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Citation
Tags
HERO ID
1257859
Reference Type
Journal Article
Title
Localized pleural thickening: smoking and exposure to Libby vermiculite
Author(s)
Christensen, KY; Kopylev, L
Year
2012
Is Peer Reviewed?
1
Journal
Journal of Exposure Science & Environmental Epidemiology
ISSN:
1559-0631
EISSN:
1559-064X
Publisher
NATURE PUBLISHING GROUP
Location
NEW YORK
Volume
22
Issue
4
Page Numbers
320-323
Language
English
PMID
22534695
DOI
10.1038/jes.2012.18
Web of Science Id
WOS:000305694000002
URL
https://search.proquest.com/docview/1024663759?accountid=171501
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Abstract
There is limited research on the combined effects of smoking and asbestos exposure on risk of localized pleural thickening (LPT). This analysis uses data from the Marysville cohort of workers occupationally exposed to Libby amphibole asbestos (LAA). Workers were interviewed to obtain work and health history, including ever/never smoking and chest X-rays. Cumulative exposure estimates were developed on the basis of fiber measurements from the plant and work history. Benchmark concentration (BMC) methodology was used to evaluate the exposure-response relationship for exposure to LAA and a 10% increased risk of LPT, considering potential confounders and statistical model forms. There were 12 LPT cases among 118 workers in the selected study population. The mean exposure was 0.42 (SD=0.77) fibers/cc-year, and the prevalence of smoking history was 75.0% among cases and 51.9% among non-cases. When controlling for LAA exposure, smoking history was of borderline statistical significance (P-value=0.099), and its inclusion improved model fit, as measured by Akaike's Information Criterion. A comparison of BMC estimates was made to gauge the potential effect of smoking status. The BMC was 0.36 fibers/cc-year, overall. The BMC for non-smokers was approximately three times as high (1.02 fibers/cc-year) as that for the full cohort, whereas the BMC for smokers was about 1/2 that of the full cohort (0.17 fibers/cc-year).
Keywords
Libby; amphibole; asbestos; vermiculite; smoking; localized pleural thickening
Tags
IRIS
•
Libby Amphibole Asbestos (Draft, 2011)
Pulmonary Function Search, Sept 2013
Database Search
Excluded Based on Title/Abstract Screening
Did not examine study question
OPPT REs
•
OPPT_Asbestos, Part I: Chrysotile_C. Engineering
Total – title/abstract screening
On topic
Peer review
Primary source
•
OPPT_Asbestos, Part I: Chrysotile_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Other forms of asbestos
•
OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
LitSearch: Sept 2020 (Undated)
ProQuest
PubMed
Toxline
WoS
Vermiculite
Legacy Uses
Health Outcomes
Additional Legacy Terms
Exposure
Additional Legacy Terms
Suggested Legacy References
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