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1027364 
Journal Article 
EXPERIMENTAL ACUTE NEPHRITIS : A STUDY OF THE ACIDOSIS, NITROGEN AND CHLORIDE RETENTION, AND OF THE PROTECTIVE ACTION OF SODIUM BICARBONATE 
Goto, K 
1918 
Yes 
Journal of Experimental Medicine
ISSN: 0022-1007
EISSN: 1540-9538 
27 
3 
413-424 
English 
19868214 
1. In experimental nephritis caused by cantharidin, arsenic, diphtheria toxin, and potassium chromate, in addition to the retention of the non-protein and urea nitrogen and of the chlorides in blood, an acidosis occurs. 2. Sodium bicarbonate given by the stomach has the power of diminishing the acidosis in these types of nephritis. 3. The degree of increase in the non-protein and urea nitrogen content in the blood in mild nephritis varies considerably in different dogs receiving the same dose per kilo of a given poison. 4. Histological examination shows little if any influence resulting from the administration of sodium bicarbonate upon the grade of the nephritis induced by the poisons. 
IRIS
• Arsenic Hazard ID
     1. Initial Lit Search
          PubMed
          ToxNet
     4. Considered through Oct 2015
     6. Cluster Filter through Oct 2015
• Arsenic (Inorganic)
     1. Literature
          PubMed
          Toxline, TSCATS, & DART
     4. Adverse Outcome Pathways/Networks Screening
          Excluded/Not relevant
               Title/Abstract screening
• Arsenic MOA
     1. MOA Literature Screening
          MOA Cluster
     3. Excluded
          Other not relevant
               Dragon Screened
• Chromium VI
     Considered
          Potentially Relevant Supplemental Material
               Mechanistic