Health & Environmental Research Online (HERO)


PFOSA (754-91-6)


361 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Degradation of octafluorodibenzo-p-dioxin by UV/Fe(II)/potassium monopersulfate system: Kinetics, influence of coexisting chemicals, degradation products and pathways

Authors: Zeng, X; Chen, J; Qu, R; Feng, M; Wang, Z (2017) HERO ID: 3841530

[Less] The photodegradation of octafluorodibenzo-p-dioxin (OFDD) in a water/acetonitrile (v/v = 4:1) mixture . . . [More] The photodegradation of octafluorodibenzo-p-dioxin (OFDD) in a water/acetonitrile (v/v = 4:1) mixture was here investigated for the first time in the presence of Fe(II) and potassium monopersulfate (PMS) under DV (lambda = 365 nm) irradiation. The degradation efficiency was found to depend on the presence of UV irradiation, and on the initial concentrations of PMS and Fe(II). OFDD with an initial dosage of 1 mg L- 1 as successfully removed by UV/Fe(II)/PMS with OFDD:PMS:Fe(II) = 1:30:5 M ratio within 10 min irradiation. The effects of humic acid, bicarbonate, chloride and solution pH were also evaluated. The degradation process of OFDD by UV/Fe(II)/PMS can be initiated by an oxidative attack of hydroxy radical on carbon atoms in the aromatic ring, the electron transfer reaction of sulfate radical with OFDD and a direct C-O bond homolysis of OFDD. The intermediates and products of OFDD photodegradation were analyzed by using LC/MS technique and the associated photochemical pathway was proposed. The combined process with Fe(II), PMS and UV could be a useful technology for the treatment of wastewater containing OFDD. (C) 2017 Elsevier B.V. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Side-chain fluorinated polymer surfactants in aquatic sediment and biosolid-augmented agricultural soil from the Great Lakes basin of North America

Authors: Chu, S; Letcher, RJ (2017) Science of the Total Environment 607-608:262-270. HERO ID: 3981239

[Less] Side-chain fluorinated polymer surfactants are the main components of fabric protector sprays and used . . . [More] Side-chain fluorinated polymer surfactants are the main components of fabric protector sprays and used extensively on furniture and textiles. The composition of these commercial protector products has changed, but there is currently a total dearth of information on these novel fluorinated polymers in the environment. Using a developed analytical approach, two complementary studies examined the distribution of Scotchgard™ fabric protector components in aquatic sediment and in agricultural soils where wastewater treatment plant (WWTP) sourced biosolid application occurred, and in samples from sites in the Laurentian Great Lakes basin of North America. The main components in the pre- and post-2002 Scotchgard™ fabric protectors were identified by MS/MS and Q-TOF-MS to contain a perfluorooctane sulfonamide (S1) and perfluorobutane sulfonamide (S2) based side-chain, respectively, and bonded to a polymer backbone. In fifteen sediment samples collected in 2012-2013 from western Lake Erie and Saginaw Bay (Lake Huron), S1 was in all sediment samples (0.18 to 461.59ng/g dry weight (d.w.)); S2 was in 80% of the sediment samples (<0.03 to 24.08ng/g d.w.). Thirteen soil samples were collected (2015) from a biosolid applied and two non-biosolid applied farm field sites in southern Ontario (Canada). S1 was detected in 100% of the soil samples from biosolid-augmented agricultural sites (mean 236.36ng/g d.w.; range 41.87 to 622.46ng/g d.w.), and at concentrations much greater than in the aquatic sediment samples. The concentration of S1 and S2 in soil and sediment samples were also much greater than the total concentration of other per-and poly-fluoroalkyl substances (PFASs) that were measured. The ratio of S1 concentration versus ∑22PFAS concentration was up to 1616 in sediment samples from Lake Erie. This results helps to explain why known PFASs account for low percentages of the total extractable organic fluorine (EOF) content in sediment.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Evidence for the Trophic Transfer of Perfluoroalkylated Substances in a Temperate Macrotidal Estuary

Authors: Munoz, G; Budzinski, H; Babut, M; Drouineau, H; Lauzent, M; Menach, KL; Lobry, J; Selleslagh, J; Simonnet-Laprade, C; Labadie, P (2017) Environmental Science and Technology 51:8450-8459. HERO ID: 3981240

[Less] The present survey examines the trophodynamics of a suite of 19 perfluoroalkyl substances (PFASs) in . . . [More] The present survey examines the trophodynamics of a suite of 19 perfluoroalkyl substances (PFASs) in a temperate macrotidal estuary (Gironde, SW France). Across the 147 biota samples (18 taxa) collected, perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and C8-C14 perfluoroalkyl carboxylates (PFCAs) were the most-recurrent analytes. ΣPFASs ranged between 0.66-45 ng per g of wet weight of the whole body. Benthic organisms had relatively high ΣPFASs compared to demersal organisms and displayed specific composition profiles with higher relative abundances of C8 and C9 PFCAs. Trophic magnification factors (TMFs) were determined through the use of linear mixed effect models including censored data, thereby considering data below detection limits as well as the interspecific variability of δ(15)N and PFAS levels (random effects). TMFs were almost consistently >1 in the benthic food web as well as when considering all data pooled together, providing evidence for the biomagnification of several PFASs in estuarine environments. In addition, in contrast with previous observations, TMFs determined in the estuarine benthic web were found to significantly decrease with increasing chain length for C8-C14 PFCAs and C6-C8 perfluoroalkyl sulfonates. This suggests that PFAS chemical structure might not be necessarily predictive of TMFs, which are also influenced by the trophic web characteristics.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Spatial and temporal trends of poly- and perfluoroalkyl substances in fish fillets and water collected from pool 2 of the Upper Mississippi River

Authors: Newsted, JL; Holem, R; Hohenstein, G; Lange, C; Ellefson, M; Reagen, W; Wolf, S (2017) Environmental Toxicology and Chemistry 36:3138-3147. HERO ID: 3981241

[Less] In 2011, poly- and perfluoroalkyl substances (PFASs) were analyzed in surface water and fish fillet . . . [More] In 2011, poly- and perfluoroalkyl substances (PFASs) were analyzed in surface water and fish fillet samples taken from Pool 2 of the Upper Mississippi River, a 33-mile stretch inclusive of the Minneapolis/St. Paul, Minnesota (USA) metropolitan area. Approximately 100 each of bluegill, freshwater drum, smallmouth bass, and white bass were sampled within the study area. Surface water samples were also collected from each of the 10 sampling reaches established for the study. Water and fillet samples were analyzed for perfluorinated carboxylic acids (C4-C12), perfluorinated sulfonic acids (C4, C6, and C8), and perfluorooctane sulfonamide. Perfluorooctane sulfonate (PFOS) was observed with the greatest frequency in fish fillets and ranged from 3.0 to 760 ng/g wet weight. Mean (geometric) PFOS concentrations in bluegill, freshwater drum, smallmouth bass, and white bass were 20, 28, 29, and 58 ng/g wet weight, respectively. When compared with fish data collected in 2009, a significant reduction (p < 0.05) in PFOS concentrations was noted. This finding was confirmed based on data from studies conducted in 2012 and 2013. Overall, between 2009 and 2013, PFOS concentrations decreased by 65, 76, and 50% for bluegill, freshwater drum, and white bass, respectively (44% decrease for smallmouth bass from 2009 to 2012). These declines in fish PFOS concentrations are consistent with ongoing efforts to effectively control sources of PFASs to the Mississippi River. Environ Toxicol Chem 2017;9999:1-10. © 2017 SETAC.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Tissue Uptake, Distribution, and Elimination of Perfluoroalkyl Substances in Juvenile Perch through Perfluorooctane Sulfonamidoethanol Based Phosphate Diester Dietary Exposure

Authors: Gaillard, J; Veyrand, B; Thomas, M; Dauchy, X; Boiteux, V; Marchand, P; Le Bizec, B; Banas, D; Feidt, C (2017) Environmental Science and Technology 51:7658-7666. HERO ID: 3981242

[Less] Perfluorooctane sulfonamidoethanol based phosphate diester (SAmPAP) is a potential perfluorooctanesulfonate . . . [More] Perfluorooctane sulfonamidoethanol based phosphate diester (SAmPAP) is a potential perfluorooctanesulfonate (PFOS) precursor. To examine whether SAmPAP exposure would result in fish contamination by perfluoroalkyl and polyfluoroalkyl substances (PFASs), juvenile Eurasian perch were dietarily exposed to this compound (dosed group) or exposed to the same tank water but fed control feed (control group). SAmPAP and metabolites were monitored in the muscle, liver, and serum during the 45-day exposure phase and 35-day depuration phase. SAmPAP was only detected in the dosed group and the absorption efficiency (0.04-2.25%) was very low, possibly related to its low bioavailability in the gastrointestinal tract, steric constraints in crossing biological membranes, and clearing by enterohepatic circulation. Although SAmPAP was biotransformed and eliminated at a slow rate (t1/2 > 18 days), its biomagnification factor was low. The observed metabolites in fish were N-ethyl perfluorooctane sulfonamidoacetic acid, perfluorooctane sulfonamidoacetic acid, perfluorooctane sulfonamide, and PFOS. Considering that SAmPAP was the only source of PFASs in the tanks, the occurrence of metabolites indicates that SAmPAP could be biotransformed in fish and contribute to PFOS bioaccumulation. However, levels of metabolites were not significantly different in the dosed and control groups, indicating that metabolite excretion followed by re-exposure to these metabolites from water was the main uptake route.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Vertical profiles, sources, and transport of PFASs in the Arctic Ocean

Authors: Yeung, LWY; Dassuncao, C; Mabury, S; Sunderland, EM; Zhang, X; Lohmann, R (2017) Environmental Science and Technology 51:6735-6744. HERO ID: 3981243

[Less] The relative importance of atmospheric versus oceanic transport for poly- and perfluorinated alkyl substances . . . [More] The relative importance of atmospheric versus oceanic transport for poly- and perfluorinated alkyl substances (PFASs) reaching the Arctic Ocean is not well understood. Vertical profiles from the Central Arctic Ocean and shelf water, snow and meltwater samples were collected in 2012; 13 PFASs (C6-C12 PFCAs; C6, 8, 10 PFSAs; MeFOSAA and EtFOSAA; and FOSA) were routinely detected (range: <5-343 pg/L). PFASs were only detectable above 150 m depth in the polar mixed layer (PML) and halocline. Enhanced concentrations were observed in snow and meltpond samples, implying atmospheric deposition as an important source of PFASs. Model results suggested atmospheric inputs to account for 34-59% (∼11-19 pg/L) of measured PFOA concentrations in the PML (mean 32 ± 15 pg/L). Modeled surface and halocline measurements for PFOS based on North Atlantic inflow (11-36 pg/L) agreed with measurements (mean, 17, range <5-41 pg/L). Modeled deep water concentrations below 200 m (5-15 pg/L) were slightly higher than measurements (<5 pg/L), suggesting the lower bound of PFAS emissions estimates from wastewater and rivers may provide the best estimate of inputs to the Arctic. Despite low concentrations in deep water, this reservoir is expected to contain most of the PFOS mass in the Arctic (63-180 Mg) and is projected to continue increasing to 2038.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Global distribution of perfluorochemicals (PFCs) in potential human exposure source-A review

Authors: Jian, JM; Guo, Y; Zeng, L; Liang-Ying, L; Lu, X; Wang, F; Zeng, EY (2017) Environment International 108:51-62. [Review] HERO ID: 3981238

[Less] Human exposure to perfluorochemicals (PFCs) has attracted mounting attention due to their potential . . . [More] Human exposure to perfluorochemicals (PFCs) has attracted mounting attention due to their potential harmful effects. Breathing, dietary intake, and drinking are believed to be the main routes for PFC entering into human body. Thus, we profiled PFC compositions and concentrations in indoor air and dust, food, and drinking water with detailed analysis of literature data published after 2010. Concentrations of PFCs in air and dust samples collected from home, office, and vehicle were outlined. The results showed that neutral PFCs (e.g., fluorotelomer alcohols (FTOHs) and perfluorooctane sulfonamide ethanols (FOSEs)) should be given attention in addition to PFOS and PFOA. We summarized PFC concentrations in various food items, including vegetables, dairy products, beverages, eggs, meat products, fish, and shellfish. We showed that humans are subject to the dietary PFC exposure mostly through fish and shellfish consumption. Concentrations of PFCs in different drinking water samples collected from various countries were analyzed. Well water and tap water contained relatively higher PFC concentrations than other types of drinking water. Furthermore, PFC contamination in drinking water was influenced by the techniques for drinking water treatment and bottle-originating pollution.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Biomonitoring of fluoroalkylated substances in Antarctica seabird plasma: Development and validation of a fast and rugged method using on-line concentration liquid chromatography tandem mass spectrometry

Authors: Munoz, G; Labadie, P; Geneste, E; Pardon, P; Tartu, S; Chastel, O; Budzinski, H (2017) Journal of Chromatography A 1513:107-117. HERO ID: 3981192

[Less] We report on a fast, accurate and rugged analytical procedure to determine a wide span of perfluoroalkyl . . . [More] We report on a fast, accurate and rugged analytical procedure to determine a wide span of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in seabird plasma. The 26 investigated compounds included perfluoroalkyl carboxylates (C5-C14 PFCAs), perfluoroalkyl sulfonates (C4, C6, C7, C8, C10 PFSAs), perfluorooctane sulfonamide (FOSA) and N-alkyl derivatives (MeFOSA, EtFOSA), N-alkyl perfluorooctane sulfonamido acetic acids (MeFOSAA, EtFOSAA), fluorotelomer sulfonates (4:2 FTSA, 6:2 FTSA, 8:2 FTSA), polyfluoroalkyl phosphate diesters (diPAPs) and perfluorooctane sulfonamide phosphate diester (diSAmPAP). The method described herein requires a reduced sample amount (25μL) and involves rapid and simple sample preparation (protein precipitation with acetonitrile but without acidification) prior to analysis by on-line solid phase extraction (Oasis HLB sorbent) coupled to high performance liquid chromatography negative electrospray ionization tandem mass spectrometry. The optimization was conducted using experimental designs to account for potential interactions between variables. Out of the 26 target analytes, 23 compounds showed excellent accuracy (±25% of the expected values). Intermediate precision and matrix effects remained acceptable for most analytes thanks to efficient internal standardization. A human serum standard reference material (NIST SRM 1957) was included in the validation scheme to evaluate method trueness, which proved satisfactory (│Z-scores│<2 for most compounds). Notwithstanding the small initial sample intake, limits of detection as low as 0.003-0.1ngg(-1) plasma were obtained. This allowed the determination of 11 target PFASs in Antarctic seabird plasma samples. ΣPFASs in Antarctic seabird plasma ranged from 0.37 to 19ngg(-1), with a predominance of PFOS (>54% of ΣPFASs on average). The reduced plasma amount required implies that the present method could also be applied to the analysis of PFASs in the plasma of smaller biological models.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Perfluorooctanesulfonate (PFOS) Conversion from N-Ethyl-N-(2-hydroxyethyl)-perfluorooctanesulfonamide (EtFOSE) in male Sprague Dawley rats after inhalation exposure

Authors: Chang, S; Mader, BT; Lindstrom, KR; Lange, CC; Hart, JA; Kestner, TA; Schulz, JF; Ehresman, DJ; Butenhoff, JL (2017) Environmental Research 155:307-313. HERO ID: 3860242

[Less] Ethyl-N-(2-hydroxyethyl)-perfluorooctanesulfonamide (EtFOSE) was one of the key building blocks for . . . [More] Ethyl-N-(2-hydroxyethyl)-perfluorooctanesulfonamide (EtFOSE) was one of the key building blocks for many of the perfluorooctanesulfonyl-based chemistry and laboratory studies have shown that EtFOSE can metabolically degrade to perfluorooctanesulfonate (PFOS). Non-occupational contribution sources to PFOS are thought to occur in general population via diets, drinking water, air and dust. For workers, however, the exposure route was mostly airborne and the exposure source was predominantly to precursor compounds such as EtFOSE. We undertook this study to investigate how much EtFOSE was converted to PFOS in the serum for male rats after 6h of exposure to EtFOSE vapor (whole body) at ambient temperature, which simulated a work place exposure scenario. There were no abnormal clinical observations and all rats gained weight during study. Interim tail-vein blood samples, collected up to 21 days after exposure, were analyzed for Et-FOSE and PFOS concentrations by LC-MS/MS. Upon inhalation exposure, the biotransformation of EtFOSE to PFOS in serum in the male rats was rapid and very little EtFOSE was detected in the serum within 24h after EtFOSE exposure. The highest conversion to PFOS in serum after exposure to EtFOSE vapor appeared to occur between Day 8-14 post exposure. Considering the potential surface and fur adsorption of test compound in the whole-body exposure system, our data would support that at least 10% of the inhaled EtFOSE was biotransformed to PFOS in the serum based on the range of lower 95% CI (confidence interval) values. This information is valuable because it quantitatively translates EtFOSE exposure into serum PFOS concentration, which serves as a matrix for internal dosimetry (of PFOS exposure) that can be used as an anchor across species as well as between different exposure routes.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Predictors of per- and polyfluoroalkyl substance (PFAS) plasma concentrations in 6-10 year old American children

Authors: Harris, MH; Rifas-Shiman, SL; Calafat, AM; Ye, X; Mora, AM; Webster, TF; Oken, E; Sagiv, SK (2017) Environmental Science and Technology 51:5193-5204. HERO ID: 3859811

[Less] Certain per- and polyfluoroalkyl substances (PFASs) are suspected developmental toxicants, but data . . . [More] Certain per- and polyfluoroalkyl substances (PFASs) are suspected developmental toxicants, but data on PFAS concentrations and exposure routes in children are limited. We measured plasma PFASs in children aged 6-10 years from the Boston-area Project Viva prebirth cohort, and used multivariable linear regression to estimate associations with sociodemographic, behavioral, and health-related factors, and maternal PFASs measured during pregnancy. PFAS concentrations in Project Viva children (sampled 2007-2010) were similar to concentrations among youth participants (aged 12-19 years) in the 2007-8 and 2009-10 National Health and Nutrition Examination Survey (NHANES); mean concentrations of most PFASs declined from 2007 to 2010 in Project Viva and NHANES. In mutually adjusted models, predictors of higher PFAS concentrations included older child age, lower adiposity, carpeting or a rug in the child's bedroom, higher maternal education, and higher neighborhood income. Concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexanesulfonate (PFHxS), and 2-(N-methyl-perfluorooctane sulfonamido) acetate (Me-PFOSA-AcOH) were 26-36% lower in children of black mothers compared to children of white mothers and increased 12-21% per interquartile range increase in maternal pregnancy PFASs. Breastfeeding duration did not predict childhood PFAS concentrations in adjusted multivariable models. Together, the studied predictors explained the observed variability in PFAS concentrations to only a modest degree.