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Citation
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HERO ID
10946
Reference Type
Journal Article
Title
Cytogenetic biomonitoring of styrene-exposed plastic boat builders
Author(s)
Artuso, M; Angotzi, G; Bonassi, S; Bonatti, S; De Ferrari, M; Gargano, D; Lastrucci, L; Miligi, L; Sbrana, C; Abbandandolo, A
Year
1995
Is Peer Reviewed?
Yes
Journal
Archives of Environmental Contamination and Toxicology
ISSN:
0090-4341
EISSN:
1432-0703
Publisher
SPRINGER VERLAG
Location
NEW YORK
Report Number
EMIC/97709
Volume
29
Issue
2
Page Numbers
270-274
Language
English
PMID
7661632
DOI
10.1007/BF00212980
Web of Science Id
WOS:A1995RG14900017
Abstract
Earlier studies have produced evidence for an association between work-related styrene exposure and cytogenetic damage, while more recent studies have failed to show such an association. In the present study, chromosome aberrations (CA) and sister chromatid exchanges (SCE) were measured in peripheral blood lymphocytes of 46 male workers employed in a fiber-reinforced plastic boat building factory and exposed to styrene. Two groups of 23 workers each, characterized by different exposure levels (ranges: 2-120 mg/rn3 and 86-1389 mg/m3 ambient air) were studied, fifty-one controls matched by sex, age and smoking habits were included. Randomized blood samples were analyzed for cytogenetic damage separately in two laboratories. Interlaboratory differences in the scoring of CA and SCE were noted. However, increases of the considered cytogenetic endpoints in exposed vs control groups were consistently observed in both laboratories. Multivariate statistical analysis of pooled data revealed increases of CA ranging between 19% (RR = 1.19; 95% C.I., 0.80-I .78; chromatid-type aberrations, low exposure group) and 144% (RR = 2.44; 95% C.I., 1.26-4.70; chromosome-type aberrations, high exposure group). Parallel excess of SCE in styrene exposed workers was also observed, although at a lesser extent (RR = 1.22; 95% C.I., 1.05-1.43, low exposure group; RR = 1.26; 95% C.I.,1.07-1.47, high exposure group). These findings suggest the presence of a causal association between occupational exposure to styrene and cytogenetic damage in the plastic boat building factory that was the object of the study.
Tags
•
Mouse Lung Tumor Workshop 2014
Cited
Session 1 – Epidemiology and Human Pathophysiology
Epidemiology
Styrene Epi
Session 4 – Cellular & Subcellular Events
Genotoxicity
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