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HERO ID
1249428
Reference Type
Journal Article
Title
Vanadium pentoxide: Use of relevant historical control data shows no evidence for a carcinogenic response in F344/N rats
Author(s)
Starr, TB; Macgregor, JA; Ehman, KD; Nikiforov, AI
Year
2012
Is Peer Reviewed?
1
Journal
Regulatory Toxicology and Pharmacology
ISSN:
0273-2300
EISSN:
1096-0295
Volume
64
Issue
1
Page Numbers
155-160
Language
English
PMID
22749912
DOI
10.1016/j.yrtph.2012.06.017
Web of Science Id
WOS:000308270400018
Abstract
The national toxicology program (NTP) chronic inhalation bioassay of vanadium pentoxide (V(2)O(5)) produced "clear" evidence of lung tumors in B6C3F1 mice, but only "some" and "equivocal" evidence in male and female F344/N rats, respectively. No significant pairwise differences or trends with V(2)O(5) concentration in male or female rat poly-3-adjusted tumor incidence were reported. The "some" and "equivocal" evidence descriptors arose from comparisons of V(2)O(5)-exposed group incidence rates with NTP-2000- and NIH-07-fed historical control (HC) group incidence ranges. NTP acknowledged that use of data from NIH-07-fed HC groups could be inappropriate because the V(2)O(5) study used the NTP-2000 diet, but few studies using this newer diet were available then. We supplemented the early NTP-2000 diet HC data with data from 25 additional NTP-2000 diet studies conducted subsequent to the V(2)O(5) bioassay. This widened the HC tumor incidence ranges, thereby weakening the limited evidence for the carcinogenicity of inhaled V(2)O(5) in rats relative to HCs. The male rat control group in the V(2)O(5) study also appeared to be a near-"outlier" relative to the expanded HC database, potentially invalidating any comparisons of exposed group incidence rates with those for HCs. We conclude that there is "no" evidence of V(2)O(5) carcinogenicity in male or female F344/N rats.
Keywords
Vanadium pentoxide; Historical controls; Weight of evidence descriptor; Carcinogenic risk assessment
Tags
IRIS
•
Vanadium Compounds - Problem Formulation
Items Screened
Literature Search: Jan 2010 - Mar 2019
PubMed
WoS
Combined data set
Dataset for title/abstract screening
Supplemental (TIAB)
Supplemental material
Reviews/no original data
•
Vanadium Inhalation
Literature Search: Jan 2010 – Mar 2019
PubMed
WoS
Combined Dataset
Dataset for title/abstract screening
Dataset for full text screening
Supplemental (full text)
Supplemental material
No original data
•
Vanadium Pentoxide (Draft, 2011)
Other
•
Mouse Lung Tumor Workshop 2014
Cited
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