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Trichloroethylene (TCE) (Final, 2011)

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  • 1.
    Book/Book Chapter
    Book/Book
    Chapter
    Cancer incidence in five continents: Volume VIII

    (2002)
    Minus Sign. Click to see only selected choices. Cancer Incidence in Five Continents (CI5) is the result of the fruitful collaboration between the International . . . Plus Sign. Click to expand choices. Cancer Incidence in Five Continents (CI5) is the result of the fruitful collaboration between the International Agency for Research on Cancer and the network of cancer registries worldwide, represented by the International Association of Cancer Registries. The eighth volume in this series of books on cancer incidence sees an expansion of geographical coverage, with data appearing for the first time from two countries in Asia (Pakistan and Oman) and Europe (Belgium, Lithuania), and with a greatly enhanced contribution from cancer registries in several countries where representation was previously more limited - notably China, India and Korea. Registries are included in the CI5 series only if they meet high standards of completeness and validity. Users of the material can therefore be confident that, in making comparisons of incidence rates within the volume, and with earlier data, any differences observed are not due to artefacts from the registration process. The material presented in Volume VIII contains printed tables in the traditional book, and data that can be inspected on, or printed from the attached CD-ROM. The latter includes the familiar tables - which were previously printed - showing age-specific incidence rates by cancer site and sex, the distribution of cancers by histological type, and age-standardized incidence rates for the 'subsites' (fourth digit codes) of the ICD categories. The CD-ROM also contains the databases used for both Volumes VII and VIII with software to analyse, present or export the information of interest. As a result, the size of the printed volume has been reduced, while it retains the statistical indicators most often required by researchers.
    Tagged With: Hazard, Cancer Epi, All References
  • 2.
    Book/Book Chapter
    Book/Book
    Chapter
    1992 directory of chemical producers: United States of America

    (1992)
    Minus Sign. Click to see only selected choices. The Directory of Chemical Producers (DCP) offers a unique view of global chemical industry producers. . . . Plus Sign. Click to expand choices. The Directory of Chemical Producers (DCP) offers a unique view of global chemical industry producers. Publishing since 1961, the DCP covers 90 countries in nine separate regions, available by searchable Internet service.
    Tagged With: Exposure, All References
  • 3.
    Book/Book Chapter
    Book/Book
    Chapter
    Handbook of carcinogenic potency and genotoxicity databases

    (1997)
    Tagged With: All References, Liver Issues

    Details
       
  • 4.
    Book/Book Chapter
    Book/Book
    Chapter
    Handbook of chemistry and physics

    (1998)
    Tagged With: All References, Exposure

    Details
       
  • 5.
    Book/Book Chapter
    Book/Book
    Chapter
    Risk factors for cancer in the workplace

    (1991)
    Minus Sign. Click to see only selected choices. The Montreal Occupational Cancer Study was the first study to address the problem of discovering occupational . . . Plus Sign. Click to expand choices. The Montreal Occupational Cancer Study was the first study to address the problem of discovering occupational carcinogens by collecting detailed job exposure information in a case-control study. This book presents the methods and results of this ground-breaking study. The core of the book is the set of tables of results describing the statistical associations between nearly 300 occupational exposures and 20 types of cancer. Research methods are explained in detail. The book will surely provide an indispensible reference resource for decades to come for epidemiologists, toxicologists, and environmental health regulators interested in environmental carcinogens.
    Tagged With: All References, Hazard, Cancer Epi, Kidney, Hazard, Immuno, Cancer Epi, Respiratory, Other Cancers, Kidney, Immuno, Respiratory, Repro/Dev, Other Cancers

    Details
       
  • 6.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Reviewed
    Journal
    Article
    A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice

    Authors: Abbas, R; Fisher, JW
    (1997) Toxicology and Applied Pharmacology 147:15-30.
    Minus Sign. Click to see only selected choices. A six-compartment physiologically based pharmacokinetic (PBPK) model for the B6C3F1 mouse was developed . . . Plus Sign. Click to expand choices. A six-compartment physiologically based pharmacokinetic (PBPK) model for the B6C3F1 mouse was developed for trichloroethylene (TCE) and was linked with five metabolite submodels consisting of four compartments each. The PBPK model for TCE and the metabolite submodels described oral uptake and metabolism of TCE to chloral hydrate (CH). CH was further metabolized to trichloroethanol (TCOH) and trichloroacetic acid (TCA). TCA was excreted in urine and, to a lesser degree, metabolized to dichloroacetic acid (DCA). DCA was further metabolized. The majority of TCOH was glucuronidated (TCOG) and excreted in the urine and feces. TCOH was also excreted in urine or converted back to CH. Partition coefficient (PC) values for TCE were determined by vial equilibrium, and PC values for nonvolatile metabolites were determined by centrifugation. The largest PC values for TCE were the fat/blood (36.4) and the blood/air (15.9) values. Tissue/blood PC values for the water-soluble metabolites were low, with all PC values under 2.0. Mice were given bolus oral doses of 300, 600, 1200, and 2000 mg/kg TCE dissolved in corn oil. At various time points, mice were sacrificed, and blood, liver, lung, fat, and urine were collected and assayed for TCE and metabolites. The 1200 mg/kg dose group was used to calibrate the PBPK model for TCE and its metabolites. Urinary excretion rate constant values were 0. 06/hr/kg for CH, 1.14/hr/kg for TCOH, 32.8/hr/kg for TCOG, and 1. 55/hr/kg for TCA. A fecal excretion rate constant value for TCOG was 4.61/hr/kg. For oral bolus dosing of TCE with 300, 600, and 2000 mg/kg, model predictions of TCE and several metabolites were in general agreement with observations. This PBPK model for TCE and metabolites is the most comprehensive PBPK model constructed for P450-mediated metabolism of TCE in the B6C3F1 mouse. Copyright 1997 Academic Press.
    Tagged With: Toxicokinetics, Absorption, Distribution, Metabolism, PBPK Modeling, Hazard, Liver, Respiratory, All References, Exposure, All References
  • 7.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice

    Authors: Abbas, RR; Seckel, CS; Kidney, JK; Fisher, JW
    (1996) Drug Metabolism and Disposition 24:1340-1346.
    Minus Sign. Click to see only selected choices. Chloral hydrate (CH) and its metabolites, trichloroacetate (TCA) and dichloroacetate (DCA), have been . . . Plus Sign. Click to expand choices. Chloral hydrate (CH) and its metabolites, trichloroacetate (TCA) and dichloroacetate (DCA), have been shown to induce liver tumors in male B6C3F1 mice. The pharmacokinetics of CH and its metabolites play an important role in its toxicity. This study was designed to characterize the kinetics of CH metabolism, and the formation and elimination of TCA, DCA, trichloroethanol (TCOH), and trichloroethanol glucuronide (TCOG) in male B6C3F1 mice. Mice were dosed with 67.8, 678, and 2034 micromol/kg of CH through the tail vein. At selected time points, mice were killed, and blood and liver samples were collected. Samples were assayed by GC for CH, TCOH, TCOG, TCA, and DCA concentrations. After intravenous administration, CH rapidly disappeared from blood with a terminal half-life ranging from 5 to 24 min. Systemic clearance decreased from 36.0 to 7.6 liters/kg-hr with increasing CH dose, demonstrating dose-dependent pharmacokinetics. TCOH, TCOG, TCA, and DCA were detected over the study period. Formation and metabolism of CH metabolites seemed to be dose-dependent. The terminal half-lives of TCOH and TCOG were similar, ranging from 0.2 to 0.7 hr. TCA and DCA were formed rapidly from the metabolism of CH and cleared slowly from systemic circulation. The area under the blood concentration-time curve for DCA was 10-20% of that for TCA. Both TCA and DCA were slowly eliminated from systemic circulation. The concentration-time profile of DCA seemed to be driven by the blood concentration of TCA, suggesting the possibility of DCA formation from TCA metabolism.
    Tagged With: Toxicokinetics, PBPK Modeling, All References
  • 8.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Determination of kinetic rate constants for chloral hydrate, trichloroethanol, trichloroacetic acid and dichloroacetic acid: A physiologically based modeling approach

    Authors: Abbas, R; Seckel, CS; MacMahon, KL; Fisher, JW
    (1997)
    Tagged With: Toxicokinetics, PBPK Modeling, All References

    Details
       
  • 9.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Reviewed
    Journal
    Article
    Neurotoxicity induced by exposure to toluene: An electrophysiologic study

    Authors: Abbate, C; Giorgianni, C; Munao, F; Brecciaroli, R
    (1993) International Archives of Occupational and Environmental Health 64:389-392.
    Minus Sign. Click to see only selected choices. The object of the present study was to evaluate, with the aid of electrophysiologic techniques, the . . . Plus Sign. Click to expand choices. The object of the present study was to evaluate, with the aid of electrophysiologic techniques, the alterations induced in the auditory nervous system by exposure to toluene in a group of rotogravure workers. From 300 workers who were apparently in good health but were professionally exposed to toluene, we selected a sample of 40 workers of normal hearing ability. They were examined with an adaptation test studied by the brainstem auditory evoked potential technique with 11 and 90 stimulus repetitions a second. The results were compared with those in a group of workers of the same age but not professionally exposed to solvents. Our study demonstrates that exposure to toluene is able to induce a statistically significant alteration in the electric responses with both 11 and 90 stimuli repetitions. This alteration can be explained as a toluene exposure-induced modification, of physiologic stimulus conduction mechanisms, even in the absence of any clinical sign of neuropathy. Furthermore, such a modification could be observed in the electric responses of the entire auditory system, from peripheral receptors to brainstem nuclei.
    Tagged With: Hazard, Neuro, All References
  • 10.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Isolation from rat kidney of a cytosolic high molecular weight cysteine-S-conjugate beta-lyase with activity toward leukotriene E4

    Authors: Abraham, D; Patel, P; Cooper, A
    (1995) Journal of Biological Chemistry 270:180-188.
    Minus Sign. Click to see only selected choices. A cytosolic high M(r) cysteine-S-conjugate beta-lyase (apparent M(r) of approximately 330,000) has been . . . Plus Sign. Click to expand choices. A cytosolic high M(r) cysteine-S-conjugate beta-lyase (apparent M(r) of approximately 330,000) has been partially purified from rat kidneys. The high M(r) lyase is also present in the mitochondria. The purified enzyme contains at least two proteins with apparent M(r) values of approximately 50,000 and approximately 70,000. Activity is stimulated by dithiothreitol, alpha-keto acids, and pyridoxal 5'-phosphate; aminooxyacetate is an inhibitor. The enzyme catalyzes a competing (half) transamination reaction between pyridoxal 5'-phosphate cofactor and cysteine-S-conjugate substrate; added alpha-keto acids promote conversion of active site pyridoxamine 5'-phosphate to pyridoxal 5'-phosphate. The enzyme also catalyzes a full (but weak) transamination between L-phenylalanine and alpha-keto-gamma-methiolbutyrate. The purified enzyme is not recognized by polyclonal rabbit antibodies to cytosolic rat kidney glutamine transaminase K (another cysteine-S-conjugate beta-lyase of rat kidney) and has no obvious similarities to other pyridoxal 5'-phosphate-containing enzymes. In addition to catalyzing elimination reactions with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,1,2,2-tetrafluoroethyl)-L-cysteine, the enzyme reacts with leukotriene E4 and 5'-S-cysteinyldopamine. Finally, the cytosolic and mitochondrial enzymes are activated by alpha-ketoglutarate. Thus, the possibility must be considered that, in kidneys of animals exposed to various cysteine conjugates, the high M(r) lyase contributes to the generation of pyruvate, ammonia, and reactive fragments in vivo. Many cysteine conjugates are nephrotoxic, and the high M(r) lyase(s) may be involved.
    Tagged With: Toxicokinetics, Metabolism, All References
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