Health & Environmental Research Online (HERO)


PFBA (375-22-4)


1,735 References Were Found:

Technical Report
Technical Report

Health Based Guidance for Water: Toxicological Summary for: Perfluorohexane sulfonate (PFHxS)

Author: MDH (2019) HERO ID: 5099262


Archival Material
Archival Material

TOX-96: Toxicity Report Tables and Curves for Short-term Studies: Perfluorinated Compounds: Sulfonates.

Author: NTP (2019) Available online at https://tools.niehs.nih.gov/cebs3/views/?action=main.dataReview&bin_id=3874. [Website] HERO ID: 5099263


Technical Report
Technical Report

Physical and chemical characteristics: Fact sheets: Per-fluoroalkyl and poly-fluoroalkyl substances (PFAS)

Author: NHMRC (2019) In Australian Drinking Water Guidelines. HERO ID: 5185316


Archival Material
Archival Material

EPA Actions to Address PFAS

Author: U.S. EPA (2019) Available online at https://www.epa.gov/pfas/epa-actions-address-pfas. [Website] HERO ID: 5099058


Technical Report
Technical Report

Summary report on the New Hampshire Department of Environmental Services development of the Maximum Contaminant Levels and Ambient Groundwater Quality Standards for perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononoic acid (PFNA) and perfluorohexanesulfonic acid (PFHxS)

Author: New Hampshire DES (2019) (R-WD-19-01). HERO ID: 5026091

[Less] The report provides the method by which NHDES derived the proposed Maximum Contaminant Levels (MCLs) . . . [More] The report provides the method by which NHDES derived the proposed Maximum Contaminant Levels (MCLs) and Ambient Groundwater Quality Standards (AGQSS) for four perflourinated componds, as authorized by the legislature in 2018 (SB309). These proposed standards were derived following a review of the draft ATSDR MRLs (note MRLs are not the same as MCLs), the 2016 EPA Health Advisories for PFOA and PFOS, toxicity values identified by other states and recent scientific studies. Many of which were recommended by the public during technical workshops. While the Legislature requested NHDES to document and consider the occurrence of these chemicals in New Hampshire, the viability of detection and treatment technologies, as well as the costs and benefits to affected parties as a result of setting the standards, the proposed standards have not been modified away from the health-based standards due to these other considerations. As such, the proposed standards address long-term, chronic exposure and were derived to be fully protective for the most sensitive populations through life, including the earliest stages of life, based on the science and studies that are available today. The NHDES Risk Assessment Team continues to review emerging research to identify information that would necessitate re-assessment of the proposed standards as described further in the report.

Data/Software
Data/ Software

ChemView

Author: U.S. EPA (2019) [Searchable database to access health and safety data about a chemical known and assessed by EPA.]. [Database] HERO ID: 2991004

[Less] Use this database to get information on chemical health and safety data received by EPA and EPA's assessments . . . [More] Use this database to get information on chemical health and safety data received by EPA and EPA's assessments and regulatory actions for specific chemicals under the Toxic Substances Control Act (TSCA). ChemView contains no confidential business information (CBI).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A transgenerational toxicokinetic model and its use in derivation of Minnesota PFOA water guidance

Authors: Goeden, HM; Greene, CW; Jacobus, JA (2019) Journal of Exposure Science and Environmental Epidemiology 29:183-195. HERO ID: 5080506

[Less] Minnesota has been grappling with extensive per- and polyfluoroalkyl substances (PFASs) groundwater . . . [More] Minnesota has been grappling with extensive per- and polyfluoroalkyl substances (PFASs) groundwater contamination since 2002, in a major metropolitan setting. As toxicological information has accumulated for these substances, the public health community has become increasingly aware of critically sensitive populations. The accumulation of some PFAS in women of childbearing age, and the placental and breastmilk transfer to their offspring, require new risk assessment methods to protect public health. The traditional water guidance paradigm is inadequate to address maternal-to-infant transfer of accumulated levels of perfluorooctanoate (PFOA), in particular. Even short exposures during infancy have dramatic impacts on serum levels for many years. In addition, developmental effects are the critical effects anchoring recent risk assessments. In response, the Minnesota Department of Health created an Excel-based model that incorporates chemical-specific properties and exposure parameters for early life stages. Serum levels were assessed in both formula-fed and breastfed infants, with placental transfer in both scenarios. Peak breastfed infant serum levels were 4.4-fold higher than in formula-fed infants, with both of these scenarios producing serum levels in excess of the adult steady-state level. The development and application of this model to PFOA are described.

Technical Report
Technical Report

Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, January 2019, Volume 2

Author: CDC (2019) Atlanta, GA: U.S. Department of Health and Human Services. HERO ID: 5185370


Technical Report
Technical Report

Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, January 2019, Volume 1

Author: CDC (2019) HERO ID: 5231431


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model

Authors: Kim, SJ; Choi, EJ; Choi, GW; Lee, YB; Cho, HY (2019) Archives of Toxicology 93:311-330. HERO ID: 5063958

[Less] Perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), which are classified as perfluoroalkyl . . . [More] Perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), which are classified as perfluoroalkyl and polyfluoroalkyl substances (PFASs), have been widely used in industrial applications as a surface protectant. PFASs have been detected in wildlife and in humans around the globe. The purposes of this study are to develop and validate a physiologically based pharmacokinetic (PBPK) model for detecting PFNA and PFDA in male and female rats, and to apply the model to a human health risk assessment regarding the sex difference. A PBPK model of PFNA and PFDA was established based on an in vivo study in male and female rats. Analytes in biological samples (plasma, nine tissues, urine, and feces) were determined by ultra-liquid chromatography coupled tandem mass spectrometry (UPLC-MS/MS) method. PFNA and PFDA showed a gender differences in the elimination half-life and volume of distribution. The tissue-plasma partition coefficients were the highest in the liver in both male and female rats. The predicted rat plasma and urine concentrations simulated and fitted were in good agreement with the observed values. The PBPK models of PFNA and PFDA in male and female rats were then extrapolated to a human PBPK model based on human physiological parameters. The external doses were calculated at 3.35 ng/kg/day (male) and 17.0 ng/kg/day (female) for PFNA and 0.530 ng/kg/day (male) and 0.661 ng/kg/day (female) for PFDA. Human risk assessment was estimated using Korean biomonitoring values considering the gender differences. This study provides valuable insight into human health risk assessment regarding PFNA and PFDA exposure.