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Biphenyl




  • 281.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Oxidative and conjugative metabolism of xenobiotics by isolated rat and hamster acinar cells

    Authors: Wiebkin, P; Schaeffer, BK; Longnecker, DS; Curphey, TJ
    (1984) Drug Metabolism and Disposition 12:427-431.
    Minus Sign. Click to see only selected choices. Isolated rat and hamster acinar cell suspensions possess the ability to carry out the cytochrome P-450-dependent . . . Plus Sign. Click to expand choices. Isolated rat and hamster acinar cell suspensions possess the ability to carry out the cytochrome P-450-dependent O-deethylation of 7-ethoxycoumarin, 2-,3-, and 4-hydroxylation of biphenyl and 3-hydroxylation of benzo(a)pyrene. Rat and hamster acinar cells isolated from 5,6-benzoflavone-pretreated animals oxidize all three substrates at measurable rates. These rates are considerably lower (16-210-fold in the rat and 290-2670-fold in the hamster) than those in incubations using hepatocytes isolated from 5,6-benzoflavone-pretreated animals. Hydroxylation of biphenyl at the 2-, 3-, and 4-positions proceeds at similar rates in rat acinar cells. The rate of 3-hydroxybiphenyl formation is barely detectable in hamster acinar cells where the rates of 2- and 4-hydroxybiphenyl formation are slower than in the rat. No detectable oxidation products of 7-ethoxycoumarin, biphenyl, or benzo(a)pyrene are found with acinar cells of either species isolated from untreated and phenobarbital-pretreated animals. The O-deethylation of 7-ethoxycoumarin in rat and hamster acinar cells is decreased in the presence of inhibitors of the cytochrome P-450-dependent monooxygenase system, 7,8-benzoflavone being much more effective than metyrapone. The deethylation product of 7-ethoxycoumarin, 7-hydroxycoumarin, is conjugated with sulfate and glucuronic acid moieties at appreciable rates by acinar cells isolated from both rat and hamster. Pretreatment of rats and hamsters with either 5,6-benzoflavone or phenobarbital has little effect on the rates of conjugation in isolated acinar cell preparations.
    Tagged With: Considered , Cited References, Toxicokinetics
  • 282.
    Book/Book Chapter
    Book/Book
    Chapter
    DNA repair and mutagenesis in liver cultures as indicators in chemical carcinogen screening

    Author: Williams, G
    (1980) In Mehlman, M. (Ed.), Mammalian cell transformation by chemical carcinogens (pp. 273-296). Princeton Junction, NJ: Senate Press.
    Tagged With: Considered

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  • 283.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Further improvements in the hepatocyte primary culture DNA repair test for carcinogens: Detection of carcinogenic biphenyl derivatives

    Author: Williams, GM
    (1978) Cancer Letters 4:69-75.
    Minus Sign. Click to see only selected choices. DNA repair in hepatocyte primary cultures was induced by simultaneous treatment with the carcinogen . . . Plus Sign. Click to expand choices. DNA repair in hepatocyte primary cultures was induced by simultaneous treatment with the carcinogen and [3H] thymidine for 18 h beginning immediately after attachment of cells. The unscheduled DNA synthesis elicited by carcinogens was determined by counting grains with an automatic grain counter. In 5 biphenyl derivatives, a correlation was found between carcinogenicity and the ability to induce DNA repair. Hence, the method offers promise as a means of screening chemical carcinogens.
    Tagged With: Considered , Excluded References, Cited References
  • 284.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals

    Authors: Williams, GM; Mori, H; Mcqueen, CA
    (1989) Mutation Research 221:263-286. [Review]
    Minus Sign. Click to see only selected choices. 312 chemicals/mixtures were tested for genotoxicity in the rat hepatocyte/DNA-repair test. A variety . . . Plus Sign. Click to expand choices. 312 chemicals/mixtures were tested for genotoxicity in the rat hepatocyte/DNA-repair test. A variety of structure-activity relationships was evident. Of the 309 pure chemicals, 142 were positive. Of these, 43 were judged by IARC to have sufficient or limited evidence of carcinogenicity and none of the remainder was a proven noncarcinogen. Among the 167 negative chemicals, 44 were carcinogens. Some of these are known to be genotoxic in other systems, but based on several lines of evidence, many are considered to be epigenetic carcinogens that lack the ability to react with DNA and rather lead to neoplasia by nongenotoxic mechanisms.
    Tagged With: Cited References, Considered , Mechanistic and genotoxic studies, Other studies
  • 285.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Cytogenetic studies of antimicrobials on cultured cells

    Authors: Yoshida, S; Masubuchi, M; Hiraga, K
    (1978) Annual Report of Tokyo Metropolitan Research Laboratory of Public Health 29:86-88.
    Minus Sign. Click to see only selected choices. Inhibition of proliferation and cytogenetic effects on Chinese hamster CHO-KI ovary cells by o-phenylphenol . . . Plus Sign. Click to expand choices. Inhibition of proliferation and cytogenetic effects on Chinese hamster CHO-KI ovary cells by o-phenylphenol (OPP), biphenyl (DIP), thiabendazole (TBZ) and butyl p-hydroxybenzoate (PHB) were studied. DIP showed the strongest inhibition of replication of the cells at concentrations > 50 mug/ml. OPP, PHB and TBZ showed similar degrees of inhibition at concentrations > 100 mug/ml. DIP at 50 mug/ml was a strong inhibitor of colony formation. There was a clear relationship between concentration and effect. OPP gave similar results. TBZ showed inhibition at 100 mug/ml. PHB showed no inhibition up to 100 mug/ml. DIP was the strongest inhibitor of cell proliferation. Effects of these agents on cell chromosomes were not detected up to 48 hr at concentrations of 25-50 mug OPP/ml, 2.5-25 mug DIP/ml, 5-50 mug TBZ/ml and 25-50 mug PHB/ml. It was concluded that none of the chemicals were mutagenic in the cell line tested.
    Tagged With: Considered

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