US EPA

1250072 

Journal Article 

Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae 

Wu, HQ; Li, L; Li, J; He, ZD; Liu, ZG; Zeng, QQ; Wang, YS 

2012 

Yes 

Chemical and Pharmaceutical Bulletin
ISSN: 0009-2363
EISSN: 1347-5223 

Chem Pharm Bull (Tokyo). 2012; 60(2):178-82. [Chemical & pharmaceutical bulletin] 

60 

2 

178-182 

English 

22293476 

10.1248/cpb.60.178 

WOS:000299579100003 

https://search.proquest.com/docview/1460456918?accountid=171501
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This study characterized the acaricidal activity of constituents of patchouli oil extracted from (Pogostemon cablin (Blanco) BENTH) against the house dust mite, Dermatophagoides farinae. A new compound, 2-(1,3-dihydroxy-but-2-enylidene)-6-methyl-3-oxo-heptanoic acid (DHEMH), was isolated from patchouli oil and characterized by (1)H-NMR, (13)C-NMR, LC-MS and elemental analysis (EA). This active component was identified as the hydrolysate of pogostone. Fifteen other constituents found in patchouli oil were also identified by GC-MS, including patchouli alcohol and pogostone. LD(50) studies carried out over 24 h using contact toxicity tests identified DHEMH as the most toxic compound to D. farinae (2.04 μg/cm(2)), followed by patchouli oil (6.11 μg/cm(2)), benzyl benzoate (BP) (9.31 μg/cm(2)) and dibutyl phthalate (DBP) (58.52 μg/cm(2)). In vapor phase toxicity tests, all of these compounds were more effective in closed than open containers, indicating that the most efficient mode of delivery for these compounds is the vapor phase. These results indicate that DHEMH and patchouli oil merit further study as potential agents for the control of D. farinae. 

natural acaricide; Dermatophagoides farinae; Pogostemon cablin (Blanco); identification; action mode