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Citation
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HERO ID
1071825
Reference Type
Journal Article
Subtype
Review
Title
Assessing nanoparticle toxicity
Author(s)
Love, SA; Maurer-Jones, MA; Thompson, JW; Lin, YS; Haynes, CL
Year
2012
Is Peer Reviewed?
Yes
Journal
Annual Review of Analytical Chemistry
ISSN:
1936-1327
Volume
5
Page Numbers
181-205
Language
English
PMID
22524221
DOI
10.1146/annurev-anchem-062011-143134
URL
https://www.annualreviews.org/doi/pdf/10.1146/annurev-anchem-062011-143134
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Abstract
Nanoparticle toxicology, an emergent field, works toward establishing the hazard of nanoparticles, and therefore their potential risk, in light of the increased use and likelihood of exposure. Analytical chemists can provide an essential tool kit for the advancement of this field by exploiting expertise in sample complexity and preparation as well as method and technology development. Herein, we discuss experimental considerations for performing in vitro nanoparticle toxicity studies, with a focus on nanoparticle characterization, relevant model cell systems, and toxicity assay choices. Additionally, we present three case studies (of silver, titanium dioxide, and carbon nanotube toxicity) to highlight the important toxicological considerations of these commonly used nanoparticles. Expected final online publication date for the Annual Review of Analytical Chemistry Volume 5 is June 15, 2012. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
Keywords
in vitro; characterization; assay; silver; titanium dioxide; carbon nanotube
Tags
•
Nanoscale Carbon
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