Health & Environmental Research Online (HERO)


Fatty alcohols (112-92-5, 661-19-8, 629-96-9, & 143-28-2)


159 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

RIFM fragrance ingredient safety assessment, (Z)-Octadec-9-enol, CAS Registry Number 143-28-2

Authors: Api, AM; Belsito, D; Botelho, D; Bruze, M; Burton, GA; Buschmann, J; Dagli, ML; Date, M; Dekant, W; Deodhar, C; Francis, M; Fryer, AD; Jones, L; Joshi, K; La Cava, S; Lapczynski, A; Liebler, DC; O'Brien, D; Patel, A; Penning, TM; Ritacco, G; Romine, J; Sadekar, N; Salvito, D; Schultz, TW; Sipes, IG; Sullivan, G; Thakkar, Y; Tokura, Y; Tsang, S (2018) Food and Chemical Toxicology 118:S156-S161. HERO ID: 4929246

[Less] Highlights: • (Z)-Octadec-9-enol, safety assessment based on RIFM's criteria. • Safety assessment . . . [More] Highlights:
• (Z)-Octadec-9-enol, safety assessment based on RIFM's criteria.
• Safety assessment based on 7 human health endpoints plus environmental.
• All endpoints were cleared using target data, read-across, and/or TTC.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Allergic contact dermatitis caused by wet wipes containing steareth-10: Is stearyl alcohol to blame?

Authors: Aerts, O; Naessens, T; Dandelooy, J; Leysen, J; Lambert, J; Apers, S (2017) Contact Dermatitis 77:117-119. HERO ID: 4929237

[Less] Steareths, such as steareth-10 (CAS no. 9005-00-9/13149-86-5), are emulsifiers that are apparently associated . . . [More] Steareths, such as steareth-10 (CAS no. 9005-00-9/13149-86-5), are emulsifiers that are apparently associated with a low risk of sensitization. They are prepared by the chemical reaction of ethylene oxide with stearyl alcohol, and the numerical suffix indicates the average number of ethylene oxide units used. We here report a rare case of allergic contact dermatitis caused by steareth-10 present in makeup-removing wet wipes, and we discuss the residual presence of stearyl alcohol in these wipes as a potential culprit.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Temporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment

Authors: Hao, D; Sarfaraz, MO; Farshidfar, F; Bebb, DG; Lee, CY; Card, CM; David, M; Weljie, AM (2016) Metabolomics 12:58. HERO ID: 4929283

[Less] Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few . . . [More] Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate the feasibility of metabolites as temporal biomarkers of clinical outcomes. Serial serum specimens collected prospectively from lung cancer patients were analyzed using both nuclear magnetic resonance (1H-NMR) spectroscopy and gas chromatography mass spectrometry (GC-MS). Multivariate statistical analysis consisted of unsupervised principal component analysis or orthogonal partial least squares discriminant analysis with significance assessed using a cross-validated ANOVA. The metabolite profiles were reflective of the temporal distinction between patient samples before during and after receiving therapy (1H-NMR, p < 0.001: and GC-MS p < 0.01). Disease progression and survival were strongly correlative with the GC-MS metabolite data whereas stage and cancer type were associated with 1H-NMR data. Metabolites such as hydroxylamine, tridecan-1-ol, octadecan-1-ol, were indicative of survival (GC-MS p < 0.05) and metabolites such as tagatose, hydroxylamine, glucopyranose, and threonine that were reflective of progression (GC-MS p < 0.05). Metabolite profiles have the potential to act as prognostic markers of clinical outcomes for lung cancer patients. Serial 1H-NMR measurements appear to detect metabolites diagnostic of tumor pathology, while GC-MS provided data better related to prognostic clinical outcomes, possibility due to physiochemical bias related to specific biochemical pathways. These results warrant further study in a larger cohort and with various treatment options.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Severe allergic contact dermatitis caused by a rubber glove coated with a moisturizer

Authors: Vanden Broecke, K; Zimerson, E; Bruze, M; Goossens, A (2014) Contact Dermatitis 71:117-119. HERO ID: 4936314

[Less] A 65-year-old non-atopic man presented in 1 July 2012 to the emergency department of our hospital with . . . [More] A 65-year-old non-atopic man presented in 1 July 2012 to the emergency department of our hospital with a well-demarcated severe oedematous and vesicular reaction on the back of his right hand, extending to his wrist and forearm (Fig. 1); on the back of his left hand, he showed only a very discrete papulovesicular itching reaction. Three days previously, he had cleaned his garden shed with ammonia diluted in water by use of a sponge, thereby wearing a rubber glove on his right hand only (Vileda Comfort and Care, Comfort plus, extra-absorbent®; Vileda, Verviers, Belgium), the interior side being coated with a moisturizer, said to contain perfume and chamomile. With the left (ungloved) hand, he had occasionally held the wet sponge. He had noticed that some of the ammonia solution had spilled into the glove, but he had continued cleaning for ∼2 hr without taking it off, without any discomfort. It was only on the next day that the itching, redness and swelling started to develop. The lesions had become really severe, despite using a corticosteroid cream (Fucicort®; Leo, Wilrijk, Belgium). At the emergency unit, the patient received treatment with oral steroids, application of a wet dressing for 15 min twice daily, Diprosone® cream (Schering-Plough, Heist-op-den-Berg, Belgium), and systemic antihistamines and ibuprofen; this was followed by gradual improvement of the skin lesions after 2 weeks; the treatment was further reduced, and a moisturizer was prescribed. However, the patient was seen by us in October, and mentioned that he had stopped using the moisturizer, as it had again produced worsening of his skin lesions.

The patient had been patch tested in 2009, and had been shown to be allergic to cetrimide, (a quaternary ammonium compound), isopropanol, iodine, and povidone iodine, which had been considered to be relevant to skin lesions that he had developed during wound treatment of his left elbow following osteosynthesis. The dermatitis had been treated with Fucicort® cream. Later on, he had experienced a skin reaction on his knee following the application of an ointment, the name of which he could not recall.

As a retired endive farmer, he had been wearing rubber gloves for > 20 years without any skin problems.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages

Authors: Montserrat-De la Paz, S; García-Giménez, MD; Ángel-Martín, M; Pérez-Camino, MC; Fernández Arche, A (2014) Journal of Ethnopharmacology 151:131-136. HERO ID: 2232626

[Less] ETHNOPHARMACOLOGICAL RELEVANCE: Evening primrose (Oenothera biennis L., Onagraceae) . . . [More] ETHNOPHARMACOLOGICAL RELEVANCE: Evening primrose (Oenothera biennis L., Onagraceae) is a wild medicinal plant of Central American origin that is now one of the most widely used herbal medicines in different parts of the world. Oil extracted from it seeds is traditionally used in the treatment of eczema, asthma, rheumatoid arthritis, breast problem, premenstrual and menopausal syndrome, all they have an inflammatory component. The present study demonstrates the in vitro anti-inflammatory effect of long-chain fatty alcohols, minor compounds isolated from Evening primrose oil (EPO).

MATERIAL AND METHODS: A mixture of long chain fatty alcohols (LCFAs) was isolated from the non-triacylglycerol fraction of the EPO. Hexacosanol (C26OH: 38.65%), tetracosanol (C24OH: 31.59%), docosanol (C22OH: 11.36%) and octocosanol (C28OH: 7.64%), were the major constituents, identified and quantified by GC and GC-MS. LCFA was tested with LPS stimulated murine peritoneal macrophage. This fraction, significantly and dose-dependently decreased nitric oxide production induced by LPS (P<0.001) and the inhibitory effect seems to be consequence of an action at the level of the inducible nitric-oxide synthethase (iNOS) gene enzyme expression rather than to a direct inhibitory action on enzyme activity. The release of PLA2 and TXB2 also was significantly inhibited by LCFAs (P<0.001) although LCFAs did not affect to PGE2 generation, however the western blot assay showed that LCFAs reduced cyclooxygenase-2 enzyme gene expression at all doses assayed. In the same way, the secretion of inflammatory cytokines interleukin 1β (IL-1β) and tumour necrosis factor α (TNF-α) from LPS-stimulated murine macrophage, were also significantly reduced (P<0.001).

CONCLUSION: These results demonstrates the anti-inflammatory activity of LCFAs, providing an additional value about the role of bioactive minor compounds in the beneficial effect of EPO and supports its traditional uses in inflammatory processes management.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics

Authors: Fiume, MM; Bergfeld, WF; Belsito, DV; Hill, RA; Klaassen, CD; Liebler, D; Marks, JG; Shank, RC; Slaga, TJ; Snyder, PW; Andersen, FA (2012) International Journal of Toxicology 31:141S-6S. [Review] HERO ID: 4936487

[Less] Stearyl heptanoate is an ester of stearyl alcohol and heptanoic acid that functions in cosmetics as . . . [More] Stearyl heptanoate is an ester of stearyl alcohol and heptanoic acid that functions in cosmetics as a skin conditioning agent and is in the general class of chemicals called stearyl alkanoates. Stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are stearyl alkanoates with similar chemical structures, toxicokinetics, and functions in cosmetics. These water-insoluble stearyl alkanoates, when metabolized, yield stearyl alcohol and a corresponding fatty acid. The available information supports the safety of all of the related stearyl alkanoates. The Expert Panel concluded that stearyl heptanoate, stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are safe in the present practices of use and concentration.

Journal Article
Journal Article

Evaluation of certain food additive and contaminants

Author: WHO (2011) 1-226, back cover. HERO ID: 1497467

[Less] This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the . . . [More] This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various flavouring agents, with a view to concluding as to safety concerns and to preparing specifications for identity and purity. The Committee also evaluated the risk posed by two food contaminants, with the aim of deriving tolerable intakes where appropriate and advising on risk management options for the purpose of public health protection. The first part of the report contains a general discussion of the principles governing the toxicological evaluation of and assessment of dietary exposure to food additives (particularly flavouring agents) and contaminants. A summary follows of the Committee's evaluations of technical, toxicological and dietary exposure data for 12 groups of flavouring agents (alicyclic ketones, secondary alcohols and related esters; alicyclic primary alcohols, aldehydes, acids and related esters; aliphatic acyclic and alicyclic alpha-diketones and related alpha-hydroxyketones; aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances; aliphatic and aromatic amines and amides; aliphatic lactones; aliphatic primary alcohols, aldehydes, carboxylic acids, acetals and esters containing additional oxygenated functional groups; aliphatic secondary alcohols, ketones and related esters and acetals; aromatic substituted secondary alcohols, ketones and related esters; benzyl derivatives; phenol and phenol derivatives; and simple aliphatic and aromatic sulfides and thiols) and two food contaminants (cadmium and lead). Specifications for the following food additives were revised: activated carbon, cassia gum, indigotine, steviol glycosides, sucrose esters of fatty acids, sucrose monoesters of lauric, palmitic or stearic acid and titanium dioxide. Specifications for the following flavouring agents were revised: 4-carvomenthol and 5,6,7,8-tetrahydroquinoxaline. Annexed to the report are tables summarizing the Committee's recommendations for dietary exposures to and toxicological evaluations of the flavouring agents and contaminants considered.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

[Docosanol (Erazaban), dermal use]

(2011) Journal de Pharmacie de Belgique 53-54. HERO ID: 4929335


Journal Article
Journal Article

N-octyl alcohol and n-decyl alcohol; exemption from the requirement of a tolerance

Author: U.S. EPA (2011) Federal Register 76(24):6342-6347. HERO ID: 4940935

[Less] This regulation establishes an exemption from the requirement of a tolerance for residues of n-octyl . . . [More] This regulation establishes an exemption from the requirement of a tolerance for residues of n-octyl alcohol (CAS Reg. No. 111–87–5); and n-decyl alcohol (CAS Reg. No. 112–30–1) when used as an inert ingredient (solvent or co-solvent) in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest under EPA regulations. Technology Sciences Group Inc., on behalf of AMVAC, Chemical Corporation, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of n-octyl alcohol and n-decyl alcohol.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Topical n-docosanol for management of recurrent herpes labialis

Authors: Treister, NS; Woo, SBin (2010) Expert Opinion on Pharmacotherapy 11:853-860. [Review] HERO ID: 4940326

[Less] Importance of the field: Recurrent herpes labialis (RHL) is a significant disorder with social and health . . . [More] Importance of the field: Recurrent herpes labialis (RHL) is a significant disorder with social and health consequences that affects upwards of 20 – 40% of the adult population. Docosanol is the only FDA-approved topical agent that is available over the counter for management of RHL. Its mechanism of action is unique compared with other available antiviral agents.

Areas covered in this review: The authors conducted a comprehensive search of the published preclinical and clinical literature on topical docosanol for RHL. All of the published literature relating to docosanol and its use for the management of recurrent herpes labialis was reviewed, from the first report of docosanol to 31 January 2010.

What the reader will gain: The objective of this review was to summarize and critically evaluate the available literature with respect to topical docosanol's mechanism, safety and efficacy in the management of RHL.

Take home message: Ten percent docosanol cream is a safe and effective topical treatment for the management of RHL in immunocompetent adults, with essentially equivalent efficacy compared with other available prescription topical antiviral agents. Owing to its unique mechanism of action, there is little to no risk of developing resistance.