Long-term exposure to traffic-related air pollution associated with blood pressure and self-reported hypertension in a Danish cohort
Sørensen, M; Hoffmann, B; Hvidberg, M; Ketzel, M; Jensen, SS; Andersen, ZJ; Tjønneland, A; Overvad, K; Raaschou-Nielsen, O
HERO ID
1065945
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 1065945 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Long-term exposure to traffic-related air pollution associated with blood pressure and self-reported hypertension in a Danish cohort |
| Authors | Sørensen, M; Hoffmann, B; Hvidberg, M; Ketzel, M; Jensen, SS; Andersen, ZJ; Tjønneland, A; Overvad, K; Raaschou-Nielsen, O |
| Journal | Environmental Health Perspectives |
| Volume | 120 |
| Issue | 3 |
| Page Numbers | 418-424 |
| Abstract | <strong>BACKGROUND: </strong>Short-term exposure to air pollution has been associated with changes in blood pressure (BP) and emergency department visits for hypertension, but little is known about the effects of long-term exposure to traffic-related air pollution on BP and hypertension.<br /><br /><strong>OBJECTIVES: </strong>We studied whether long-term exposure to air pollution is associated with BP and hypertension.<br /><br /><strong>METHODS: </strong>In 1993-1997, 57,053 participants 50-64 years of age were enrolled in a population-based cohort study. Systolic and diastolic BP (SBP and DBP, respectively) were measured at enrollment. Self-reported incident hypertension during a mean follow-up of 5.3 years was assessed by questionnaire. We used a validated dispersion model to estimate residential long-term nitrogen oxides (NO(x)), a marker of traffic-related air pollution, for the 1- and 5-year periods prior to enrollment and before a diagnosis of hypertension. We conducted a cross-sectional analysis of associations between air pollution and BP at enrollment with linear regression, adjusting for traffic noise, measured short-term NO(x), temperature, relative humidity, and potential lifestyle confounders (n = 44,436). We analyzed incident hypertension with Cox regression, adjusting for traffic noise and potential confounders.<br /><br /><strong>RESULTS: </strong>A doubling of NO(x) exposure during 1- and 5-year periods preceding enrollment was associated with 0.53-mmHg decreases [95% confidence interval (CI): -0.88, -0.19 mmHg] and 0.50-mmHg decreases (95% CI: -0.84, -0.16 mmHg) in SBP, respectively. Long-term exposure also was associated with a lower prevalence of baseline self-reported hypertension (per doubling of 5-year mean NO(x): odds ratio = 0.96; 95% CI: 0.91, 1.00), whereas long-term NO(x) exposure was not associated with incident self-reported hypertension during follow-up.<br /><br /><strong>CONCLUSIONS: </strong>Long-term exposure to traffic-related air pollution was associated with a slightly lower prevalence of BP at baseline, but was not associated with incident hypertension. |
| Doi | 10.1289/ehp.1103631 |
| Pmid | 22214647 |
| Wosid | WOS:000301394700031 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000301394700031 |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution; blood pressure; hypertension; epidemiology; nitrogen oxide |
| Is Qa | No |