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PCBs (1336-36-3)

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The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Experimental and Theoretical Insights into the Involvement of Radicals in Triclosan Phototransformation

Authors: Kliegman, S; Eustis, SN; Arnold, WA; Mcneill, K (In Press) Environmental Science and Technology. HERO ID: 1609851

[Less] The phototransformation of triclosan has been a matter of longstanding interest due to both its prevalence . . . [More] The phototransformation of triclosan has been a matter of longstanding interest due to both its prevalence in the environment and the discovery of 2,8-dichlorodibenzodioxin as a photoproduct. In this study, photolysis of triclosan resulted in several primary photoproducts including the following: 2,8-dichlorodibenzodioxin (4%), 4,5'-dichloro-[1,1'-biphenyl]-2,2'-diol (10%), 5-chloro-2-(4-chlorophenoxy)phenol (0.5%), and 2,4-dichlorophenol (7%). Trapping studies using d(8)-isopropanol showed deuterium incorporation in 5-chloro-2-(4-chlorophenoxy)phenol, providing strong evidence for the involvement of organic radicals in this reaction. Density functional calculations of the excited states of triclosan support the involvement of a radical intermediate in the mechanisms responsible for the dioxin, biphenyl, and phenoxyphenol photoproducts. The pathways for C-Cl bond cleavage and cyclization reactions are discussed.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

AhR signalling and dioxin toxicity

Author: Sorg, O (In Press) HERO ID: 2149430

[Less] Dioxins are a family of molecules associated to several industrial accidents such as Ludwigshafen in . . . [More] Dioxins are a family of molecules associated to several industrial accidents such as Ludwigshafen in 1953 or Seveso in 1976, to the Agent Orange used during the war of Vietnam, and more recently to the poisoning of the former president of Ukraine, Victor Yushchenko. These persistent organic pollutants are by-products of industrial activity and bind to an intracellular receptor, AhR, with a high potency. In humans, exposure to dioxins, in particular 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a cutaneous syndrome known as chloracne, consisting in the development of many small skin lesions (hamartoma), lasting for 2-5 years. Although TCDD has been classified by the WHO as a human carcinogen, its carcinogenic potential to humans is not clearly demonstrated. It was first believed that AhR activation accounted for most, if not all, biological properties of dioxins. However, certain AhR agonists found in vegetables do not induce chloracne, and other chemicals, in particular certain therapeutic agents, may induce a chloracne-like syndrome without activating AhR. It is time to rethink the mechanism of dioxin toxicity and analyse in more details the biological events following exposure to these compounds and other AhR agonists, some of which have a very different chemical structure than TCDD. In particular various food-containing AhR agonists are non-toxic and may on the contrary have beneficial properties to human health.

Technical Report
Technical Report

[Letter to Dr. Laura Carlson concerning a request for information on Provost et al. 1999]

Author: Provost, T (2019) [Personal Communication] HERO ID: 5020417


Archival Material
Archival Material

[Email to Dr. Laura Carlson regarding study evaluation details on Storm et al. 1981]

Authors: Smith, RF; Carlson, L (2019) [Personal Communication] HERO ID: 5024163


Archival Material
Archival Material

[Email to Laura Carlson related to study quality evaluation for the PCB assessment regarding (Zahalka et al, 2001)]

Author: Lau, C (2019) [Personal Communication] HERO ID: 5024649


Archival Material
Archival Material

[Email to Laura Carlson related to study quality evaluation for the PCB assessment regarding (Gilbert et al, 2000)]

Author: Gilbert, ME (2019) [Personal Communication] HERO ID: 5024650


Archival Material
Archival Material

[Email to Laura Carlson regarding study quality evaluation for Fanini et al. 1990]

Author: Fanini, D (2019) [Personal Communication] HERO ID: 5092212


Archival Material
Archival Material

[Email to Laura Carlson regarding study quality evaluation for Geller et al. 2001]

Authors: Boyes, W; Geller, A; Beasley, T; Oshiro, W (2019) [Personal Communication] HERO ID: 5092213


Archival Material
Archival Material

[Email to Laura Carlson regarding quality details for Reilly et al., 2015]

Author: Gore, AC (2019) [Personal Communication] HERO ID: 5092231


Archival Material
Archival Material

[Email to Laura Carlson regarding study evaluation for (Curran et al., 2011)]

Authors: Curran, C; Nebert, D (2019) [Personal Communication] HERO ID: 5097858