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Citation
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HERO ID
1005409
Reference Type
Journal Article
Title
Lung function in asbestos-exposed workers, a systematic review and meta-analysis
Author(s)
Wilken, D; Velasco Garrido, M; Manuwald, U; Baur, X
Year
2011
Is Peer Reviewed?
1
Journal
Journal of Occupational Medicine and Toxicology
EISSN:
1745-6673
Volume
6
Page Numbers
21
Language
English
PMID
21791077
DOI
10.1186/1745-6673-6-21
Web of Science Id
WOS:000208615800021
Abstract
BACKGROUND:
A continuing controversy exists about whether, asbestos exposure is associated with significant lung function impairments when major radiological abnormalities are lacking. We conducted a systematic review and meta-analysis in order to assess whether asbestos exposure is related to impairment of lung function parameters independently of the radiological findings.
METHODS:
MEDLINE was searched from its inception up to April 2010. We included studies that assessed lung function parameters in asbestos exposed workers and stratified subjects according to radiological findings. Estimates of VC, FEV1 and FEV1/VC with their dispersion measures were extracted and pooled.
RESULTS:
Our meta-analysis with data from 9,921 workers exposed to asbestos demonstrates a statistically significant reduction in VC, FEV1 and FEV1/VC, even in those workers without radiological changes. Less severe lung function impairments are detected if the diagnoses are based on (high resolution) computed tomography rather than the less sensitive X-ray images. The degree of lung function impairment was partly related to the proportion of smokers included in the studies.
CONCLUSIONS:
Asbestos exposure is related to restrictive and obstructive lung function impairment. Even in the absence of radiological evidence of parenchymal or pleural diseases there is a trend for functional impairment.
Keywords
Asbestos; lung function; chest X-ray; computed tomography; meta-analysis
Tags
IRIS
•
Libby Amphibole Asbestos (Draft, 2011)
Pulmonary Function Search, Sept 2013
Database Search
Full Text Screening
Not primary source but additional resource
OPPT REs
•
OPPT_Asbestos, Part I: Chrysotile_C. Engineering
Total – title/abstract screening
On topic
Peer review
Secondary source/Review
•
OPPT_Asbestos, Part I: Chrysotile_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_F. Human Health
Total – title/abstract screening
On topic
Peer review
Secondary source/ Review
On topic - additional tags for titles/abstracts
Human hazard ID
•
OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
LitSearch: Sept 2020 (Undated)
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