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HERO ID
1056128
Reference Type
Journal Article
Title
The impact of environmental metals in young urbanites' brains
Author(s)
Calderón-Garcidueñas, L; Serrano-Sierra, A; Torres-Jardón, R; Zhu, H; Yuan, Y; Smith, D; Delgado-Chávez, R; Cross, JV; Medina-Cortina, H; Kavanaugh, M; Guilarte, TR
Year
2013
Is Peer Reviewed?
Yes
Journal
Experimental and Toxicologic Pathology
ISSN:
0940-2993
EISSN:
1618-1433
Volume
65
Issue
5
Page Numbers
503-511
Language
English
PMID
22436577
DOI
10.1016/j.etp.2012.02.006
Web of Science Id
WOS:000322292700006
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878363193&doi=10.1016%2fj.etp.2012.02.006&partnerID=40&md5=00d35369276d6dd9d0c53cbfbbe6acca
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Abstract
Air pollution exposures are linked to cognitive and olfaction deficits, oxidative stress, neuroinflammation and neurodegeneration including frontal hyperphosphorylated tau and diffuse amyloid plaques in Mexico City children and young adults. Mexico City residents are chronically exposed to fine particulate matter (PM(2.5)) concentrations (containing toxic combustion and industrial metals) above the annual standard (15μg/m(3)) and to contaminated water and soil. Here, we sought to address the brain-region-specific effects of metals and key neuroinflammatory and DNA repair responses in two air pollution targets: frontal lobe and olfactory bulb from 12 controls vs. 47 Mexico City children and young adults average age 33.06±4.8 SE years. Inductively coupled plasma mass spectrometry (metal analysis) and real time PCR (for COX2, IL1β and DNA repair genes) in target tissues. Mexico City residents had higher concentrations of metals associated with PM: manganese (p=0.003), nickel and chromium (p=0.02) along with higher frontal COX2 mRNA (p=0.008) and IL1β (p=0.0002) and COX2 (p=0.005) olfactory bulb indicating neuroinflammation. Frontal metals correlated with olfactory bulb DNA repair genes and with frontal and hippocampal inflammatory genes. Frontal manganese, cobalt and selenium increased with age in exposed subjects. Together, these findings suggest PM-metal neurotoxicity causes brain damage in young urbanites, the olfactory bulb is a target of air pollution and participates in the neuroinflammatory response and since metal concentrations vary significantly in Mexico City urban sub-areas, place of residency has to be integrated with the risk for CNS detrimental effects particularly in children.
Keywords
Air pollution; Children; DNA repair; Frontal; Humans; Lungs; Megacities; Metals; Manganese; Olfactory bulb; Fine particulate matter PM2.5
Tags
IRIS
•
Cobalt
LitSearch: January 2008 - August 2018
PubMed
WoS
•
Methylmercury
Literature Search: Jan 1998 - March 2017
Science Direct
•
ISA-PM (2019)
Considered
1st Draft
Chapter 4
Final ISA
Chapter 4
•
PM Provisional Assessment (2012 Project Page)
Epidemiological Studies
Non-U.S.
Other (CNS, cancer)
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