Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1257853
Reference Type
Journal Article
Title
Lung function predicts mortality: 10-year follow-up after lung cancer screening among asbestos-exposed workers
Author(s)
Vehmas, T; Pallasaho, P; Piirilä, P
Year
2013
Is Peer Reviewed?
Yes
Journal
International Archives of Occupational and Environmental Health
ISSN:
0340-0131
EISSN:
1432-1246
Volume
86
Issue
6
Page Numbers
667-672
Language
English
PMID
22865327
DOI
10.1007/s00420-012-0803-3
Web of Science Id
WOS:000322261300006
Abstract
PURPOSE: To assess the predictive value of lung function impairment on mortality among asbestos-exposed workers. METHODS: A total of 590 workers originally screened for occupational lung disease including spirometry and pulmonary diffusing capacity measurements were followed up for mortality data (ICD-10 classification). The mean follow-up time was 10.5 years. Associations of different lung function parameters with mortality from all causes and from cardiovascular (I00-I99) and non-malignant respiratory diseases (J00-J99) were analysed. Factor analysis was used to create obstructive and restrictive factors. RESULTS: A total of 191 deaths were found altogether. Most measured lung function variables were associated with increased mortality when studied separately. Both decreased forced expiratory flow in one second (hazard ratio/measurement unit = 0.977, 95 % CI 0.969-0.988, p < 0.001) and impaired diffusing capacity (0.973, 0.965-0.981, p < 0.001) were independently associated with mortality from all causes, as well as from cardiovascular and non-malignant respiratory diseases. Both obstructive factor alone and the sum of obstructive and restrictive factors were associated with all studied mortality categories. The restrictive factor alone was associated with all-cause and respiratory mortality. CONCLUSIONS: Deteriorated lung function predicts deaths. The reasons for impaired lung function should be medically explored to enable restoring measures aiming thus to prevent premature deaths.
Keywords
Asbestos; Mortality; Occupational; Pulmonary diffusing capacity; Respiratory function tests
Tags
IRIS
•
Libby Amphibole Asbestos (Draft, 2011)
OPPT REs
•
OPPT_Asbestos, Part I: Chrysotile_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
On topic - additional tags for titles/abstracts
Human hazard ID
•
OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
LitSearch: Sept 2020 (Undated)
ProQuest
PubMed
Toxline
WoS
Legacy Uses
Health Outcomes
Exposure
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity