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Citation
Tags
HERO ID
1027372
Reference Type
Journal Article
Title
CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS
Author(s)
Brown, WH; Pearce, L
Year
1915
Is Peer Reviewed?
Yes
Journal
Journal of Experimental Medicine
ISSN:
0022-1007
EISSN:
1540-9538
Volume
22
Issue
5
Page Numbers
535-543
Language
English
PMID
19867936
Abstract
1. Toxic doses of all arsenicals of which we have any knowledge produce definite pathological changes in the adrenals of guinea pigs. These changes include congestion, hemorrhage, disturbances in the lipoid content, cellular degenerations and necroses, and reduction in the chromaffin content. 2. The character and severity of the injury produced by different arsenicals varies with the chemical constitution of the compounds. 3. From these facts, we believe that adrenal injury is an important factor in arsenical intoxication and suggest that therapeutic doses of some arsenicals may produce adrenal stimulation.
Tags
IRIS
•
Arsenic Hazard ID
1. Initial Lit Search
PubMed
ToxNet
4. Considered through Oct 2015
6. Cluster Filter through Oct 2015
•
Arsenic (Inorganic)
1. Literature
PubMed
Toxline, TSCATS, & DART
4. Adverse Outcome Pathways/Networks Screening
Excluded/Not relevant
Title/Abstract screening
•
Arsenic MOA
1. MOA Literature Screening
MOA Cluster
3. Excluded
Other not relevant
Dragon Screened
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