Health & Environmental Research Online (HERO)


PFNA (375-95-1)


739 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Selective associations of recent low concentrations of perfluoroalkyl substances with liver function biomarkers: nhanes 2011 to 2014 data on us adults aged ≥20 years

Authors: Jain, RB; Ducatman, A (2019) Journal of Occupational and Environmental Medicine 61:293-302. HERO ID: 5080621

[Less] OBJECTIVE: Perfluoroalkyl substances (PFAS) and liver function biomarkers were reexamined . . . [More] OBJECTIVE: Perfluoroalkyl substances (PFAS) and liver function biomarkers were reexamined for relatively lower serum concentrations of PFAS observed in recent years.

METHODS: National Health and Nutrition Examination Survey 2011 to 2014 data were analyzed for obese and nonobese participants for serum perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorodecanoic acid (PFDA), perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA) as well as four liver function biomarkers in risk-adjusted analysis.

RESULTS: Among obese participants only, alanine aminotransferase (ALT) was positively associated with PFOA (β = 0.07065, P < 0.01), PFHxS (β = 0.051349, P < 0.01), and with PFNA (β = 0.072742, P < 0.01). PFOA (β = 0.07422, P = 0.03) and PFNA (β = 0.077995, P < 0.01) were associated with gamma glutamyl transferase (GGT) in obese participants.

CONCLUSIONS: Recent lower levels of PFOA, PFHxS, and PFNA are associated with higher serum liver functions but only among obese participants. The findings are consistent with PFAS animal toxicology concerning steatosis.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Species-specific profiles and risk assessment of perfluoroalkyl substances in coral reef fishes from the South China Sea

Authors: Pan, CG; Yu, KF; Wang, YH; Zhang, RJ; Huang, XY; Wei, CS; Wang, WQ; Zeng, WB; Qin, ZJ (2018) Chemosphere 191:450-457. HERO ID: 4238463

[Less] The contamination profiles of sixteen perfluoroalkyl substances (PFAS) were examined in coral reef fish . . . [More] The contamination profiles of sixteen perfluoroalkyl substances (PFAS) were examined in coral reef fish samples collected from the South China Sea (SCS) where no information about this topic was available in the literature. The results revealed that six PFAS were found in coral reef fish samples from the SCS. Perfluorooctane sulfonate (PFOS) was the most predominant PFAS contaminant detected in most of the samples, with the highest concentration value of 27.05 ng/g wet weight (ww) observed in Cephalopholis urodelus. Perfluoroundecanoic acid (PFUnDA) and Perfluorotridecanoic acid (PFTrDA) were the second and third dominant PFAS, respectively. Mean PFOS concentrations in muscle of seven coral reef fish varied from 0.29 ng/g ww in Lethrinus olivaceus to 10.78 ng/g ww in Cephalopholis urodelus. No significant linear relationship was observed between PFOS levels and coral reef fish traits (length, weight) collected in this region. Average daily intake of PFOS for the seven coral reef fishes ranged from 0.79 ng/kg/d for Lethrinus olivaceus to 29.53 ng/kg/d for Cephalopholis urodelus. The hazard ratio (HR) values for human consumption of PFOS-contaminated coral reef fishes ranged from 0.04 to 1.48, with Cephalopholis urodelus having the highest HR value of 1.18 (higher than 1) among the species, indicating frequent consumption of Cephalopholis urodelus might pose potential health risk to local population. The present work have provided the first hand data of PFAS in coral reef fishes in the SCS and indirectly demonstrated the existence of low level PFAS pollution in the SCS in China.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Detection of perfluoroalkyl acids and sulphonates in Italian eel samples by HPLC-HRMS Orbitrap

Authors: Chiesa, LM; Nobile, M; Pasquale, E; Balzaretti, C; Cagnardi, P; Tedesco, D; Panseri, S; Arioli, F (2018) Chemosphere 193:358-364. HERO ID: 4220315

[Less] Perfluoroalkyl substances (PFASs) contain one or more carbon-bound hydrogens substituted by fluorine. . . . [More] Perfluoroalkyl substances (PFASs) contain one or more carbon-bound hydrogens substituted by fluorine. Since the 1950s, these compounds have been used to manufacture fat- and water-resistant fabrics, paper and food containers, and to produce photographic films, firefighting foams, detergents and insecticides. The widespread use and global distribution of PFASs, have led to their accumulation in the environment. Food, particularly fish and other seafood, is considered the main route of human exposure to PFASs. Consequently, the European Food Safety Authority (EFSA) recommends that more data be collected, to build a database on the contamination levels of the individual PFASs in food, to evaluate a reliable chronic risk to the European consumers. This requires high-sensitivity analytical methods, to increase the number of quantifiable samples and, thereby, improve the credibility of exposure assessments. In this context, the aim of the present research is to develop and validate a sensitive and specific method based on high-performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) analysis, to monitor the presence of 16 PFASs in Italian eels (Anguilla anguilla) from the Italian Lake Garda. The detection limits (CCα) and detection capability (CCβ) in the order of pg g-1, the recoveries between 80 and 101% and the other validation parameters fulfilled the requirements of Commission Decision 657/2002/EC. The identification and quantification of PFASs, up to 11 in the same sample, showed a similar distribution among 90 eels. Perfluorooctane sulphonic acid (PFOS) and perfluorobutanoic acid (PFBA) were the analytes more frequently found in the eel samples (94 and 82%, respectively).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Identification and quantification of linear and branched isomers of perfluorooctanoic and perfluorooctane sulfonic acids in contaminated groundwater in the veneto region

Authors: Pellizzaro, A; Zaggia, A; Fant, M; Conte, L; Falletti, L (2018) Journal of Chromatography A 1533:143-154. HERO ID: 4238287

[Less] Perfluoroalkylated acids (PFAAs) are ubiquitous xenobiotic substances characterized by high persistency, . . . [More] Perfluoroalkylated acids (PFAAs) are ubiquitous xenobiotic substances characterized by high persistency, bioaccumulation potential and toxicity. They have generated global concern because of their widespread presence both in water and biota compartments. In the past four years, alarming levels of these pollutants have been found in both surface and groundwater collected in an area covering more than 150 square kilometers in the south-western part of the province of Vicenza (Veneto region, Italy). One of the sources of the contamination recognized by local authorities is a fluorochemicals production plant that produced PFAAs since late sixties by electrochemical fluorination involving the obtainment of a complex mixture of linear and branched isomers. Branched isomers account for a significant part of total long chain homologues (22%-35%). Because of the potential threat to public health and the absence of specific limits set for these pollutants by Directive 98/83/EC, local authorities have established the following performance limits for drinking water: 90 ng L-1for PFOA + PFOS, (reduced to 40 ng L-1in the most contaminated municipalities), 30 ng L-1for PFOS and 300 ng L-1for the sum of all other PFAAs. Given the non-negligible incidence of branched isomers, it appears very important to correctly identify and quantify their contribution to total PFAAs. A liquid chromatography-electrospray ionization tandem spectrometry LC-MS/MS method, coupled with solid phase extraction, was developed to identify and quantify 25 PFAAs including six branched isomers of PFOS and four branched isomers of PFOA. Expanded uncertainty, recovery and precision were determined and found to agree with the reference EPA method 537:2009. The quantification limit is comprised in the 1-5 ng L-1range.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Retention performance of three widely used SPE sorbents for the extraction of perfluoroalkyl substances from seawater

Authors: Brumovský, M; Bečanová, J; Karásková, P; Nizzetto, L (2018) Chemosphere 193:259-269. HERO ID: 4238425

[Less] Some per- and polyfluoroalkyl substances (PFASs) have been detected ubiquitously in the environment. . . . [More] Some per- and polyfluoroalkyl substances (PFASs) have been detected ubiquitously in the environment. Owing to the polar character conferred by the presence of the carboxylic or sulfonic acid groups and their resistance to degradation, aquatic environments became their major reservoirs, including marine waters. The procedure of PFAS analysis in aqueous matrices consists usually of solid-phase extraction (SPE) followed by high-performance liquid chromatography coupled to tandem mass spectrometry. Moreover, passive sampling approach using various SPE sorbents may be applied. This study deals with the assessment of retention characteristics of a selected group of PFASs in marine water on three sorbent media widely used in SPE or passive sampling techniques. The influence of type of sorbent, matrix pH, salinity and eluent on the PFAS recovery from aquatic samples was investigated. The best overall extraction conditions were found to be at pH 8 and 50%/100% matrix seawater content using Oasis®HLB/Strata™-X as SPE sorbents and methanol as eluent. The matrix properties found to be the most appropriate for extraction of investigated PFASs from aqueous samples (i.e., pH and salinity levels) match well the natural properties of marine and brackish waters. Acid-base behavior was found to be the main driver influencing the recovery of PFASs. These research findings can be used to optimize PFAS extraction conditions from aquatic samples and also to develop efficient extraction procedures for multiresidual analyses.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

PFOS induces proliferation, cell-cycle progression, and malignant phenotype in human breast epithelial cells

Authors: Pierozan, P; Karlsson, O (2018) Archives of Toxicology 92:705-716. HERO ID: 4238459

[Less] Perfluorooctanesulfonic acid (PFOS) is a synthetic fluorosurfactant widely used in the industry and . . . [More] Perfluorooctanesulfonic acid (PFOS) is a synthetic fluorosurfactant widely used in the industry and a prominent environmental toxicant. PFOS is persistent, bioaccumulative, and toxic to mammalian species. Growing evidence suggests that PFOS has the potential to interfere with estrogen homeostasis, posing a risk of endocrine-disrupting effects. Recently, concerns about a potential link between PFOS and breast cancer have been raised, but the mechanisms underlying its actions as a potential carcinogen are unknown. By utilizing cell proliferation assays, flow cytometry, immunocytochemistry, and cell migration/invasion assays, we examined the potentially tumorigenic activity of PFOS (100 nM-1 mM) in MCF-10A breast cell line. The results showed that the growth of MCF-10A cells exposed to 1 and 10 µM PFOS was higher compared to that of the control. Mechanistic studies using 10 µM PFOS demonstrated that the compound promotes MCF-10A proliferation through accelerating G0/G1-to-S phase transition of the cell cycle after 24, 48, and 72 h of treatment. In addition, PFOS exposure increased CDK4 and decreased p27, p21, and p53 levels in the cells. Importantly, treatment with 10 µM PFOS for 72 h also stimulated MCF-10A cell migration and invasion, illustrating its capability to induce neoplastic transformation of human breast epithelial cells. Our experimental results suggest that exposure to low levels of PFOS might be a potential risk factor in human breast cancer initiation and development.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Endocrine disruptor effect of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on porcine ovarian cell steroidogenesis

Authors: Chaparro-Ortega, A; Betancourt, M; Rosas, P; Vázquez-Cuevas, FG; Chavira, R; Bonilla, E; Casas, E; Ducolomb, Y (2018) Toxicology In Vitro 46:86-93. HERO ID: 4238500

[Less] Previous studies with perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) indicate . . . [More] Previous studies with perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) indicate that they act as endocrine disruptors, in addition to inducing alterations and damaging reproductive health; however, the biological mechanisms by which these disorders are produced are not yet understood. The aim of this study was to analyze the effect of PFOS and PFOA on in vitro steroidogenic secretion in porcine theca and granulosa cells, with or without gonadotropic stimulation. Granulosa and theca cells were isolated and cultured. Cell nature was performed by immunocytochemistry. PFOS and PFOA effect on steroid secretion was analyzed by chemiluminescence. In the present study, alterations in steroidogenic secretion were found when administering PFOS (0.12, 1.2, 12, 120 or 240μM) or PFOA (0.012, 0.12, 1.2, 12 or 24μM) to theca and granulosa cells. When theca and granulosa cells were stimulated with 500ng/mL LH or 500ng/mL FHS, respectively and immediately followed with 1.2μM of PFOS or PFOA, the perfluorinated compounds inhibited the secretion of steroid hormones in both stimulated cell types. The results indicate that PFOS and PFOA act on steroidogenic ovarian cells as endocrine disruptors, which could affect the dependent functions of sexual steroids.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Food safety traits of mussels and clams: distribution of PCBs, PBDEs, OCPs, PAHs and PFASs in sample from different areas using HRMS-Orbitrap® and modified QuEChERS extraction followed by GC-MS/MS

Authors: Chiesa, LM; Nobile, M; Malandra, R; Pessina, D; Panseri, S; Labella, GF; Arioli, F (2018) Food Additives & Contaminants: Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment 35:959-971. HERO ID: 5016895

[Less] Reviewing the presence of contaminant residues is important both for food safety and for monitoring . . . [More] Reviewing the presence of contaminant residues is important both for food safety and for monitoring of environmental pollution. Here, the occurrence of 6 polychlorinated biphenyls (PCBs), 15 organochlorine pesticides (OCPs), 7 polybrominated diphenyl ethers (PBDEs), 4 polycyclic aromatic hydrocarbons (PAHs) and 17 perfluoroalkyl substances (PFASs) was evaluated in mussels and clams. A liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) and an innovative QuEChERS extraction followed by gas chromatography-tandem mass spectrometry (GC-MS/MS) methods were developed, validated and applied. We demonstrate good linearity, repeatability and accuracy of these methods, confirming that they are suitable for the analyses of mollusc samples. The prevalence of PCBs, OCPs and PAHs was higher in mussels than in clams. For PFASs, contamination was higher in clams than in mussels. The samples were all compliant with the regulations, and, for the compounds without legislative limits, a risk assessment confirmed that the values were lower than the tolerable intakes.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid

Authors: Borghoff, SJ; Fitch, S; Rager, JE; Huggett, D (2018) Regulatory Toxicology and Pharmacology 99:168-181. [Review] HERO ID: 5017765

[Less] Perfluorohexanoic acid (PFHxA) is a potential impurity and environmental degradation product of C6-based . . . [More] Perfluorohexanoic acid (PFHxA) is a potential impurity and environmental degradation product of C6-based fluorotelomer products. Considering the potential endocrine activity of perfluoroalkyl acids, a hypothesis-driven weight-of-evidence (WoE) analysis was conducted to evaluate the potential endocrine disruptor activity of PFHxA, as defined by World Health Organization (WHO), across estrogen (E), androgen (A), thyroid (T), and steroidogenesis (S) pathways. A comprehensive literature search identified primary and secondary studies across species for review. The ToxCast/Tox21 database provided in vitro data. Studies identified were reviewed for reliability, and relevance, with endocrine endpoints ranked, and lines of evidence evaluated across pathways. Overall, PFHxA showed no endocrine effects in Japanese medaka, juvenile rainbow trout, chickens or reproductive parameters in northern bobwhite with no significant activity in rodent repeated-dose toxicity, lifetime cancer, or reproductive and developmental studies. In vitro, there was weak or negative activity for T transport protein or activation of E, A or T receptors. PFHxA was also negative in vitro and in vivo for disrupting steroidogenesis. Based on this WoE endocrine analysis, PFHxA exposure did not cause adverse effects associated with alterations in endocrine activity in these models, as such would not be characterized as an endocrine disruptor according to the WHO definition.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluoroalkyl substances (PFASs) influence the structure and function of soil bacterial community: Greenhouse experiment

Authors: Qiao, W; Xie, Z; Zhang, Y; Liu, X; Xie, S; Huang, J; Yu, L (2018) Science of the Total Environment 642:1118-1126. HERO ID: 5079694

[Less] Environmental threats posed by perfluoroalkyl substances (PFASs) have received a great deal of attention . . . [More] Environmental threats posed by perfluoroalkyl substances (PFASs) have received a great deal of attention in recent years. However, little is known about the influences of PFASs on microorganisms in the environment. In this study, several typical PFASs were selected, and their effects on bacterial communities were measured by Illumina MiSeq sequencing. The richness (Chao1 estimator), diversity (Shannon index) and community structure of the bacterial community changed after the exposure to PFASs (1 μg PFOS/g soil). The amendment of PFASs increased bacterial richness but decreased bacterial diversity, because PFASs stimulated the growth of some bacteria (e.g., Firmicutes, Acidobacteria and Actinobacteria) but inhibited other bacteria such as Latescibacteria and Chloroflexi. When low concentrations (0.01 μg/g and 0.1 μg/g) of perfluorooctane sulphonate (PFOS) were added, the promotion action was stronger than the toxic effect on soil bacteria. Conversely, the toxicity was stronger than the promotion action under high concentrations of PFOS (10 μg PFOS/g soil). PFASs pollution obviously disrupted the normal function of soil microorganisms. PFBS and PFHxS could activate sucrase and urease, while PFOS and 6:2FTS could inhibit these enzymes' activities. The reduction of soil functional genes also confirmed that PFOS, 6:2FTS and 6:2F53B inhibited soil enzyme activity and further destroyed the cellular structure, immune system and gene expression of soil bacteria. The effects of PFASs with long carbon chains on soil bacterial community and function was more obvious than that of short-chain PFASs.