Health & Environmental Research Online (HERO)


Biphenyl


394 References Were Found:

Technical Report
Technical Report

Integrated Risk Information System Program

Author: U.S. EPA (2015) Washington, DC: U.S. Environmental Protection Agency, IRIS. HERO ID: 192196

[Less] The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) Program provides . . . [More] The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) Program provides health effects information on chemicals to which the public may be exposed, providing a critical part of the scientific foundation for EPA's decisions to protect public health. EPA has made several changes to this important Program over the past few years, streamlining the assessment development process, improving transparency, and creating efficiencies within the Program. In April 2011, the National Research Council (NRC) made several recommendations to EPA for improving the development of IRIS assessments. The N RC's recommendations were focused on the development of draft assessments, and the NRC was clear that their intent was not to delay assessments. EPA has made progress in implementing these recommendations. Consistent with the advice of the NRC, EPA is implementing these recommendations using a phased approach and is making the most extensive changes to documents that are in the earlier steps of the assessment development process. For assessments that are in the later stages of development, including assessments that have been posted on the IRIS database since the release of the NRC report, EPA is implementing the recommendations as feasible without taking the assessments backwards to earlier steps of the process. Phase 1 of implementing the NRC recommendations has focused on editing and streamlining documents and using more tables, figures, and appendices. EPA is now in Phase 2 of implementing the NRC recommendations and will soon publicly release two draft IRIS assessments that represent a major advancement in implementing the NRC recommendations. EPA is using a new document structure for these draft assessments, including an Executive Summary presenting major conclusions, a Preamble describing methods used to develop the assessment, distinct sections on Hazard Identification and Dose-Response Analysis, and more tables and figures to clearly present data. Additionally as part of Phase 2, EPA is addressing all of the short-term recommendations provided by the NRC. As part of this effort, EPA will make several changes to IRIS assessments. Highlights include: evaluating and describing the strengths and weaknesses of critical studies in a more uniform way; including toxicity values for multiple effects associated with the chemical, if applicable and where the data allow; routinely considering the use of multiple data sets of combined multiple responses in deriving toxicity values, where appropriate; and evaluating existing guidelines to establish clearer criteria for study selection. Phase 3 of implementation will incorporate the longer-term scientific recommendations made by the NRC. The U.S. Congress has directed EPA to issue a progress report to the House and Senate Committees on Appropriations and relevant Congressional authorizing committees to describe EPA's implementation of the NRC recommendations. This report provides Congress, stakeholders, and the public with an update on the IRIS Program and EPA's progress toward implementing the NRC recommendations and improving the Program.

Technical Report
Technical Report

Toxiocological review of biphenyl

Author: U.S. EPA (2013) (EPA/635/R-11/005D). HERO ID: 1592150


Technical Report
Technical Report

Toxicological review of biphenyl (CAS 92-52-4). In support of summary information on the Integrated Risk Information System (IRIS)

Author: U.S. EPA (2013) (EPA/635/R-11/005F). U.S. Environmental Protection Agency. HERO ID: 1592071


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Brain pharmacokinetics of non-imidazole biphenyl H3 receptor antagonists: a liquid chromatography/electrospray-mass spectrometry and ex vivo binding study in rats

Authors: Vacondio, F; Silva, C; Flammini, L; Ballabeni, V; Barocelli, E; Mor, M (2012) Chemistry & Biodiversity 9:1231-1239. HERO ID: 1290634

[Less] In the present article, we report on the kinetics of brain penetration in rats of the H3R antagonist . . . [More] In the present article, we report on the kinetics of brain penetration in rats of the H3R antagonist 1,1'-[1,1'-biphenyl-4,4'-diylbis(methylene)]bis-[piperidine] (1), which had shown a favorable in vitro pharmacological profile and in vivo potency in preventing scopolamine-induced amnesia. Two different approaches were employed: high-performance liquid chromatography/electrospray-mass spectrometry (HPLC/ESI-MS) and ex vivo binding against the labeled agonist [(3)H]-(R)-α-methylhistamine ([(3)H]RAMHA). Starting from the structure of 1, the rigid piperidine ring was replaced by a flexible dipropylamino group (see 2) or by a morpholino ring (see 3), endowed with lower basicity. The effect of replacement on rat plasma and brain disposition in the 24 h after administration was analyzed. High (μM) and persistent concentrations of 1 were found in rat plasma, while plasma levels were significantly lower (range: 0-200 nM) for the other two derivatives. This could be explained, among other factors, by the higher stability, observed for 1, to liver metabolic cleavage. The applied chemical modulation had an important effect on in vivo brain disposition, as, despite the comparable physico-chemical properties, 2 did not show the tendency to accumulate within the brain, as stated by its brain vs. plasma concentration ratios, if compared to 1. These structureproperty relationships should be taken into account in the pharmacokinetic optimization of new series of H3 receptor antagonists.

Technical Report
Technical Report

Benchmark dose technical guidance

Author: U.S. EPA (2012) (EPA/100/R-12/001). Washington, DC: U.S. Environmental Protection Agency, Risk Assessment Forum. HERO ID: 1239433


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Reversible acute kidney injury caused by paroxysmal nocturnal hemoglobinuria

Authors: Qi, K; Zhang, XG; Liu, SW; Yin, Z; Chen, XM; Wu, D (2011) HERO ID: 1290531

[Less] The authors report a 57-year-old male patient who presented with diarrhea, darkened urine, jaundice . . . [More] The authors report a 57-year-old male patient who presented with diarrhea, darkened urine, jaundice and increased blood urea nitrogen and creatinine. Initially, his symptoms, which included hemolytic anemia, acute renal failure and low platelet count, seemed to be caused by renal injuries associated with thrombotic microangiopathy, hemolytic-uremic syndrome in particular. However, a renal biopsy indicated acute tubular necrosis and hemosiderin deposition. A CD55 and CD59 assay, Ham test and sugar-water hemolysis test confirmed the diagnosis of paroxysmal nocturnal hemoglobinuria. After fluid infusion, diuresis and urine alkalization, the patient gradually regained nearly normal renal function. This case illustrates that paroxysmal nocturnal hemoglobinuria may present with acute kidney injury when hemolysis, diarrhea and hemosiderin deposits in the renal tubular epithelial cells and renal tubules are present. Early diagnosis and treatment is crucial to prevent disease progression and irreversible chronic renal failure.

Book/Book Chapter
Book/ Chapter

Laboratory assessment of kidney disease: glomerular filtration rate, urinalysis, and proteinuria

Authors: Israni, AK; Kasiske, BL (2011) In Taal, MW; Chertow, GM; Marsden, PA; Skorecki, K; Yu, ASL (Eds.), Brenner & Rector's The Kidney (9th). Philadelphia, PA: Saunders Elsevier. HERO ID: 1576847


Archival Material
Archival Material

E-mail communication from Dr. Kang-Sickel to Yumi Umeda re: Historical control data for BDF1 mouse liver tumors

Author: Kang-Sickel, C. Umeda, Y. (2011) HERO ID: 1592072


Archival Material
Archival Material

E-mail communication from Dr. Kang-Sickel to Dr. Yumi Umeda re: historical control data for BDF1 mouse liver tumors

Author: Kang-Sickel, C. Umeda, Y. (2011) HERO ID: 1592148


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Coordinated expression of cell death genes regulates neuroblast apoptosis

Authors: Tan, Y; Yamada-Mabuchi, M; Arya, R; St Pierre, S; Tang, W; Tosa, M; Brachmann, C; White, K (2011) Development (Cambridge) 138:2197-2206. HERO ID: 782866

[Less] Properly regulated apoptosis in the developing central nervous system is crucial for normal morphogenesis . . . [More] Properly regulated apoptosis in the developing central nervous system is crucial for normal morphogenesis and homeostasis. In Drosophila, a subset of neural stem cells, or neuroblasts, undergo apoptosis during embryogenesis. Of the 30 neuroblasts initially present in each abdominal hemisegment of the embryonic ventral nerve cord, only three survive into larval life, and these undergo apoptosis in the larvae. Here, we use loss-of-function analysis to demonstrate that neuroblast apoptosis during embryogenesis requires the coordinated expression of the cell death genes grim and reaper, and possibly sickle. These genes are clustered in a 140 kb region of the third chromosome and show overlapping patterns of expression. We show that expression of grim, reaper and sickle in embryonic neuroblasts is controlled by a common regulatory region located between reaper and grim. In the absence of grim and reaper, many neuroblasts survive the embryonic period of cell death and the ventral nerve cord becomes massively hypertrophic. Deletion of grim alone blocks the death of neuroblasts in the larvae. The overlapping activity of these multiple cell death genes suggests that the coordinated regulation of their expression provides flexibility in this crucial developmental process.