Health & Environmental Research Online (HERO)


Fatty alcohols (112-92-5, 661-19-8, 629-96-9, & 143-28-2)


217 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

RIFM fragrance ingredient safety assessment, (Z)-Octadec-9-enol, CAS Registry Number 143-28-2

Authors: Api, AM; Belsito, D; Botelho, D; Bruze, M; Burton, GA; Buschmann, J; Dagli, ML; Date, M; Dekant, W; Deodhar, C; Francis, M; Fryer, AD; Jones, L; Joshi, K; La Cava, S; Lapczynski, A; Liebler, DC; O'Brien, D; Patel, A; Penning, TM; Ritacco, G; Romine, J; Sadekar, N; Salvito, D; Schultz, TW; Sipes, IG; Sullivan, G; Thakkar, Y; Tokura, Y; Tsang, S (2018) Food and Chemical Toxicology 118:S156-S161. HERO ID: 4929246

[Less] Highlights: • (Z)-Octadec-9-enol, safety assessment based on RIFM's criteria. • Safety assessment . . . [More] Highlights:
• (Z)-Octadec-9-enol, safety assessment based on RIFM's criteria.
• Safety assessment based on 7 human health endpoints plus environmental.
• All endpoints were cleared using target data, read-across, and/or TTC.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Allergic contact dermatitis caused by wet wipes containing steareth-10: Is stearyl alcohol to blame?

Authors: Aerts, O; Naessens, T; Dandelooy, J; Leysen, J; Lambert, J; Apers, S (2017) Contact Dermatitis 77:117-119. HERO ID: 4929237

[Less] Steareths, such as steareth-10 (CAS no. 9005-00-9/13149-86-5), are emulsifiers that are apparently associated . . . [More] Steareths, such as steareth-10 (CAS no. 9005-00-9/13149-86-5), are emulsifiers that are apparently associated with a low risk of sensitization. They are prepared by the chemical reaction of ethylene oxide with stearyl alcohol, and the numerical suffix indicates the average number of ethylene oxide units used. We here report a rare case of allergic contact dermatitis caused by steareth-10 present in makeup-removing wet wipes, and we discuss the residual presence of stearyl alcohol in these wipes as a potential culprit.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Phytochemical profile, antimicrobial potential and GC-MS analysis of wild variety of Olea Europaea (Olive) cultivated in Pakistan

Authors: Ahmad, W; Ali, N; Afridi, MS; Rahman, H; Adnan, M; Ullah, N; Muhammad, U; Ilyas, M; Khan, H (2017) Pure and Applied Biology 6:337-345. HERO ID: 4941774

[Less] Olive plant produces a variety of bioactive molecules and thus has important medicinal value in folk . . . [More] Olive plant produces a variety of bioactive molecules and thus has important medicinal value in folk medicine. In this study, different leaf and fruit extracts of Pakistani wild variety of Olea europaea was tested for their phytochemical content, antimicrobial activity and mass spectrometric analysis. Olive leaves and fruit samples were extracted with five different solvents to obtain the crude extract and screened for various kinds of phytochemicals. Phytochemicals were further confirmed through Fourier Transmission Infra-red Spectroscopy (FTIR). The plant extract showed significant antimicrobial activity against all the strains tested. Methanol, ethanol and ethyl acetate extracts were found more effective against most of the pathogenic bacteria with high zone of inhibition. Gas Chromatography-Mass Spectrometry (GC-MS) analysis revealed that olive fruits have Oleic acid, Palmitic acid, Linoleic acid, Octadecadienoic acid, Stearic acid, Palmitoleic acid and Tridecanoic acid as oil contents. In this work, the antimicrobial potential and phytochemical contents were explored which may further pave the way for the bio-industrial applications.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Oxidative decomposition of thin films of oleyl and stearyl alcohols on steel surface

Authors: Brazinskiene, D; Straksys, A; Voisniene, V; Vilkauskaite, R; Asadauskas, S (2017) Lietuvos Mokslu Akademija. Chemija 28:1-8. HERO ID: 4657051

[Less] Fatty alcohols and their derivatives are popular additives in shampoos, cosmetics, paints, lubricants . . . [More] Fatty alcohols and their derivatives are popular additives in shampoos, cosmetics, paints, lubricants and other functional fluids, whose films are exposed to the environment. Often these films degrade due to oxidative, thermal, catalytic and other stress factors, producing volatile emissions. Decomposition of fatty materials is rarely viewed as a significant contributor to vapour losses, however, it cannot be assumed that fatty alcohols are completely non-volatile. In this study, oxidative degradation of thin films of oleyl and stearyl alcohols was investigated on the steel surface. Tests at 90 degrees C showed that within several hours significant portions of these alcohols were lost to volatile emissions. Initially the absolute evaporation rates did not depend on the film thickness and appeared quite similar for both alcohols. In later stages, the evaporation rate of thinner films went down due to the formation of oxidative polymers and functional group oxidation. Acidity of oleyl alcohol increased much more rapidly than that of stearyl. After long-term degradation oleyl alcohol produced gel-like solids, while films of stearyl alcohol began to retain a liquid state at room temperature. Since the volatile emissions amounted to more than 60%, the decomposition products in final applications should be investigated in more detail when stearyl or oleyl alcohols are used as major constituents in commercial liquids.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Temporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment

Authors: Hao, D; Sarfaraz, MO; Farshidfar, F; Bebb, DG; Lee, CY; Card, CM; David, M; Weljie, AM (2016) Metabolomics 12:58. HERO ID: 4929283

[Less] Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few . . . [More] Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate the feasibility of metabolites as temporal biomarkers of clinical outcomes. Serial serum specimens collected prospectively from lung cancer patients were analyzed using both nuclear magnetic resonance (1H-NMR) spectroscopy and gas chromatography mass spectrometry (GC-MS). Multivariate statistical analysis consisted of unsupervised principal component analysis or orthogonal partial least squares discriminant analysis with significance assessed using a cross-validated ANOVA. The metabolite profiles were reflective of the temporal distinction between patient samples before during and after receiving therapy (1H-NMR, p < 0.001: and GC-MS p < 0.01). Disease progression and survival were strongly correlative with the GC-MS metabolite data whereas stage and cancer type were associated with 1H-NMR data. Metabolites such as hydroxylamine, tridecan-1-ol, octadecan-1-ol, were indicative of survival (GC-MS p < 0.05) and metabolites such as tagatose, hydroxylamine, glucopyranose, and threonine that were reflective of progression (GC-MS p < 0.05). Metabolite profiles have the potential to act as prognostic markers of clinical outcomes for lung cancer patients. Serial 1H-NMR measurements appear to detect metabolites diagnostic of tumor pathology, while GC-MS provided data better related to prognostic clinical outcomes, possibility due to physiochemical bias related to specific biochemical pathways. These results warrant further study in a larger cohort and with various treatment options.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Comparison of oleo- vs petro-sourcing of fatty alcohols via cradle-to-gate life cycle assessment

Authors: Shah, J; Arslan, E; Cirucci, J; O'Brien, J; Moss, D (2016) Journal of Surfactants and Detergents 19:1333-1351. HERO ID: 3457657

[Less] Alcohol ethoxylates surfactants are produced via ethoxylation of fatty alcohol (FA) with ethylene oxide. . . . [More] Alcohol ethoxylates surfactants are produced via ethoxylation of fatty alcohol (FA) with ethylene oxide. The source of FA could be either palm kernel oil (PKO) or petrochemicals. The study aimed to compare the potential environmental impacts for PKO-derived FA (PKO-FA) and petrochemicals-derived FA (petro-FA). Cradle-to-gate life cycle assessment has been performed for this purpose because it enables understanding of the impacts across the life cycle and impact categories. The results show that petro-FA has overall lower average greenhouse gas (GHG) emissions (~2.97 kg CO2e) compared to PKO-FA (~5.27 kg CO2e). (1) The practices in land use change for palm plantations, (2) end-of-life treatment for palm oil mill wastewater effluent and (3) end-of-life treatment for empty fruit bunches are the three determining factors for the environmental impacts of PKO-FA. For petro-FA, n-olefin production, ethylene production and thermal energy production are the main factors. We found the judicious decisions on land use change, effluent treatment and solid waste treatment are key to making PKO-FA environmentally sustainable. The sensitivity results show the broad distribution for PKO-FA due to varying practices in palm cultivation. PKO-FA has higher impacts on average for 12 out of 18 impact categories evaluated. For the base case, when accounted for uncertainty and sensitivity analyses results, the study finds that marine eutrophication, agricultural land occupation, natural land occupation, fossil depletion, particulate matter formation, and water depletion are affected by the sourcing decision. The sourcing of FA involves trade-offs and depends on the specific practices through the PKO life cycle from an environmental impact perspective.

Technical Report
Technical Report

Hexadecan-1-ol: long-term toxicity to fish: 001 key | experimental result

Author: ECHA (2015) HERO ID: 5094817


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Biodegradation of artificial monolayers applied to water storages to reduce evaporative loss

Authors: Pittaway, P; Herzig, M; Stuckey, N; Larsen, K (2015) Water, Science and Technology 72:1334-1340. HERO ID: 4335934

[Less] Repeat applications of an artificial monolayer to the interfacial boundary layer of large agricultural . . . [More] Repeat applications of an artificial monolayer to the interfacial boundary layer of large agricultural water storages during periods of high evaporative demand remains the most commercially feasible water conservation strategy. However, the interfacial boundary layer (or microlayer) is ecologically distinct from subsurface water, and repeat monolayer applications may adversely affect microlayer processes. In this study, the natural cleansing mechanisms operating within the microlayer were investigated to compare the biodegradability of two fatty alcohol (C16OH and C18OH) and one glycol ether (C18E1) monolayer compound. The C16OH and C18OH compounds were more susceptible to microbial degradation, but the C18E1 compound was most susceptible to indirect photodegradation. On clean water the surface pressure and evaporation reduction achieved with a compressed C18E1 monolayer was superior to the C18OH monolayer, but on brown water the surface pressure dropped rapidly. These results suggest artificial monolayers are readily degraded by the synergy between photo and microbial degradation. The residence time of C18OH and C18E1 monolayers on clear water is sufficient for cost-effective water conservation. However, the susceptibility of C18E1 to photodegradation indicates the application of this monolayer to brown water may not be cost-effective.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Severe allergic contact dermatitis caused by a rubber glove coated with a moisturizer

Authors: Vanden Broecke, K; Zimerson, E; Bruze, M; Goossens, A (2014) Contact Dermatitis 71:117-119. HERO ID: 4936314

[Less] A 65-year-old non-atopic man presented in 1 July 2012 to the emergency department of our hospital with . . . [More] A 65-year-old non-atopic man presented in 1 July 2012 to the emergency department of our hospital with a well-demarcated severe oedematous and vesicular reaction on the back of his right hand, extending to his wrist and forearm (Fig. 1); on the back of his left hand, he showed only a very discrete papulovesicular itching reaction. Three days previously, he had cleaned his garden shed with ammonia diluted in water by use of a sponge, thereby wearing a rubber glove on his right hand only (Vileda Comfort and Care, Comfort plus, extra-absorbent®; Vileda, Verviers, Belgium), the interior side being coated with a moisturizer, said to contain perfume and chamomile. With the left (ungloved) hand, he had occasionally held the wet sponge. He had noticed that some of the ammonia solution had spilled into the glove, but he had continued cleaning for ∼2 hr without taking it off, without any discomfort. It was only on the next day that the itching, redness and swelling started to develop. The lesions had become really severe, despite using a corticosteroid cream (Fucicort®; Leo, Wilrijk, Belgium). At the emergency unit, the patient received treatment with oral steroids, application of a wet dressing for 15 min twice daily, Diprosone® cream (Schering-Plough, Heist-op-den-Berg, Belgium), and systemic antihistamines and ibuprofen; this was followed by gradual improvement of the skin lesions after 2 weeks; the treatment was further reduced, and a moisturizer was prescribed. However, the patient was seen by us in October, and mentioned that he had stopped using the moisturizer, as it had again produced worsening of his skin lesions.

The patient had been patch tested in 2009, and had been shown to be allergic to cetrimide, (a quaternary ammonium compound), isopropanol, iodine, and povidone iodine, which had been considered to be relevant to skin lesions that he had developed during wound treatment of his left elbow following osteosynthesis. The dermatitis had been treated with Fucicort® cream. Later on, he had experienced a skin reaction on his knee following the application of an ointment, the name of which he could not recall.

As a retired endive farmer, he had been wearing rubber gloves for > 20 years without any skin problems.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages

Authors: Montserrat-De la Paz, S; García-Giménez, MD; Ángel-Martín, M; Pérez-Camino, MC; Fernández Arche, A (2014) Journal of Ethnopharmacology 151:131-136. HERO ID: 2232626

[Less] ETHNOPHARMACOLOGICAL RELEVANCE: Evening primrose (Oenothera biennis L., Onagraceae) . . . [More] ETHNOPHARMACOLOGICAL RELEVANCE: Evening primrose (Oenothera biennis L., Onagraceae) is a wild medicinal plant of Central American origin that is now one of the most widely used herbal medicines in different parts of the world. Oil extracted from it seeds is traditionally used in the treatment of eczema, asthma, rheumatoid arthritis, breast problem, premenstrual and menopausal syndrome, all they have an inflammatory component. The present study demonstrates the in vitro anti-inflammatory effect of long-chain fatty alcohols, minor compounds isolated from Evening primrose oil (EPO).

MATERIAL AND METHODS: A mixture of long chain fatty alcohols (LCFAs) was isolated from the non-triacylglycerol fraction of the EPO. Hexacosanol (C26OH: 38.65%), tetracosanol (C24OH: 31.59%), docosanol (C22OH: 11.36%) and octocosanol (C28OH: 7.64%), were the major constituents, identified and quantified by GC and GC-MS. LCFA was tested with LPS stimulated murine peritoneal macrophage. This fraction, significantly and dose-dependently decreased nitric oxide production induced by LPS (P<0.001) and the inhibitory effect seems to be consequence of an action at the level of the inducible nitric-oxide synthethase (iNOS) gene enzyme expression rather than to a direct inhibitory action on enzyme activity. The release of PLA2 and TXB2 also was significantly inhibited by LCFAs (P<0.001) although LCFAs did not affect to PGE2 generation, however the western blot assay showed that LCFAs reduced cyclooxygenase-2 enzyme gene expression at all doses assayed. In the same way, the secretion of inflammatory cytokines interleukin 1β (IL-1β) and tumour necrosis factor α (TNF-α) from LPS-stimulated murine macrophage, were also significantly reduced (P<0.001).

CONCLUSION: These results demonstrates the anti-inflammatory activity of LCFAs, providing an additional value about the role of bioactive minor compounds in the beneficial effect of EPO and supports its traditional uses in inflammatory processes management.