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1291040 
Journal Article 
Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood 
Olsen, GW; Huang, HY; Helzlsouer, KJ; Hansen, KJ; Butenhoff, JL; Mandel, JH 
2005 
Yes 
Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924 
113 
539-545 
English 
The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a large community health study. The study included a total of 356 samples (178 from each time period). These samples were analyzed by high-pressure liquid chromatography/tandem mass spectrometry methods. The median 1974 and 1989 fluorochemical concentrations, respectively, were as follows: PFOS, 29.5 ng/mL vs. 34.7 ng/mL; PFOA, 2.3 ng/mL vs. 5.6 ng/mL; perfluorohexanesulfonate (PFHS), 1.6 ng/mL vs. 2.4 ng/mL; and N-ethyl perfluorooctanesulfonamidoacetate (PFOSAA), less than the lower limit of quantitation (LLOQ; 1.6 ng/mL, vs. 3.4 ng/mL). For N-methyl perfluorooctanesulfonamidoacetate (M570), perfluorooctanesulfonamide, and perfluorooctanesulfonamidoacetate, median serum concentrations in both years were less than the LLOQ values (1.0, 1.0, and 2.5 ng/mL, respectively). Statistical analysis of 58 paired samples indicated that serum concentrations of PFOS, PFOSAA, PFOA, PFHS, and M570 were significantly (p < 0.001) higher in 1989 than in 1974. The data from 1989 were then compared with geometric mean fluorochemical concentrations of serum samples collected in 2001 from 108 American Red Cross adult blood donors from the same region. Except for M570, there were no statistically significant (p < 0.05) geometric mean fluorochemical concentration differences between the 1989 and 2001 samples. In conclusion, based on this study population, PFOS and other serum fluorochemical concentrations have increased between 1974 and 1989. Comparison with other regional data collected in 2001 did not suggest a continued increase in concentrations since 1989. 
fluorochemicals; perfluorohexanesulfonate; perfluorooctanesulfonate; perfluorooctanoate; PFHS; PFOA; PFOS 
PFAS
• NMeFOSAA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFHxS (355-46-4)
          Literature search
               Pubmed
               WOS
     PFOSA (754-91-6)
          Literature Search
               Pubmed
     NMeFOSAA (2355-31-9)
          Literature Search
               Pubmed
               WOS
• PFHxS
     Literature Search
          PubMed
          Toxline
          WOS
     Screening Results
          Excluded/Not on Topic
               PubMed
     Title and Abstract Screening
          Excluded
               Not relevant to PECO
• PFOSA
     Literature Search
          Pubmed
     Screening Results
          Excluded/Not on Topic