Synthesis of novel L-series 2',3'-dideoxy-3'-hydroxymethylnucleosides and a convenient method for the separation of nucleoside anomers
Gould, JHM; Mann, J
| HERO ID | 1188503 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Synthesis of novel L-series 2',3'-dideoxy-3'-hydroxymethylnucleosides and a convenient method for the separation of nucleoside anomers |
| Authors | Gould, JHM; Mann, J |
| Volume | 16 |
| Issue | 1-2 |
| Page Numbers | 193-213 |
| Abstract | Photoinduced addition of methanol to 5(R)-(tert- butyldimethylsilyloxymethyl) -2(5H)-furan-2-one (derived from L-gulono-1,4- lactone) provided the photoadduct 5(R)-(tert-butyldimethylsiloxymethyl)- 4(S)-hydroxymethyl-tetrahydrofuran-2-one, which was converted into two L- series-2',3'-dideoxy-3'-hydroxymethyl-nucleosides. In addition, we describe a new method for the chromatographic separation of cytidine anomers using a N- 2-(4-nitrophenyl)ethyl carbamate derivative. |
| Doi | 10.1080/07328319708002533 |
| Wosid | WOS:A1997WL66400018 |
| Url | http://www.tandfonline.com/doi/abs/10.1080/07328319708002533 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science A1997WL66400018 Journal:NUCLEOSIDES & NUCLEOTIDES |
| Is Public | Yes |
| Language Text | English |
| Keyword | article; chromatography; drug synthesis; hepatitis; nonhuman; nucleotide metabolism; protein structure; protein targeting; structure analysis |
| Is Qa | No |