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Tetrachloroethylene (Perc) (Final, 2012)

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  • 1.
    Book/Book Chapter
    Book/Book
    Chapter
    Biological monitoring and surveillance of workers exposed to chemicals

    (1984)
    Minus Sign. Click to see only selected choices. This book contains the proceedings of a symposium held in Finland in 1980, attended wholly by European . . . Plus Sign. Click to expand choices. This book contains the proceedings of a symposium held in Finland in 1980, attended wholly by European experts. The 8 sections following the introductory 2 chapters deal with the biological monitoring of metals and metalloids, industrial solvents, "miscellaneous compounds", combined exposures, cancer risk and genotoxic chemicals as well as sources of error and quality control, early organ effects in surveillance, and future developments. Contents: Objectives, theory and practice; metals and metalloids (lead, mercury, cadmium, chromium, nickel, arsenic); industrial solvents (benzene, xylene, styrene, trichloroethylene, tetrachloroethylene, 1,1,1-trichloroethane, dimethylformamide); other compounds (carbon monoxide, phenol, aniline, nitrobenzene, fluorides, ethylene glycol dinitrate, N-nitroso compounds, pesticides); combined exposures (chemical and biochemical interactions, solvents and ethanol, urinary thioether excretion, enzyme induction); sources of error and quality control; early organ effects; cancer risk and genotoxic chemicals; development and future prospects of biological monitoring
    Tagged With: All References, Exposure

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  • 2.
    Book/Book Chapter
    Book/Book
    Chapter
    CRC Handbook of Chemistry and Physics

    (1990) Boca Raton, FL: CRC Press.
    Tagged With: Exposure

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  • 3.
    Journal Article
    Journal
    Article
    Determination not to initiate a rebuttable presumption against registration (RPAR) of pesticide products containing carbaryl; availability of decision document

    (1980)
    Abstract: N/A.
    Tagged With: All References, Exposure

    Details
       
  • 4.
    Book/Book Chapter
    Book/Book
    Chapter
    Environmental toxicology and pharmacology of human development

    (1997)
    Tagged With: Exposure

    Details
       
  • 5.
    Journal Article
    Journal
    Article
    Proposed guidelines for registering pesticides in the United States; hazard evaluation: humans and domestic animals

    (1978)
    Tagged With: All References, Exposure

    Details
       
  • 6.
    Journal Article
    Journal
    Article
    Proposed health effects test standards for toxic substances control act test rules and proposed good laboratory practice standards for health effects

    (1979)
    Tagged With: All References, Exposure

    Details
       
  • 7.
    Book/Book Chapter
    Book/Book
    Chapter
    Risk factors for cancer in the workplace

    (1991)
    Minus Sign. Click to see only selected choices. The Montreal Occupational Cancer Study was the first study to address the problem of discovering occupational . . . Plus Sign. Click to expand choices. The Montreal Occupational Cancer Study was the first study to address the problem of discovering occupational carcinogens by collecting detailed job exposure information in a case-control study. This book presents the methods and results of this ground-breaking study. The core of the book is the set of tables of results describing the statistical associations between nearly 300 occupational exposures and 20 types of cancer. Research methods are explained in detail. The book will surely provide an indispensible reference resource for decades to come for epidemiologists, toxicologists, and environmental health regulators interested in environmental carcinogens.
    Tagged With: All References, Cancer Epi, Hazard, Immuno, Kidney, Other Cancers, Repro/Dev, Respiratory

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  • 8.
    Journal Article
    Journal
    Article
    Tetrachloroethylene: water quality criteria

    (1979)
    Tagged With: All References, Exposure

    Details
       
  • 9.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Aneuploidy: A report of an ECETOC task force

    Authors: Aardema, MJ; Albertini, S; Arni, P; Henderson, LM; Kirsch-Volders, M; Mackay, JM; Sarrif, AM; Stringer, DA; Taalman, RDF
    (1998) Mutation Research: Reviews in Mutation Research 410:3-79. [Review]
    Minus Sign. Click to see only selected choices. Aneuploidy plays a significant role in adverse human health conditions including birth defects, pregnancy . . . Plus Sign. Click to expand choices. Aneuploidy plays a significant role in adverse human health conditions including birth defects, pregnancy wastage and cancer. Although there is clear evidence of chemically induced aneuploidy in experimental systems, to date there are insufficient data to determine with certainty if chemically induced aneuploidy contributes to human disease. However, since there is no reason to assume that chemically induced aneuploidy will not occur in human beings, it is prudent to address the aneugenic potential of chemicals in the safety assessment process. A wide range of methods has been described for the detection of chemically induced aneuploidy including subcellular systems, tests with fungi, plants and Drosophila as well as in vitro mammalian systems and in vivo mammalian somatic and germ cell assays. However, none of these methods is sufficiently validated or widely used in routine screening. Underlying the efforts to develop aneuploidy-specific assays is the presumption that current genetic toxicology tests do not detected chemicals that have aneuploidy-inducing potential. To address this, we have critically evaluated data from standard genetic toxicology assays for 16 known or suspected aneugens. The conclusions from the review are listed below. 1. At present there are only nine chemicals that can be classified as definitive aneugens, as determined by positive results in in vivo rodent assays. 2. As expected, the majority of definitive and suspected aneugens are negative in the bacterial mutation assay. 3. The majority of definitive aneugens evaluated induce polyploidy in vitro. With few exception, they also induced structural chromosome aberrations in vitro. 4. All of the definitive aneugens that have been sufficiently tested induce micronuclei in rodent bone marrow cells in vivo. A number of these chemicals also induced structural chromosome aberrations in vivo. 5. There is no evidence for a unique germ cell aneugen, that is a chemical that induces aneuploidy in germ cells and not in somatic cells. Furthermore, an analysis of several databases indicates the proportion of chemicals which induce polyploidy and not chromosome aberrations in vitro is low. Based on these conclusions, the following recommendations are made: for screening purposes, a standard genotoxicity test battery (including an in vitro cytogenetic assay with an assessment of polyploidy and clastogenicity at the same harvest time) should be performed; in the absence of polyploidy induction in vitro no further evaluation of aneuploidy-inducing potential is needed; if polyploidy is observed, in vitro follow-up testing to investigate further the aneuploidy-inducing potential should be conducted; such follow-up testing will generally start with the conduct of a standard in vivo somatic cell micronucleus assay; if the in vivo somatic cell micronucleus assay is negative, with adequate evidence of exposure of the bone marrow to the test compound, no further testing of aneuploidy-inducing potential is needed; if the in vivo somatic cell micronucleus assay is positive, further information on mechanisms of micronucleus induction can be obtained by using kinetochore/centromeric staining in vitro and/or in vivo; an assessment of potential germ cell aneuploidy activity may then be considered; aneuploidy induction which does not involve the direct interaction of a chemical or its metabolite(s) with DNA is expected to have a threshold. This must be considered in the risk assessment of such chemicals; this is not addressed by current risk assessment guidelines.
    Tagged With: All References, Exposure
  • 10.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice

    Authors: Abbas, R; Fisher, JW
    (1997) Toxicology and Applied Pharmacology 147:15-30.
    Minus Sign. Click to see only selected choices. A six-compartment physiologically based pharmacokinetic (PBPK) model for the B6C3F1 mouse was developed . . . Plus Sign. Click to expand choices. A six-compartment physiologically based pharmacokinetic (PBPK) model for the B6C3F1 mouse was developed for trichloroethylene (TCE) and was linked with five metabolite submodels consisting of four compartments each. The PBPK model for TCE and the metabolite submodels described oral uptake and metabolism of TCE to chloral hydrate (CH). CH was further metabolized to trichloroethanol (TCOH) and trichloroacetic acid (TCA). TCA was excreted in urine and, to a lesser degree, metabolized to dichloroacetic acid (DCA). DCA was further metabolized. The majority of TCOH was glucuronidated (TCOG) and excreted in the urine and feces. TCOH was also excreted in urine or converted back to CH. Partition coefficient (PC) values for TCE were determined by vial equilibrium, and PC values for nonvolatile metabolites were determined by centrifugation. The largest PC values for TCE were the fat/blood (36.4) and the blood/air (15.9) values. Tissue/blood PC values for the water-soluble metabolites were low, with all PC values under 2.0. Mice were given bolus oral doses of 300, 600, 1200, and 2000 mg/kg TCE dissolved in corn oil. At various time points, mice were sacrificed, and blood, liver, lung, fat, and urine were collected and assayed for TCE and metabolites. The 1200 mg/kg dose group was used to calibrate the PBPK model for TCE and its metabolites. Urinary excretion rate constant values were 0. 06/hr/kg for CH, 1.14/hr/kg for TCOH, 32.8/hr/kg for TCOG, and 1. 55/hr/kg for TCA. A fecal excretion rate constant value for TCOG was 4.61/hr/kg. For oral bolus dosing of TCE with 300, 600, and 2000 mg/kg, model predictions of TCE and several metabolites were in general agreement with observations. This PBPK model for TCE and metabolites is the most comprehensive PBPK model constructed for P450-mediated metabolism of TCE in the B6C3F1 mouse. Copyright 1997 Academic Press.
    Tagged With: All References, All References, Exposure, Toxicokinetics, Absorption, Distribution, Metabolism, PBPK Modeling, Hazard, Liver, Respiratory
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