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Trichloroethylene (TCE) (Final, 2011)

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  • 1881.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells

    Authors: Zhou, H; Randers-Pehrson, G; Geard, CR; Brenner, DJ; Hall, EJ; Hei, TK
    (2003) Radiation Research 160:512-516.
    Minus Sign. Click to see only selected choices. Two conflicting phenomena, the bystander effect and the adaptive response, are important in determining . . . Plus Sign. Click to expand choices. Two conflicting phenomena, the bystander effect and the adaptive response, are important in determining biological responses at low doses of radiation and have the potential to have an impact on the shape of the dose-response relationship. Using the Columbia University charged-particle microbeam and the highly sensitive AL cell mutagenic assay, we reported previously that nonirradiated cells acquired mutagenesis through direct contact with cells whose nuclei had previously been traversed with either a single or 20 alpha particles each. Here we show that pretreatment of cells with a low dose of X rays 4 h before alpha-particle irradiation significantly decreased this bystander mutagenic response. Furthermore, bystander cells showed an increase in sensitivity after a subsequent challenging dose of X rays. Results from the present study address some of the pressing issues regarding both the actual target size and the radiation dose response and can improve on our current understanding of radiation risk assessment.
    Tagged With: All References, Hazard, Cancer Epi, Liver Issues
  • 1882.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
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    Article
    Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids

    Authors: Zhou, YC; Waxman, DJ
    (1998) Environmental Health Perspectives 106 Suppl 4:983-988.
    Minus Sign. Click to see only selected choices. Trichloroethylene (TCE) and related hydrocarbons constitute an important class of environmental pollutants . . . Plus Sign. Click to expand choices. Trichloroethylene (TCE) and related hydrocarbons constitute an important class of environmental pollutants whose adverse effects on liver, kidney, and other tissues may, in part, be mediated by peroxisome proliferator-activated receptors (PPARs), ligand-activated transcription factors belonging to the steroid receptor superfamily. Activation of PPAR induces a dramatic proliferation of peroxisomes in rodent hepatocytes and ultimately leads to hepatocellular carcinoma. To elucidate the role of PPAR in the pathophysiologic effects of TCE and its metabolites, it is important to understand the mechanisms whereby PPAR is activated both by TCE and endogenous peroxisome proliferators. The investigations summarized in this article a) help clarify the mechanism by which TCE and its metabolites induce peroxisome proliferation and b) explore the potential role of the adrenal steroid and anticarcinogen dehydroepiandrosterone 3beta-sulfate (DHEA-S) as an endogenous PPAR activator. Transient transfection studies have demonstrated that the TCE metabolites trichloroacetate and dichloroacetate both activate PPAR alpha, a major liver-expressed receptor isoform. TCE itself was inactive when tested over the same concentration range, suggesting that its acidic metabolites mediate the peroxisome proliferative potential of TCE. Although DHEA-S is an active peroxisome proliferator in vivo, this steroid does not stimulate trans-activation of PPAR alpha or of two other PPAR isoforms, gamma and delta/Nuc1, when evaluated in COS-1 cell transfection studies. To test whether PPAR alpha mediates peroxisomal gene induction by DHEA-S in intact animals, DHEA-S has been administered to mice lacking a functional PPAR alpha gene. DHEA-S was thus shown to markedly increase hepatic expression of two microsomal P4504A proteins associated with the peroxisomal proliferative response in wild-type mice. In contrast, DHEA-S did not induce these hepatic proteins in PPAR alpha-deficient mice. Thus, despite its unresponsiveness to steroidal peroxisome proliferators in transfection assays, PPAR alpha is an obligatory mediator of DHEA-S-stimulated hepatic peroxisomal gene induction. DHEA-S, or one of its metabolites, may thus serve as an important endogenous regulator of liver peroxisomal enzyme expression
    Tagged With: All References, Exposure, Hazard, Liver
  • 1883.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
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    Article
    Selected volatile organic compounds in residential air in the city of Ottawa, Canada

    Authors: Zhu, J; Newhook, R; Marro, L; Chan, CC
    (2005) Environmental Science and Technology 39:3964-3971.
    Minus Sign. Click to see only selected choices. Airborne levels of selected volatile organic chemicals (VOCs) that are priorities for exposure assessment . . . Plus Sign. Click to expand choices. Airborne levels of selected volatile organic chemicals (VOCs) that are priorities for exposure assessment under the Canadian Environmental Protection Act (CEPA) 1999 were measured in both indoor air and outdoor air of 75 residential houses, in the city of Ottawa, Canada, during the winter of 2002/2003. The houses were randomly selected using Ottawa 2001 population census data. VOCs were collected on adsorbent tubes and measured by thermal desorption GC/MS. Among 37 chemicals monitored, 17 were detected with a frequency greater than 80% in indoor air; 9 were between 30% and 80%; 7 were between 1% and 30%; and 4 were not detected. Concentrations of VOCs in both indoor and outdoor air are presented. Virtually all of the target VOCs were detected more frequently and were present at significantly higher levels, in indoor air than in outdoor air. As an indication of the contribution of indoor levels of these chemicals, ratios of the concentration found in indoor air to outdoor air (I/O) and the indoor source strength expressed in estimated emission rate per house are also presented. Compared with earlier published studies including a 1991/1992 Canadian national survey of VOCs in residential air, levels of target analytes in indoor air in this study were lower for a number of chemicals, indicating a possible trend toward decreased inhalation exposure to these chemicals in residential environments. This study has yielded up-to-date information on levels of a variety of priority airborne chemicals in residential air, which is being used to estimate current exposure to these substances as input to health risk assessments and risk management actions under CEPA 1999.
    Tagged With: All References, Exposure
  • 1884.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Reviewed
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    [Metabolic implications of benzene and trichloroethylene: Part I: The effect trichloroethylene on phenol elimination in rats]

    Authors: Zielinska-Psuja, B; Orlowski, J; Kowalowka, J; Zieba-Proc, B
    (1998) Bromatologia i Chemia Toksykologiczna 31:13-20.
    Minus Sign. Click to see only selected choices. The influence of three different concentrations of trichloroethylene on urine phenol excretion was studied . . . Plus Sign. Click to expand choices. The influence of three different concentrations of trichloroethylene on urine phenol excretion was studied in rats exposed to equimolar and heteromolar trichloroethylene/benzene mixtures. Three benzene and trichloroethylene concentrations of 1.5, 4.5 and 13.5 mmol/m3 air were used in the experiment. The rats were exposed to the chemicals in a dynamic exposure chamber for five consecutive days, 6 hours daily. After termination of the inhalation, the rate of phenol excretion in urine samples collected during 48 hours since termination of the inhalational exposure was evaluated by gas chromatography. Phenol excretion was inhibited by trichloroethylene in all test groups. In the group exposed to benzene at 1.5 mmol/m3 air, phenol excretion was reduced by trichloroethylene at 1.5, 4.5 and 13.5 mmol/m3 air by 34%, 43% and 63%, respectively. Phenol excretion in rats exposed to benzene at 4.5 mmol/m3 air decreased by 20%, 63% and 80%, respectively. Trichloroethylene at 1.5 and 4.5 mmol/m3 air reduced phenol excretion in rats exposed simultaneously to benzene at 13.5 mmol/m3 air by 31% and 35%, respectively, while the corresponding reduction for 13.5 mmol/m3 air trichloroethylene was 57%.
    Tagged With: All References, Exposure

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  • 1885.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
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    Article
    General health state of women professionally exposed to trichloroethylene vapours

    Author: Zielinski, A
    (1973)
    Tagged With: All References, Hazard, Repro/Dev, Susceptibility

    Details
       
  • 1886.
    Technical Report
    Technical
    Report
    Volatile organic compounds in the nation's ground water and drinking-water supply wells

    Authors: Zogorski, JS; Carter, JM; Ivahnenko, T; Lapham, WW; Moran, MJ; Rowe, BL; Squillace, PJ; Toccalino, PL
    (2006) (Circular 1292). Reston, VA: U.S. Department of the Interior, U.S. Geological Survey.
    Minus Sign. Click to see only selected choices. This report is one of a series of publications, The Quality of Our Nation’s Waters, that describe major . . . Plus Sign. Click to expand choices. This report is one of a series of publications, The Quality of Our Nation’s Waters, that describe major findings of the National Water-Quality Assessment (NAWQA) Program on water-quality issues of national and regional concern. This report is on volatile organic compounds (VOCs) in ground water and drinking-water supply wells. It is a synthesis of NAWQA and other investigations. Fifty-five VOCs are emphasized in NAWQA’s field studies, and these compounds are the focus of this report. During NAWQA’s first decade of Study-Unit investigations, samples from more than 2,500 wells were analyzed for VOCs. In addition, carefully selected VOC data from more than 1,700 well samples were compiled from other agencies or collected in other USGS studies. Collectively, these VOC analyses are the basis for this report’s assessment, which is (1) the first national assessment of a large number of VOCs in the Nation’s aquifers and (2) the most recent national characterization of VOCs in samples from domestic and public wells used for drinking water.
    Tagged With: All References, Exposure
  • 1887.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Chloral hydrate is recombinogenic in the wing spot test in Drosophila melanogaster

    Authors: Zordan, M; Osti, M; Pesce, M; Costa, R
    (1994) Mutation Research 322:111-116.
    Minus Sign. Click to see only selected choices. In order to characterise the response of the wing spot test in Drosophila melanogaster to the effects . . . Plus Sign. Click to expand choices. In order to characterise the response of the wing spot test in Drosophila melanogaster to the effects of compounds with known aneugenic properties, experiments were performed with chloral hydrate (CH). Following chronic exposure of 72-h-old larvae to rising concentrations of CH, significant increases in the frequency of small (1-2 cells) single spots were observed. Comparison of results obtained in parallel from the wings of marker-trans-heterozygous individuals and individuals heterozygous for one of two different balancer chromosomes suggests that practically all the single clones originated from recombinational events. Twin clone frequencies were, however, only weakly affected. These results are discussed with reference to the literature regarding the effects of CH in different experimental systems and to the characteristics of Drosophila as a tester organism.
    Tagged With: All References, Hazard, Genotox, Hazard, Genotox
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