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HERO ID
1249830
Reference Type
Journal Article
Title
Prenatal di-n-butyl phthalate exposure alters reproductive functions at adulthood in male rats
Author(s)
Giribabu, N; Sainath, SB; Reddy, PS
Year
2014
Is Peer Reviewed?
Yes
Journal
Environmental Toxicology
ISSN:
1520-4081
EISSN:
1522-7278
Book Title
Environ Toxicol.
Volume
29
Issue
5
Page Numbers
534-544
Language
English
PMID
22489061
DOI
10.1002/tox.21779
Web of Science Id
WOS:000333918700005
URL
https://search.proquest.com/docview/1539448341?accountid=171501
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Abstract
This study was aimed to investigate the reproductive health in adult male rats exposed to di-n-butyl phthalate (DBP) during embryonic development. Pregnant rats were injected with DBP and F1 male rats were weaned and on postnatal day 100, used for mating with normal cycling females to assess reproductive performance. After completion of cohabitation period, rats were analyzed for other reproductive end points. Transplacental exposure to DBP significantly decreased fertility in adult male rats. Prenatal exposure to DBP significantly decreased sperm density, number of motile sperms, viable sperms, and hypoosmotic swelling tail coiled sperms with an increase in morphological abnormalities in sperms. Testicular steroidogenic enzyme activity levels and serum testosterone levels were significantly decreased in rats exposed to DBP during embryonic development. In conclusion, transplacental exposure to DBP impairs male reproductive performance by decreasing steroidogenesis and spermatogenesis.
Keywords
sperm; rat; di-n-butyl phthalate; reproductive performance; testosterone
Tags
•
Dibutyl Phthalate (DBP)
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Pubmed
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Litsearch September 2014 - February 2015
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LitSearch Nov 2012
PubMed
Merged reference set
LitSearch Jan 2014 - Sep 2014
PubMed
Web of Science
Studies with Health Effects Data
Animal toxicology studies
•
Phthalates – Targeted Search for Epidemiological Studies
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Pubmed
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Source – Dec 2014 Update (Private)
Pubmed
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