Health & Environmental Research Online (HERO)


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24 References Were Found:

Technical Report
Technical Report

Systematic review of immunotoxicity associated with exposure to perfluorooctanoic acid (pfoa) or perfluorooctane sulfonate (pfos)

Author: NTP (2016) National Toxicology Program. HERO ID: 3861540


Technical Report
Technical Report

Health effects support document for perfluorooctanoic acid (PFOA)

Author: U.S. EPA (2016) (EPA 822-R-16-003). Washington, DC: U.S. Environmental Protection Agency, Office of Water, Health and Ecological Criteria Division. [EPA Report] HERO ID: 3603279


Technical Report
Technical Report

Health effects support document for perfluorooctane sulfonate (PFOS)

Author: U.S. EPA (2016) (EPA 822-R-16-002). Washington, DC: U.S. Environmental Protection Agency, Office of Water, Health and Ecological Criteria Division. [EPA Report] HERO ID: 3603365


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Dermal penetration potential of perfluorooctanoic acid (PFOA) in human and mouse skin

Authors: Franko, J; Meade, BJ; Frasch, HF; Barbero, AM; Anderson, SE (2012) Journal of Toxicology and Environmental Health, Part A: Current Issues 75:50-62. HERO ID: 1290879

[Less] Recent data, using a murine model, have indicated that dermal exposure to perfluorooctanoic acid (PFOA) . . . [More] Recent data, using a murine model, have indicated that dermal exposure to perfluorooctanoic acid (PFOA) induces immune modulation, suggesting that this may be an important route of PFOA exposure. To investigate the dermal penetration potential of PFOA, serum concentrations were analyzed in mice following topical application. Statistically significant and dose-responsive increases in serum PFOA concentrations were identified. In vitro dermal penetration studies also demonstrated that PFOA permeates both mouse and human skin. Investigation into the mechanisms mediating PFOA penetration demonstrated that dermal absorption was strongly dependent upon the ionization status of PFOA. In addition, PFOA solid, but not 1% PFOA/acetone solution, was identified as corrosive using a cultured epidermis in vitro model. Despite its corrosive potential, expression of inflammatory cytokines in the skin of topically exposed mice was not altered. These data suggest that PFOA is dermally absorbed and that under certain conditions the skin may be a significant route of exposure.

Technical Report
Technical Report

Committee for risk assessment RAC: Annex 1: Background document to the opinion proposing harmonised classification and labelling at community level of ammoniumpentadecafluorooctanoate (APFO)

Author: ECHA (2011) HERO ID: 4467664


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the rat (vol 91, pg 341, 2006)

Authors: Fasano, WJ; Carpenter, SC; Gannon, SA; Snow, TA; Stadler, JC; Kennedy, GL; Buck, RC; Korzeniowski, SH; Hinderliter, PM; Kemper, RA (2008) HERO ID: 3859495


Technical Report
Technical Report

A framework for assessing health risk of environmental exposures to children

Author: U.S. EPA (2006) (1-145). (EPA/600/R-05/093F). Washington, DC: U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment. HERO ID: 194567

[Less] EPA has released a final report entitled, A Framework for Assessing Health Risk of Environmental Exposures . . . [More] EPA has released a final report entitled, A Framework for Assessing Health Risk of Environmental Exposures to Children, which examines the impact of potential exposures during developmental lifestages and subsequent lifestages, while emphasizing the iterative nature of the analysis phase with a multidisciplinary team.

Major findings and conclusions: This report outlines the framework in which mode of action(s) (MOA) can be considered across life stages. The framework is based upon existing approaches adopted in the Framework on Cumulative Risk Assessment and identifies existing guidance, guidelines and policy papers that relate to children's health risk assessment. It emphasizes the importance of an iterative approach between hazard, dose response, and exposure analyses. In addition, it includes discussion of principles for weight of evidence consideration across life stages for the hazard characterization database.

Key science/assessment issues:This framework addresses the questions of why and how an improved children's health risk assessment will strengthen the overall risk assessment process across the Agency. This approach improves the scientific explanation of children's risk and will add value by: 1) providing for a more complete evaluation of the potential for vulnerability at different life stages, including a focus on the underlying biological events and critical developmental periods for incorporating MOA considerations; 2) evaluating of the potential for toxicity after exposure during all developmental life stages; and 3) integrating of adverse health effects and exposure information across life stages.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The toxicology of perfluorooctanoate

Authors: Kennedy, GL; Jr; Butenhoff, JL; Olsen, GW; Connor, JCO; Seacat, AM; Perkins, RG; Biegel, LB; Murphy, , SR; Farrar, DG (2004) Critical Reviews in Toxicology 34:351-384. [Review] HERO ID: 724950

[Less] PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic . . . [More] PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic of PPAR agonists. These effects include increased beta-oxidation of fatty acids, increases in several cytochrome P-450 (CYP450)-mediated reactions, and inhibition of the secretion of very low-density lipoproteins and cholesterol from the liver. These effects on lipid metabolism and transport result in a reduction of cholesterol and triglycerides in serum and an accumulation of lipids in the liver. The triad of tumors observed (liver, Leydig cell, and pancreatic acinar-cell) is typical of many PPAR agonists and is believed to involve nongenotoxic mechanisms. The hepatocellular tumors observed in rats are likely to have been the result of the activation of the peroxisome proliferator activated receptor alpha (PPARalpha). The tumors observed in the testis (Leydig-cell) have been hypothesized to be associated with an increased level of serum estradiol in concert with testicular growth factors. The mechanism responsible for the acinar-cell tumors of the pancreas in rats remains the subject of active investigation. The mechanism resulting in the hepatocellular tumors in rats (PPARalpha activation) is not likely to be relevant to humans. Similarly, the proposed mechanism for Leydig-cell tumor formation is of questionable relevance to humans. Acinar tumors of the pancreas are rare in humans, and the relevance of the these tumors, as found in rats, to humans is uncertain. Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects

Technical Report
Technical Report

Dermal sensitization test—Buehler method.

Author: Moore, GE (2001) HERO ID: 4467672


Technical Report
Technical Report

Acute dermal toxicity study of T-7485 applied to Sprague-Dawley rats

Author: 3M (2000) (Study number: 132-010). St. Paul, MN: 3M Corporate Toxicology. HERO ID: 4322450