US EPA

1248055 

Journal Article 

Viremia and serum antibodies in Macacus rhesus monkey after inapparent infection with European tick-borne encephalitis virus 

Slonim, D; Závadová, H 

1977 

Yes 

Journal of Hygiene, Epidemiology, Microbiology and Immunology
ISSN: 0022-1732 

21 

4 

460-464 

English 

417136 

1. Inapparent infection was called forth in M. rhesus monkeys by means of subcutaneous inoculation of ETBE virus. 2. Viremia was found in 18 (86 per cent) of 21 monkeys. In all the 18 monkeys, specific virus-neutralizing antibodies were found; in 17 of them complement-fixing antibodies developed in addition. 3. Neutralizing antibodies (N greater than or equal to 1.7 log10) were first recorded on 10th day with a peak on 32nd day, retaining, after a small decrease, a relatively high level in all reacting animals. 4. Complement-fixing antibodies were first found on 18th day, showing a peak on 22nd day whereafter they dropped considerably or even disappeared so that on 150th day they were present in a low titre in only 35 per cent of the originally reacting monkeys. 5. The findings were compared with the situation in naturally infected humans and in hamsters infected inapparently (experimentally) with ETBE virus.