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PCBs (1336-36-3)

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58,362 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Experimental and Theoretical Insights into the Involvement of Radicals in Triclosan Phototransformation

Authors: Kliegman, S; Eustis, SN; Arnold, WA; Mcneill, K (In Press) Environmental Science and Technology. HERO ID: 1609851

[Less] The phototransformation of triclosan has been a matter of longstanding interest due to both its prevalence . . . [More] The phototransformation of triclosan has been a matter of longstanding interest due to both its prevalence in the environment and the discovery of 2,8-dichlorodibenzodioxin as a photoproduct. In this study, photolysis of triclosan resulted in several primary photoproducts including the following: 2,8-dichlorodibenzodioxin (4%), 4,5'-dichloro-[1,1'-biphenyl]-2,2'-diol (10%), 5-chloro-2-(4-chlorophenoxy)phenol (0.5%), and 2,4-dichlorophenol (7%). Trapping studies using d(8)-isopropanol showed deuterium incorporation in 5-chloro-2-(4-chlorophenoxy)phenol, providing strong evidence for the involvement of organic radicals in this reaction. Density functional calculations of the excited states of triclosan support the involvement of a radical intermediate in the mechanisms responsible for the dioxin, biphenyl, and phenoxyphenol photoproducts. The pathways for C-Cl bond cleavage and cyclization reactions are discussed.

Journal Article
Journal Article

Safety and effectiveness of combined scoring balloon and paclitaxel-coated balloon angioplasty for stenosis in the hemodialysis access circuit

Authors: Zheng, J; Cui, J; Meiyan Qing, J; Irani, Z (2019) HERO ID: 5882759

[Less] PURPOSE: To evaluate the safety and effectiveness of combined scoring balloon (SB) . . . [More] PURPOSE: To evaluate the safety and effectiveness of combined scoring balloon (SB) and paclitaxel-coated balloon (PCB) angioplasty for stenosis in the dysfunctional hemodialysis access circuit.

MATERIAL AND METHODS: Patients were referred from outpatient dialysis centers by their nephrologists because of dysfunctional dialysis access circuit. Fistulogram/graftogram was performed by experienced interventional radiologists. Those with in-stent stenosis, stent edge stenosis or vessel diameter at the culprit segment larger than 6mm were excluded. Angioplasty of the stenotic segment was performed with SB and followed by PCB. All study outcomes were defined according to the Society of Interventional Radiology technology assessment committee reporting standards for percutaneous interventional procedures in dialysis access circuit.

RESULTS: A total of 23 patients received combined SB/PCB angioplasty for stenosis of hemodialysis access circuit which included 15 fistulas and 8 grafts. There were 10 men and 13 women with a mean age of 63.3±2.7 (SD) years (range: 37-85years). The technical success and clinical success rates were both 100%. There were no complications during or after the procedures. The target lesion primary patency rates at 3, 6 and 12months were 91.3%, 69.6%, and 45.2%, respectively and the estimated median target lesion restenosis (TLR) free duration was 11.0months (95% confidence interval [CI]: 5.1-16.9months). In patients with a recurrent stenosis, the median TLR-free duration of combined angioplasty was significantly higher than that of prior angioplasty with plain balloon (10.2months [95% CI: 6.4-14.0months] vs. 4.2months [95%CI: 2.1-6.4months]) (P=0.047). The mean TLR-free duration was significantly higher in patients with a juxta-anastomotic stenosis than those with non-juxta-anastomotic lesion (21.3months [95% CI: 14.7-28.0months] vs. 8.2months [95% CI: 5.1-11.4months]) (P=0.004).

CONCLUSION: Combined SB/PCB angioplasty is safe and effective for the hemodialysis access stenosis.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Deposition flux and mass inventory of polychlorinated biphenyls in sediments of the Yangtze River Estuary and inner shelf, East China Sea: Implications for contributions of large-river input and e-waste dismantling

Authors: Zhao, T; Guo, Z; Yao, P; Hu, L; Wu, Z; Lin, T (2019) HERO ID: 5882760

[Less] Surface sediment samples were collected from the Yangtze River Estuary (YRE) to the inner-shelf mud . . . [More] Surface sediment samples were collected from the Yangtze River Estuary (YRE) to the inner-shelf mud area of the East China Sea (ECS) for a comprehensive study of the sources and fates of polychlorinated biphenyls (PCBs) based on their spatial distribution, deposition flux, and mass inventory. The total concentrations of 32 PCBs (Σ32PCBs) varied from 0.3 to 11.9 ng/g dry weight. Under strong hydrodynamic conditions, the weak correlations between TOC or MD and Σ32PCB concentrations were observed in the YRE. In contrast, there were relatively well relationships of PCBs with TOC content and sediment grain size in the inner shelf of the ECS due to the influence of hydrological sorting from the YRE to the inner shelf of the ECS. This suggests that the Yangtze River input plays a considerable role in controlling the distribution of PCBs in the coastal ECS. Compared with the annual discharge of Σ32PCBs from the Yangtze River to the sea (3.21 t/yr), the deposition flux was estimated to be ~2.63 t/yr. Furthermore, a total mass inventory of 50 tons in the sediments suggests that the YRE and inner shelf mud of the ECS represents an important global sink of PCBs. Estimated 21-39% of sedimentary PCBs were derived from local emissions (mainly dismantling of electronic waste) aside from Yangtze River input. Higher proportions of penta-CBs were also observed near the central Zhejiang Coast, providing further evidence that the local emission from e-waste dismantling near the coast is a significant contributor to sedimentary PCBs in the coastal ECS.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Kinetics and reaction pathway of Aroclor 1254 removal by novel bimetallic catalysts supported on activated carbon

Authors: Xu, J; Liu, Y; Tao, F; Sun, Y (2019) HERO ID: 5882769

[Less] Bimetallic catalysts supported on activated carbon (AC) with high metal loadings were prepared by an . . . [More] Bimetallic catalysts supported on activated carbon (AC) with high metal loadings were prepared by an ion-exchange method. AC-supported Ni-Cu, Ni-Zn and Ni-Pd bimetallic catalysts were used to decompose Aroclor 1254, which is one of the most commonly used commercial mix of polychlorinated biphenyls. Characterization by scanning electron microscopy and energy-dispersive X-ray analysis showed that the metals were uniformly distributed on the surfaces and inside the catalysts. The efficiencies of Aroclor 1254 decomposition were measured at different reaction temperatures and times. With increasing temperature, the catalytic activities increased and the activation energies of the reactions decreased, resulting in higher decomposition efficiencies. At 300 °C in a nitrogen atmosphere, Aroclor 1254 decomposition efficiencies of 99.3%, 99.4% and 99.5% were achieved for reactions with Ni-Cu/C, Ni-Zn/C and Ni-Pd/C, respectively. The kinetics and pathway of the decomposition reaction were discussed, and we concluded that the reactivity of the chlorine atoms located on the benzene rings followed the order para-position > meta-position > ortho-position. The PCBs were dechlorinated stepwise to form the final biphenyl product. The design concept and synthetic strategy developed in this study are of great significance in the disposal of chlorinated organic compounds, for use with the existing adsorption technology of AC.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Authors: Schmit, SL; Edlund, CK; Schumacher, FR; Gong, J; Harrison, TA; Huyghe, , JR; Qu, C; Melas, M; Van Den Berg, DJ; Wang, H; Tring, S; Plummer, SJ; Albanes, D; Alonso, MH; Amos, CI; Anton, K; Aragaki, AK; Arndt, V; Barry, EL; Berndt, SI; Bezieau, S; Bien, S; Bloomer, A; Boehm, J; Boutron-Ruault, MC; Brenner, H; Brezina, S; Buchanan, DD; Butterbach, K; Caan, BJ; Campbell, PT; Carlson, CS; Castelao, JE; Chan, AT; Chang-Claude, J; Chanock, SJ; Cheng, I; Cheng, YW; Chin, LS; Church, JM; Church, T; Coetzee, GA; Cotterchio, M; Cruz Correa, M; Curtis, KR; Duggan, D; Easton, DF; English, D; Feskens, EJM; Fischer, R; Fitzgerald, LM; Fortini, BK; Fritsche, LG; Fuchs, CS; Gago-Dominguez, M; Gala, M; Gallinger, SJ; Gauderman, WJ; Giles, GG; Giovannucci, EL; Gogarten, SM; Gonzalez-Villalpando, C; Gonzalez-Villalpando, EM; Grady, WM; Greenson, JK; Gsur, A; Gunter, M; Haiman, CA; Hampe, J; Harlid, S; Harju, JF; Hayes, RB; Hofer, P; Hoffmeister, M; Hopper, JL; Huang, SC; Huerta, JM; Hudson, TJ; Hunter, DJ; Idos, GE; Iwasaki, M; Jackson, RD; Jacobs, EJ; Jee, SH; Jenkins, MA; Jia, WH; Jiao, S; Joshi, AD; Kolonel, LN; Kono, S; Kooperberg, C; Krogh, V; Kuehn, T; Küry, S; Lacroix, A; Laurie, CA; Lejbkowicz, F; Lemire, M; Lenz, HJ; Levine, D; Li, CI; Li, L; Lieb, W; Lin, Y; Lindor, NM; Liu, YR; Loupakis, F; Lu, Y; Luh, F; Ma, J; Mancao, C; Manion, FJ; Markowitz, SD; Martin, V; Matsuda, K; Matsuo, K; Mcdonnell, KJ; Mcneil, CE; Milne, R; Molina, AJ; Mukherjee, B; Murphy, N; Newcomb, PA; Offit, K; Omichessan, H; Palli, D; Cotoré, JPP; Pérez-Mayoral, J; Pharoah, PD; Potter, JD; Qu, C; Raskin, L; Rennert, G; Rennert, HS; Riggs, BM; Schafmayer, C; Schoen, RE; Sellers, TA; Seminara, D; Severi, G; Shi, W; Shibata, D; Shu, XO; Siegel, EM; Slattery, ML; Southey, M; Stadler, ZK; Stern, MC; Stintzing, S; Taverna, D; Thibodeau, SN; Thomas, DC; Trichopoulou, A; Tsugane, S; Ulrich, CM; van Duijnhoven, FJB; van Guelpan, B; Vijai, J; Virtamo, J; Weinstein, SJ; White, E; Win, AK; Wolk, A; Woods, M; Wu, AH; Wu, K; Xiang, YB; Yen, Y; Zanke, BW; Zeng, YX; Zhang, B; Zubair, N; Kweon, SS; Figueiredo, JC; Zheng, W; Marchand, LL; Lindblom, A; Moreno, V; Peters, U; Casey, G; Hsu, L; Conti, DV; Gruber, SB (2019) HERO ID: 5882806

[Less] BACKGROUND: Previous genome-wide association studies (GWAS) have identified 42 loci . . . [More] BACKGROUND: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.

METHODS: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided.

RESULTS: The discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0.

CONCLUSIONS: This study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screening.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Zwitterionic Hydrogels Based on a Degradable Disulfide Carboxybetaine Cross-Linker

Authors: Jain, P; Hung, HC; Li, B; Ma, J; Dong, D; Lin, X; Sinclair, A; Zhang, P; O'Kelly, MB; Niu, L; Jiang, S (2019) HERO ID: 5882885

[Less] We report the synthesis of a zwitterionic carboxybetaine disulfide cross-linker (CBX-SS) and biodegradable . . . [More] We report the synthesis of a zwitterionic carboxybetaine disulfide cross-linker (CBX-SS) and biodegradable poly(carboxybetaine) (PCB) hydrogels and nanocages (NCs) made using this cross-linker. The structure of CBX-SS combines zwitterionic carboxybetaine to confer nonfouling properties and a disulfide linkage to facilitate degradation. The physical, mechanical, and fouling characteristics of PCB hydrogels cross-linked with CBX-SS were investigated. Then, the degradation characteristics of CBX-SS-cross-linked hydrogels were evaluated through their weight loss and release of an encapsulated protein in a reducing environment. Furthermore, CBX-SS was applied to prepare degradable PCB NCs. Results show that encapsulating the highly immunogenic enzyme uricase in degradable PCB NCs eliminates or prevents an in vivo immune response to both the protein and polymer.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The status and distribution of PCBs along the coast of Vietnam

Authors: Hanh, PTM; Nghi, DT; Lan, TD; Van Quan, N; Ba, DT; Viet, PH (2019) HERO ID: 5882906

[Less] Polychlorinated biphenyls (PCBs), well-known as an important scientific achievement, are now considered . . . [More] Polychlorinated biphenyls (PCBs), well-known as an important scientific achievement, are now considered as one of the most persistent organic pollutants (POPs) that need to be strictly controlled and forbidden worldwide (the Stockholm convention on POPs). Vietnam is one of the countries that encounters with serious issues from PCB contamination. This study presented a comprehensive review on the status and contamination of PCBs along the coast of Vietnam. The contaminated PCBs data in the water, sediment and biological samples from 18 provinces along Vietnam coastline were collected from various sources. A comparison in PCBs contamination between Vietnam and other Asian countries was included. The status on PCBs contamination in Vietnam since participated as a party of the Stockholm convention on POPs in 2002 was also assessed. The results showed that Vietnam is facing serious PCBs contamination problems as it evidences the spread and accumulation of PCBs in the marine environment. The implementation of the Stockholm convention on POPs (PCBs in particular) has not yet demonstrated significant effect on the reduction in PCBs contamination in the environment. This information on PCBs contamination in Vietnam urges government to strengthen the mechanism, policy and legislation, the management capacity for PCBs as well as applying advanced and modern technologies in reducing, disposing and eliminating PCBs from the environment.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes

Authors: Furue, M; Uchi, H; Mitoma, C; Hashimoto-Hachiya, A; Tanaka, Y; Ito, T; Tsuji, G (2019) HERO ID: 5882919

[Less] Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen . . . [More] Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen species (ROS) and mediates photocarcinogenesis and photoaging. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct generated by UVB exposure. FICZ exhibits similar biological effects to UVB, including AHR ligation and ROS production. FICZ also acts as a potent photosensitizer for UVA and the production of ROS is synergistically augmented in the simultaneous presence of FICZ and UVA. In contrast, FICZ upregulates the expression of terminal differentiation molecules such as filaggrin and loricrin via AHR. In parallel with this, the administration of FICZ inhibits skin inflammation in a murine psoriasis and dermatitis model. In this article, we summarize the harmful and beneficial aspects of FICZ in skin pathology.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Biomonitoring programs in Michigan, Minnesota and New York to assess human exposure to Great Lakes contaminants

Authors: Wattigney, WA; Irvin-Barnwell, E; Li, Z; Davis, SI; Manente, S; Maqsood, J; Scher, D; Messing, R; Schuldt, N; Hwang, SA; Aldous, KM; Lewis-Michl, EL; Ragin-Wilson, A (2019) HERO ID: 5883062

[Less] Over the past century, industrialization and urban practices have resulted in the contamination of the . . . [More] Over the past century, industrialization and urban practices have resulted in the contamination of the Great Lakes ecosystem-the world's largest surface freshwater system-that provides drinking water and recreation to more than 40 million residents. In 2010, the Great Lakes Restoration Initiative was launched to accelerate efforts to protect and restore the Great Lakes and surrounding areas. Funded by GLRI, the Agency for Toxic Substances and Disease Registry initiated the Biomonitoring of Great Lakes Populations (BGLP) program. The objective of the program is to assess human exposure to legacy and emerging contaminants in the Great Lakes by measuring the body burden of contaminants in potentially susceptible populations. The BGLP program consists of a series of cross-sectional studies carried out collaboratively with states that are funded through ATSDR. The first BGLP Program (BGLP-I) began in 2010 and was completed in September 2015 through cooperative agreements with state health departments in Michigan, Minnesota, and New York. The three state programs targeted susceptible adult populations living in designated areas of contamination. Contaminants measured in all populations include mercury, lead, mirex, hexachlorobenzene, dichlorodiphenyltrichloroethane, and selected polychlorinated biphenyl congeners. In addition, some chemicals of emerging concern, such as per- and polyfluoroalkyl substances, were measured in several populations. The biomonitoring results helped guide public health actions to mitigate chemical exposures in these vulnerable Great Lakes populations. We provide an overview of the BGLP-I program's study populations, designs, and general methods. This overview provides a lead-in for subsequent manuscripts that present human biomonitoring data for legacy and emerging contaminants in culturally diverse susceptible populations-i.e., shoreline anglers, sport anglers, American Indians, and Burmese immigrants-residing in seven areas of concern.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

In vivo effects of PCB-126 and genistein on vitellogenin expression in zebrafish

Authors: Licata, P; Tardugno, R; Pergolizzi, S; Capillo, G; Aragona, M; Colombo, A; Gervasi, T; Pellizzeri, V; Cicero, N; Calò, M (2019) HERO ID: 5883166

[Less] In this study, the vitellogenin (Vtg) modulation by genistein and polychlorinated biphenyl-126 (PCB-126) . . . [More] In this study, the vitellogenin (Vtg) modulation by genistein and polychlorinated biphenyl-126 (PCB-126) exposure in zebrafishes has been investigated. Both PCB-126 and genistein have been identified as aquatic pollutants and can further increase estrogenicity of waterways. Vtg is egg yolk precursor protein release by the hepatocytes during vitellogenesis. This process occurs normally in the hepatocytes in response to the activation with the estrogens such as 17-β-estradiol. Our immunohistochemical findings showed a Vtg expression that increases at 12 h and at 72 h in the liver of treated fishes with both PCB-126 and genistein, individually and in combination. Furthermore, for the first time, also hepatic stellate cells (HSC) in the liver parenchyma were strongly positive for vitellogenin.