-D-enantiomeric peptide developed for the treatment of Alzheimer's disease, a progressive neurodegenerative disease finally leading to dementia. Due to RD2's highly hydrophilic properties, the sample preparation and the chromatographic separation and quantification were very challenging. The chromatographic separation of RD2 and its internal standard were accomplished on an Acquity UPLC BEH C18 column (2.1 × 100 mm, 1.7 μm particle size) within 6.5 min at 50 °C with a flow rate of 0.5 mL/min. Mobile phases consisted of water and acetonitrile with 1% formic acid and 0.025% heptafluorobutyric acid, respectively. Ions were generated by electrospray ionization (ESI) in the positive mode and the peptide was quantified by QTOF-MS. The developed extraction method for RD2 from mouse plasma revealed complete recovery. The linearity of the calibration curve was in the range of 5.3 ng/mL to 265 ng/mL (r2 > 0.999) with a lower limit of detection (LLOD) of 2.65 ng/mL and a lower limit of quantification (LLOQ) of 5.3 ng/mL. The intra-day and inter-day accuracy and precision of RD2 in plasma ranged from -0.54% to 2.21% and from 1.97% to 8.18%, respectively. Moreover, no matrix effects were observed and RD2 remained stable in extracted mouse plasma at different conditions. Using this validated bioanalytical method, plasma samples of unlabeled RD2 or placebo treated mice were analyzed. The herein developed UHPLC-ESI-QTOF-MS method is a suitable tool for the quantitative analysis of unlabeled RD2 in plasma samples of treated mice.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Thiolactone Chemistry-Based Combinatorial Methodology to Construct Multifunctional Polymers for Efficacious Gene Delivery

Authors: Zha, Z; Hu, Y; Mukerabigwi, JF; Chen, W; Wang, Y; He, C; Ge, Z (2018) Bioconjugate Chemistry 29:23-28. HERO ID: 4220312

[Less] Hydrophobic segments and amino moieties in polymeric nonviral gene vectors play important roles in overcoming . . . [More] Hydrophobic segments and amino moieties in polymeric nonviral gene vectors play important roles in overcoming a cascade of barriers for efficient gene delivery. However, it remains a great challenge to facilely construct well-defined multifunctional polymers through optimization of the amino and hydrophobic groups. Herein, we choose thiolactone chemistry to perform the ring opening reaction of varying hydrophobic groups-modified thiolactones by various amines to generate mercapto groups for further Michael addition reaction with poly[2-(acryloyloxy)ethyl methacrylate] (PAOEMA). Based on the combinatorial methodology, a series of multifunctional polymers were prepared and screened. The polymer (P3D) from tetraethylenepentamine and heptafluorobutyric acid-functionalized thiolactone is the most efficacious one with significantly higher gene transfection efficiency and lower cytotoxicity compared with polyethylenimine (PEI) (branched average Mw ∼ 25 000 Da) and Lipofectamine 2000. Cellular uptake and intracellular distribution studies indicate that P3D complexes show high-efficiency endocytosis and excellent endosomal escape. Accordingly, thiolactone chemistry-based combinatorial methodology allows for facile integration of multifunctional groups to prepare simultaneous efficacious and low-cytotoxic gene delivery vectors.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

An integrated method for simultaneously determining 10 classes of per- and polyfluoroalkyl substances in one drop of human serum

Authors: Gao, K; Fu, J; Xue, Q; Li, Y; Liang, Y; Pan, Y; Zhang, A; Jiang, G (2018) Analytica Chimica Acta 999:76-86. HERO ID: 4220310

[Less] Per- and polyfluoroalkyl substances (PFASs) represent a group of synthetic chemicals, and they have . . . [More] Per- and polyfluoroalkyl substances (PFASs) represent a group of synthetic chemicals, and they have quite different physicochemical properties, which result in difficulties of their simultaneous determination in a single injection. A sensitive, reliable, and fully automated method was developed for simultaneously detecting 10 classes of PFASs (total of 43) in human serum using online Turboflow SPE-UHPLC-MS/MS. This method provided high linearity of matrix-matched calibration standards (R > 0.99), excellent method limits of detection (MLODs) (0.013-0.089 ng mL-1), satisfactory matrix spiked recoveries (84.3-109%) and relative standard deviations (RSDs) (intra-day RSDs: 1.3-12.6%, inter-day RSDs: 1.7-13.8%, inter-week RSDs: 1.8-13.5%, inter-month RSDs: 3.1-12.4%), short analysis time (19 min per sample) and small sample amount requirement (25 μL), which were suitable for large-scale epidemiologic studies. Moreover, the method provided the feasibility of real-time monitoring for the degradation kinetics of PFASs precursors both in vitro and in vivo. The quality of the present method was further verified by repetitive analysis of a standard reference material (SRM 1957), with the deviations of the targeted PFAS concentrations ranging from 1.9% to 14.2% (n = 5) between the detected and reference values. The present study also determined values for several PFASs in SRM 1957 other than those on the certificate, for the first time, such as N-EtFOSA, 6:2 Cl-PFESA, and PFBA. Finally, the established method was applied to detect PFASs in serum samples of 15 ordinary people and 15 occupational workers, and 6:2 FTSA was found as the dominant precursor.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Relationship between peroxisome proliferator-activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells

Authors: Rosenmai, AK; Ahrens, L; le Godec, T; Lundqvist, J; Oskarsson, A (2018) Journal of Applied Toxicology 38:219-226. HERO ID: 4220319

[Less] Peroxisome proliferator-activated receptor alpha (PPARα) is a molecular target for perfluoroalkyl substances . . . [More] Peroxisome proliferator-activated receptor alpha (PPARα) is a molecular target for perfluoroalkyl substances (PFASs). Little is known about the cellular uptake of PFASs and how it affects the PPARα activity. We investigated the relationship between PPARα activity and cellular concentration in HepG2 cells of 14 PFASs, including perfluoroalkyl carboxylates (PFCAs), perfluoroalkyl sulfonates and perfluorooctane sulfonamide (FOSA). Cellular concentrations were determined by high-performance liquid chromatography-tandem mass spectrometry and PPARα activity was determined in transiently transfected cells by reporter gene assay. Cellular uptake of the PFASs was low (0.04-4.1%) with absolute cellular concentrations in the range 4-2500 ng mg-1 protein. Cellular concentration of PFCAs increased with perfluorocarbon chain length up to perfluorododecanoate. PPARα activity of PFCAs increased with chain length up to perfluorooctanoate. The maximum induction of PPARα activity was similar for short-chain (perfluorobutanoate and perfluoropentanoate) and long-chain PFCAs (perfluorododecanoate and perfluorotetradecanoate) (approximately twofold). However, PPARα activities were induced at lower cellular concentrations for the short-chain homologs compared to the long-chain homologs. Perfluorohexanoate, perfluoroheptanoate, perfluorooctanoate, perfluorononanoate (PFNA) and perfluorodecanoate induced PPARα activities >2.5-fold compared to controls. The concentration-response relationships were positive for all the tested compounds, except perfluorooctane sulfonate PFOS and FOSA, and were compound-specific, as demonstrated by differences in the estimated slopes. The relationships were steeper for PFCAs with chain lengths up to and including PFNA than for the other studied PFASs. To our knowledge, this is the first report establishing relationships between PPARα activity and cellular concentration of a broad range of PFASs.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Analysis and validation of perfluorinated compounds in water, sediment and fish with LC-ESI-MS/MS

Authors: Kaupmees, S; Rebane, R (2017) HERO ID: 4220320

[Less] The analysis of perfluorinated compounds (PFCs) in environmental matrices is challenging, as the concentrations . . . [More] The analysis of perfluorinated compounds (PFCs) in environmental matrices is challenging, as the concentrations are generally low, but the risk of contamination is high. Sample preparation is a critical step and it is necessary to minimise the possibility of contamination. In this study, we successfully applied and validated a modified ion pair extraction method to quantify PFCs in sediment and fish samples. A large volume injection method was validated and used to quantify PFCs in different water matrices. Isotope internal standard of every analyte was applied to correct matrix effects. The recoveries of the analytes were 92-106% for water matrix, 93-119% for fish matrix and 86-103% for soil matrix whereas the achieved limit of quantitation values were 1.3-14.9ng/L for water, 0.19-0.28g/kg for fish and 0.14-0.41 for soil samples. Thirty-one surface water, 8 stormwater and 41 sediment samples collected all over Estonia were analysed and 4 (out of 8 analysed) PFCs were found in quantitative amount. The most frequently detected analyte perfluorobutanoic acid (PFBA) was found in 26% of the water samples with a maximum concentration of 137ng/L.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Rotational spectroscopic and theoretical study of the perfluorobutyric acid center dot center dot center dot formic acid complex

Authors: Thomas, J; Carrillo, MJ; Serrato, A III; Lin, Wei; Jaeger, W; Xu, Y (2017) Journal of Molecular Spectroscopy 335:88-92. HERO ID: 3858433

[Less] Perfluorinated carboxylic acids are a special class of compounds with considerable industrial applications. . . . [More] Perfluorinated carboxylic acids are a special class of compounds with considerable industrial applications. In this study, we applied chirped pulse and cavity-based Fourier transform microwave spectroscopy to investigate the structural and possible tunneling properties of the perfluorobutyric acid center dot center dot center dot formic acid complex, together with high level ab initio calculations. Only one clearly dominant conformer, featuring an eight-membered double hydrogen-bonded ring, was predicted for the hetero acid dimer and detected experimentally. The rotational constants calculated at the B3LYP-D3BJ/6-311++G(2d, p) level are in excellent agreement with the experimental ones, better than those from MP2 calculations. No tunneling splittings were detected in the experimental spectra. Detailed analyses of the non-covalent intermolecular interactions in the hetero acid dimer provide an explanation for the absence of double proton transfer, and also identify the presence of F center dot center dot center dot F attractive interactions. (C) 2017 Elsevier Inc. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The use of carbon adsorbents for the removal of perfluoroalkyl acids from potable reuse systems

Authors: Inyang, M; Dickenson, ERV (2017) Chemosphere 184:168-175. HERO ID: 3858250

[Less] Bench- and pilot-scale sorption tests were used to probe the performance of several biochars at removing . . . [More] Bench- and pilot-scale sorption tests were used to probe the performance of several biochars at removing perfluoroalkyl acids (PFAA) from field waters, compared to granular activated carbon (GAC). Screening tests using organic matter-free water resulted in hardwood (HWC) (Kd = 41 L g(-1)) and pinewood (PWC) (Kd = 49 L g(-1)) biochars having the highest perfluorooctanoic acid (PFOA) removal performance that was comparable to bituminous coal GAC (Kd = 41 L g(-1)). PWC and HWC had a stronger affinity for PFOA sorbed in Lake Mead surface water (KF = 11 mg((1-n)) L(n) g(-1)) containing a lower (2 mg L(-1)) dissolved organic carbon (DOC) concentration than in a tertiary-filtered wastewater (KF = 8 mg((1-n)) L(n) g(-1)) with DOC of 4.9 mg L(-1). A pilot-scale study was performed using three parallel adsorbers (GAC, anthracite, and HWC biochar) treating the same tertiary-filtered wastewater. Compared to HWC, and anthracite, GAC was the most effective in mitigating perfluoropentanoic acid (PFPnA), perfluorohexanoic acid (PHxA), PFOA, perfluorooctane sulfonic acid (PFOS), and DOC (45-67% removed at 4354 bed volumes) followed by HWC, and then anthracite. Based on bench- and pilot-scale results, shorter-chain PFAA [perfluorobutanoic acid (PFBA), PFPnA, or PFHxA] were more difficult to remove with both biochar and GAC than the longer-chain, PFOS and PFOA.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Deriving environmental quality standards for perfluorooctanoic acid (PFOA) and related short chain perfluorinated alkyl acids

Authors: Valsecchi, S; Conti, D; Crebelli, R; Polesello, S; Rusconi, M; Mazzoni, M; Preziosi, E; Carere, M; Lucentini, L; Ferretti, E; Balzamo, S; Simeone, MG; Aste, F (2017) Journal of Hazardous Materials 323:84-98. HERO ID: 3748953

[Less] The evidence that in Northern Italy significant sources of perfluoroalkylacids (PFAA) are present induced . . . [More] The evidence that in Northern Italy significant sources of perfluoroalkylacids (PFAA) are present induced the Italian government to establish a Working Group on Environmental Quality Standard (EQS) for PFAA in order to include some of them in the list of national specific pollutants for surface water monitoring according to the Water Framework Directive (2000/60/EC). The list of substances included perfluorooctanoate (PFOA) and related short chain PFAA such as perfluorobutanoate (PFBA), perfluoropentanoate (PFPeA), perfluorohexanoate (PFHxA) and perfluorobutanesulfonate (PFBS), which is a substitute of perfluorooctanesulfonate. For each of them a dossier collects available data on regulation, physico-chemical properties, emission and sources, occurrence, acute and chronic toxicity on aquatic species and mammals, including humans. Quality standards (QS) were derived for the different protection objectives (pelagic and benthic communities, predators by secondary poisoning, human health via consumption of fishery products and water) according to the European guideline. The lowest QS is finally chosen as the relevant EQS. For PFOA a QS for biota was derived for protection from secondary poisoning and the corresponding QS for water was back-calculated, obtaining a freshwater EQS of 0.1μgL(-1). For PFBA, PFPeA, PFHxA and PFBS threshold limits proposed for drinking waters were adopted as EQS.