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HERO ID
1071956
Reference Type
Journal Article
Title
Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice
Author(s)
Fujitani, T; Ohyama, K; Hirose, A; Nishimura, T; Nakae, D; Ogata, A
Year
2012
Is Peer Reviewed?
1
Journal
Journal of Toxicological Sciences
ISSN:
0388-1350
EISSN:
1880-3989
Volume
37
Issue
1
Page Numbers
81-89
Language
English
PMID
22293413
Abstract
A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs were suspended in 2% carboxymethyl cellulose and given intraperitoneally or intra-tracheally to pregnant ICR mice on day 9 of the gestation. All fetuses were removed from the uterus on day 18 of the gestation, and were examined for external and skeletal anomalies. In the intraperitoneal study, various types of malformation were observed in all MWCNT-treated groups (2, 3, 4 and 5 mg/kg body weight, intraperitoneal). In contrast, such malformations were observed in groups given 4 or 5 mg/kg body weight, but not in that treated with 3 mg/kg in the intratracheal study. In either study, the number of litters having fetuses with external malformation and that of litters having fetuses with skeletal malformations were both increased in proportion to the doses of MWCNT. The present results are the first to report that MWCNT possesses the teratogenicity at least under the present experimental conditions. Mechanism(s) to result such malformations is yet unclear and further experiment is necessary.
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Nanoscale Carbon
All References Cited
External Review Draft
Impacts
Analytical Methods
Peer Reviewed Draft
Impacts
Priority Area: Ch. 5 and Appendix F
Research Planning: Ch. 6
Final Case Study
Impacts
Priority Area: Ch. 5 and Appendix F
Research Planning: Ch. 6
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