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HERO ID
1248942
Reference Type
Journal Article
Title
Influence of age on arsenic-induced oxidative stress in rat
Author(s)
Jain, A; Flora, GJ; Bhargava, R; Flora, SJ
Year
2012
Is Peer Reviewed?
Yes
Journal
Biological Trace Element Research
ISSN:
0163-4984
EISSN:
1559-0720
Volume
149
Issue
3
Page Numbers
382-390
Language
English
PMID
22614922
DOI
10.1007/s12011-012-9432-7
Web of Science Id
WOS:000311310800012
Abstract
Influence of age on arsenic-induced (0.05, 0.1, and 0.2 lethal dose to 50 % population (LD(50)) given intraperitoneally) oxidative stress was investigated in young, adult, and old rats at days 7 and 14 post-exposure. A significant dose-dependent effect of arsenic on biochemical variables suggestive of oxidative stress was noted at day 7 following exposure in old rats. The parameters which were significantly altered include an increased reactive oxygen species, thiobarbituric acid reactive substances (TBARS), catalase activity accompanied by a decreased glutathione level. At day 14 following arsenic exposure (0.05 and 0.1 LD(50) dose), we observed a significant oxidative injury as evident from significant depletion of superoxide dismutase (SOD) and catalase activities in blood and tissues in addition to more pronounced accumulation of arsenic in blood and tissues. Interestingly, the toxicity was pronounced in young and old rats compared with adult rats. Accumulation of arsenic found to be more prominent in old rats compared with young and adult, which might be due to impaired metabolism with ageing. We conclude that young and old animals are more vulnerable to the arsenic-induced oxidative injury which is comparable with arsenic accumulation in blood and tissues and duration of exposure.
Keywords
Arsenic; Oxidative stress; Glutathione; Age dependent
Tags
•
Arsenic Hazard ID
1. Initial Lit Search
PubMed
ToxNet
WOS
Considered New
2. Lit Search Updates through Oct 2015
WOS
Considered
4. Considered through Oct 2015
5. Additions through Oct 2015
6. Cluster Filter through Oct 2015
7. Other Studies through Oct 2015
MOA
iAs MOA Literature Categorization
Cytotoxicity and Regenerative Proliferation
Epigenetic Mechanisms
Immune
Susceptibility Category
Lifestages
Health Effect Category
Not Relevant
•
Arsenic (Inorganic)
1. Literature
PubMed
Toxline, TSCATS, & DART
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
4. Adverse Outcome Pathways/Networks Screening
Relevant
5. Susceptibility Screening
Relevant
Animal
•
Arsenic MOA
4. Adverse Outcome Pathways
Oxidative stress related effects (includes non-specific SH reactions)
5. Health Effect
Hematology, Hematopoietic System
1. MOA Literature Screening
Health Effect Screening
MOA Cluster
•
Arsenic Susceptibility
4. Susceptibility and Lifestages
Lifestages
5. Health Effect
Not Relevant
1. Susceptibility Literature Screening
Keyword Search
Life Stages Citation Mapping
10%-15%
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